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Transient receptor potential cation channel subfamily V member 3 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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(2R)-2-[[3-Fluoro-6-[4-(trifluoromethyl)cyclohexyl]pyridin-2-yl]methylamino]-3-methylbutan-1-olIC50290.0 [1], 310.0 [2], 340.0 [3]
3-[(S)-Hydroxy(pyridin-2-yl)methyl]-1-methyl-3-[4-(trifluoromethyl)pyridin-2-yl]cyclobutan-1-olIC50380.0 [1], 930.0 [2]
1-(8-Methyl-3,4-dihydro-2H-quinolin-1-yl)-2-[5-(trifluoromethyl)pyridin-2-yl]sulfanylethanoneIC50200.0 [1], 500.0 [2]
2-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]sulfanyl-1-(8-methyl-3,4-dihydro-2H-quinolin-1-yl)ethanoneIC50200.0 [1], 500.0 [2]
2-(3-Chloro-pyridin-2-ylsulfanyl)-1-(8-methyl-3,4-dihydro-2H-quinolin-1-yl)-ethanoneIC50200.0 [1], 1000.0 [2]
2-(5-Chloro-pyridin-2-ylsulfanyl)-1-(8-methyl-3,4-dihydro-2H-quinolin-1-yl)-ethanoneIC50500.0 [1]
1-(8-Methyl-3,4-dihydro-2H-quinolin-1-yl)-2-[3-(trifluoromethyl)pyridin-2-yl]sulfanylethanoneIC501000.0 [1], 5000.0 [2]
1-(3,4-Dihydro-2H-quinolin-1-yl)-2-[5-(trifluoromethyl)pyridin-2-yl]sulfanylethanoneIC501000.0 [1], 5000.0 [2]
1-(8-Methyl-3,4-dihydro-2H-quinolin-1-yl)-2-pyridin-2-ylsulfanylethanoneIC505000.0 [1], 10000.0 [2]
2-(5-Chloropyridin-2-yl)sulfanyl-1-(3,4-dihydro-2H-quinolin-1-yl)ethanoneIC505000.0 [1]
1-(8-Methyl-3,4-dihydro-2H-quinolin-1-yl)-2-(5-methylpyridin-2-yl)sulfanylethanoneIC505000.0 [1], 10000.0 [2]
6-[2-(8-Methyl-3,4-dihydro-2H-quinolin-1-yl)-2-oxoethyl]sulfanylpyridine-3-carbonitrileIC505000.0 [1], 10000.0 [2]
2-[3-Fluoro-5-(trifluoromethyl)pyridin-2-yl]sulfanyl-1-(8-methyl-3,4-dihydro-2H-quinolin-1-yl)ethanoneIC50200.0 [1]
2-(3,5-Dichloropyridin-2-yl)sulfanyl-1-(8-methyl-3,4-dihydro-2H-quinolin-1-yl)ethanoneIC50200.0 [1]
2-[2-(8-Methyl-3,4-dihydro-2H-quinolin-1-yl)-2-oxoethyl]sulfanylpyridine-3-carbonitrileIC50500.0 [1], 1000.0 [2]
2-[2-(8-Methyl-3,4-dihydro-2H-quinolin-1-yl)-2-oxoethyl]sulfanylpyridine-4-carbonitrileIC5010000.0 [1]
2-(3-Chloropyridin-2-yl)sulfanyl-1-(8-methoxy-3,4-dihydro-2H-quinolin-1-yl)ethanoneIC50500.0 [1]
2-(3,4-Dimethylpyridin-2-yl)sulfanyl-1-(8-methyl-3,4-dihydro-2H-quinolin-1-yl)ethanoneIC501000.0 [1], 5000.0 [2]
2-(4,5-Dimethylpyridin-2-yl)sulfanyl-1-(8-methyl-3,4-dihydro-2H-quinolin-1-yl)ethanoneIC50200.0 [1]
2-(5-Bromopyridin-2-yl)sulfanyl-1-(8-methyl-3,4-dihydro-2H-quinolin-1-yl)ethanoneIC50500.0 [1]
2-[3-Ethyl-5-(trifluoromethyl)pyridin-2-yl]sulfanyl-1-(8-methyl-3,4-dihydro-2H-quinolin-1-yl)ethanoneIC505000.0 [1]
