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Translocator protein Inhibitors (IC50, Ki)

Structure
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▼
Compound Name
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▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
1-(2-Chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamideIC501.1 [1], 2.5 [2], 490.0 [3]
1-(2-Chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamideKi4.5 [1], 7.11 [2], 29.2 [3], 36.0 [4]
N,N-Diethyl-2-(2-(4-methoxyphenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)acetamideKi6.68 [1], 8.2 [2], 19.5 [3], 98.8 [4]
N-(2,5-Dimethoxybenzyl)-N-(5-fluoro-2-phenoxyphenyl)acetamideKi0.19 [1], 0.2 [2], 0.24 [3]
2-[1-Methyl-2-(4-nitrophenyl)indol-3-yl]-2-oxo-N,N-dipropylacetamideKi1.57 [1], 1.82 [2], 9.53 [3]
EmapunilKi6.4 [1], 31.3 [2]
N,N-Diethyl-2-[2-(4-methoxyphenyl)-4,6-dimethylindol-1-yl]acetamideKi28.13 [1], 806.0 [2]
N,N-Diethyl-2-[2-(4-methoxyphenyl)-4,6-dimethylbenzimidazol-1-yl]acetamideKi224.46 [1], 398.18 [2]
N,N-Diethyl-2-[2-(4-methoxyphenyl)-5,7-dimethylimidazo[4,5-b]pyridin-3-yl]acetamideKi29.11 [1], 144.33 [2]
N,N-Diethyl-2-[8-(4-methoxyphenyl)-2,6-dimethylpurin-9-yl]acetamideKi10000.0 [1]
9H-Carbazole-9-acetamide, N,N-diethyl-Ki30.1 [1], 176.6 [2]
N,N-Diethyl-2-[3-(4-methoxyphenyl)carbazol-9-yl]acetamideKi28.9 [1], 93.4 [2]
N,N-Diethyl-2-[3-(2-methoxyphenyl)carbazol-9-yl]acetamideKi25.4 [1], 137.3 [2]
N-Benzyl-2-(3-bromocarbazol-9-yl)-N-ethylacetamideKi54.3 [1], 123.4 [2]
N-Benzyl-2-carbazol-9-yl-N-ethylacetamideKi91.6 [1], 459.6 [2]
2-(3-Bromocarbazol-9-yl)-N,N-diethylacetamideKi31.5 [1], 160.9 [2]
N,N-Diethyl-2-(3-phenylcarbazol-9-yl)acetamideKi31.6 [1], 159.8 [2]
DiazepamIC50123594743.3 [1]
LorazepamIC50285759054.3 [1]
ClonazepamIC50555904257.3 [1]
FlunitrazepamIC50263026799.2 [1]
OxazepamIC5055590425.73 [1]
NitrazepamIC50100000000.0 [1]
TemazepamIC5062517269.28 [1]
NordazepamIC50106414301.8 [1]
N,N-Dihexyl-2-(4-fluorophenyl)indole-3-acetamideKi3.25 [1]
DelorazepamIC50555904257.3 [1]
N-(2-Methoxybenzyl)-N-(4-phenoxypyridin-3-yl)acetamideKi2.5 [1]
5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-carboxamideIC502000.0 [1]
HalazepamIC5010864256.24 [1]
7-AminoflunitrazepamIC5015381546.4 [1]
NorfludiazepamIC50500034535.0 [1]
2H-1,4-Benzodiazepin-2-one, 5-(2-chlorophenyl)-1,3-dihydro-3-methyl-7-nitro-, (R)-IC50833681184.6 [1]
Acetamide, N-(5-fluoro-2-phenoxyphenyl)-N-((2-methoxy-5-(methoxy-11C)phenyl)methyl)-Ki0.24 [1]
7-AminoclonazepamIC5013335214.32 [1]
Unii-FS47vof3O7Ki1.0 [1]
NaluzotanKi2000.0 [1]
NorflunitrazepamIC50666806769.2 [1]
1,3-Dihydro-5-phenyl-2H-1,4-benzodiazepin-2-oneIC502857590.54 [1]
7-AminonitrazepamIC502588212.92 [1]
5-(2-Chlorophenyl)-1,3-dihydro-1-methyl-7-nitro-2H-1,4-benzodiazepin-2-oneIC50454988060.2 [1]
MivebresibIC50800.0 [1]
(3r)-5-(2-Fluorophenyl)-1,3-dimethyl-7-nitro-1,3-dihydro-2h-1,4-benzodiazepin-2-oneIC50142889395.9 [1]
