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Toll-like receptor 2 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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(2Z)-2-[(2E,4E)-5-[1-[6-[2-[3-[3-[3-[2-[2-[3-[[2-[2-[[(2R)-1-[[2-[[(2R)-1-[3-[2-[2-[3-[[2-(2-Amino-2-oxoethoxy)acetyl]amino]propoxy]ethoxy]ethoxy]propylamino]-3-hydroxy-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-[(2R)-2,3-di(hexadecanoyloxy)propyl]sulfanyl-1-oxopropan-2-yl]amino]-2-oxoethoxy]acetyl]amino]propoxy]ethoxy]ethoxy]propylamino]-3-oxopropyl]sulfanyl-2,5-dioxopyrrolidin-1-yl]ethylamino]-6-oxohexyl]-5-sulfo-3H-indol-1-ium-2-yl]penta-2,4-dienylidene]-1-ethyl-3H-indole-5-sulfonateKi11.0 [1], 67.0 [2]
3-[2-[[(2R)-3-[(3R)-3-Dodecanoyloxydecoxy]-2-(tetradecanoylamino)propoxy]-hydroxyphosphoryl]oxyethylamino]-2-[(4-hydroxyphenyl)methyl]-3-oxopropanoic acidIC501600.0 [1], 3070.0 [2]
[(2R)-3-[(2R)-2-[[2-[2-[3-[2-[2-(3-Acetamidopropoxy)ethoxy]ethoxy]propylamino]-2-oxoethoxy]acetyl]amino]-3-[[2-[[(2R)-1-[3-[2-[2-[3-[[2-(2-amino-2-oxoethoxy)acetyl]amino]propoxy]ethoxy]ethoxy]propylamino]-3-hydroxy-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-oxopropyl]sulfanyl-2-hexadecanoyloxypropyl] hexadecanoateKi25.0 [1], 91.0 [2]
N-[(2R)-3-[(2R)-3-[[(2S)-1-[[(2S)-6-Amino-1-[[(2S)-6-amino-1-[[(2S)-6-amino-1-[[(2S)-1,6-diamino-1-oxohexan-2-yl]amino]-1-oxohexan-2-yl]amino]-1-oxohexan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-oxo-2-(tetradecanoylamino)propyl]sulfanyl-1-(octylamino)-1-oxopropan-2-yl]tetradecanamideIC505000.0 [1]
(2S)-6-Amino-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2R)-2-amino-3-[(2R)-2,3-di(hexadecanoyloxy)propyl]sulfanylpropanoyl]amino]-3-hydroxypropanoyl]amino]hexanoyl]amino]hexanoyl]amino]hexanoyl]amino]hexanoic acidIC50426.3 [1]
3-[[(2S)-2-(Hexadecanoylamino)-3-[hydroxy-[2-[[(2S,3S)-3-methyl-2-[[2-(5-phenyl-1H-indol-3-yl)acetyl]amino]pentanoyl]amino]ethoxy]phosphoryl]oxypropanoyl]amino]propyl dodecanoateIC50230.0 [1]
3-[2-[[(2S)-3-[[(3R)-3-Dodecanoyloxydecyl]amino]-3-oxo-2-(tetradecanoylamino)propoxy]-hydroxyphosphoryl]oxyethylamino]-2-[(4-hydroxyphenyl)methyl]-3-oxopropanoic acidIC50900.0 [1]
(2S)-6-Amino-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2R)-2-amino-3-[(2R)-2-[5-(decanoylamino)pentanoyloxy]-3-hexadecanoyloxypropyl]sulfanylpropanoyl]amino]-3-hydroxypropanoyl]amino]hexanoyl]amino]hexanoyl]amino]hexanoyl]amino]hexanoic acidIC504651.0 [1]
(2S)-6-Amino-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2R)-2-amino-3-[(2R)-3-[11-(butanoylamino)undecanoyloxy]-2-hexadecanoyloxypropyl]sulfanylpropanoyl]amino]-3-hydroxypropanoyl]amino]hexanoyl]amino]hexanoyl]amino]hexanoyl]amino]hexanoic acidIC504363.0 [1]
(2S)-6-Amino-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2R)-2-amino-3-[(2R)-2-[3-(dodecanoylamino)propanoyloxy]-3-hexadecanoyloxypropyl]sulfanylpropanoyl]amino]-3-hydroxypropanoyl]amino]hexanoyl]amino]hexanoyl]amino]hexanoyl]amino]hexanoic acidIC501682.0 [1]
(2S)-6-Amino-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2R)-2-amino-3-[(2R)-3-hexadecanoyloxy-2-[6-(nonanoylamino)hexanoyloxy]propyl]sulfanylpropanoyl]amino]-3-hydroxypropanoyl]amino]hexanoyl]amino]hexanoyl]amino]hexanoyl]amino]hexanoic acidIC504755.0 [1]
(2S)-6-Amino-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2R)-2-amino-3-[(2R)-3-hexadecanoyloxy-2-[7-(octanoylamino)heptanoyloxy]propyl]sulfanylpropanoyl]amino]-3-hydroxypropanoyl]amino]hexanoyl]amino]hexanoyl]amino]hexanoyl]amino]hexanoic acidIC503373.0 [1]
(2S)-6-Amino-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2R)-2-amino-3-[(2R)-2-hexadecanoyloxy-3-[9-(hexanoylamino)nonanoyloxy]propyl]sulfanylpropanoyl]amino]-3-hydroxypropanoyl]amino]hexanoyl]amino]hexanoyl]amino]hexanoyl]amino]hexanoic acidIC507519.0 [1]
