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Toll-like receptor 4 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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▼
6-(2-Aminophenoxy)benzo[d]isothiazol-3-amineIC503000.0 [1], 7000.0 [2]
[(2R,3R,4R,5S,6R)-4-Decoxy-5-hydroxy-6-[[(2R,3R,4R,5S,6S)-6-methoxy-4-[(3R)-3-methoxydecoxy]-3-[[(Z)-octadec-11-enoyl]amino]-5-phosphonooxyoxan-2-yl]oxymethyl]-3-(3-oxotetradecanoylamino)oxan-2-yl] dihydrogen phosphateIC501.5 [1]
CarvedilolIC5032220.0 [1]
ResatorvidIC50680.0 [1]
Ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-enecarboxylateIC503.2 [1]
N-[(2S)-4-Amino-1-[[(2S,3R)-1-[[(2S)-4-amino-1-oxo-1-[[(3S,6S,9S,12S,15R,18R,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-3-[(1R)-1-hydroxyethyl]-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]-6-methylheptanamide;(6S)-N-[(2S)-4-amino-1-[[(2S,3R)-1-[[(2S)-4-amino-1-oxo-1-[[(3S,6S,9S,12S,15R,18R,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-3-[(1R)-1-hydroxyethyl]-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]-6-methyloctanamideIC501230.0 [1]
Unii-8nlo017hhaIC502.4 [1]
CID 71158523IC5032550.0 [1]
1-[[1-[(2-Chlorophenyl)methyl]-3,5-dimethylpyrazol-4-yl]methyl-methylamino]-3-(4-ethoxyphenoxy)propan-2-olIC5034170.0 [1]
N,N-(p-Xylylidene)bisaminoguanidine dihydrochlorideIC50164000.0 [1]
Ethyl 7-[N-(2-chloro-4-fluorophenyl)sulfamoyl]cyclohept-1-ene-1-carboxylateIC50240.0 [1]
Ethyl 2-[N-(2-chloro-4-fluorophenyl)sulfamoyl]benzoateIC5010000.0 [1]
Ethyl 5-[N-(2-chloro-4-fluorophenyl)sulfamoyl]cyclopent-1-ene-1-carboxylateIC50110.0 [1]
6-(4-Chloro-2-fluoro-phenylsulfamoyl)-cyclohex-1-enecarboxylic acid ethyl esterIC50160.0 [1]
Disodium;[(2R,3R,4R,5S,6R)-3-(dodecanoylamino)-4-dodecanoyloxy-6-(hydroxymethyl)-5-[hydroxy(oxido)phosphoryl]oxyoxan-2-yl] hydrogen phosphateIC501700.0 [1]
Disodium;[(2R,3R,4R,5S,6R)-3-(decanoylamino)-4-decanoyloxy-6-(hydroxymethyl)-5-[hydroxy(oxido)phosphoryl]oxyoxan-2-yl] hydrogen phosphateIC5042000.0 [1]
1-[(1-Benzyl-3,5-dimethylpyrazol-4-yl)methyl-methylamino]-3-(9H-carbazol-4-yloxy)propan-2-olIC5031540.0 [1]
1-(9H-Carbazol-4-yloxy)-3-[[1-[(4-chlorophenyl)methyl]-3,5-dimethylpyrazol-4-yl]methyl-methylamino]propan-2-olIC5013640.0 [1]
1-(9H-Carbazol-4-yloxy)-3-[[1-[(2-fluorophenyl)methyl]-3,5-dimethylpyrazol-4-yl]methyl-methylamino]propan-2-olIC5034640.0 [1]
4-(9H-Carbazol-4-yloxy)-1-[[1-[(2-chlorophenyl)methyl]-3,5-dimethylpyrazol-4-yl]methyl-methylamino]butan-2-olIC5015110.0 [1]
