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Transforming protein p21/H-Ras-1 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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StallimycinIC50200.0 [1], 200000.0 [2]
N-[(3R,4R,5S,6R)-2-[(3,4-Dihydroxyphenyl)methyl-phenylmethoxyamino]-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamideIC5080000.0 [1], 122000.0 [2]
LonafarnibIC5070.0 [1]
CID 513441IC50300000.0 [1]
4-[3-[[(6As)-2-methoxy-11-oxo-6a,7,8,9-tetrahydropyrrolo[2,1-c][1,4]benzodiazepin-3-yl]oxy]propanoylamino]-N-[5-[[5-[(3-amino-3-iminopropyl)carbamoyl]-1-methylpyrrol-3-yl]carbamoyl]-1-methylpyrrol-3-yl]-1-methylpyrrole-2-carboxamideIC508000.0 [1]
Benzyl N-[(2S)-3-(1H-imidazol-5-yl)-1-oxo-1-[[2-oxo-2-(2-phenylmethoxyethylamino)ethyl]-[(4-phenylmethoxyphenyl)methyl]amino]propan-2-yl]carbamateIC5014300.0 [1]
Benzyl N-[(2S)-3-(1H-imidazol-5-yl)-1-oxo-1-[[2-oxo-2-(2-phenylethylamino)ethyl]-[(4-phenylmethoxyphenyl)methyl]amino]propan-2-yl]carbamateIC504300.0 [1]
Benzyl N-[(2S)-3-(1H-imidazol-5-yl)-1-oxo-1-[[2-oxo-2-(2-phenylpropylamino)ethyl]-[(4-phenylmethoxyphenyl)methyl]amino]propan-2-yl]carbamateIC50310.0 [1]
Benzyl N-[(2S)-3-(1H-imidazol-5-yl)-1-oxo-1-[[2-oxo-2-[[(2S)-1-phenylpropan-2-yl]amino]ethyl]-[(4-phenylmethoxyphenyl)methyl]amino]propan-2-yl]carbamateIC506300.0 [1]
Benzyl N-[(2S)-3-(1H-imidazol-5-yl)-1-oxo-1-[[2-oxo-2-[[(2R)-2-phenylpropyl]amino]ethyl]-[(4-phenylmethoxyphenyl)methyl]amino]propan-2-yl]carbamateIC50570.0 [1]
Benzyl N-[(2S)-3-(1H-imidazol-5-yl)-1-oxo-1-[[2-oxo-2-(2-phenylpentylamino)ethyl]-[(4-phenylmethoxyphenyl)methyl]amino]propan-2-yl]carbamateIC501000.0 [1]
Benzyl N-[(2S)-3-(1H-imidazol-5-yl)-1-oxo-1-[[2-oxo-2-[[(2S)-2-phenylpropyl]amino]ethyl]-[(4-phenylmethoxyphenyl)methyl]amino]propan-2-yl]carbamateIC50300.0 [1]
Benzyl N-[(2S)-3-(1H-imidazol-5-yl)-1-oxo-1-[[2-oxo-2-[(1-phenylcyclobutyl)methylamino]ethyl]-[(4-phenylmethoxyphenyl)methyl]amino]propan-2-yl]carbamateIC5088.0 [1]
Benzyl N-[(2S)-1-[[2-[(2-ethyl-2-phenylbutyl)amino]-2-oxoethyl]-[(4-phenylmethoxyphenyl)methyl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]carbamateIC501000.0 [1]
Benzyl N-[(2S)-3-(1H-imidazol-5-yl)-1-oxo-1-[[2-oxo-2-[(1-phenylcyclopropyl)methylamino]ethyl]-[(4-phenylmethoxyphenyl)methyl]amino]propan-2-yl]carbamateIC50180.0 [1]
Benzyl N-[(2S)-3-(1H-imidazol-5-yl)-1-oxo-1-[[2-oxo-2-[[(2R)-1-phenylpropan-2-yl]amino]ethyl]-[(4-phenylmethoxyphenyl)methyl]amino]propan-2-yl]carbamateIC50710.0 [1]
Benzyl N-[(2S)-3-(1H-imidazol-5-yl)-1-oxo-1-[[2-oxo-2-(2-phenylbutylamino)ethyl]-[(4-phenylmethoxyphenyl)methyl]amino]propan-2-yl]carbamateIC50400.0 [1]
Benzyl N-[(2S)-1-[[2-[(2-cyano-2-phenylethyl)amino]-2-oxoethyl]-[(4-phenylmethoxyphenyl)methyl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]carbamateIC50190.0 [1]
Benzyl N-[(2S)-3-(1H-imidazol-5-yl)-1-oxo-1-[[2-oxo-2-[(1-phenylcyclopentyl)methylamino]ethyl]-[(4-phenylmethoxyphenyl)methyl]amino]propan-2-yl]carbamateIC50330.0 [1]
