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Thyroid hormone receptor alpha Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
LiothyronineIC500.24 [1], 3.2 [2]
LiothyronineKi0.22 [1], 0.33 [2], 2.33 [3]
{3,5-Dichloro-4-[4-Hydroxy-3-(Propan-2-Yl)phenoxy]phenyl}acetic AcidIC5025.0 [1], 25.12 [2]
{3,5-Dichloro-4-[4-Hydroxy-3-(Propan-2-Yl)phenoxy]phenyl}acetic AcidKi7.18 [1], 7.79 [2]
2-Methyl-3-(3,5-diiodo-4-carboxymethoxybenzyl)benzofuranIC502200.0 [1], 4500.0 [2]
3,5-Dibromo-4-(4-hydroxy-3-isopropylphenoxy)phenylacetic acidIC501.4 [1], 1.55 [2]
3,5-Dibromo-4-[4-hydroxy-3,5-bis(propan-2-yl)phenoxy]benzoic acidIC501100.0 [1], 1600.0 [2]
2-[3,5-Dibromo-4-(hexyloxy)phenyl]acetic acidIC50700.0 [1], 5200.0 [2], 5248.07 [3]
3-[3,5-Dibromo-4-(hexyloxy)phenyl]propanoic acidIC50600.0 [1], 1096.48 [2], 1100.0 [3]
2-[3,5-Dibromo-4-(2-ethylbutoxy)phenyl]acetic AcidIC50820.0 [1], 6900.0 [2], 6918.31 [3]
DetrothyronineIC500.24 [1]
TiratricolIC500.14 [1]
Thyropropic acidIC500.04 [1]
Phosphonic acid, p-((4-((4-hydroxy-3-(1-methylethyl)phenyl)methyl)-3,5-dimethylphenoxy)methyl)-Ki35.2 [1]
3,5-Dibromo-4-(3-Isopropyl-Phenoxy)benzoic AcidIC500.1 [1]
2-[4-(3-Bromo-4-propanamidophenoxy)-3,5-dichlorophenyl]acetic acidIC503300.0 [1], 3311.31 [2]
2-{4-[3-Bromo-4-(2-ethylbutanamido)phenoxy]-3,5-dichlorophenyl}acetic acidIC50610.0 [1], 616.6 [2]
3-{3,5-Dichloro-4-[4-hydroxy-3-(propan-2-yl)phenoxy]phenyl}propanoic acidIC500.76 [1]
2-[3,5-Dibromo-4-(3-methylbutoxy)phenyl]acetic AcidIC5012882.5 [1], 13000.0 [2]
3-[3,5-Dibromo-4-(2-ethylbutoxy)phenyl]propanoic AcidIC501584.89 [1], 1600.0 [2]
2-[3,5-Dibromo-4-(pentyloxy)phenyl]acetic acidIC5019952.62 [1], 20000.0 [2]
3-[3,5-Dibromo-4-(3-methylbutoxy)phenyl]propanoic AcidIC504365.16 [1], 4400.0 [2]
2-{4-[3-Bromo-4-(2-methylpentanamido)phenoxy]-3,5-dichlorophenyl}acetic acidIC501288.25 [1], 1300.0 [2]
2-{4-[3-Bromo-4-(2-propylpentanamido)phenoxy]-3,5-dichlorophenyl}acetic acidIC501200.0 [1], 1202.26 [2]
3,5-Dichloro-4-[4-hydroxy-3-(propan-2-yl)phenoxy]benzoic acidIC50128.82 [1], 130.0 [2]
2-(3,5-Dibromo-4-butoxyphenyl)acetic acidIC5026000.0 [1], 26302.68 [2]
3,5-Dibromo-4-(4-hydroxy-3-isopropylphenoxy)benzoic acidIC509.7 [1], 9.77 [2]