1-(9H-Carbazol-4-yloxy)-3-[[1-[(2-chlorophenyl)methyl]-3,5-dimethylpyrazol-4-yl]methyl-methylamino]propan-2-olIC5012450.0 [1]
1-[[1-[(2-Chlorophenyl)methyl]-3,5-dimethylpyrazol-4-yl]methyl-methylamino]-4-(4-propylphenoxy)butan-2-olIC5024680.0 [1]
4-(4-Tert-butylphenoxy)-1-[[1-[(2-chlorophenyl)methyl]-3,5-dimethylpyrazol-4-yl]methyl-methylamino]butan-2-olIC5016680.0 [1]
1-[[1-[(2-Chlorophenyl)methyl]-3,5-dimethylpyrazol-4-yl]methyl-methylamino]-4-(4-fluorophenoxy)butan-2-olIC5055390.0 [1]
1-[[1-[(2-Chlorophenyl)methyl]-3,5-dimethylpyrazol-4-yl]methyl-methylamino]-4-(4-methylphenoxy)butan-2-olIC5051540.0 [1]
1-[[3,5-Dimethyl-1-[(2-methylphenyl)methyl]pyrazol-4-yl]methyl-methylamino]-4-(4-ethoxyphenoxy)butan-2-olIC5054600.0 [1]
1-[[1-[(2-Chlorophenyl)methyl]-3,5-dimethylpyrazol-4-yl]methyl-methylamino]-4-(4-ethylphenoxy)butan-2-olIC5026020.0 [1]
[2-[[3-(9H-Carbazol-4-yloxy)-2-hydroxypropyl]amino]-5-chlorophenyl]-phenylmethanoneIC5021120.0 [1]
1-(9H-Carbazol-4-yloxy)-3-(9H-fluoren-3-ylamino)propan-2-olIC5012390.0 [1]
1-(9H-Carbazol-4-yloxy)-3-(naphthalen-2-ylamino)propan-2-olIC5028530.0 [1]
1-(9H-Carbazol-4-yloxy)-3-(4-phenylanilino)propan-2-olIC5021710.0 [1]
1-[[1-[(4-Chlorophenyl)methyl]-3,5-dimethylpyrazol-4-yl]methyl-methylamino]-4-(4-ethoxyphenoxy)butan-2-olIC5025920.0 [1]
(NE)-N-[1-(6-methoxy-1,3-benzoxazol-2-yl)-2-(4-methoxyphenyl)ethylidene]hydroxylamineIC50540.0 [1]
(NE)-N-[1-(6-methyl-1,3-benzoxazol-2-yl)-2-phenylethylidene]hydroxylamineIC5019250.0 [1]
(NE)-N-[2-(4-fluorophenyl)-1-(5-methyl-1,3-benzoxazol-2-yl)ethylidene]hydroxylamineIC5045650.0 [1]
(NE)-N-[1-(6-chloro-1,3-benzoxazol-2-yl)-2-(4-methoxyphenyl)ethylidene]hydroxylamineIC505420.0 [1]
[(E)-1-(1,3-Benzoxazol-2-yl)ethylideneamino] 2-methoxybenzoateIC5025900.0 [1]
1-(4-Fluorophenyl)-2-[5-(2-hydroxy-5-methoxybenzoyl)pyrimidin-2-yl]guanidineIC5016600.0 [1]
2-[Methyl-[(4-oxo-5-phenyl-3H-thieno[2,3-d]pyrimidin-2-yl)methyl]amino]-N-(4-morpholin-4-ylphenyl)acetamideIC50167500.0 [1]
3-[2-[[(2S)-3-[(3R)-3-Dodecanoyloxydecoxy]-2-(tetradecanoylamino)propoxy]-hydroxyphosphoryl]oxyethylamino]-2-[(4-hydroxyphenyl)methyl]-3-oxopropanoic acidIC50250.0 [1]
3-[2-[[(2R)-3-[(3S)-3-Dodecanoyloxydecoxy]-2-(tetradecanoylamino)propoxy]-hydroxyphosphoryl]oxyethylamino]-2-[(4-hydroxyphenyl)methyl]-3-oxopropanoic acidIC50160.0 [1]
3-[2-[[(2S)-3-[(3S)-3-Dodecanoyloxydecoxy]-2-(tetradecanoylamino)propoxy]-hydroxyphosphoryl]oxyethylamino]-2-[(4-hydroxyphenyl)methyl]-3-oxopropanoic acidIC5080.0 [1]
3-[2-[[(2R)-3-[(3R)-3-Dodecanoyloxydecoxy]-2-(tetradecanoylamino)propoxy]-hydroxyphosphoryl]oxyethylamino]-2-[(4-hydroxyphenyl)methyl]-3-oxopropanoic acidIC50350.0 [1]