1H-1,4-Benzodiazepine-7-carbonitrile, 2,3-dihydro-1-methyl-2-oxo-5-phenyl-IC502630267.99 [1]
5-(2-Fluorophenyl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-oneIC5071449632.61 [1]
2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-5-phenyl-7-(trifluoromethyl)-IC5076913044.03 [1]
7-Fluoro-5-phenyl-1,3-dihydro-2h-1,4-benzodiazepin-2-oneIC5025003453.62 [1]
N-(4-Chloro-2-phenoxyphenyl)-N-(2-isopropoxybenzyl)acetamideIC500.92 [1]
N-(3-(3,6-Dibromo-9H-carbazol-9-yl)-2-fluoropropyl)-3-methoxyanilineIC502000.0 [1]
CID 53245590Ki2540.0 [1]
5-(2-Fluorophenyl)-7-iodo-1-methyl-1,3-dihydro-2h-1,4-benzodiazepin-2-oneIC50345143739.3 [1]
1,3-Dihydro-7-nitro-5-(alpha,alpha,alpha-trifluoro-o-tolyl)2H-1,4-benzodiazepin-2-oneIC50285759054.3 [1]
7-Fluoro-5-(2-fluorophenyl)-1-methyl-3H-1,4-benzodiazepin-2-oneIC50195884467.4 [1]
5-Acetyl-6-(2-chloro-4-phenylmethoxyphenyl)-1-hydroxy-9,9-dimethyl-6,8,10,11-tetrahydrobenzo[b][1,4]benzodiazepin-7-oneIC5030000000.0 [1]
N-(6-Fluoro-4-phenoxypyridin-3-yl)-N-[(2-methoxyphenyl)methyl]acetamideKi1.19 [1]
7-Chloro-5-(2,6-dichlorophenyl)-1-methyl-1H-benzo[e][1,4]diazepin-2(3H)-oneIC50181970085.9 [1]
5-(2-Fluorophenyl)-7,8-dichloro-1H-1,4-benzodiazepin-2(3H)-oneIC50277971326.8 [1]
7-Chloro-5-(2,6-dichlorophenyl)-1,3-dihydro-1,4-benzodiazepin-2-oneIC50142889395.9 [1]
5-Phenyl-7-ethenyl-1H-1,4-benzodiazepin-2(3H)-oneIC5041686938.35 [1]
7,8-Dichloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-oneIC5025003453.62 [1]
5-(2-Fluorophenyl)-8-chloro-7-methyl-1H-1,4-benzodiazepin-2(3H)-oneIC5071449632.61 [1]
2H-1,4-Benzodiazepin-2-one, 7-chloro-1-(1,1-dimethylethyl)-1,3-dihydro-5-phenyl-IC501614358.56 [1]
MotrazepamIC502328091.26 [1]
7-Ethyl-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-oneIC5027797132.68 [1]
5-(2-Chlorophenyl)-1-methyl-3H-1,4-benzodiazepin-2-oneIC50263026799.2 [1]
(6-Chloro-1,3-benzodioxol-5-yl)methyl 4-(2-oxo-3H-benzimidazol-1-yl)piperidine-1-carboxylateIC501040.0 [1]
N,N-Dibutyl-2-[6,8-dichloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl]acetamideKi2.68 [1]
Unii-82MI0GT75ZKi2.47 [1]
2-[4-[4-(3-Methoxyphenyl)piperazin-1-yl]butyl]-4-methyl-1,2,4-triazine-3,5-dioneKi10000.0 [1]
1,3-Dihydro-5-(2-fluorophenyl)-2H-1,4-benzodiazepin-2-oneIC5047643098.68 [1]
7-Bromo-5-(2,6-difluorophenyl)-1-methyl-3H-1,4-benzodiazepin-2-oneIC50416869383.5 [1]
2H-1,4-Benzodiazepin-2-one, 5-(2-fluorophenyl)-1,3-dihydro-7-(hydroxyamino)-1-methyl-IC5010423174.29 [1]
4-Fluoro-N-methyl-N-(4-(6-(methylamino)pyrimidin-4-yl)-1,3-thiazol-2-yl)benzamideKi10000.0 [1]
5-(2-Fluorophenyl)-1-methyl-2-oxo-3H-1,4-benzodiazepine-7-carbonitrileIC5033342641.28 [1]
7-Amino-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-oneIC502172701.18 [1]
8-Chloro-5-(2,6-difluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepine-2-oneIC5035727283.82 [1]
7-Chloro-5-(2,6-difluorophenyl)-1H-benzo[e][1,4]diazepin-2(3H)-oneIC50625172692.8 [1]
7-Acetyl-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepine-2-oneIC5055590425.73 [1]