N-[5-[[5-[(3-Amino-3-iminopropyl)carbamoyl]-1-methylpyrrol-3-yl]carbamoyl]-1-methylpyrrol-3-yl]-4-formamido-1-methylpyrrole-2-carboxamide;methyl 3-[[(6aS)-2-methoxy-11-oxo-6a,7,8,9-tetrahydropyrrolo[2,1-c][1,4]benzodiazepin-3-yl]oxy]propanoateIC50200000.0 [1]
N-[5-[[5-[[5-[(3-Amino-3-iminopropyl)carbamoyl]-1-methylpyrrol-3-yl]carbamoyl]-1-methylpyrrol-3-yl]carbamoyl]-1-methylpyrrol-3-yl]-5-[[4-[bis(2-chloroethyl)amino]benzoyl]amino]-1-methylindole-2-carboxamide;hydrochlorideIC5015.0 [1]
N-[5-[[5-[[5-[(3-Amino-3-iminopropyl)carbamoyl]-1-methylpyrrol-3-yl]carbamoyl]-1-methylpyrrol-3-yl]carbamoyl]-1-methylpyrrol-3-yl]-5-[bis(2-chloroethyl)amino]-1-methylindole-2-carboxamide;hydrochlorideIC5020.0 [1]
N-(3-Amino-3-iminopropyl)-4-[[4-[[4-[[5-[[4-[bis(2-chloroethyl)amino]benzoyl]amino]-1-benzofuran-2-carbonyl]amino]-1-methylpyrrole-2-carbonyl]amino]-1-methylpyrrole-2-carbonyl]amino]-1-methylpyrrole-2-carboxamide;hydrochlorideIC5015.0 [1]
N-[5-[[5-[[5-[(3-Amino-3-iminopropyl)carbamoyl]-1-methylpyrrol-3-yl]carbamoyl]-1-methylpyrrol-3-yl]carbamoyl]-1-methylpyrrol-3-yl]-5-[bis(2-chloroethyl)amino]-1H-indole-2-carboxamide;hydrochlorideIC5020.0 [1]
N-[5-[[5-[[5-[(3-Amino-3-iminopropyl)carbamoyl]-1-methylpyrrol-3-yl]carbamoyl]-1-methylpyrrol-3-yl]carbamoyl]-1-methylpyrrol-3-yl]-5-[[4-[bis(2-chloroethyl)amino]benzoyl]amino]-1H-indole-2-carboxamide;hydrochlorideIC5015.0 [1]
N-(3-Amino-3-iminopropyl)-4-[[4-[[4-[[5-[bis(2-chloroethyl)amino]-1-benzofuran-2-carbonyl]amino]-1-methylpyrrole-2-carbonyl]amino]-1-methylpyrrole-2-carbonyl]amino]-1-methylpyrrole-2-carboxamide;hydrochlorideIC5015.0 [1]
Benzyl N-[(2S)-3-(1H-imidazol-5-yl)-1-[[2-[(2-methyl-2-phenylpropyl)amino]-2-oxoethyl]-[(4-phenylmethoxyphenyl)methyl]amino]-1-oxopropan-2-yl]carbamateIC50180.0 [1]
N-[5-[[5-[[5-[(3-Amino-3-iminopropyl)carbamoyl]-1-methylpyrrol-3-yl]carbamoyl]-1-methylpyrrol-3-yl]carbamoyl]-1-methylpyrrol-3-yl]-5-[[4-[bis(2-chloroethyl)amino]benzoyl]amino]-1H-benzimidazole-2-carboxamideIC5015.0 [1]
Ethyl (E)-4-[(2R,6R)-6-(4-chloro-6-methoxy-3-methylpyrazolo[3,4-b]quinolin-1-yl)-4-(2-nitrophenyl)sulfanylmorpholin-2-yl]but-2-enoateIC5016000.0 [1]
(E)-5-[(2R,6R)-6-(4-Chloro-6-methoxy-3-methylpyrazolo[3,4-b]quinolin-1-yl)-4-(4-nitrophenyl)sulfanylmorpholin-2-yl]pent-3-en-2-oneIC503000.0 [1]
[(2S,6R)-4-(Benzenesulfonyl)-6-(4-chloro-6-methoxy-3-methylpyrazolo[3,4-b]quinolin-1-yl)morpholin-2-yl]methoxy-tert-butyl-dimethylsilaneIC5014000.0 [1]
[(2S,6R)-4-(Benzenesulfonyl)-6-(4-chloro-6-methoxy-3-methylpyrazolo[3,4-b]quinolin-1-yl)morpholin-2-yl]methanolIC5012000.0 [1]
3-[[(3As,4R,6R,6aR)-6-(4-chloro-6-methoxy-3-methylpyrazolo[3,4-b]quinolin-1-yl)-2-sulfanylidene-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl]oxy]-3-hydroxy-1-phenylpropan-1-oneIC501500.0 [1]
(E)-4-[(2R,6R)-6-(4-Chloro-6-methoxy-3-methylpyrazolo[3,4-b]quinolin-1-yl)-4-(4-nitrophenyl)sulfonylmorpholin-2-yl]-1-phenylbut-2-en-1-oneIC507000.0 [1]
[(2R,3R,4R,5R)-3,4-Dibenzoyloxy-5-(4-chloro-6-methoxy-3-methylpyrazolo[3,4-b]quinolin-1-yl)oxolan-2-yl]methyl benzoateIC5010000.0 [1]
