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Thromboxane-A synthase Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
DazoxibenIC50250.0 [1]
IsbogrelIC5026.0 [1]
RidogrelIC507.0 [1]
OzagrelIC5060.0 [1]
(R,S)-8-((4-Chlorophenylsulfonyl)amino)-4-(3-(3-pyridinyl)propyl)octanoic acidIC502.0 [1]
DazmegrelIC5028.0 [1]
(Z)-6-[(2S,4S,5R)-2-(2-Chlorophenyl)-4-(2-hydroxyphenyl)-1,3-dioxan-5-yl]hex-4-enoic acidIC5010000.0 [1], 100000.0 [2]
(Z)-7-Phenyl-7-pyridin-3-ylhept-6-enoic acidIC500.9 [1], 36.0 [2]
2-(9-Chloro-1h-Phenanthro[9,10-D]imidazol-2-Yl)benzene-1,3-DicarbonitrileIC503000.0 [1], 40000.0 [2]
CID 11526708IC50950.0 [1], 1000.0 [2]
SamixogrelIC504.0 [1]
2-Imidazol-1-ylmethyl-1,3-dimethyl-1H-indole-5-carboxylic acidIC5032.0 [1]
Ethyl 4-[[1-imidazol-1-yl-3-[(4-methoxyphenyl)methoxy]propan-2-yl]oxymethyl]benzoateIC50540.0 [1], 5300.0 [2]
2-Ethyl-4-(3-pyridyl)-1(2H)-phthalazinoneIC501600.0 [1], 2300.0 [2], 27900.0 [3]
2-Methyl-4-(5-thiazolyl)-1(2H)-phthalazinoneIC50500.0 [1], 3900.0 [2], 8700.0 [3]
IndomethacinIC50100.0 [1], 100000.0 [2]
(E)-2-Methyl-3-(4-(3-pyridinylmethyl)phenyl)-2-propenoic acid sodium saltIC504.3 [1], 3000.0 [2]
PirmagrelIC503.0 [1], 3.2 [2]
6-Hydroxy-5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)benzothiazoleIC509.0 [1], 90.0 [2]
3-Isopropyl-3-(1-imidazolylmethyl)indoleIC5015.0 [1]
3-(1-(4-Chlorobenzyl)-5-(2-fluorobiphenyl-4-yl)-3-methyl-1H-indol-2-yl)-2,2-dimethylpropanoic acidIC501000.0 [1], 1400.0 [2]
8-(1H-Imidazol-1-yl)octanoic acid hydrochlorideIC5032.0 [1]
7-Imidazol-1-ylheptanoic acid;hydrochlorideIC5039.0 [1]
3-[1-[2-[(4-Fluorophenyl)sulfonylamino]ethyl]-3-(imidazol-1-ylmethyl)-2-methylindol-5-yl]propanoic acidIC5039.0 [1]
11-[2-(Pyridin-3-ylsulfonylamino)ethylsulfanyl]-6,11-dihydrobenzo[c][1]benzoxepine-2-carboxylic acidIC501400.0 [1]
8-(4-Chloro-benzenesulfonylamino)-4-[2-(pyridin-3-yloxy)-ethyl]-octanoic acidIC502.6 [1], 3.0 [2]
3-[1-[2-[(4-Fluorophenyl)sulfonylamino]ethyl]-2-methyl-3-(pyridin-3-ylmethyl)indol-5-yl]propanoic acidIC5061.0 [1]
Ethyl 5-[(E)-[[4-[9-(2-chlorophenyl)-3,7-dimethyl-17-thia-2,4,5,8,14-pentazatetracyclo[8.7.0.02,6.011,16]heptadeca-1(10),3,5,8,11(16)-pentaene-14-carbonyl]phenyl]-pyridin-3-ylmethylidene]amino]oxypentanoateIC5072.0 [1]
(Z)-6-[3-[(N'-Tert-butyl-N-cyanocarbamimidoyl)amino]phenyl]-6-pyridin-3-ylhex-5-enoic acidIC504.0 [1], 1600.0 [2]
(E)-7-{4-[4-(Cyclopropylmethyl-carbamoyl)-oxazol-2-yl]-phenyl}-7-pyridin-3-yl-hept-6-enoic acidIC5025.0 [1]
(E)-7-[4-[4-(Benzylcarbamoyl)-1,3-oxazol-2-yl]phenyl]-7-pyridin-3-ylhept-6-enoic acidIC5024.7 [1]
(E)-7-[4-(4-Pentylcarbamoyl-oxazol-2-yl)-phenyl]-7-pyridin-3-yl-hept-6-enoic acidIC5031.2 [1]
Ethyl 5-[(E)-[[3-[9-(2-chlorophenyl)-3,7-dimethyl-17-thia-2,4,5,8,14-pentazatetracyclo[8.7.0.02,6.011,16]heptadeca-1(10),3,5,8,11(16)-pentaene-14-carbonyl]phenyl]-pyridin-3-ylmethylidene]amino]oxypentanoateIC5065.0 [1]