Methyl 5-chloro-6-[2-(8-methyl-3,4-dihydro-2H-quinolin-1-yl)-2-oxoethyl]sulfanylpyridine-3-carboxylateIC505000.0 [1]
2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamideIC5010000.0 [1]
(1e,3e)-1-(4-Fluorophenyl)-2-methylpent-1-en-3-one oximeIC5010000.0 [1]
N-[2-Methyl-3-[[4-[4-[[4-(trifluoromethoxy)phenyl]methoxy]piperidin-1-yl]-1,3,5-triazin-2-yl]amino]phenyl]acetamideIC5010000.0 [1]
CID 121513880IC5030000.0 [1]
(R)-8-{5-[3-Methyl-4-(trifluoromethyl)phenyl]oxazol-2-ylamino}-1,2,3,4-tetrahydronaphthalen-2-olIC50100000.0 [1]
4-[3-(3-Methoxypropoxy)phenyl]-2-sulfanylidene-3,4-dihydro-1H-indeno[1,2-d]pyrimidin-5-oneIC5010000.0 [1]
N-[2-[4-(Difluoromethoxy)phenyl]ethyl]-2-(8-methyl-4-oxoquinazolin-3-yl)acetamideIC5020000.0 [1]
6-[[(S)-(3-Fluoropyridin-2-yl)-[3-fluoro-4-(trifluoromethoxy)phenyl]methyl]carbamoyl]pyridine-3-carboxylic acidIC5020000.0 [1]
5-[2-(Trifluoromethyl)phenyl]-1H-indazoleIC5030000.0 [1]
6-Chloro-5-[2-(trifluoromethyl)phenyl]-1H-indazoleIC5030000.0 [1]
6-Methyl-5-[2-(trifluoromethyl)phenyl]-1H-indazoleIC5030000.0 [1]
6-Methoxy-5-[2-(trifluoromethyl)phenyl]-1H-indazoleIC5030000.0 [1]
6-(Cyclopropylmethoxy)-5-[2-(trifluoromethyl)phenyl]-1H-indazoleIC5030000.0 [1]
6-(Trifluoromethoxy)-5-[2-(trifluoromethyl)phenyl]-1H-indazoleIC5030000.0 [1]
2-(1,3-Dimethyl-2,4-dioxoquinazolin-5-yl)-N-[4-[4-(2-methylpropoxy)phenyl]-1,3-thiazol-2-yl]acetamideIC5010000.0 [1]
N-[4-[3,5-Difluoro-4-(3,3,3-trifluoropropyl)phenyl]-1,3-thiazol-2-yl]-2-(1,3-dimethyl-2,4-dioxofuro[2,3-d]pyrimidin-5-yl)acetamideIC5010000.0 [1]
N-[4-(4-Bromophenyl)-1,3-thiazol-2-yl]-2-(5-methyl-4-oxo-7,8-dihydroimidazo[2,1-b]purin-3-yl)acetamideIC5010000.0 [1]
N-[4-(4-Tert-butylphenyl)-1,3-thiazol-2-yl]-2-(5-methyl-4-oxo-7,8-dihydroimidazo[2,1-b]purin-3-yl)acetamideIC5010000.0 [1]
2-(6-Chlorospiro[3,4-dihydrochromene-2,1'-cyclobutane]-4-yl)-N-[(2-cyclopentyloxy-3-methoxyphenyl)methyl]acetamideIC50725.3 [1]
N-[4-(5-Chloro-2-fluorophenyl)-1,3-thiazol-2-yl]-2-(1,3-dimethyl-2,4-dioxoquinazolin-5-yl)acetamideIC501000.0 [1]
N-[4-(3,4-Dichlorophenyl)-1,3-thiazol-2-yl]-2-(1,3-dimethyl-2,4-dioxoquinazolin-5-yl)acetamideIC5010000.0 [1]
N-[4-(3-Chloro-2-fluorophenyl)-1,3-thiazol-2-yl]-2-(1,3-dimethyl-2,4-dioxoquinazolin-5-yl)acetamideIC501000.0 [1]
N-[4-(3-Chloro-4-fluorophenyl)-1,3-thiazol-2-yl]-2-(1,3-dimethyl-2,4-dioxoquinazolin-5-yl)acetamideIC501000.0 [1]
N-[4-[3,5-Difluoro-4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]-2-(1,3-dimethyl-2,4-dioxoquinazolin-5-yl)acetamideIC5010000.0 [1]
N-[4-[2,4-Difluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]-2-(1,3-dimethyl-2,4-dioxoquinazolin-5-yl)acetamideIC5010000.0 [1]