(E)-3-[(2S,3S,4R,5R)-5-(4-Chloro-6-methoxy-3-methylpyrazolo[3,4-b]quinolin-1-yl)-3,4-dihydroxyoxolan-2-yl]oxy-1-phenylprop-2-en-1-oneIC5010000.0 [1]
[(2S,5R)-5-(4-Chloro-6-methoxy-3-methylpyrazolo[3,4-b]quinolin-1-yl)-2,5-dihydrofuran-2-yl]methyl benzoateIC5080000.0 [1]
(E)-4-[(2R,6R)-6-(4-Chloro-6-methoxy-3-methylpyrazolo[3,4-b]quinolin-1-yl)-4-(2-nitrophenyl)sulfanylmorpholin-2-yl]-1-phenylbut-2-en-1-oneIC504700.0 [1]
[(3Ar,4R,6R,6aR)-4-(4-chloro-6-methoxy-3-methylpyrazolo[3,4-b]quinolin-1-yl)-2-sulfanylidene-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-6-yl]methyl benzoateIC5015000.0 [1]
(E)-4-[(2R,6R)-6-(4-Chloro-6-methoxy-3-methylpyrazolo[3,4-b]quinolin-1-yl)-4-(4-nitrophenyl)sulfanylmorpholin-2-yl]-1-phenylbut-2-en-1-oneIC507400.0 [1]
Tert-butyl-[[(2S,6R)-6-(4-chloro-6-methoxy-3-methylpyrazolo[3,4-b]quinolin-1-yl)-4-(4-nitrophenyl)sulfanylmorpholin-2-yl]methoxy]-dimethylsilaneIC5050000.0 [1]
[(2S,6R)-6-(4-Chloro-6-methoxy-3-methylpyrazolo[3,4-b]quinolin-1-yl)-4-(4-nitrophenyl)sulfanylmorpholin-2-yl]methanolIC506700.0 [1]
Tert-butyl-[[(2S,6R)-6-(4-chloro-6-methoxy-3-methylpyrazolo[3,4-b]quinolin-1-yl)-4-(2-nitrophenyl)sulfanylmorpholin-2-yl]methoxy]-dimethylsilaneIC501000.0 [1]
[(2R,3R,4R,5R)-5-(4-Chloro-6-methoxy-3-methylpyrazolo[3,4-b]quinolin-1-yl)-3,4-bis(furan-2-carbonyloxy)oxolan-2-yl]methyl furan-2-carboxylateIC5010500.0 [1]
[(2S,6R)-6-(4-Chloro-6-methoxy-3-methylpyrazolo[3,4-b]quinolin-1-yl)-4-(4-nitrophenyl)sulfonylmorpholin-2-yl]methanolIC508000.0 [1]
[(2S,6R)-6-(4-Chloro-6-methoxy-3-methylpyrazolo[3,4-b]quinolin-1-yl)-4-(2-nitrophenyl)sulfanylmorpholin-2-yl]methanolIC5014000.0 [1]
N-[4-[(2S,6R)-2-[[Tert-butyl(dimethyl)silyl]oxymethyl]-6-(4-chloro-6-methoxy-3-methylpyrazolo[3,4-b]quinolin-1-yl)morpholin-4-yl]sulfonylphenyl]acetamideIC5027000.0 [1]
(E)-3-[[(2S,5R)-5-(4-Chloro-6-methoxy-3-methylpyrazolo[3,4-b]quinolin-1-yl)-2,5-dihydrofuran-2-yl]oxy]-1-phenylprop-2-en-1-oneIC5035000.0 [1]
4-[(Phenylmethoxyamino)methyl]benzene-1,2-diolIC50320000.0 [1]
(3R,4S,5S,6R)-2-[(3,4-Dihydroxyphenyl)methyl-phenylmethoxyamino]-6-(hydroxymethyl)oxane-3,4,5-triolIC5080000.0 [1]
(2S,3R,4S,5R,6R)-2-[(2R,3S,4R,5R)-6-[(3,4-Dihydroxyphenyl)methyl-phenylmethoxyamino]-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triolIC50100000.0 [1]
Tert-butyl-[[(2S,6R)-6-(4-chloro-6-methoxy-3-methylpyrazolo[3,4-b]quinolin-1-yl)-4-(4-nitrophenyl)sulfonylmorpholin-2-yl]methoxy]-dimethylsilaneIC505000.0 [1]
Items per page: 1 - 10 of 52
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References

This online tool may be cited as follows

MLA

"Quest Database™ Transforming protein p21/H-Ras-1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Nov. 2024, https://www.aatbio.com/data-sets/transforming-protein-p21-h-ras-1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 20). Quest Database™ Transforming protein p21/H-Ras-1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/transforming-protein-p21-h-ras-1-inhibitors-ic50-ki.
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