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Transcription factor AP1 Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
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Standard Type
▲
▼
Standard Values (in nM)
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▼
(1E,4Z,6E)-5-Hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,4,6-trien-3-oneIC506.9 [1], 480000.0 [2]
3-[2-Isobutoxy-5-(4-isobutoxybenzoyl)phenyl]propionic acidIC505000.0 [1], 610000.0 [2]
3-[2-Isobutoxy-5-(3-isobutoxybenzoyl)phenyl]propionic acidIC505800.0 [1], 600000.0 [2]
(R)-4-(4-Methylpentanoyl)-8-(4-methylpentylidene)-1-thia-4-azaspiro[4.5]decane-3-carboxylic acidIC5011800.0 [1], 650000.0 [2]
(R)-8-(3-Methylbutylidene)-4-(5-methylhexanoyl)-1-thia-4-aza-spiro[4.5]decane-3-carboxylic acidIC5013300.0 [1], 460000.0 [2]
Nordihydroguaiaretic acidIC507.9 [1]
Dihydroguaiaretic acidIC50210.0 [1]
3-[5-(4-Cyclopentyloxy-2-hydroxybenzoyl)-2-[(3-oxo-1,2-benzoxazol-6-yl)methoxy]phenyl]propanoic acidIC50200000.0 [1]
Momordine IIC50130000.0 [1]
(1E,4Z,6E)-1,7-Bis(3-methoxyphenyl)-5-hydroxy-1,4,6-heptatriene-3-oneIC505400.0 [1]
2-Phenyl-4-(2,5-dioxo-3-methyl-3-pyrroline-1-ylamino)pyrimidine-5-carboxylic acid ethyl esterIC50100.0 [1]
Ethyl 4-(3-methyl-2,5-dioxo-2H-pyrrol-1(5H)-ylamino)-2-(trifluoromethyl)pyrimidine-5-carboxylateIC501000.0 [1]
2-(2-Thienyl)-4-(2,5-dioxo-3-methyl-3-pyrroline-1-ylamino)pyrimidine-5-carboxylic acid ethyl esterIC5020.0 [1]
Ethyl 2-(4-fluorophenyl)-4-(3-methyl-2,5-dioxo-2H-pyrrol-1(5H)-ylamino)pyrimidine-5-carboxylateIC50700.0 [1]
Ethyl 2-(3-methoxyphenyl)-4-(3-methyl-2,5-dioxo-2H-pyrrol-1(5H)-ylamino)pyrimidine-5-carboxylateIC505000.0 [1]
Ethyl 2-(4-methoxyphenyl)-4-(3-methyl-2,5-dioxo-2H-pyrrol-1(5H)-ylamino)pyrimidine-5-carboxylateIC50900.0 [1]
Ethyl 2-(furan-2-carbonyl)-4-(3-methyl-2,5-dioxo-2H-pyrrol-1(5H)-ylamino)pyrimidine-5-carboxylateIC50700.0 [1]
Ethyl 2-(1-benzothiophen-2-yl)-4-[(3-methyl-2,5-dioxopyrrol-1-yl)amino]pyrimidine-5-carboxylateIC504000.0 [1]
Ethyl 2-(5-chlorothiophen-2-yl)-4-[(3-methyl-2,5-dioxopyrrol-1-yl)amino]pyrimidine-5-carboxylateIC50300.0 [1]
Ethyl 2-(3,5-dimethylpyrazol-1-yl)-4-[(3-methyl-2,5-dioxopyrrol-1-yl)amino]pyrimidine-5-carboxylateIC5010000.0 [1]
2-(4-Pyridinyl)-4-(2,5-dioxo-3-methyl-3-pyrroline-1-ylamino)pyrimidine-5-carboxylic acid ethyl esterIC506000.0 [1]
Ethyl 2-(cyclohexenylmethyl)-4-(3-methyl-2,5-dioxo-2H-pyrrol-1(5H)-ylamino)pyrimidine-5-carboxylateIC502000.0 [1]
2-Cyclopropyl-4-(2,5-dioxo-3-methyl-3-pyrroline-1-ylamino)pyrimidine-5-carboxylic acid ethyl esterIC501000.0 [1]
Ethyl 4-[(3-methyl-2,5-dioxopyrrol-1-yl)amino]-2-(2-methyl-1,3-thiazol-4-yl)pyrimidine-5-carboxylateIC508000.0 [1]
Ethyl 4-(3-methyl-2,5-dioxo-2H-pyrrol-1(5H)-ylamino)-2-(quinolin-3-yl)pyrimidine-5-carboxylateIC506000.0 [1]
Ethyl 2-(2,6-dichloropyridin-4-yl)-4-[(3-methyl-2,5-dioxopyrrol-1-yl)amino]pyrimidine-5-carboxylateIC502000.0 [1]
Ethyl 2-(3,5-dichlorophenyl)-4-(3-methyl-2,5-dioxo-2H-pyrrol-1(5H)-ylamino)pyrimidine-5-carboxylateIC50300.0 [1]