N-[4-[2,3-Difluoro-4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]-2-(1,3-dimethyl-2,4-dioxoquinazolin-5-yl)acetamideIC501000.0 [1]
N-[4-[3,5-Difluoro-4-(2,2,2-trifluoroethoxy)phenyl]-1,3-thiazol-2-yl]-2-(1,3-dimethyl-2,4-dioxoquinazolin-5-yl)acetamideIC5010000.0 [1]
2-(1,3-Dimethyl-2,4-dioxoquinazolin-5-yl)-N-[4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]acetamideIC5010000.0 [1]
N-[1-(4-Chlorophenyl)pyrazol-3-yl]-2-(1,3-dimethyl-2,4-dioxoquinazolin-5-yl)acetamideIC5010000.0 [1]
N-[4-(3-Chlorophenyl)-1,3-thiazol-2-yl]-2-(1,3-dimethyl-2,4-dioxoquinazolin-5-yl)acetamideIC501000.0 [1]
2-(1,3-Dimethyl-2,4-dioxoquinazolin-5-yl)-N-[4-(4-iodophenyl)-1,3-thiazol-2-yl]acetamideIC5010000.0 [1]
2-(1,3-Dimethyl-2,4-dioxoquinazolin-5-yl)-N-[1-[3-(trifluoromethyl)phenyl]pyrazol-3-yl]acetamideIC5010000.0 [1]
N-[4-(4-Bromophenyl)-1,3-thiazol-2-yl]-2-(1,3-dimethyl-2,4-dioxoquinazolin-5-yl)acetamideIC5010000.0 [1]
2-(1,3-Dimethyl-2,4-dioxoquinazolin-5-yl)-N-[4-[3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]acetamideIC502100.0 [1]
N-[4-(4-Cyclohexylphenyl)-1,3-thiazol-2-yl]-2-(1,3-dimethyl-2,4-dioxoquinazolin-5-yl)acetamideIC5010000.0 [1]
2-(1,3-Dimethyl-2,4-dioxoquinazolin-5-yl)-N-[4-[3-(trifluoromethoxy)phenyl]-1,3-thiazol-2-yl]acetamideIC501000.0 [1]
N-[4-(4-Tert-butylphenyl)-1,3-thiazol-2-yl]-2-(1,3-dimethyl-2,4-dioxoquinazolin-5-yl)acetamideIC5010000.0 [1]
2-(1,3-Dimethyl-2,4-dioxoquinazolin-5-yl)-N-[4-[4-(3-methylbutoxy)phenyl]-1,3-thiazol-2-yl]acetamideIC5010000.0 [1]
N-[4-(2,4-Difluorophenyl)-1,3-thiazol-2-yl]-2-(1,3-dimethyl-2,4-dioxoquinazolin-5-yl)acetamideIC501000.0 [1]
2-(1,3-Dimethyl-2,4-dioxoquinazolin-5-yl)-N-[4-(4-methylphenyl)-1,3-thiazol-2-yl]acetamideIC5010000.0 [1]
2-(1,3-Dimethyl-2,4-dioxoquinazolin-5-yl)-N-[4-(4-propan-2-ylphenyl)-1,3-thiazol-2-yl]acetamideIC501000.0 [1]
N-[4-(2,3-Difluorophenyl)-1,3-thiazol-2-yl]-2-(1,3-dimethyl-2,4-dioxoquinazolin-5-yl)acetamideIC5010000.0 [1]
2-(1,3-Dimethyl-2,4-dioxoquinazolin-5-yl)-N-[4-[3-fluoro-4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]acetamideIC5010000.0 [1]
2-(1,3-Dimethyl-2,4-dioxoquinazolin-5-yl)-N-[4-[4-fluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]acetamideIC501000.0 [1]
2-(1,3-Dimethyl-2,4-dioxoquinazolin-5-yl)-N-[4-[2-fluoro-4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]acetamideIC501000.0 [1]
N-[4-[4-Chloro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]-2-(1,3-dimethyl-2,4-dioxoquinazolin-5-yl)acetamideIC5010000.0 [1]
N-[4-[3,5-Dichloro-4-(2,2-dimethylpropoxy)phenyl]-1,3-thiazol-2-yl]-2-(4,6-dimethyl-5,7-dioxopyrazolo[4,3-d]pyrimidin-1-yl)acetamideIC5010000.0 [1]
