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Transient receptor potential cation channel subfamily V member 4 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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2-Methyl-1-(3-morpholin-4-ylpropyl)-5-phenyl-N-[3-(trifluoromethyl)phenyl]pyrrole-3-carboxamideIC5029.0 [1], 48.0 [2], 57.0 [3]
[6-[[4-(2,4-Dimethyl-1,3-thiazol-5-yl)-1,3-thiazol-2-yl]amino]pyridin-3-yl]-[3-[5-(trifluoromethyl)pyrimidin-2-yl]-3,8-diazabicyclo[3.2.1]octan-8-yl]methanoneIC500.22 [1], 0.4 [2], 10000.0 [3]
9-[6-[[4-(2,4-Dimethyl-1,3-thiazol-5-yl)-1,3-thiazol-2-yl]amino]pyridine-3-carbonyl]-3-oxa-9-azabicyclo[3.3.1]nonan-7-oneIC503.1 [1], 19.0 [2]
2,4-Dichloro-N-isopropyl-N-(2-isopropylaminoethyl)benzenesulfonamideIC502300.0 [1]
2-Methyl-1-(3-morpholin-4-ylpropyl)-N,5-diphenylpyrrole-3-carboxamideIC501500.0 [1]
2-Methyl-1-(3-morpholin-4-ylpropyl)-N,5-diphenylpyrrole-3-carboxamideKi678.0 [1]
CID 121513880IC50420.0 [1], 570.0 [2]
CID 49783953IC503000.0 [1], 10000.0 [2]
8-[6-[[4-(2,4-Dimethyl-1,3-thiazol-5-yl)-1,3-thiazol-2-yl]amino]pyridine-3-carbonyl]-8-azabicyclo[3.2.1]octan-3-oneIC5024.0 [1]
[3-(5-Chloropyrimidin-2-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl]-[6-[[4-(2,4-dimethyl-1,3-thiazol-5-yl)-1,3-thiazol-2-yl]amino]pyridin-3-yl]methanoneIC500.3 [1]
[6-[[4-(2,4-Dimethyl-1,3-thiazol-5-yl)-1,3-thiazol-2-yl]amino]pyridin-3-yl]-[(1S,5R)-3-hydroxy-8-azabicyclo[3.2.1]octan-8-yl]methanoneIC5032.0 [1], 650.0 [2]
[6-[[4-(2,4-Dimethyl-1,3-thiazol-5-yl)-1,3-thiazol-2-yl]amino]pyridin-3-yl]-[3-[6-(trifluoromethyl)pyridazin-3-yl]-3,8-diazabicyclo[3.2.1]octan-8-yl]methanoneIC501.3 [1], 2.2 [2]
[6-[[4-(2,4-Dimethyl-1,3-thiazol-5-yl)-1,3-thiazol-2-yl]amino]pyridin-3-yl]-[3-[5-(trifluoromethyl)pyrazin-2-yl]-3,8-diazabicyclo[3.2.1]octan-8-yl]methanoneIC500.71 [1], 2.6 [2]
[6-[[4-(2,4-Dimethyl-1,3-thiazol-5-yl)-1,3-thiazol-2-yl]amino]pyridin-3-yl]-[3-[5-(trifluoromethyl)pyridin-2-yl]-3,8-diazabicyclo[3.2.1]octan-8-yl]methanoneIC501.4 [1], 2.2 [2]
[6-[[4-(2,4-Dimethyl-1,3-thiazol-5-yl)-1,3-thiazol-2-yl]amino]pyridin-3-yl]-[3-[2-(trifluoromethyl)pyrimidin-5-yl]-3,8-diazabicyclo[3.2.1]octan-8-yl]methanoneIC506.3 [1], 23.0 [2]
4-[[1-[(2,4-Dichlorophenyl)sulfonyl]-4-hydroxypiperidine-4-yl]methoxy]-2-fluorobenzonitrileIC5012.9 [1], 130.0 [2]
4-((1-((2,4-Dichlorophenyl)sulfonyl)-3-hydroxyazetidin-3-yl)methoxy)-2-fluorobenzonitrileIC503.8 [1], 50.0 [2]
