Tissue-type plasminogen activator Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Razaxaban	Ki	33000.0 [1]
	6-(N-Phenylcarbamyl)-2-naphthalenecarboxamidine	IC50	125000.0 [1]
	6-(N-Phenylcarbamyl)-2-naphthalenecarboxamidine	Ki	31800.0 [1], 32000.0 [2]
	3-{5-[Amino(iminio)methyl]-1H-indol-2-YL}-1,1'-biphenyl-2-olate	Ki	35.0 [1], 100.0 [2]
	Amiloride	IC50	220000.0 [1], 250000.0 [2]
	Efegatran	IC50	34.0 [1], 21000.0 [2]
	Naphthalene-2-carboximidamide	Ki	100000.0 [1]
	2-[3-(Aminomethyl)phenyl]-N-[2-fluoro-4-(2-methylsulfonylphenyl)phenyl]-5-(trifluoromethyl)pyrazole-3-carboxamide;hydrochloride	Ki	45000.0 [1]
	6-Chloro-2-(2-Hydroxybiphenyl-3-yl)-1H-Indole-5-Carboxamidine	Ki	110.0 [1], 8800.0 [2]
	1-[[5-(5-Chlorothiophen-2-yl)-1,2-oxazol-3-yl]methyl]-N-(1-propan-2-ylpiperidin-4-yl)indole-2-carboxamide	Ki	100000.0 [1]
	4-[(E)-(5-Oxo-2-phenyl-1,3-oxazol-4-ylidene)methyl]benzenecarboximidamide	IC50	68510.0 [1], 100000.0 [2]
	6-[N-(4-(Aminomethyl)phenyl)carbamyl]-2-naphthalenecarboxamidine	IC50	62000.0 [1]
	6-[N-(4-(Aminomethyl)phenyl)carbamyl]-2-naphthalenecarboxamidine	Ki	58400.0 [1]
	Diphenyl N-(benzyloxycarbonyl)amino(4-amidinophenyl)methanephosphonate	IC50	2500.0 [1], 66000.0 [2]
	2-(3-Bromo-5-chloro-2-pyridinyl)guanidine	Ki	272000.0 [1]
	6-Carbamimidoyl-4-(furan-3-yl)-N-phenylnaphthalene-2-carboxamide	Ki	176.0 [1], 180.0 [2]
	6-Carbamimidoyl-N-phenyl-4-(pyrimidin-2-ylamino)naphthalene-2-carboxamide	Ki	810.0 [1]
	(2R)-2-(Benzylsulfonylamino)-N-[(2S)-1-[[2-[4-(diaminomethylideneamino)phenyl]-1-diphenoxyphosphorylethyl]amino]-1-oxopropan-2-yl]-3-hydroxypropanamide	IC50	280.0 [1]
	N-[(1S)-1-[4-(3-Amino-1H-indazol-6-yl)pyridin-2-yl]-2-phenylethyl]-4-(aminomethyl)cyclohexane-1-carboxamide	Ki	21900.0 [1]
	Benzyl N-[(2R)-1-[[(2S)-1-[[2-[4-(diaminomethylideneamino)phenyl]-1-diphenoxyphosphorylethyl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]carbamate	IC50	4600.0 [1], 14000.0 [2]
	6-Methyl-2-(2-hydroxy-3-biphenylyl)-1H-indole-5-carboxamidine	Ki	210.0 [1], 39000.0 [2]
	6-Methoxy-2-(2-hydroxy-3-biphenylyl)-1H-indole-5-carboxamidine	Ki	3900.0 [1], 18000.0 [2]
	4-Chloro-2-(2-hydroxy-3-biphenylyl)-1H-indole-5-carboxamidine	Ki	3000.0 [1], 3300.0 [2]
	6-Hydroxy-2-(2-hydroxy-3-biphenylyl)-1H-indole-5-carboxamidine	Ki	19000.0 [1], 46000.0 [2]
	Benzyl N-[2-[4-(diaminomethylideneamino)phenyl]-1-diphenoxyphosphorylethyl]carbamate	IC50	12000.0 [1]
	Benzyl N-[3-(4-carbamimidoylphenyl)-1-diphenoxyphosphorylpropyl]carbamate	IC50	68000.0 [1]
	Benzyl N-[4-(diaminomethylideneamino)-1-diphenoxyphosphorylbutyl]carbamate	IC50	44000.0 [1]