2-(5,7-Dimethyl-4,6-dioxo-[1,2]thiazolo[5,4-d]pyrimidin-3-yl)-N-[4-[3-fluoro-5-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]acetamideIC501000.0 [1]
2-(1,3-Dimethyl-2,4-dioxofuro[2,3-d]pyrimidin-5-yl)-N-[4-[3-fluoro-4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]acetamideIC501000.0 [1]
2-(1,3-Dimethyl-2,4-dioxofuro[2,3-d]pyrimidin-5-yl)-N-[4-[4-fluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]acetamideIC501000.0 [1]
2-(1,3-Dimethyl-2,4-dioxofuro[2,3-d]pyrimidin-5-yl)-N-[4-[2-fluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]acetamideIC501000.0 [1]
2-(1,3-Dimethyl-2,4-dioxofuro[2,3-d]pyrimidin-5-yl)-N-[4-[3-fluoro-5-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]acetamideIC501000.0 [1]
N-[4-[3,5-Dichloro-4-(2,2,2-trifluoroethoxy)phenyl]-1,3-thiazol-2-yl]-2-(1,3-dimethyl-2,4-dioxofuro[2,3-d]pyrimidin-5-yl)acetamideIC5010000.0 [1]
N-[4-[3-Chloro-5-fluoro-4-(2,2,2-trifluoroethoxy)phenyl]-1,3-thiazol-2-yl]-2-(1,3-dimethyl-2,4-dioxofuro[2,3-d]pyrimidin-5-yl)acetamideIC5010000.0 [1]
N-[4-[3,5-Difluoro-4-(2-methylpropoxy)phenyl]-1,3-thiazol-2-yl]-2-(1,3-dimethyl-2,4-dioxofuro[2,3-d]pyrimidin-5-yl)acetamideIC5010000.0 [1]
N-[4-[4-Fluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]-2-(1,3,6-trimethyl-2,4-dioxofuro[2,3-d]pyrimidin-5-yl)acetamideIC501000.0 [1]
N-[4-[2-Fluoro-4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]-2-(1,3,6-trimethyl-2,4-dioxofuro[2,3-d]pyrimidin-5-yl)acetamideIC501000.0 [1]
N-[4-[2-Fluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]-2-(1,3,6-trimethyl-2,4-dioxofuro[2,3-d]pyrimidin-5-yl)acetamideIC501000.0 [1]
N-[4-[3-Fluoro-5-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]-2-(1,3,6-trimethyl-2,4-dioxofuro[2,3-d]pyrimidin-5-yl)acetamideIC5010000.0 [1]
N-[4-[4-Chloro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]-2-(1,3,6-trimethyl-2,4-dioxofuro[2,3-d]pyrimidin-5-yl)acetamideIC501000.0 [1]
N-[4-[3-Fluoro-4-(trifluoromethoxy)phenyl]-1,3-thiazol-2-yl]-2-(1,3,6-trimethyl-2,4-dioxofuro[2,3-d]pyrimidin-5-yl)acetamideIC501000.0 [1]
N-[4-[4-Fluoro-3-(trifluoromethoxy)phenyl]-1,3-thiazol-2-yl]-2-(1,3,6-trimethyl-2,4-dioxofuro[2,3-d]pyrimidin-5-yl)acetamideIC501000.0 [1]
N-[4-[4-Chloro-3-(trifluoromethoxy)phenyl]-1,3-thiazol-2-yl]-2-(1,3,6-trimethyl-2,4-dioxofuro[2,3-d]pyrimidin-5-yl)acetamideIC501000.0 [1]
N-[4-[3-Chloro-4-(trifluoromethoxy)phenyl]-1,3-thiazol-2-yl]-2-(1,3,6-trimethyl-2,4-dioxofuro[2,3-d]pyrimidin-5-yl)acetamideIC504450.0 [1]
