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TNF-alpha Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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6,7-Dimethyl-3-[[methyl-[2-[methyl-[[1-[3-(trifluoromethyl)phenyl]indol-3-yl]methyl]amino]ethyl]amino]methyl]chromen-4-oneIC505000.0 [1], 15000.0 [2], 22000.0 [3]
RolipramIC50200.0 [1], 500.0 [2], 12000.0 [3]
MesalamineIC5020000.0 [1], 20600000.0 [2]
1-Propyl-2,4-dioxo-1,4-dihydropteridine-3(2H)-butyric acid ethyl esterIC503000.0 [1], 5000.0 [2]
4-N-Benzyl-4-N-[2-[3-(2-piperazin-1-ylpyrimidin-5-yl)phenyl]phenyl]pyrimidine-2,4-diamineIC501100.0 [1], 1200.0 [2]
N-(3-Chloro-4-hydroxyphenyl)-2-oxo-1,2-dihydrobenzo[cd]indole-6-sulfonamideIC5042300.0 [1], 45700.0 [2]
9-N,11-N-Bis(4-hydroxyphenyl)-3-oxo-2-thiatricyclo[6.3.1.04,12]dodeca-1(11),4,6,8(12),9-pentaene-9,11-disulfonamideIC5014000.0 [1], 25300.0 [2]
3-[4-[1-(Benzenesulfonyl)indole-3-carbonyl]piperazine-1-carbonyl]chromen-4-oneIC5015000.0 [1], 40000.0 [2]
N-Methyl-N-[2-[methyl-(4-oxochromene-3-carbonyl)amino]ethyl]-1-(3-nitrophenyl)sulfonylindole-3-carboxamideIC5020000.0 [1], 40000.0 [2]
3-[4-[1-(3-Nitrophenyl)sulfonylindole-3-carbonyl]piperazine-1-carbonyl]chromen-4-oneIC5020000.0 [1], 40000.0 [2]
1-(3-Aminophenyl)sulfonyl-N-methyl-N-[2-[methyl-(4-oxochromene-3-carbonyl)amino]ethyl]indole-3-carboxamideIC5020000.0 [1], 25000.0 [2]
3-[4-[1-(3-Aminophenyl)sulfonylindole-3-carbonyl]piperazine-1-carbonyl]chromen-4-oneIC5020000.0 [1], 40000.0 [2]
Phenyl-[4-[[1-[3-(trifluoromethyl)phenyl]indol-3-yl]methyl]piperazin-1-yl]methanoneIC5015000.0 [1], 20000.0 [2]
1-(Benzenesulfonyl)-N-[3-[(4-oxochromene-3-carbonyl)amino]propyl]indole-3-carboxamideIC5020000.0 [1], 40000.0 [2]
6-Methyl-3-[[methyl-[2-[methyl-[[1-[3-(trifluoromethyl)phenyl]indol-3-yl]methyl]amino]ethyl]amino]methyl]chromen-4-oneIC5010000.0 [1], 30000.0 [2]
6-Methyl-3-[[4-[[1-[3-(trifluoromethyl)phenyl]indol-3-yl]methyl]piperazin-1-yl]methyl]chromen-4-oneIC5015000.0 [1], 30000.0 [2]
N-[2-[(6,7-Dimethyl-4-oxochromene-3-carbonyl)-methylamino]ethyl]-N-methyl-1-[3-(trifluoromethyl)phenyl]indole-3-carboxamideIC5020000.0 [1], 60000.0 [2]
3-[4-[5-Amino-1-(3-aminophenyl)indole-3-carbonyl]piperazine-1-carbonyl]chromen-4-oneIC5040000.0 [1]
3-[4-[5-Nitro-1-(3-nitrophenyl)indole-3-carbonyl]piperazine-1-carbonyl]chromen-4-oneIC5015000.0 [1], 20000.0 [2]
3-[4-[1-(3-Aminophenyl)indole-3-carbonyl]piperazine-1-carbonyl]chromen-4-oneIC5010000.0 [1], 20000.0 [2]
1-(Benzenesulfonyl)-N-methyl-N-[2-[methyl-(4-oxochromene-3-carbonyl)amino]ethyl]indole-3-carboxamideIC5060000.0 [1]
3-[4-[[1-[3-(Trifluoromethyl)phenyl]indol-3-yl]methyl]piperazine-1-carbonyl]chromen-4-oneIC5010000.0 [1], 20000.0 [2]
Naphthalen-2-yl-[4-[[1-[3-(trifluoromethyl)phenyl]indol-3-yl]methyl]piperazin-1-yl]methanoneIC5020000.0 [1], 40000.0 [2]
6,7-Dimethyl-3-[[4-[[1-[3-(trifluoromethyl)phenyl]indol-3-yl]methyl]piperazin-1-yl]methyl]chromen-4-oneIC5010000.0 [1], 15000.0 [2]
PentoxifyllineIC5085000.0 [1]
4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinoneIC5050000.0 [1]
MarimastatIC501001.0 [1]
BergeninIC5012500.0 [1]
(E)-2-(Pyridin-4-ylmethylene)-2,3-dihydroinden-1-oneIC505750.0 [1]