1-[2-[(2-Chloro-6-fluorophenyl)methylsulfanyl]ethyl]-2-methyl-5-phenyl-N-[3-(trifluoromethyl)phenyl]pyrrole-3-carboxamideIC501200.0 [1], 1600.0 [2]
2-Methyl-5-phenyl-1-(3-piperidin-1-ylpropyl)-N-[3-(trifluoromethyl)phenyl]pyrrole-3-carboxamideIC5082.0 [1]
2-Methyl-5-phenyl-1-(3-piperidin-1-ylpropyl)-N-[3-(trifluoromethyl)phenyl]pyrrole-3-carboxamideKi327.0 [1]
5-Tert-butyl-2-methyl-1-(3-morpholin-4-ylpropyl)-N-[3-(trifluoromethyl)phenyl]pyrrole-3-carboxamideIC50360.0 [1]
5-Tert-butyl-2-methyl-1-(3-morpholin-4-ylpropyl)-N-[3-(trifluoromethyl)phenyl]pyrrole-3-carboxamideKi197.0 [1]
1-(3-Hydroxypropyl)-2-methyl-5-phenyl-N-[3-(trifluoromethyl)phenyl]pyrrole-3-carboxamideIC502300.0 [1]
1-(3-Hydroxypropyl)-2-methyl-5-phenyl-N-[3-(trifluoromethyl)phenyl]pyrrole-3-carboxamideKi1059.0 [1]
2-Methyl-1-(3-morpholin-4-ylpropyl)-N-[3-(trifluoromethyl)phenyl]pyrrole-3-carboxamideIC508900.0 [1]
2-Methyl-1-(3-morpholin-4-ylpropyl)-N-[3-(trifluoromethyl)phenyl]pyrrole-3-carboxamideKi1454.0 [1]
1-[2-Methyl-1-(3-morpholin-4-ylpropyl)-5-phenylpyrrol-3-yl]-3-[3-(trifluoromethyl)phenyl]ureaIC503900.0 [1]
1-[2-Methyl-1-(3-morpholin-4-ylpropyl)-5-phenylpyrrol-3-yl]-3-[3-(trifluoromethyl)phenyl]ureaKi1611.0 [1]
2-Methyl-1-(2-morpholin-4-ylethyl)-5-phenyl-N-[3-(trifluoromethyl)phenyl]pyrrole-3-carboxamideIC50400.0 [1]
2-Methyl-1-(2-morpholin-4-ylethyl)-5-phenyl-N-[3-(trifluoromethyl)phenyl]pyrrole-3-carboxamideKi443.0 [1]
Methyl N-[3-[2-methyl-5-phenyl-3-[[3-(trifluoromethyl)phenyl]carbamoyl]pyrrol-1-yl]propyl]carbamateIC501800.0 [1]
Methyl N-[3-[2-methyl-5-phenyl-3-[[3-(trifluoromethyl)phenyl]carbamoyl]pyrrol-1-yl]propyl]carbamateKi936.0 [1]
N-[2-Methyl-1-(3-morpholin-4-ylpropyl)-5-phenylpyrrol-3-yl]-3-(trifluoromethyl)benzenesulfonamideIC507400.0 [1]
N-[2-Methyl-1-(3-morpholin-4-ylpropyl)-5-phenylpyrrol-3-yl]-3-(trifluoromethyl)benzenesulfonamideKi1801.0 [1]
1-[3-(Methanesulfonamido)propyl]-2-methyl-5-phenyl-N-[3-(trifluoromethyl)phenyl]pyrrole-3-carboxamideIC50860.0 [1]
1-[3-(Methanesulfonamido)propyl]-2-methyl-5-phenyl-N-[3-(trifluoromethyl)phenyl]pyrrole-3-carboxamideKi427.0 [1]
1-(3-Morpholin-4-ylpropyl)-5-phenyl-2-(trifluoromethyl)-N-[3-(trifluoromethyl)phenyl]pyrrole-3-carboxamideIC503800.0 [1]
1-(3-Morpholin-4-ylpropyl)-5-phenyl-2-(trifluoromethyl)-N-[3-(trifluoromethyl)phenyl]pyrrole-3-carboxamideKi1707.0 [1]
1-(3-Acetamidopropyl)-2-methyl-5-phenyl-N-[3-(trifluoromethyl)phenyl]pyrrole-3-carboxamideIC503200.0 [1]