(E)-7-(3-Pyridinyl)-7-[4-[4-(4-cyclohexylbutylcarbamoyl)oxazole-2-yl]phenyl]-6-heptenoic acidIC5055.0 [1]
3-[5-(4-Fluoro-benzenesulfonylamino)-3-pyridin-3-ylmethyl-indol-1-yl]-propionic acidIC5048.0 [1]
Butyl 4-[[1-imidazol-1-yl-3-[(4-methoxyphenyl)methoxy]propan-2-yl]oxymethyl]benzoateIC50200.0 [1], 2000.0 [2]
Benzyl 4-[[1-imidazol-1-yl-3-[(4-methoxyphenyl)methoxy]propan-2-yl]oxymethyl]benzoateIC501490.0 [1], 7100.0 [2]
2-Imidazol-1-ylmethyl-4,5,6,7-tetrahydro-benzo[b]thiophene-6-carboxylic acidIC5020.0 [1], 26.0 [2]
3-[5-(4-Fluoro-benzenesulfonylamino)-3-imidazol-1-ylmethyl-indol-1-yl]-propionic acidIC5034.0 [1]
4-[2-Imidazol-1-yl-1-(4-methoxy-benzyloxymethyl)-ethoxymethyl]-benzoic acidIC501100.0 [1], 6700.0 [2]
(Z)-7-[(2S,3S)-3-[(E,3R)-3-Hydroxyoct-1-enyl]-7-oxabicyclo[2.2.1]heptan-2-yl]hept-5-enoic acidIC50770000.0 [1], 1000000.0 [2]
3-[1-[2-[(4-Fluorophenyl)sulfonylamino]ethyl]-2-(imidazol-1-ylmethyl)-3-methylindol-5-yl]propanoic acidIC50135.0 [1]
ImitrodastIC506.0 [1], 13.0 [2]
SodiumIC502000.0 [1]
ImidazoleIC50670000.0 [1]
NitrendipineIC501000000.0 [1]
AminoglutethimideIC5018500.0 [1]
Ozagrel hydrochlorideIC5011.0 [1]
7-[3-(4-Acetyl-3-hydroxy-2-propylphenoxy)-2-hydroxypropoxy]-4-oxo-8-propylchromene-2-carboxylic acidIC5010000.0 [1]
SulotrobanIC5094100.0 [1]
3-Methyl-2-(3-pyridyl)-1-indoleoctanoic acidIC5012.0 [1]
7-Phenyl-7-(3-pyridyl)-6-heptenoic acidIC50100000.0 [1]
TerbogrelIC504.0 [1]
2,3,5-Trimethyl-6-(3-pyridylmethyl)-1,4-benzoquinoneIC50400.0 [1]
1-(2,3-Bis((4-methoxyphenyl)methoxy)propyl)-1H-imidazoleIC509900.0 [1]
AblukastIC506000.0 [1]
3-(4-Aminophenyl)-3-cyclohexylpiperidine-2,6-dioneIC50150.0 [1]
6-(Pyridin-3-yl)-3,4-dihydroquinolin-2(1H)-oneIC50540.0 [1]
N-Benzyl-2-(pyridin-3-yl)quinazolin-4-amineIC505800.0 [1]
3-Imidazol-1-ylmethyl-1H-indoleIC5025.0 [1]
1-[5-Chloro-6-(4-chlorophenyl)-1,3-benzoxazol-2-yl]-N-[(1S,3S)-3-(hydroxymethyl)cyclohexyl]piperidine-4-carboxamideIC5050000.0 [1]
N-[4-(3,4-Dichlorophenyl)phenyl]-4-hydroxy-1,1-dioxo-2H-1lambda6,2-benzothiazine-3-carboxamideIC50100000.0 [1]
6-(2-(1-Methyl-1-(2-nitro-4-tolyloxy)ethyl)-4-(3-pyridyl)-1,3-dioxan-5-yl)hex-4-enoic acidIC5019.0 [1]
CID 16730275IC5030000.0 [1]
5-[2-(Imidazol-1-yl)ethyl]-7,8-dihydroquinolineIC50290.0 [1]
7-[(Imidazol-1-yl)methyl]isoquinolineIC505400.0 [1]
5-[(Imidazol-1-yl)methyl]-7,8-dihydroquinolineIC501500.0 [1]
5-Chloro-1-methyl-2-(3-pyridyl)-3-indolehexanoic acidIC502.0 [1]
1-NonylimidazoleIC50400.0 [1]
11-[2-(Benzenesulfonamido)ethylsulfanyl]-6,11-dihydrobenzo[c][1]benzoxepine-2-carboxylic acidIC5024000.0 [1]
3-{3-[2-(4-Chloro-benzenesulfonylamino)-ethyl]-5-pyridin-3-ylmethyl-phenyl}-propionic acidIC5039.0 [1]