1-[2-(2-Thienyl)-5-(4-methyl-2-oxazolyl)pyrimidine-4-ylamino]-3-methyl-3-pyrroline-2,5-dioneIC50200.0 [1]
4-(3-Methyl-2,5-dioxo-2H-pyrrol-1(5H)-ylamino)-2-(thiophen-2-yl)pyrimidine-5-carbonitrileIC505000.0 [1]
Ethyl 4-(3-methyl-2,5-dioxo-2H-pyrrol-1(5H)-ylamino)-2-(3-nitrophenyl)pyrimidine-5-carboxylateIC507000.0 [1]
Ethyl 2-(3-bromophenyl)-4-(3-methyl-2,5-dioxo-2H-pyrrol-1(5H)-ylamino)pyrimidine-5-carboxylateIC50700.0 [1]
1-[2-(2-Thienyl)5-(2-methyl-2H-tetrazole-5-yl)pyrimidine-4-ylamino]-3-methyl-3-pyrroline-2,5-dioneIC50200.0 [1]
Ethyl 4-[(3-methyl-2,5-dioxopyrrol-1-yl)amino]-2-(5-methylthiophen-2-yl)pyrimidine-5-carboxylateIC50200.0 [1]
2-(3-Thienyl)-4-(2,5-dioxo-3-methyl-3-pyrroline-1-ylamino)pyrimidine-5-carboxylic acid ethyl esterIC50100.0 [1]
1-[2-(2-Thienyl)5-(3-methyl-5-isoxazolyl)pyrimidine-4-ylamino]-3-methyl-3-pyrroline-2,5-dioneIC50300.0 [1]
2-(Trifluoromethyl)-4-(2,5-dioxo-3-pyrroline-1-ylamino)pyrimidine-5-carboxylic acid ethyl esterIC5010000.0 [1]
1-[2-(2-Thienyl)-5-(2-oxazoline-2-yl)pyrimidine-4-ylamino]-3-methyl-3-pyrroline-2,5-dioneIC50200.0 [1]
Ethyl 4-(2,5-dioxo-3-phenyl-2H-pyrrol-1(5H)-ylamino)-2-(trifluoromethyl)pyrimidine-5-carboxylateIC5020000.0 [1]
Ethyl 4-(3,4-dimethyl-2,5-dioxo-2H-pyrrol-1(5H)-ylamino)-2-(trifluoromethyl)pyrimidine-5-carboxylateIC5010000.0 [1]
3-Methyl-1-[[5-(5-methyl-1,3,4-oxadiazol-2-yl)-2-thiophen-2-ylpyrimidin-4-yl]amino]pyrrole-2,5-dioneIC50300.0 [1]
2-Phenoxy-4-(2,5-dioxo-3-methyl-3-pyrroline-1-ylamino)pyrimidine-5-carboxylic acid ethyl esterIC5015000.0 [1]
2-Benzyl-4-(2,5-dioxo-3-methyl-3-pyrroline-1-ylamino)pyrimidine-5-carboxylic acid ethyl esterIC507000.0 [1]
2-Ethyl-4-[methyl(2,5-dioxo-3-methyl-3-pyrroline-1-yl)amino]pyrimidine-5-carboxylic acid ethyl esterIC5010000.0 [1]
Ethyl 2-(4-fluorophenyl)-4-[methyl-(3-methyl-2,5-dioxopyrrol-1-yl)amino]pyrimidine-5-carboxylateIC503000.0 [1]
2-(Phenylthio)-4-(2,5-dioxo-3-methyl-3-pyrroline-1-ylamino)pyrimidine-5-carboxylic acid ethyl esterIC501000.0 [1]
Ethyl 2-(4-chlorophenyl)-4-(3-methyl-2,5-dioxo-2H-pyrrol-1(5H)-ylamino)pyrimidine-5-carboxylateIC50300.0 [1]
2-(Methylthio)-4-(2,5-dioxo-3-methyl-3-pyrroline-1-ylamino)pyrimidine-5-carboxylic acid ethyl esterIC50200.0 [1]
Ethyl 4-[(3-methyl-2,5-dioxopyrrol-1-yl)amino]-2-[4-(trifluoromethyl)phenyl]pyrimidine-5-carboxylateIC50400.0 [1]
2-Methyl-4-(2,5-dioxo-3-methyl-3-pyrroline-1-ylamino)pyrimidine-5-carboxylic acid ethyl esterIC5016000.0 [1]
2-Ethyl-4-(2,5-dioxo-3-methyl-3-pyrroline-1-ylamino)pyrimidine-5-carboxylic acid ethyl esterIC5010000.0 [1]
Ethyl 4-[methyl-(3-methyl-2,5-dioxopyrrol-1-yl)amino]-2-thiophen-2-ylpyrimidine-5-carboxylateIC501000.0 [1]
Ethyl 4-[acetyl-(3-methyl-2,5-dioxopyrrol-1-yl)amino]-2-phenylpyrimidine-5-carboxylateIC504000.0 [1]
Ethyl 4-(3-methyl-2,5-dioxo-2H-pyrrol-1(5H)-ylamino)-2-(phenylsulfonyl)pyrimidine-5-carboxylateIC5010000.0 [1]
Ethyl 4-(methyl(3-methyl-2,5-dioxo-2H-pyrrol-1(5H)-yl)amino)-2-phenylpyrimidine-5-carboxylateIC502000.0 [1]