1-(3-Acetamidopropyl)-2-methyl-5-phenyl-N-[3-(trifluoromethyl)phenyl]pyrrole-3-carboxamideKi1134.0 [1]
1-(4-Aminocyclohexyl)-5-tert-butyl-2-methyl-N-[3-(trifluoromethyl)phenyl]pyrrole-3-carboxamideIC504100.0 [1], 5300.0 [2]
5-Tert-butyl-1-[4-(methanesulfonamido)cyclohexyl]-2-methyl-N-[3-(trifluoromethyl)phenyl]pyrrole-3-carboxamideIC506000.0 [1], 8700.0 [2]
2-Methyl-1-[3-(3-oxopiperazin-1-yl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]pyrrole-3-carboxamideIC50260.0 [1]
2-Methyl-1-[3-(3-oxopiperazin-1-yl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]pyrrole-3-carboxamideKi196.0 [1]
1-[3-[Bis(2-hydroxyethyl)amino]propyl]-2-methyl-5-phenyl-N-[3-(trifluoromethyl)phenyl]pyrrole-3-carboxamideIC50130.0 [1]
1-[3-[Bis(2-hydroxyethyl)amino]propyl]-2-methyl-5-phenyl-N-[3-(trifluoromethyl)phenyl]pyrrole-3-carboxamideKi191.0 [1]
N-Methyl-N-[3-[2-methyl-5-phenyl-3-[[3-(trifluoromethyl)phenyl]carbamoyl]pyrrol-1-yl]propyl]-1,2-oxazole-5-carboxamideIC50510.0 [1]
N-Methyl-N-[3-[2-methyl-5-phenyl-3-[[3-(trifluoromethyl)phenyl]carbamoyl]pyrrol-1-yl]propyl]-1,2-oxazole-5-carboxamideKi251.0 [1]
2-Methyl-1-(3-morpholin-4-ylpropyl)-5-phenyl-N-[4-(trifluoromethyl)phenyl]pyrrole-3-carboxamideIC50340.0 [1]
2-Methyl-1-(3-morpholin-4-ylpropyl)-5-phenyl-N-[4-(trifluoromethyl)phenyl]pyrrole-3-carboxamideKi755.0 [1]
1-[3-[Acetyl(methyl)amino]propyl]-2-methyl-5-phenyl-N-[3-(trifluoromethyl)phenyl]pyrrole-3-carboxamideIC50590.0 [1]
1-[3-[Acetyl(methyl)amino]propyl]-2-methyl-5-phenyl-N-[3-(trifluoromethyl)phenyl]pyrrole-3-carboxamideKi1682.0 [1]
1-(3-Methoxypropyl)-2-methyl-5-phenyl-N-[3-(trifluoromethyl)phenyl]pyrrole-3-carboxamideIC50800.0 [1]
1-(3-Methoxypropyl)-2-methyl-5-phenyl-N-[3-(trifluoromethyl)phenyl]pyrrole-3-carboxamideKi714.0 [1]
2-Methyl-1-(3-morpholin-4-ylpropyl)-5-phenyl-N-[2-(trifluoromethyl)phenyl]pyrrole-3-carboxamideIC502400.0 [1]
2-Methyl-1-(3-morpholin-4-ylpropyl)-5-phenyl-N-[2-(trifluoromethyl)phenyl]pyrrole-3-carboxamideKi2484.0 [1]
1-[3-[Cyclopentanecarbonyl(methyl)amino]propyl]-2-methyl-5-phenyl-N-[3-(trifluoromethyl)phenyl]pyrrole-3-carboxamideIC50240.0 [1]
1-[3-[Cyclopentanecarbonyl(methyl)amino]propyl]-2-methyl-5-phenyl-N-[3-(trifluoromethyl)phenyl]pyrrole-3-carboxamideKi418.0 [1]
2-Methyl-1-[3-[methyl(2-methylpropyl)amino]propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]pyrrole-3-carboxamideIC50640.0 [1]
