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Thioredoxin reductase Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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N'-(2-Naphthalen-2-ylacetyl)-5-nitrofuran-2-carbohydrazideIC5018.0 [1], 215.0 [2], 16000.0 [3]
Ellagic acidIC5078300.0 [1], 275300.0 [2]
Palmarumycin CP(1)IC50350.0 [1], 12000.0 [2]
Flavellagic acidIC5041700.0 [1], 51700.0 [2]
(2E)-3-(3-Nitrophenyl)-1-(2,4,6-trimethoxyphenyl)prop-2-en-1-oneIC503500.0 [1], 12800.0 [2]
Cladospirone bisepoxideIC504500.0 [1], 13500.0 [2]
8'-Hydroxyspiro[1,3-dioxolane-2,4'-naphthalene]-1'-oneIC503400.0 [1], 8800.0 [2]
8'-(Pyridin-3-ylmethoxy)spiro[2,4-dioxatricyclo[7.3.1.05,13]trideca-1(12),5,7,9(13),10-pentaene-3,4'-naphthalene]-1'-oneIC5050000.0 [1]
8'-(Pyridin-4-ylmethoxy)spiro[2,4-dioxatricyclo[7.3.1.05,13]trideca-1(12),5,7,9(13),10-pentaene-3,4'-naphthalene]-1'-oneIC5050000.0 [1]
8'-(Pyridin-2-ylmethoxy)spiro[2,4-dioxatricyclo[7.3.1.05,13]trideca-1(12),5,7,9(13),10-pentaene-3,4'-naphthalene]-1'-oneIC5041800.0 [1], 50000.0 [2]
8'-Prop-2-enoxyspiro[2,4-dioxatricyclo[7.3.1.05,13]trideca-1(12),5,7,9(13),10-pentaene-3,4'-naphthalene]-1'-oneIC5023200.0 [1], 50000.0 [2]
8'-(Furan-3-ylmethoxy)spiro[2,4-dioxatricyclo[7.3.1.05,13]trideca-1(12),5,7,9(13),10-pentaene-3,4'-naphthalene]-1'-oneIC5023200.0 [1], 50000.0 [2]
8'-[(4-Methoxyphenyl)methoxy]spiro[2,4-dioxatricyclo[7.3.1.05,13]trideca-1(12),5,7,9(13),10-pentaene-3,4'-naphthalene]-1'-oneIC5050000.0 [1]
8'-(2-Methylprop-2-enoxy)spiro[2,4-dioxatricyclo[7.3.1.05,13]trideca-1(12),5,7,9(13),10-pentaene-3,4'-naphthalene]-1'-oneIC504800.0 [1], 50000.0 [2]
8'-[(4-Bromophenyl)methoxy]spiro[2,4-dioxatricyclo[7.3.1.05,13]trideca-1(12),5,7,9(13),10-pentaene-3,4'-naphthalene]-1'-oneIC5050000.0 [1]
8'-[(4-Chlorophenyl)methoxy]spiro[2,4-dioxatricyclo[7.3.1.05,13]trideca-1(12),5,7,9(13),10-pentaene-3,4'-naphthalene]-1'-oneIC5050000.0 [1]
Coruleoellagic AcidIC503000.0 [1], 4200.0 [2]
(1S,3R,6S,8S,11S,13R,16S,18R,21S,23R,26S,28S,31S,33R)-10-[[4-(Dimethylamino)phenyl]tellanylmethyl]-5,15,20,25,30,35-hexakis(hydroxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29,32,34-tetradecaoxaoctacyclo[31.2.2.23,6.28,11.213,16.218,21.223,26.228,31]nonatetracontane-36,37,38,39,40,41,42,43,44,45,46,47,48,49-tetradecolIC50260.0 [1], 3400.0 [2]
(1S,3R,6S,8S,11S,13R,16S,18R,21S,23S,26S,28R,31S,33R)-5,10,15,20,30,35-Hexakis(hydroxymethyl)-25-(phenylselanylmethyl)-2,4,7,9,12,14,17,19,22,24,27,29,32,34-tetradecaoxaoctacyclo[31.2.2.23,6.28,11.213,16.218,21.223,26.228,31]nonatetracontane-36,37,38,39,40,41,42,43,44,45,46,47,48,49-tetradecolIC5017800.0 [1], 18000.0 [2]
(1S,3R,6S,8R,11S,13R,16S,18R,21S,23S,26S,28R,31S,33S)-5,10,15,20,30,35-Hexakis(hydroxymethyl)-25-[[(1S,3S,6S,8S,11S,13R,16S,18R,21S,23R,26S,28R,31S,33R)-36,37,38,39,40,41,42,43,44,45,46,47,48,49-tetradecahydroxy-5,15,20,25,30,35-hexakis(hydroxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29,32,34-tetradecaoxaoctacyclo[31.2.2.23,6.28,11.213,16.218,21.223,26.228,31]nonatetracontan-10-yl]methyltellanylmethyl]-2,4,7,9,12,14,17,19,22,24,27,29,32,34-tetradecaoxaoctacyclo[31.2.2.23,6.28,11.213,16.218,21.223,26.228,31]nonatetracontane-36,37,38,39,40,41,42,43,44,45,46,47,48,49-tetradecolIC50500.0 [1], 2400.0 [2]