2-Tert-Butyl-4-(2,5-dioxo-3-methyl-3-pyrroline-1-ylamino)pyrimidine-5-carboxylic acid ethyl esterIC501000.0 [1]
(1E,4Z,6E)-5-Hydroxy-1,7-bis(4-methylphenyl)hepta-1,4,6-trien-3-oneIC508980.0 [1]
3-[2-Benzyloxy-5-(4-isobutoxybenzoyl)phenyl]propionic acidIC50420000.0 [1]
3-[2-Isobutoxy-5-(4-propoxybenzoyl)phenyl]propionic acidIC50930000.0 [1]
3-(5-Benzoyl-2-isobutoxyphenyl)propionic acidIC502000000.0 [1]
3-[5-(4-Isobutoxybenzoyl)-2-propoxyphenyl]propionic acidIC50910000.0 [1]
3-[3-(4-Isobutoxybenzoyl)phenyl]propionic acidIC502000000.0 [1]
2-[[(1S,2R,4As,6aR,6aS,6bR,8aR,10S,12aR,14bS)-10-(2-carboxybenzoyl)oxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picen-4a-yl]methoxycarbonyl]benzoic acidIC504000.0 [1]
Disodium;2-[[(1S,2R,4aS,6aR,6aS,6bR,8aR,10S,12aR,14bS)-10-(2-carboxylatobenzoyl)oxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picen-4a-yl]methoxycarbonyl]benzoateIC504000.0 [1]
(3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-Amino-2-[[(2S)-2-aminopropanoyl]amino]-5-oxopentanoyl]amino]-4-methylpentanoyl]amino]-3-carboxypropanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-4-(carboxymethylamino)-4-oxobutanoic acidIC50100000.0 [1]
(3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-Aminoacetyl)amino]propanoyl]amino]-4-methylpentanoyl]amino]-3-carboxypropanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-4-(carboxymethylamino)-4-oxobutanoic acidIC50100000.0 [1]
(3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-Amino-2-[(2-aminoacetyl)amino]-5-oxopentanoyl]amino]propanoyl]amino]-3-carboxypropanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-4-(carboxymethylamino)-4-oxobutanoic acidIC50100000.0 [1]
(3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-Amino-2-[(2-aminoacetyl)amino]-5-oxopentanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-4-(carboxymethylamino)-4-oxobutanoic acidIC50200000.0 [1]
(3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-Amino-2-[(2-aminoacetyl)amino]-5-oxopentanoyl]amino]-4-methylpentanoyl]amino]-3-carboxypropanoyl]amino]propanoyl]amino]propanoyl]amino]-4-(carboxymethylamino)-4-oxobutanoic acidIC50100000.0 [1]
(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-Amino-2-[(2-aminoacetyl)amino]-5-oxopentanoyl]amino]-4-methylpentanoyl]amino]-3-carboxypropanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]butanedioic acidIC50100000.0 [1]
(3S)-3-[[(2S)-2-[[(2S)-5-Amino-2-[(2-aminoacetyl)amino]-5-oxopentanoyl]amino]-4-methylpentanoyl]amino]-4-[[(2S)-1-[[(2S)-1-[[(2S)-1-(carboxymethylamino)-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-oxobutanoic acidIC50100000.0 [1]
(3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-Amino-2-[(2-aminoacetyl)amino]-5-oxopentanoyl]amino]-4-methylpentanoyl]amino]-3-carboxypropanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-4-[[(1S)-1-carboxyethyl]amino]-4-oxobutanoic acidIC50100000.0 [1]