2-Methyl-1-[3-[methyl(2-methylpropyl)amino]propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]pyrrole-3-carboxamideKi1612.0 [1]
1-[3-(4-Acetylpiperazin-1-yl)propyl]-2-methyl-5-phenyl-N-[3-(trifluoromethyl)phenyl]pyrrole-3-carboxamideIC502600.0 [1]
1-[3-(4-Acetylpiperazin-1-yl)propyl]-2-methyl-5-phenyl-N-[3-(trifluoromethyl)phenyl]pyrrole-3-carboxamideKi1436.0 [1]
2-Methyl-1-(3-morpholin-4-ylpropyl)-5-pyridin-3-yl-N-[3-(trifluoromethyl)phenyl]pyrrole-3-carboxamideIC50610.0 [1]
2-Methyl-1-(3-morpholin-4-ylpropyl)-5-pyridin-3-yl-N-[3-(trifluoromethyl)phenyl]pyrrole-3-carboxamideKi379.0 [1]
1-[3-(Dimethylamino)propyl]-2-methyl-5-phenyl-N-[3-(trifluoromethyl)phenyl]pyrrole-3-carboxamideIC50330.0 [1]
1-[3-(Dimethylamino)propyl]-2-methyl-5-phenyl-N-[3-(trifluoromethyl)phenyl]pyrrole-3-carboxamideKi169.0 [1]
2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamideIC5010000.0 [1]
(1e,3e)-1-(4-Fluorophenyl)-2-methylpent-1-en-3-one oximeIC5010000.0 [1]
7-Bromo-N-(1-phenylcyclopropyl)-3-[(4-piperidin-1-ylpiperidin-1-yl)methyl]-2-[3-(trifluoromethyl)phenyl]quinoline-4-carboxamideIC5040.0 [1]
N-[2-Methyl-3-[[4-[4-[[4-(trifluoromethoxy)phenyl]methoxy]piperidin-1-yl]-1,3,5-triazin-2-yl]amino]phenyl]acetamideIC5010000.0 [1]
4-(2,4-Dimethyl-1,3-thiazol-5-yl)-N-pyridin-2-yl-1,3-thiazol-2-amineIC5010.0 [1]
2',4'-Dimethyl-N-(pyridin-3-yl)-4,5'-bi-1,3-thiazol-2-amineIC50490.0 [1]
[2-(4-Chloro-2-fluoroanilino)-5-methyl-1,3-thiazol-4-yl]-[(2S,3S)-2,3-dimethylpiperidin-1-yl]methanoneIC5012500.0 [1]
N-(4-Bromophenyl)-4-(2,4-dimethyl-1,3-thiazol-5-yl)-1,3-thiazol-2-amineIC5034.0 [1]
(R)-8-{5-[3-Methyl-4-(trifluoromethyl)phenyl]oxazol-2-ylamino}-1,2,3,4-tetrahydronaphthalen-2-olIC50100000.0 [1]
4-[3-(3-Methoxypropoxy)phenyl]-2-sulfanylidene-3,4-dihydro-1H-indeno[1,2-d]pyrimidin-5-oneIC5010000.0 [1]
4-(2,4-Dimethyl-1,3-thiazol-5-yl)-N-pyridin-4-yl-1,3-thiazol-2-amineIC503300.0 [1]
N-[(1R)-2-Amino-2-oxo-1-phenylethyl]-N-[(1R)-1-(3,5-difluorophenyl)ethyl]benzamideIC5030000.0 [1]
[6-[[4-(2,4-Dimethyl-1,3-thiazol-5-yl)-1,3-thiazol-2-yl]amino]pyridin-3-yl]-[(1R,5S)-3-methoxy-8-azabicyclo[3.2.1]octan-8-yl]methanoneIC502.4 [1]
6-[[4-(2,4-Dimethyl-1,3-thiazol-5-yl)-1,3-thiazol-2-yl]amino]pyridine-3-carbonitrileIC5022.0 [1]
N-(4-Chlorophenyl)-6-[[4-(2,4-dimethyl-1,3-thiazol-5-yl)-1,3-thiazol-2-yl]amino]pyridine-3-sulfonamideIC50290.0 [1]
[6-[[4-(2,4-Dimethyl-1,3-thiazol-5-yl)-1,3-thiazol-2-yl]amino]pyridin-3-yl]-piperidin-1-ylmethanoneIC5037.0 [1]