1-(3-Carboxypropyl)-3,7-dimethylxanthineIC50200000.0 [1]
Methyl 3-phthalimido-3-(3,4-dimethoxyphenyl)propionateIC502900.0 [1]
(2R,3R)-1-[4-[(2-Chloro-4-fluorophenyl)methoxy]phenyl]sulfonyl-N,3-dihydroxy-3-methylpiperidine-2-carboxamideIC5010.4 [1]
3-Phthalimido-3-(3,4-dimethoxyphenyl)propionamideIC5012000.0 [1]
Methyl 3-(5-amino-1,3-dioxoisoindolin-2-yl)-3-(3,4-dimethoxyphenyl)propanoateIC50380.0 [1]
(2S,3R)-N-[(2S)-3,3-Dimethyl-1-(methylamino)-1-oxobutan-2-yl]-N'-hydroxy-3-(hydroxymethyl)-2-(4-methoxyphenyl)butanediamideIC5048.0 [1]
3-(3,4-Dimethoxyphenyl)-3-phthalimidopropanoic acidIC5060000.0 [1]
1,3-Dihydro-1,3-dioxo-beta-phenyl-2H-isoindole-2-propanamideIC50260000.0 [1]
2-(2,6-Dioxo-piperidin-3-yl)-4,5,6,7-tetrafluoro-isoindole-1,3-dioneIC50400.0 [1]
N-(3-Chloro-4-hydroxyphenyl)-4-fluorobenzenesulfonamideIC50100000.0 [1]
(2S,3R)-N-[(2S)-3,3-Dimethyl-1-(methylamino)-1-oxobutan-2-yl]-N'-hydroxy-3-(hydroxymethyl)-2-(4-methylphenyl)butanediamideIC50269.0 [1]
3-Propyl-7-methyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purine-1-butyric acid ethyl esterIC505000.0 [1]
3-Phthalimido-3-(3,4-diethoxyphenyl)propionamideIC505600.0 [1]
6-Amino-4-oxo-3,4-dihydroquinazoline-3-butyric acid ethyl esterIC504000.0 [1]
Methyl 3-(4-amino-1,3-dioxoisoindol-2-yl)-3-(3,4-dimethoxyphenyl)propanoateIC50450.0 [1]
(3-Bromo-phenyl)-(6,7-dimethoxy-isoquinolin-1-yl)-amineIC5037000.0 [1]
4-(2-Dimethylamino-6,7-dimethoxy-quinazolin-4-yloxy)-butyric acid ethyl esterIC5025000.0 [1]
4-(4-Bromo-6,7-dimethoxy-1-oxoisoquinolin-2-yl)-N-methylbutanamideIC50100000.0 [1]
Ethyl 4-[6,7-bis(ethoxycarbonyloxy)-1-oxoisoquinolin-2-yl]butanoateIC5011000.0 [1]
1-Oxo-1,2-dihydroisoquinoline-2-butyric acid ethyl esterIC505000.0 [1]
4-(1-Methyl-2,4-dioxopteridin-3-yl)butanoic acidIC50200000.0 [1]
Ethyl 4-(1-butyl-2,4-dioxopteridin-3-yl)butanoateIC5015000.0 [1]
(4-Bromo-phenyl)-(6,7-dimethoxy-isoquinolin-1-yl)-amineIC5038000.0 [1]
4-Acetyl-6,7-dimethoxy-1-oxo-1,2-dihydroisoquinoline-2-butyric acid ethyl esterIC5015000.0 [1]
2-(4-Azidoanilino)-6,7-dimethoxy-4-oxo-3,4-dihydroquinazoline-3-butyric acid ethyl esterIC5050000.0 [1]
2-(6,7-Dimethoxy-isoquinolin-1-ylamino)-ethanolIC5055000.0 [1]
4-(4-Oxo-4H-quinazolin-3-yl)-butyric acid ethyl esterIC5025000.0 [1]
4-(4-Methyl-5,7-dioxo-[1,2,5]thiadiazolo[3,4-d]pyrimidin-6-yl)butanoic acidIC50200000.0 [1]
4-(7-Chloro-4-oxo-4H-quinazolin-3-yl)-butyric acid ethyl esterIC5025000.0 [1]
(4-Chloro-phenyl)-(6,7-dimethoxy-isoquinolin-1-yl)-amineIC5035000.0 [1]
Ethyl 4-(1-benzyl-2,4-dioxopteridin-3-yl)butanoateIC50175000.0 [1]
Ethyl 4-(4-bromo-6,7-dihydroxy-1-oxoisoquinolin-2-yl)butanoateIC501000.0 [1]
5-(Acetylamino)-6,7-dimethoxy-4-oxo-3,4-dihydroquinazoline-3-butyric acid ethyl esterIC50100000.0 [1]
Ethyl 4-(4-bromo-6,7-dimethoxy-1-oxoisoquinolin-2-yl)butanoateIC5051000.0 [1]
Ethyl 4-[2-(4-bromoanilino)-6,7-dimethoxyquinazolin-4-yl]oxybutanoateIC5025000.0 [1]
3-(3,5-Dimethoxy-phenyl)-3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propionamideIC5039000.0 [1]
2-Azido-6,7-dimethoxy-4-oxo-3,4-dihydroquinazoline-3-butyric acid ethyl esterIC5014000.0 [1]
3-(3,4-Dimethoxy-phenyl)-3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-N-methyl-propionamideIC5012000.0 [1]