3,5-Dichloro-4-(3-bromo-4-isobutyramidophenoxy)phenylacetic acidIC50630.0 [1], 630.96 [2]
4,6-Dichloro-5-(4-hydroxy-3-isopropylphenoxy)-1H-indole-2-carboxylic acidIC501.4 [1], 1.41 [2]
2-[3,5-Dibromo-4-(cyclohexylmethoxy)phenyl]acetic AcidIC50420.0 [1], 2700.0 [2]
4,6-Dibromo-5-(4-hydroxy-3-isopropylphenoxy)-1H-indole-2-carboxylic acidIC502.5 [1], 2.51 [2]
3-[3,5-Dibromo-4-(cyclohexylmethoxy)phenyl]propanoic AcidIC50460.0 [1], 530.0 [2]
(2R)-2-Amino-3-{4-[4-hydroxy-3-(propan-2-yl)phenoxy]-3,5-diiodophenyl}propanoic acidIC500.14 [1]
(2-Butyl-1-benzofuran-3-yl)-[4-[2-(diethylamino)ethyl]-3,5-diiodophenyl]methanoneIC50650.0 [1], 10000.0 [2]
6-(4-Hydroxy-3-isopropylphenoxy)-5,7-dimethylquinoline-2-carboxylic acidIC50199.53 [1], 200.0 [2]
5,7-Dibromo-6-(4-hydroxy-3-propan-2-ylphenoxy)-4-oxo-1H-quinoline-2-carboxylic acidIC50250.0 [1], 251.19 [2]
5,7-Dichloro-6-(4-hydroxy-3-propan-2-ylphenoxy)-4-oxo-1H-quinoline-2-carboxylic acidIC503467.37 [1], 3500.0 [2]
6-(4-Hydroxy-3-propan-2-ylphenoxy)-5,7-dimethyl-4-oxo-1H-quinoline-2-carboxylic acidIC50616.6 [1], 620.0 [2]
3-{3,5-Dibromo-4-[(3-bromophenyl)methoxy]phenyl}propanoic acidIC5090.0 [1], 99.0 [2]
AmiodaroneIC50650.0 [1]
MifepristoneKi1250.0 [1]
SobetiromeKi1.09 [1]
EprotiromeKi9.6 [1]
2-[4-(4-Hydroxy-3-propan-2-ylphenoxy)-3,5-dimethylanilino]-2-oxoacetic acidKi0.51 [1]
Unii-3Z11398fnqKi12500.0 [1]
Thyromimetic, 5bIC50950.0 [1]
(2S)-2-Amino-3-[3,5-dibromo-4-[4-hydroxy-3-[(6-oxo-1H-pyridazin-3-yl)methyl]phenoxy]phenyl]propanoic acidKi8.72 [1]
1-(4-Hexylphenyl)prop-2-en-1-oneIC5045200.0 [1]
N-(5,6,7,8-Tetrahydronaphthalen-1-yl)butanamideIC5085300.0 [1]
2-[3,5-Dichloro-4-(4-hydroxy-3-phenylphenoxy)phenyl]acetic acidIC50128.82 [1]
2-[[1-[(4-Hydroxy-3-propan-2-ylphenyl)methyl]-7-methylindol-4-yl]amino]-2-oxoacetic acidIC50190.0 [1]
2-(3,5-Dibromo-4-{4-hydroxy-3-[(2-phenylethyl)carbamoyl]phenoxy}phenyl)acetic acidIC5015.14 [1]
2-{3,5-Dichloro-4-[4-hydroxy-3-(piperidine-1-carbonyl)-phenoxy]-phenyl}-2H-[1,2,4]triazine-3,5-dioneKi20.0 [1]
Unii-9XZ07VI986Ki3.0 [1]
2-[4-[[4-Hydroxy-3-(4-nitrophenyl)-5-propan-2-ylphenyl]methyl]-3,5-dimethylphenoxy]acetic acidIC505000.0 [1]
3,5-Dibromo-4-ethoxyphenylacetic acidIC50160000.0 [1]