N-[(4-Chlorophenyl)methyl]-6-[[4-(2,4-dimethyl-1,3-thiazol-5-yl)-1,3-thiazol-2-yl]amino]pyridine-3-carboxamideIC50200.0 [1]
4-Chloro-N-[6-[[4-(2,4-dimethyl-1,3-thiazol-5-yl)-1,3-thiazol-2-yl]amino]pyridin-3-yl]benzamideIC5010000.0 [1]
4-Chloro-N-[6-[[4-(2,4-dimethyl-1,3-thiazol-5-yl)-1,3-thiazol-2-yl]amino]pyridin-3-yl]benzenesulfonamideIC50240.0 [1]
N-(4-Chlorophenyl)-6-[[4-(2,4-dimethyl-1,3-thiazol-5-yl)-1,3-thiazol-2-yl]amino]-N-methylpyridine-3-carboxamideIC5050.0 [1]
N-(4-Chlorophenyl)-6-[[4-(2,4-dimethyl-1,3-thiazol-5-yl)-1,3-thiazol-2-yl]amino]pyridine-3-carboxamideIC509.5 [1]
N-Cyclohexyl-6-[[4-(2,4-dimethyl-1,3-thiazol-5-yl)-1,3-thiazol-2-yl]amino]pyridine-3-carboxamideIC5029.0 [1]
4-(2,4-Dimethyl-1,3-thiazol-5-yl)-N-(5-methoxypyridin-2-yl)-1,3-thiazol-2-amineIC5035.0 [1]
6-[[4-(2,4-Dimethyl-1,3-thiazol-5-yl)-1,3-thiazol-2-yl]amino]-N-ethylpyridine-3-carboxamideIC5010000.0 [1]
N-[4-(4-Propan-2-ylpiperazin-1-yl)sulfonylphenyl]benzamideIC508530.0 [1]
4-Tert-butyl-N-[4-(4-propan-2-ylpiperazin-1-yl)sulfonylphenyl]benzamideIC50390.0 [1]
N-[4-(4-Propan-2-ylpiperazin-1-yl)sulfonylphenyl]-4-(trifluoromethyl)benzamideIC50710.0 [1]
N-[4-(4-Propan-2-ylpiperazin-1-yl)sulfonylphenyl]-3-(trifluoromethyl)benzamideIC502170.0 [1]
N-[4-(4-Propan-2-ylpiperazin-1-yl)sulfonylphenyl]-4-(trifluoromethyl)benzenesulfonamideIC5010000.0 [1]
N-[4-(4-Propan-2-ylpiperazine-1-carbonyl)phenyl]-4-(trifluoromethyl)benzamideIC5010000.0 [1]
N-[4-[(4-Propan-2-yl-1,4-diazepan-1-yl)sulfonyl]phenyl]-4-(trifluoromethyl)benzamideIC501320.0 [1]
N-[4-[4-(Dimethylamino)piperidin-1-yl]sulfonylphenyl]-4-(trifluoromethyl)benzamideIC502110.0 [1]
N-[4-[4-(Diethylamino)piperidin-1-yl]sulfonylphenyl]-4-(trifluoromethyl)benzamideIC50910.0 [1]
N-[4-[4-[Ethyl(methyl)amino]piperidin-1-yl]sulfonylphenyl]-4-(trifluoromethyl)benzamideIC501280.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Transient receptor potential cation channel subfamily V member 4 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/transient-receptor-potential-cation-channel-subfamily-v-member-4-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ Transient receptor potential cation channel subfamily V member 4 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/transient-receptor-potential-cation-channel-subfamily-v-member-4-inhibitors-ic50-ki.
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