(4S)-4-[(2-Aminoacetyl)amino]-5-[[(2S)-1-[[(2S)-3-carboxy-1-[[(2S)-1-[[(2S)-1-[[(2S)-3-carboxy-1-(carboxymethylamino)-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-oxopentanoic acidIC50200000.0 [1]
(3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-Amino-2-[(2-aminoacetyl)amino]hexanoyl]amino]-4-methylpentanoyl]amino]-3-carboxypropanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-4-(carboxymethylamino)-4-oxobutanoic acidIC50200000.0 [1]
(3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-Amino-2-[(2-aminoacetyl)amino]-4-oxobutanoyl]amino]-4-methylpentanoyl]amino]-3-carboxypropanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-4-(carboxymethylamino)-4-oxobutanoic acidIC50100000.0 [1]
(3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-Amino-2-[(2-aminoacetyl)amino]-5-oxopentanoyl]amino]-4-methylpentanoyl]amino]-3-carboxypropanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-4-(carboxymethylamino)-4-oxobutanoic acidIC508000.0 [1]
(3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-3-Carboxy-2-[[(2S)-2-[[(2S)-2,5-diamino-5-oxopentanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-4-(carboxymethylamino)-4-oxobutanoic acidIC50100000.0 [1]
(3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-Amino-2-[(2-aminoacetyl)amino]-5-oxopentanoyl]amino]-4-methylpentanoyl]amino]-3-carboxypropanoyl]amino]-3-cyclohexylpropanoyl]amino]propanoyl]amino]-4-(carboxymethylamino)-4-oxobutanoic acidIC50100000.0 [1]
(3S)-3-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-Amino-2-[(2-aminoacetyl)amino]-5-oxopentanoyl]amino]-4-methylpentanoyl]amino]-3-carboxypropanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]-4-(carboxymethylamino)-4-oxobutanoic acidIC50200000.0 [1]
(3S)-3-[[(2S)-2-[[(2S)-5-Amino-2-[(2-aminoacetyl)amino]-5-oxopentanoyl]amino]-4-methylpentanoyl]amino]-4-[[(2S)-1-[[(2S)-1-[[(2S)-4-amino-1-(carboxymethylamino)-1,4-dioxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-oxobutanoic acidIC5052000.0 [1]
(3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-Amino-2-[(2-aminoacetyl)amino]-5-oxopentanoyl]amino]-3-cyclohexylpropanoyl]amino]-3-carboxypropanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-4-(carboxymethylamino)-4-oxobutanoic acidIC50100000.0 [1]
2-[(4R,10S,13S,16S,19S,22S,25S,31R)-31-Acetamido-25-(3-amino-3-oxopropyl)-4-carbamoyl-19-(carboxymethyl)-13-methyl-16,22-bis(2-methylpropyl)-6,9,12,15,18,21,24,27,30-nonaoxo-1,2-dithia-5,8,11,14,17,20,23,26,29-nonazacyclodotriacont-10-yl]acetic acidIC508000.0 [1]
Items per page: 1 - 10 of 81
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References

This online tool may be cited as follows

MLA

"Quest Database™ Transcription factor AP1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/transcription-factor-ap1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 20). Quest Database™ Transcription factor AP1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/transcription-factor-ap1-inhibitors-ic50-ki.
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