2-{3,5-Dichloro-4-[4-hydroxy-3-(pyridin-2-yl)phenoxy]phenyl}acetic acidIC501513.56 [1]
2-{3,5-Dichloro-4-[4-hydroxy-3-(pyridin-4-yl)phenoxy]phenyl}acetic acidIC50144.54 [1]
2-{3,5-Dichloro-4-[4-hydroxy-3-(1,3-thiazol-2-yl)phenoxy]phenyl}acetic acidIC50562.34 [1]
AxitiromeKi40.0 [1]
N,N'-(Methylenedi-4,1-phenylene)bis(3-nitrobenzamide)IC5018100.0 [1]
3-(Dibutylamino)-1-(4-hexylphenyl)propan-1-oneIC506900.0 [1]
2-{3,5-Dichloro-4-[4-hydroxy-3-(pyrimidin-5-yl)phenoxy]phenyl}acetic acidIC50269.15 [1]
2-{4-[3-Bromo-4-(2-methylbutanamido)phenoxy]-3,5-dichlorophenyl}acetic acidIC50240.0 [1]
2-(3,5-Dichloro-4-{4-hydroxy-3-[3-(trifluoromethyl)phenyl]phenoxy}phenyl)acetic acidIC5039.81 [1]
2-(3,5-Dichloro-4-{4-hydroxy-3-[3-(propan-2-yl)phenyl]phenoxy}phenyl)acetic acidIC50123.03 [1]
2-{3,5-Dichloro-4-[4-hydroxy-3-(3-phenylphenyl)phenoxy]phenyl}acetic acidIC50457.09 [1]
2-{3,5-Dichloro-4-[4-hydroxy-3-(3-methoxyphenyl)phenoxy]phenyl}acetic acidIC50295.12 [1]
2-(3,5-Dichloro-4-{3-[3-(difluoromethoxy)phenyl]-4-hydroxyphenoxy}phenyl)acetic acidIC5030.2 [1]
2-(3,5-Dichloro-4-{4-hydroxy-3-[3-(trifluoromethoxy)phenyl]phenoxy}phenyl)acetic acidIC50100.0 [1]
2-{3,5-Dichloro-4-[4-hydroxy-3-(2-hydroxyphenyl)phenoxy]phenyl}acetic acidIC501047.13 [1]
2-{3,5-Dichloro-4-[4-hydroxy-3-(3-hydroxyphenyl)phenoxy]phenyl}acetic acidIC501174.9 [1]
2-{3,5-Dichloro-4-[4-hydroxy-3-(4-hydroxyphenyl)phenoxy]phenyl}acetic acidIC50851.14 [1]
2-{3,5-Dichloro-4-[4-hydroxy-3-(pyridin-3-yl)phenoxy]phenyl}acetic acidIC50812.83 [1]
2-[3,5-Dibromo-4-(4-hydroxy-3-phenoxyphenoxy)phenyl]acetic acidIC50123.03 [1]
2-(3,5-Dibromo-4-{4-hydroxy-3-[2-(trifluoromethyl)phenoxy]phenoxy}phenyl)acetic acidIC50245.47 [1]
2-(3,5-Dibromo-4-{4-hydroxy-3-[3-(trifluoromethyl)phenoxy]phenoxy}phenyl)acetic acidIC5050.12 [1]
2-{3,5-Dibromo-4-[4-hydroxy-3-(3-phenylphenoxy)phenoxy]phenyl}acetic acidIC50501.19 [1]
2-{3,5-Dibromo-4-[4-hydroxy-3-(2-hydroxyphenoxy)phenoxy]phenyl}acetic acidIC501479.11 [1]
2-{3,5-Dibromo-4-[4-hydroxy-3-(3-hydroxyphenoxy)phenoxy]phenyl}acetic acidIC50549.54 [1]
2-{3,5-Dibromo-4-[4-hydroxy-3-(4-hydroxyphenoxy)phenoxy]phenyl}acetic acidIC50239.88 [1]
2-{3,5-Dibromo-4-[4-hydroxy-3-(phenylcarbamoyl)phenoxy]phenyl}acetic acidIC50426.58 [1]