	2-(2-Hydroxy-3-biphenylyl)-6-fluoro-1H-indole-5-carboxamidine	Ki	350.0 [1], 3600.0 [2]
	Dabigatran	Ki	45360.0 [1]
	Benzamidine	Ki	910000.0 [1]
	Argatroban	Ki	87800.0 [1]
	Gabexate	IC50	15360.0 [1]
	Melagatran	Ki	1510.0 [1]
	5-(N,N-Hexamethylene)amiloride	IC50	10000.0 [1]
	Betrixaban	IC50	10000.0 [1]
	1-Phenylguanidine	Ki	733000.0 [1]
	Vaborbactam	IC50	1000000.0 [1]
	Acetylphenylalanyl-prolyl-boroarginine	Ki	5.7 [1]
	Tert-butyloxy carbonyl-D-Phe-pro-Arg-H	IC50	950.0 [1]
	(2S)-3-(7-Carbamimidoylnaphthalen-2-yl)-2-[4-[(3S)-1-ethanimidoylpyrrolidin-3-yl]oxyphenyl]propanoic acid	Ki	21000.0 [1]
	6-[2-(2-Methyl-1-propan-2-yl-3,4-dihydro-1H-isoquinolin-7-yl)cyclopropyl]naphthalene-2-carboximidamide	Ki	6230.0 [1]
	Bms-262084	IC50	8250.0 [1]
	Unii-IF979jqu3S	Ki	27200.0 [1]
	Letaxaban	IC50	44000.0 [1]
	(3R,8R,11S,14S,17S,20S,23S,26S,29S,32S)-3-Amino-11-(carboxymethyl)-20-[3-(diaminomethylideneamino)propyl]-23-(hydroxymethyl)-17,26-bis[(4-hydroxyphenyl)methyl]-29-methyl-14-(2-methylpropyl)-2,10,13,16,19,22,25,28,31-nonaoxo-5,6-dithia-1,9,12,15,18,21,24,27,30-nonazabicyclo[30.3.0]pentatriacontane-8-carboxylic acid	Ki	1000000.0 [1]
	Wx-uk1 free base	Ki	4900.0 [1]
	4-[[(3S)-3-[(7-Methoxynaphthalen-2-yl)sulfonyl-methylamino]-2-oxopyrrolidin-1-yl]methyl]thiophene-2-carboximidamide	Ki	8600.0 [1]
	2-{5-[Amino(iminio)methyl]-1H-benzimidazol-2-YL}benzenolate	Ki	75000.0 [1]
	Bms-740808	Ki	2800.0 [1]
	Unii-1Y3JD5pems	IC50	25100.0 [1]
	Cyanopeptolin 1020	IC50	2500.0 [1]
	Unii-vwj4vvz3OU	Ki	6200.0 [1]
	6-[1-[3-(6-Chloronaphthalen-2-yl)sulfonylpropanoyl]piperidin-4-yl]-3-methyl-7H-imidazo[1,5-c]imidazol-5-one	Ki	60000.0 [1]
	2-(2-Hydroxy-biphenyl)-1h-benzoimidazole-5-carboxamidine	Ki	1000.0 [1]
	2-(2-Hydroxyphenyl)-1H-indole-5-carboxamidine	Ki	9400.0 [1]
	2-{5-[Amino(iminio)methyl]-1H-indol-2-YL}-6-bromo-4-methylbenzenolate	Ki	460.0 [1]
	3-[[(3S)-3-[(7-Methoxynaphthalen-2-yl)sulfonylamino]-2-oxopyrrolidin-1-yl]methyl]benzenecarboximidamide	Ki	10000.0 [1]
	N-[(1R,2S,5S)-2-[(5-Chloro-1H-indole-2-carbonyl)amino]-5-(dimethylcarbamoyl)cyclohexyl]-5-methyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-2-carboxamide	Ki	68200.0 [1]
	Unii-FS64O4K98A	Ki	433.0 [1]
	2-[[4-Chloro-1-(diaminomethylideneamino)isoquinolin-7-yl]sulfonylamino]-2-methylpropanoic acid	Ki	40000.0 [1]
	3-[[(3S)-3-(Naphthalen-2-ylsulfonylamino)-2-oxopyrrolidin-1-yl]methyl]benzenecarboximidamide	Ki	10000.0 [1]
	3-Chloro-N-[4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]-6-methoxyphenyl]-4-[[4,5-dihydro-1,3-oxazol-2-yl(methyl)amino]methyl]thiophene-2-carboxamide	Ki	5000.0 [1]