(2S)-6-Amino-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2R)-2-amino-3-[(2R)-2-hexadecanoyloxy-3-[12-(propanoylamino)dodecanoyloxy]propyl]sulfanylpropanoyl]amino]-3-hydroxypropanoyl]amino]hexanoyl]amino]hexanoyl]amino]hexanoyl]amino]hexanoic acidIC503938.0 [1]
(2S)-6-Amino-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2R)-2-amino-3-[(2R)-3-hexadecanoyloxy-2-[4-(undecanoylamino)butanoyloxy]propyl]sulfanylpropanoyl]amino]-3-hydroxypropanoyl]amino]hexanoyl]amino]hexanoyl]amino]hexanoyl]amino]hexanoic acidIC501962.0 [1]
(2S)-6-Amino-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2R)-2-amino-3-[(2R)-2-hexadecanoyloxy-3-[10-(pentanoylamino)decanoyloxy]propyl]sulfanylpropanoyl]amino]-3-hydroxypropanoyl]amino]hexanoyl]amino]hexanoyl]amino]hexanoyl]amino]hexanoic acidIC506427.0 [1]
[(2S)-3-(3-Hydroxyhexadecylamino)-2-(icosanoylamino)-3-oxopropyl] 2-[[(2S,3S)-2-[[2-(1H-indol-3-yl)acetyl]amino]-3-methylpentanoyl]amino]ethyl hydrogen phosphateIC50460.0 [1]
3-[2-[[(2S)-3-[(3R)-3-Dodecanoyloxydecoxy]-3-oxo-2-(tetradecanoylamino)propoxy]-hydroxyphosphoryl]oxyethylamino]-2-[(4-hydroxyphenyl)methyl]-3-oxopropanoic acidIC50950.0 [1]
3-[2-[[(2R)-3-[(3R)-3-Dodecanoyloxydecoxy]-2-tetradecanoyloxypropoxy]-hydroxyphosphoryl]oxyethylamino]-2-[(4-hydroxyphenyl)methyl]-3-oxopropanoic acidIC501250.0 [1]
[(3R)-1-[(2R)-3-[Hydroxy-[2-[3-(4-hydroxyphenyl)propanoylamino]ethoxy]phosphoryl]oxy-2-(tetradecanoylamino)propoxy]decan-3-yl] dodecanoateIC502150.0 [1]
3-[2-[[(2R)-3-[(3R)-3-(Dodecanoylamino)decoxy]-2-(tetradecanoylamino)propoxy]-hydroxyphosphoryl]oxyethylamino]-2-[(4-hydroxyphenyl)methyl]-3-oxopropanoic acidIC505200.0 [1]
3-[2-[[(2S)-3-[(3R)-3-Dodecanoyloxydecoxy]-2-(tetradecanoylamino)propoxy]-hydroxyphosphoryl]oxyethylamino]-2-[(4-hydroxyphenyl)methyl]-3-oxopropanoic acidIC5022000.0 [1]
3-[2-[[(2R)-3-[(3S)-3-Dodecanoyloxydecoxy]-2-(tetradecanoylamino)propoxy]-hydroxyphosphoryl]oxyethylamino]-2-[(4-hydroxyphenyl)methyl]-3-oxopropanoic acidIC506460.0 [1]
3-[2-[[(2S)-3-[(3S)-3-Dodecanoyloxydecoxy]-2-(tetradecanoylamino)propoxy]-hydroxyphosphoryl]oxyethylamino]-2-[(4-hydroxyphenyl)methyl]-3-oxopropanoic acidIC506900.0 [1]
[(2S)-3-(3-Hydroxyhexadecylamino)-2-(icosanoylamino)-3-oxopropyl] 2-[[(2S,3S)-3-methyl-2-[[2-(5-phenylmethoxy-1H-indol-3-yl)acetyl]amino]pentanoyl]amino]ethyl hydrogen phosphateIC50240.0 [1]
(2R,3S)-4-[2-[[(2S)-3-(3-Dodecanoyloxydecylamino)-3-oxo-2-(tetradecanoylamino)propoxy]-hydroxyphosphoryl]oxyethylamino]-3-[[2-(4-hydroxyphenyl)acetyl]amino]-2-methyl-4-oxobutanoic acidIC50900.0 [1]
[(2R)-3-[2-[[(2R)-2-Amino-3-hydroxypropanoyl]amino]ethylsulfanyl]-2-hexadecanoyloxypropyl] hexadecanoateIC501200.0 [1]
[(2R)-3-[(2R)-3-[[2-[[(2R)-1-[3-[2-[2-[3-[[2-(2-Amino-2-oxoethoxy)acetyl]amino]propoxy]ethoxy]ethoxy]propylamino]-3-hydroxy-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-oxo-2-[[2-[2-oxo-2-[3-[2-[2-[3-(3-sulfanylpropanoylamino)propoxy]ethoxy]ethoxy]propylamino]ethoxy]acetyl]amino]propyl]sulfanyl-2-hexadecanoyloxypropyl] hexadecanoateKi25.0 [1]
[(2R)-3-[(2R)-2-Amino-3-[[(2S)-3-hydroxy-1-methoxy-1-oxopropan-2-yl]amino]-3-oxopropyl]sulfanyl-2-(hexadecanoylamino)propyl] hexadecanoateIC5048.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Toll-like receptor 2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/toll-like-receptor-2-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ Toll-like receptor 2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/toll-like-receptor-2-inhibitors-ic50-ki.
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