2-(3,5-Dibromo-4-{4-hydroxy-3-[(3-phenylpropyl)carbamoyl]phenoxy}phenyl)acetic acidIC50204.17 [1]
2-(3,5-Dibromo-4-{4-hydroxy-3-[(4-phenylbutyl)carbamoyl]phenoxy}phenyl)acetic acidIC50281.84 [1]
2-[3,5-Dibromo-4-(4-hydroxy-3-{[2-(4-methoxyphenyl)ethyl]carbamoyl}phenoxy)phenyl]acetic acidIC50229.09 [1]
2-[3,5-Dibromo-4-(4-hydroxy-3-{[2-(3-methoxyphenyl)ethyl]carbamoyl}phenoxy)phenyl]acetic acidIC5093.33 [1]
2-[3,5-Dibromo-4-(4-hydroxy-3-{[2-(2-methoxyphenyl)ethyl]carbamoyl}phenoxy)phenyl]acetic acidIC5095.5 [1]
2-(3,5-Dibromo-4-{3-[(2,2-diphenylethyl)carbamoyl]-4-hydroxyphenoxy}phenyl)acetic acidIC5018.2 [1]
2-[3,5-Dibromo-4-(4-hydroxy-3-{[2-(pyridin-2-yl)ethyl]carbamoyl}phenoxy)phenyl]acetic acidIC501148.15 [1]
2-[[1-[(4-Hydroxy-3-propan-2-ylphenyl)methyl]-2-methylindol-4-yl]amino]-2-oxoacetic acidIC50230.0 [1]
1-(4-(Hexyloxy)phenyl)-3-(piperidin-1-yl)propan-1-oneIC509200.0 [1]
(2S)-2-[[2-[3,5-Dibromo-4-(3-fluoro-4-hydroxy-5-propan-2-ylphenoxy)phenyl]acetyl]amino]-3-methylbutanoic acidIC5088.0 [1]
3-[4-(5-Bromo-6-hydroxynaphthalen-1-yl)-3,5-dichloroanilino]propanoic acidIC5013.0 [1]
3-{3,5-Dibromo-4-[(3-methylphenyl)methoxy]phenyl}propanoic acidIC50360.0 [1]
3-{3,5-Dibromo-4-[(4-methylphenyl)methoxy]phenyl}propanoic acidIC50600.0 [1]
3-[[7-[3-[2-(4-Fluorophenyl)ethyl]-4-hydroxyphenoxy]-6-methyl-2,3-dihydro-1H-inden-4-yl]amino]-3-oxopropanoic acidKi228.0 [1]
3-[[7-[3-[2-(3,4-Difluorophenyl)ethyl]-4-hydroxyphenoxy]-6-methyl-2,3-dihydro-1H-inden-4-yl]amino]-3-oxopropanoic acidKi186.0 [1]
3-[3,5-Dibromo-4-(3-amino-benzyloxy)phenyl]propionic acidIC502600.0 [1]
3-[[6-Bromo-7-(4-hydroxy-3-propan-2-ylphenoxy)-2,3-dihydro-1H-inden-4-yl]amino]-3-oxopropanoic acidKi69.3 [1]
3-[[7-[3-[(4-Fluorophenyl)methyl]-4-hydroxyphenoxy]-6-methyl-2,3-dihydro-1H-inden-4-yl]amino]-3-oxopropanoic acidKi30.5 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Thyroid hormone receptor alpha Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/thyroid-hormone-receptor-alpha-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ Thyroid hormone receptor alpha Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/thyroid-hormone-receptor-alpha-inhibitors-ic50-ki.
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