Methyl 3-(3,4-dimethoxyphenyl)-3-(4-hydroxy-1,3-dioxoisoindol-2-yl)propanoateIC5015000.0 [1]
3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-(3,4-dipropoxy-phenyl)-propionamideIC5055000.0 [1]
Ethyl 4-(4-methyl-5,7-dioxo-[1,2,5]thiadiazolo[3,4-d]pyrimidin-6-yl)butanoateIC5025000.0 [1]
(3-Chloro-phenyl)-(6,7-dimethoxy-isoquinolin-1-yl)-amineIC5033000.0 [1]
4-(2-Chloro-6,7-dimethoxyquinazoline-4-yloxy)butyric acid ethyl esterIC5068000.0 [1]
Ethyl 4-(8-bromo-3,7-dimethyl-2,6-dioxopurin-1-yl)butanoateIC5060000.0 [1]
4-(6,7-Difluoro-4-oxo-4H-quinazolin-3-yl)-butyric acid ethyl esterIC5025000.0 [1]
3-(3,4-Dimethoxy-phenyl)-3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-N-ethyl-propionamideIC5053000.0 [1]
7-Amino-4-oxo-3,4-dihydroquinazoline-3-butyric acid ethyl esterIC509000.0 [1]
6,7-Dimethoxy-1-oxo-1,2-dihydroisoquinoline-2-butyric acid ethyl esterIC505000.0 [1]
6,7-Dimethoxy-1-oxo-1,2-dihydroisoquinoline-2-valeric acid ethyl esterIC5021000.0 [1]
Ethyl 3-(3,7-dimethyl-2,6-dioxopurin-1-yl)propanoateIC5010000.0 [1]
4-(2,4-Dioxo-1-propylpteridin-3-yl)butanoic acidIC50200000.0 [1]
Ethyl 4-(3,7-dimethyl-2,6-dioxo-8-sulfanylidene-9H-purin-1-yl)butanoateIC50100000.0 [1]
Ethyl 4-(2-chloro-6,7-dimethoxy-4-oxoquinazolin-3-yl)butanoateIC5048000.0 [1]
Methyl 3-(3,4-dimethoxyphenyl)-3-(5-nitro-1,3-dioxoisoindol-2-yl)propanoateIC5034000.0 [1]
Ethyl 4-(6-amino-4-oxo-1,2-dihydroquinazolin-3-yl)butanoateIC5010000.0 [1]
4-(6-Chloro-4-oxo-4H-quinazolin-3-yl)-butyric acid ethyl esterIC5025000.0 [1]
7-Nitro-4-oxo-3,4-dihydroquinazoline-3-butyric acid ethyl esterIC5025000.0 [1]
Ethyl 3-(6,7-dimethoxy-4-oxoquinazolin-3(4H)-yl)propanoateIC509000.0 [1]
3-(3-Cyano-phenyl)-3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propionamideIC5089000.0 [1]
Ethyl 4-[1-(2-methylpropyl)-2,4-dioxopteridin-3-yl]butanoateIC5020000.0 [1]
4-(6-Bromo-4-oxo-4H-quinazolin-3-yl)-butyric acid ethyl esterIC5025000.0 [1]
Methyl 4-[(8-bromo-3,7-dimethyl-2,6-dioxopurin-1-yl)methyl]benzoateIC50200000.0 [1]
Methyl 3-(5,6-dichloro-1,3-dioxoisoindol-2-yl)-3-(3,4-dimethoxyphenyl)propanoateIC5013000.0 [1]
N-Benzyl-3-(3,4-dimethoxy-phenyl)-3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propionamideIC5084000.0 [1]
4-(6,7-Dihydroxy-1-oxo-1H-isoquinolin-2-yl)-butyric acid ethyl esterIC502000.0 [1]
Ethyl 4-(2,4-dioxo-1-pentylpteridin-3-yl)butanoateIC5016000.0 [1]
5-Azido-6,7-dimethoxy-4-oxo-3,4-dihydroquinazoline-3-butyric acid ethyl esterIC5025000.0 [1]
4-Nitro-6,7-dimethoxy-1-oxo-1,2-dihydroisoquinoline-2-butyric acid ethyl esterIC5035000.0 [1]
4-(1-Methyl-2,4-dioxoquinazolin-3-yl)butanoic acidIC50200000.0 [1]
Ethyl 4-(7-fluoro-4-oxoquinazolin-3-yl)butanoateIC5025000.0 [1]
6-Heptyl-4-methyl-[1,2,5]thiadiazolo[3,4-d]pyrimidine-5,7-dioneIC5075000.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ TNF-alpha Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 22 Feb. 2025, https://www.aatbio.com/data-sets/tnf-alpha-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 22). Quest Database™ TNF-alpha Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/tnf-alpha-inhibitors-ic50-ki.
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