2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-5-(2-fluorophenyl)-1-(2-hydroxyethyl)-IC5040831938.63 [1]
2-Oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepine-7-carbaldehydeIC5023280912.58 [1]
7-Fluoro-5-(2-fluorophenyl)-1,3-dihydro-1,4-benzodiazepin-2-oneIC50135207256.3 [1]
3,7-Dichloro-5-(2-fluorophenyl)-1,3-dihydro-1,4-benzodiazepin-2-oneIC50188799134.9 [1]
1,7-Dichloro-3-methyl-5-phenyl-3H-1,4-benzodiazepin-2-oneIC5020417379.45 [1]
5-(2-Fluorophenyl)-8-methyl-1,3-dihydro-1,4-benzodiazepin-2-oneIC5052601726.64 [1]
1-Tert-butyl-5-(2-fluorophenyl)-7-nitro-3H-1,4-benzodiazepin-2-oneIC503334264.13 [1]
7-Fluoro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-oneIC5058884365.54 [1]
7-Chloro-5-(2-chloro-6-fluorophenyl)-1,3-dihydro-1,4-benzodiazepin-2-oneIC50333426412.8 [1]
7-Azido-5-(2-fluorophenyl)-1,3-dihydro-1,4-benzodiazepin-2-oneIC50188799134.9 [1]
7-Chloro-5-(2,6-difluorophenyl)-1-methyl-1H-benzo[e][1,4]diazepin-2(3H)-oneIC50243781081.8 [1]
5-(2,6-Difluorophenyl)-1,3-dihydro-1,4-benzodiazepin-2-oneIC5052601726.64 [1]
N-[(2,5-Dimethoxyphenyl)methyl]-N-(4-fluoro-2-phenoxyphenyl)acetamideIC501.6 [1]
(111C)Methyl 2-[(N-acetyl-2-phenoxyanilino)methyl]benzoateKi1.4 [1]
(4S)-N,N-Diethyl-9-(2-fluoroethyl)-1,2,3,4-tetrahydrocarbazole-4-carboxamideKi0.87 [1]
18,19-Dimethoxy-13-methyl-15-phenyl-5,7-dioxa-13-azapentacyclo[10.7.1.02,10.04,8.016,20]icosa-1(20),2,4(8),9,16,18-hexaeneKi2897.0 [1]
19-[(4-Bromophenyl)methoxy]-18-methoxy-13-methyl-5,7-dioxa-13-azapentacyclo[10.7.1.02,10.04,8.016,20]icosa-1(20),2,4(8),9,16,18-hexaeneKi900.0 [1]
N-[(2S)-Butan-2-yl]-1-(2-chlorophenyl)-N-(111C)methylisoquinoline-3-carboxamideKi4.5 [1]
Ethyl (1S,2R,3S,4R,5S)-4-[2-chloro-6-(dicyclopropylmethylamino)purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hexane-1-carboxylateKi2100.0 [1]
Propyl (1S,2R,3S,4R,5S)-4-[2-chloro-6-(dicyclopropylmethylamino)purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hexane-1-carboxylateKi2200.0 [1]
N-(2-Aminoethyl)-3-[(21S,22S)-16-ethenyl-11-ethyl-4-hydroxy-12,17,21,26-tetramethyl-7,23,24,25-tetrazahexacyclo[18.2.1.15,8.110,13.115,18.02,6]hexacosa-1,4,6,8(26),9,11,13(25),14,16,18(24),19-undecaen-22-yl]propanamideIC505600.0 [1]
N-[6-[3-[(21S,22S)-16-Ethenyl-11-ethyl-4-hydroxy-12,17,21,26-tetramethyl-7,23,24,25-tetrazahexacyclo[18.2.1.15,8.110,13.115,18.02,6]hexacosa-1,4,6,8(26),9,11,13(25),14,16,18(24),19-undecaen-22-yl]propanoylamino]hexyl]-1-(2-iodophenyl)isoquinoline-3-carboxamideIC50310.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Translocator protein Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Nov. 2024, https://www.aatbio.com/data-sets/translocator-protein-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 20). Quest Database™ Translocator protein Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/translocator-protein-inhibitors-ic50-ki.
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