(11E)-11-(2-Imidazol-1-ylethylidene)-6H-benzo[c][1]benzoxepine-2-carboxylic acidIC50450.0 [1]
5-[(Imidazol-1-yl)methyl]-5,6,7,8-tetrahydroquinolineIC502000.0 [1]
4,5,6,7-Tetrahydro-4-[(E)-2-(1H-imidazole-1-yl)ethylidene]benzo[b]thiopheneIC501700.0 [1]
4,5,6,7-Tetrahydro-4-[(Z)-2-(1H-imidazole-1-yl)ethylidene]benzo[b]thiopheneIC501260.0 [1]
4-[2-(1H-Imidazole-1-yl)ethyl]benzo[b]thiopheneIC505300.0 [1]
5-[3-(Imidazol-1-yl)propyl]-7,8-dihydroquinolineIC50680.0 [1]
4,5,6,7-Tetrahydro-4-[(Z)-2-(1H-imidazole-1-yl)ethylidene]benzofuranIC504100.0 [1]
5-[2-(Imidazol-1-yl)ethyl]quinolineIC501200.0 [1]
2-(6-Chloro-9-(3-hydroxy-3-methylbut-1-ynyl)-1H-phenanthro[9,10-d]imidazol-2-yl)isophthalonitrileIC50800.0 [1]
11-Oxo-2-propan-2-yl-N-(4-pyridin-3-ylbutyl)pyrido[2,1-b]quinazoline-8-carboxamideIC50200.0 [1]
2-Methyl-11-oxo-N-(4-pyridin-3-ylbutyl)pyrido[2,1-b]quinazoline-8-carboxamideIC50100.0 [1]
2-Methoxy-11-oxo-N-(4-pyridin-3-ylbutyl)pyrido[2,1-b]quinazoline-8-carboxamideIC50200.0 [1]
11-Oxo-2-propan-2-yloxy-N-(4-pyridin-3-ylbutyl)pyrido[2,1-b]quinazoline-8-carboxamideIC5060.0 [1]
11-Oxo-N-(4-pyridin-3-ylbutyl)pyrido[2,1-b]quinazoline-8-carboxamideIC5020.0 [1]
2-Bromo-11-oxo-N-(4-pyridin-3-ylbutyl)pyrido[2,1-b]quinazoline-8-carboxamideIC50100.0 [1]
2-Hydroxy-11-oxo-N-(4-pyridin-3-ylbutyl)pyrido[2,1-b]quinazoline-8-carboxamideIC5060.0 [1]
11-Oxo-2-propan-2-yl-N-(4-pyridin-2-ylbutyl)pyrido[2,1-b]quinazoline-8-carboxamideIC5010000.0 [1]
11-Oxo-2-propan-2-yl-N-(7-pyridin-3-ylheptyl)pyrido[2,1-b]quinazoline-8-carboxamideIC50200.0 [1]
11-Oxo-2-propan-2-yl-N-(4-pyrimidin-5-ylbutyl)pyrido[2,1-b]quinazoline-8-carboxamideIC50200.0 [1]
3-Methoxy-11-oxo-N-(4-pyridin-3-ylbutyl)pyrido[2,1-b]quinazoline-8-carboxamideIC5020.0 [1]
3-Chloro-11-oxo-N-(4-pyridin-3-ylbutyl)pyrido[2,1-b]quinazoline-8-carboxamideIC5020.0 [1]
1-(2-Phenoxy-ethyl)-1H-imidazoleIC50660.0 [1]
N-(2-Methyl-5-pyridin-3-ylpentan-2-yl)-11-oxo-2-propan-2-ylpyrido[2,1-b]quinazoline-8-carboxamideIC50500.0 [1]
3,4-Dihydro-6-(1H-imidazol-1-yl)quinolin-2(1H)-oneIC502000.0 [1]
(Z)-7-[(2R,3R)-3-[(E,3S)-3-Hydroxyoct-1-enyl]-7-oxabicyclo[2.2.1]heptan-2-yl]hept-5-enoic acidIC501000000.0 [1]
(Z)-7-[(2R,3S)-3-[(E,3S)-3-Hydroxyoct-1-enyl]-7-oxabicyclo[2.2.1]heptan-2-yl]hept-5-enoic acidIC501000000.0 [1]
5-(1-Imidazolyl)pentanoic acid hydrochlorideIC501000.0 [1]
6-(1H-Imidazol-1-yl)hexanoic acid hydrochlorideIC501000.0 [1]
CID 56589615IC503000.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Thromboxane-A synthase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/thromboxane-a-synthase-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ Thromboxane-A synthase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/thromboxane-a-synthase-inhibitors-ic50-ki.
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