6-(4,5-Dihydro-thiazol-2-ylsulfamoyl)-cyclohex-1-enecarboxylic acid ethyl esterIC5010000.0 [1]
(2S)-2-[[(3R)-3-Hexoxytetradecanoyl]amino]-3-[(2R,3R,4R,5S,6R)-3-[[(3R)-3-hexoxytetradecanoyl]amino]-4-[(3R)-3-hexoxytetradecanoyl]oxy-6-(hydroxymethyl)-5-phosphonooxyoxan-2-yl]oxypropanoic acidIC505.3 [1]
2-[(E)-[4-[(E)-(Diaminomethylidenehydrazinylidene)methyl]-2,3-dihexoxyphenyl]methylideneamino]guanidine;dihydrochlorideIC506110.0 [1]
2-[(E)-[4-[(E)-(Diaminomethylidenehydrazinylidene)methyl]-2,3-bis(prop-2-enoxy)phenyl]methylideneamino]guanidine;dihydrochlorideIC5061400.0 [1]
2-[(E)-[2,3-Dibutoxy-4-[(E)-(diaminomethylidenehydrazinylidene)methyl]phenyl]methylideneamino]guanidine;dihydrochlorideIC509400.0 [1]
2-[(E)-[4-[(E)-(Diaminomethylidenehydrazinylidene)methyl]-2,3-dipentoxyphenyl]methylideneamino]guanidine;dihydrochlorideIC5010500.0 [1]
2-[(E)-[4-[(E)-(Diaminomethylidenehydrazinylidene)methyl]-2,3-dipropoxyphenyl]methylideneamino]guanidine;dihydrochlorideIC5027600.0 [1]
2-[(E)-[4-[(E)-(Diaminomethylidenehydrazinylidene)methyl]-2,3-dimethoxyphenyl]methylideneamino]guanidine;dihydrochlorideIC50175000.0 [1]
2-[(E)-[4-[(E)-(Diaminomethylidenehydrazinylidene)methyl]-2,3-dioctoxyphenyl]methylideneamino]guanidine;dihydrochlorideIC504500.0 [1]
2-[(E)-[4-[(E)-(Diaminomethylidenehydrazinylidene)methyl]-2,3-di(tetradecoxy)phenyl]methylideneamino]guanidine;dihydrochlorideIC50190000.0 [1]
2-[(E)-[4-[(E)-(Diaminomethylidenehydrazinylidene)methyl]-2,3-diethoxyphenyl]methylideneamino]guanidine;dihydrochlorideIC5035600.0 [1]
[(2R,3S,4R,5R,6R)-2-(Hydroxymethyl)-3,6-diphosphonooxy-5-(tetradecanoylamino)oxan-4-yl] tetradecanoateIC507700.0 [1]
6-[[(2R)-2-(1,3-Benzothiazol-2-yl)pyrrolidin-1-yl]methyl]-2-N-(2-methylphenyl)-1,3,5-triazine-2,4-diamineIC5064100.0 [1]
2-[(E)-[4-[(E)-(Diaminomethylidenehydrazinylidene)methyl]-2,3-dihydroxyphenyl]methylideneamino]guanidineIC5059100.0 [1]
Items per page: 1 - 10 of 57
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References

This online tool may be cited as follows

MLA

"Quest Database™ Toll-like receptor 4 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 19 Feb. 2025, https://www.aatbio.com/data-sets/toll-like-receptor-4-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 19). Quest Database™ Toll-like receptor 4 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/toll-like-receptor-4-inhibitors-ic50-ki.
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