N-[4-[3-Chloro-4-(2,2,2-trifluoroethoxy)phenyl]-1,3-thiazol-2-yl]-2-(1,3,6-trimethyl-2,4-dioxofuro[2,3-d]pyrimidin-5-yl)acetamideIC5010000.0 [1]
N-[4-[4-(2,2-Dimethylpropoxy)-3,5-difluorophenyl]-1,3-thiazol-2-yl]-2-(1,3,6-trimethyl-2,4-dioxofuro[2,3-d]pyrimidin-5-yl)acetamideIC5010000.0 [1]
N-[4-[3,5-Dichloro-4-(2-methylpropoxy)phenyl]-1,3-thiazol-2-yl]-2-(1,3,6-trimethyl-2,4-dioxofuro[2,3-d]pyrimidin-5-yl)acetamideIC5010000.0 [1]
N-[4-[2,4-Difluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]-2-(1,3,6-trimethyl-2,4-dioxofuro[2,3-d]pyrimidin-5-yl)acetamideIC501000.0 [1]
N-[4-[3,5-Difluoro-4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]-2-(1,3,6-trimethyl-2,4-dioxofuro[2,3-d]pyrimidin-5-yl)acetamideIC501000.0 [1]
N-[4-[2,4-Difluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]-2-(1,3-dimethyl-2,4-dioxothieno[2,3-d]pyrimidin-5-yl)acetamideIC5010000.0 [1]
2-(6-Ethyl-1,3-dimethyl-2,4-dioxothieno[2,3-d]pyrimidin-5-yl)-N-[4-[3-fluoro-4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]acetamideIC501000.0 [1]
N-[4-[4-(Difluoromethoxy)-3,5-difluorophenyl]-1,3-thiazol-2-yl]-2-(6-ethyl-1,3-dimethyl-2,4-dioxothieno[2,3-d]pyrimidin-5-yl)acetamideIC5010000.0 [1]
2-(1,3-Dimethyl-2,4-dioxo-6-propan-2-ylthieno[2,3-d]pyrimidin-5-yl)-N-[4-[3-fluoro-4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]acetamideIC5010000.0 [1]
N-[4-(3,4-Dichlorophenyl)-1,3-thiazol-2-yl]-2-(1,3,6-trimethyl-2,4-dioxothieno[2,3-d]pyrimidin-5-yl)acetamideIC5010000.0 [1]
N-[4-[3,5-Difluoro-4-(2,2,2-trifluoroethoxy)phenyl]-1,3-thiazol-2-yl]-2-(6-ethyl-1,3-dimethyl-2,4-dioxothieno[2,3-d]pyrimidin-5-yl)acetamideIC5010000.0 [1]
N-[4-[3-Chloro-4-(trifluoromethoxy)phenyl]-1,3-thiazol-2-yl]-2-(5,7-dimethyl-4,6-dioxo-[1,2]thiazolo[5,4-d]pyrimidin-3-yl)acetamideIC5010000.0 [1]
N-[4-[2,4-Difluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]-2-(5,7-dimethyl-4,6-dioxo-[1,2]thiazolo[5,4-d]pyrimidin-3-yl)acetamideIC501770.0 [1]
N-[4-[2,3-Difluoro-4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]-2-(5,7-dimethyl-4,6-dioxo-[1,2]thiazolo[5,4-d]pyrimidin-3-yl)acetamideIC502830.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Transient receptor potential cation channel subfamily V member 3 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/transient-receptor-potential-cation-channel-subfamily-v-member-3-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ Transient receptor potential cation channel subfamily V member 3 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/transient-receptor-potential-cation-channel-subfamily-v-member-3-inhibitors-ic50-ki.
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