	1-Cyano-3-(2-methyl-1-benzofuran-5-yl)-2-[(3S)-2-oxo-1-(2-oxo-2-pyrrolidin-1-ylethyl)azepan-3-yl]guanidine	Ki	3700.0 [1]
	Bms-344577	Ki	665.0 [1]
	Methyl N-[4-[5-chloro-2-[(1S)-1-[[(E)-3-[5-chloro-2-(tetrazol-1-yl)phenyl]prop-2-enoyl]amino]-2-phenylethyl]-1H-imidazol-4-yl]phenyl]carbamate	Ki	6150.0 [1]
	2-[2-(Aminomethyl)phenyl]-N-[2-fluoro-4-(2-sulfamoylphenyl)phenyl]-5-(trifluoromethyl)pyrazole-3-carboxamide	Ki	33000.0 [1]
	Tert-butyl N-[(1R)-2-[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-2-oxo-1-phenylethyl]carbamate	IC50	8700.0 [1]
	5-Chloro-N-(5-chloro-pyridin-2-yl)-2-[4-(N,N-dimethyl-carbamimidoyl)-benzoylamino]-benzamide	IC50	10000.0 [1]
	5-Chloro-N-(5-chloro-pyridin-2-yl)-2-[4-(2-imino-oxazolidin-3-ylmethyl)-benzoylamino]-benzamide	IC50	11000.0 [1]
	6-Fluoro-2-(2-hydroxy-3-isobutoxy-phenyl)-1H-benzoimidazole-5-carboxamidine	Ki	61000.0 [1]
	6-[(Z)-Amino(imino)methyl]-N-[3-(cyclopentyloxy)phenyl]-2-naphthamide	Ki	3390.0 [1]
	6-[(Z)-Amino(imino)methyl]-N-[4-(aminomethyl)phenyl]-4-(pyrimidin-2-ylamino)-2-naphthamide	Ki	680.0 [1]
	8-(Pyrimidin-2-ylamino)naphthalene-2-carboximidamide	Ki	24000.0 [1]
	6-[1-[(2S)-3-(6-Chloronaphthalen-2-yl)sulfonyl-2-hydroxypropanoyl]piperidin-4-yl]-3-methyl-7H-imidazo[1,5-c]imidazol-5-one	Ki	60000.0 [1]
	3-[6-[4-[2-[(Dimethylamino)methyl]phenyl]phenyl]-7-oxo-3-(trifluoromethyl)-4,5-dihydropyrazolo[3,4-c]pyridin-1-yl]benzamide	Ki	1800.0 [1]
	N-[2-(Diaminomethylideneamino)oxyethyl]-2-[3-[(2,2-difluoro-2-phenylethyl)amino]-6-methyl-2-oxopyrazin-1-yl]acetamide	Ki	2400.0 [1]
	2-[(3S)-3-(Benzylsulfonylamino)-2-oxopiperidin-1-yl]-N-[(3S)-1-carbamimidoyl-2-hydroxypiperidin-3-yl]acetamide	IC50	2500.0 [1]
	5-Chloro-N-((1R,2S)-2-(4-(2-oxopyridin-1(2H)-YL)benzamido) cyclopentyl)thiophene-2-carboxamide	Ki	20000.0 [1]
	(5S,11R)-24-Chloro-11-cyclohexyl-20-oxa-3,9,12,17-tetrazatricyclo[19.4.0.05,9]pentacosa-1(21),22,24-triene-4,10,13,18-tetrone	Ki	8900.0 [1]
	1H-Indole-1-acetamide,N-(5-chloro-2-pyridinyl)-2-[[[1-(1-methylethyl)-4-piperidinyl]amino]carbonyl]-	Ki	100000.0 [1]
	(E)-2-(5-Chlorothiophen-2-yl)-N-[(3S)-1-[(2S)-1-morpholin-4-yl-1-oxopropan-2-yl]-2-oxopyrrolidin-3-yl]prop-1-ene-1-sulfonamide	IC50	5010.0 [1]
	3-(6-Chloronaphthalen-2-yl)sulfonyl-N-methyl-N-[1-(2-methylpyridin-4-yl)piperidin-4-yl]propanamide	Ki	67000.0 [1]
	6-(2-(1-Isopropyl-3,4-dihydroisoquinolin-7-yl)cyclopropyl)-2-naphthimidamide	Ki	4740.0 [1]
	2-(3-Amino-1,2-benzoxazol-5-yl)-N-[4-[2-[(dimethylamino)methyl]phenyl]-2-fluorophenyl]-5-(trifluoromethyl)pyrazole-3-carboxamide	Ki	33000.0 [1]
	2-[4-[(6-Chloro-1-benzothiophen-2-yl)sulfonyl]-2-oxopiperazin-1-yl]-N-[2-(3-methylimidazol-4-yl)ethyl]acetamide	Ki	8700.0 [1]
	6-Carbamimidoyl-4-(oxolan-3-yl)-N-phenylnaphthalene-2-carboxamide	Ki	870.0 [1]
	6-[1-[3-(6-Chloronaphthalen-2-yl)sulfonylpropanoyl]piperidin-4-yl]-3-(hydroxymethyl)-7H-imidazo[1,5-c]imidazol-5-one	Ki	60000.0 [1]
	2-(5-Chlorothiophen-2-yl)-N-[(3S)-1-[(2S)-1-morpholin-4-yl-1-oxopropan-2-yl]-2-oxopyrrolidin-3-yl]ethanesulfonamide	IC50	25100.0 [1]
	(2S)-N-Cyclopentyl-N-methyl-5-[4-(methylamino)phenyl]-2-(5,6,7,8-tetrahydronaphthalen-2-ylsulfonylamino)pent-4-ynamide	Ki	200000.0 [1]
	(2S)-N-[(4-Aminocyclohexyl)methyl]-1-[(2R)-2-amino-3,3-dicyclohexylpropanoyl]pyrrolidine-2-carboxamide	Ki	137000.0 [1]
	(2S,3R)-4-Oxo-1-[4-(6-phenylhexanoyl)piperazine-1-carbonyl]-3-(2-piperidin-3-ylethyl)azetidine-2-carboxylic acid	IC50	33000.0 [1]
	5-[4-[3-(6-Chloro-2-naphthylsulfonyl)propanoyl]piperazino]imidazo[1,2-a]pyridine-2-methanol	Ki	60000.0 [1]
	(5S,11R)-22-Chloro-11-cyclohexyl-18-oxa-3,9,12,15-tetrazatricyclo[17.4.0.05,9]tricosa-1(19),20,22-triene-4,10,13,16-tetrone	Ki	7700.0 [1]
	2-[[(2R)-1-[(2S)-2-[(5-Carbamimidoylthiophen-2-yl)methylcarbamoyl]-2,5-dihydropyrrol-1-yl]-3-cyclohexyl-1-oxopropan-2-yl]amino]acetic acid	IC50	70.0 [1]
	2-[(E)-3-[3-(Pyridin-2-ylmethoxy)phenyl]but-2-enyl]-1,2,4-oxadiazolidine-3,5-dione	IC50	24000.0 [1]
	(2S)-1-[(2R)-2-Amino-2-cyclohexylacetyl]-N-[[5-chloro-2-[2-(cyclopropylamino)-2-oxoethoxy]phenyl]methyl]pyrrolidine-2-carboxamide	Ki	36000.0 [1]
	4-[(2R)-3-(3-Carbamimidoylphenyl)-2-(naphthalen-2-ylsulfonylamino)propanoyl]-N,N-dimethylpiperazine-1-carboxamide	Ki	1000000.0 [1]
	2-[(E)-3-[3-[[3,5-Bis(trifluoromethyl)phenoxy]methyl]phenyl]but-2-enyl]-1,2,4-oxadiazolidine-3,5-dione	IC50	5290.0 [1]
	2-[(E)-3-[3-[[3,5-Bis(trifluoromethyl)phenyl]methoxy]phenyl]but-2-enyl]-1,2,4-oxadiazolidine-3,5-dione	IC50	9400.0 [1]
	(S)-1-(2-Amino-2-cyclohexyl-acetyl)-pyrrolidine-2-carboxylic acid 2,5-dichloro-benzylamide	Ki	19000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Tissue-type plasminogen activator Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Nov. 2024, https://www.aatbio.com/data-sets/tissue-type-plasminogen-activator-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, November 20). Quest Database™ Tissue-type plasminogen activator Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/tissue-type-plasminogen-activator-inhibitors-ic50-ki.
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