(1S,3R,6S,8S,11S,13R,16S,18R,21S,23R,26S,28S,31S,33R)-10-(Butyltellanylmethyl)-5,15,20,25,30,35-hexakis(hydroxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29,32,34-tetradecaoxaoctacyclo[31.2.2.23,6.28,11.213,16.218,21.223,26.228,31]nonatetracontane-36,37,38,39,40,41,42,43,44,45,46,47,48,49-tetradecolIC501200.0 [1], 18000.0 [2]
(1S,3R,6S,8S,11S,13R,16S,18R,21S,23S,26S,28R,31S,33R)-5,10,15,20,30,35-Hexakis(hydroxymethyl)-25-(phenyltellanylmethyl)-2,4,7,9,12,14,17,19,22,24,27,29,32,34-tetradecaoxaoctacyclo[31.2.2.23,6.28,11.213,16.218,21.223,26.228,31]nonatetracontane-36,37,38,39,40,41,42,43,44,45,46,47,48,49-tetradecolIC501600.0 [1], 7600.0 [2]
(1S,3R,6S,8S,11S,13R,16S,18R,21S,23S,26S,28R,31S,33R)-5,10,15,20,30,35-Hexakis(hydroxymethyl)-25-[(4-methoxyphenyl)tellanylmethyl]-2,4,7,9,12,14,17,19,22,24,27,29,32,34-tetradecaoxaoctacyclo[31.2.2.23,6.28,11.213,16.218,21.223,26.228,31]nonatetracontane-36,37,38,39,40,41,42,43,44,45,46,47,48,49-tetradecolIC501600.0 [1], 7600.0 [2]
(1S,3R,6S,8S,11S,13R,16S,18R,21S,23S,26S,28R,31S,33R)-5,10,15,20,30,35-Hexakis(hydroxymethyl)-25-[(4-hydroxyphenyl)tellanylmethyl]-2,4,7,9,12,14,17,19,22,24,27,29,32,34-tetradecaoxaoctacyclo[31.2.2.23,6.28,11.213,16.218,21.223,26.228,31]nonatetracontane-36,37,38,39,40,41,42,43,44,45,46,47,48,49-tetradecolIC504000.0 [1], 18000.0 [2]
8'-[[5-(3-Chlorophenyl)furan-2-yl]methoxy]spiro[2,4-dioxatricyclo[7.3.1.05,13]trideca-1(12),5,7,9(13),10-pentaene-3,4'-naphthalene]-1'-oneIC5050000.0 [1]
8'-Methoxyspiro[1,3-dioxane-2,4'-naphthalene]-1'-oneIC5040200.0 [1], 50000.0 [2]
8'-[[5-[2-(Trifluoromethyl)phenyl]furan-2-yl]methoxy]spiro[2,4-dioxatricyclo[7.3.1.05,13]trideca-1(12),5,7,9(13),10-pentaene-3,4'-naphthalene]-1'-oneIC5050000.0 [1]
8'-[[5-[3-(Trifluoromethyl)phenyl]furan-2-yl]methoxy]spiro[2,4-dioxatricyclo[7.3.1.05,13]trideca-1(12),5,7,9(13),10-pentaene-3,4'-naphthalene]-1'-oneIC5042400.0 [1], 50000.0 [2]
8'-Prop-2-ynoxyspiro[2,4-dioxatricyclo[7.3.1.05,13]trideca-1(12),5,7,9(13),10-pentaene-3,4'-naphthalene]-1'-oneIC5013400.0 [1], 50000.0 [2]
8'-[[5-(4-Bromophenyl)furan-2-yl]methoxy]spiro[2,4-dioxatricyclo[7.3.1.05,13]trideca-1(12),5,7,9(13),10-pentaene-3,4'-naphthalene]-1'-oneIC5010200.0 [1], 20100.0 [2]
8'-[[5-(2-Chlorophenyl)furan-2-yl]methoxy]spiro[2,4-dioxatricyclo[7.3.1.05,13]trideca-1(12),5,7,9(13),10-pentaene-3,4'-naphthalene]-1'-oneIC5050000.0 [1]
2,6-DichloroindophenolIC5025000.0 [1]
XanthohumolIC5040000.0 [1]
5,8-Dihydroxy-1,4-naphthoquinoneIC5020000.0 [1]
4-Chloro-3,5-dinitrobenzotrifluorideIC50100000.0 [1]
4-AminophenylarsenoxideIC504000.0 [1]
6,7-DinitroquinoxalineIC50140000.0 [1]
3,5-DinitrobenzotrifluorideIC50200000.0 [1]
5-Nitro-1,3-benzodioxoleIC50200000.0 [1]
Sulfide, bis(2,4-dinitrophenyl)IC504000.0 [1]
4-(1,3,2-Dithiarsinan-2-yl)anilineIC501400.0 [1]
4,6-Dinitro-2,1,3-benzothiadiazoleIC502000.0 [1]
4-Nitro-2,1,3-benzothiadiazoleIC5050000.0 [1]
6-NitroquinoxalineIC50200000.0 [1]
8'-(Furan-2-ylmethoxy)spiro[2,4-dioxatricyclo[7.3.1.05,13]trideca-1(12),5,7,9(13),10-pentaene-3,4'-naphthalene]-1'-oneIC5050000.0 [1]
Spiro[2,4-dioxatricyclo[7.3.1.05,13]trideca-1(12),5,7,9(13),10-pentaene-3,8'-3,4-dihydro-2H-naphthalene]-1',5'-dioneIC502100.0 [1]
Spiro[11-oxatricyclo[4.4.1.01,6]undec-3-ene-5,3'-2,4-dioxatricyclo[7.3.1.05,13]trideca-1(12),5,7,9(13),10-pentaene]-2,7-dioneIC5044000.0 [1]
8'-(2-Phenylethoxy)spiro[2,4-dioxatricyclo[7.3.1.05,13]trideca-1(12),5,7,9(13),10-pentaene-3,4'-naphthalene]-1'-oneIC5050000.0 [1]
8'-[(3-Methoxyphenyl)methoxy]spiro[2,4-dioxatricyclo[7.3.1.05,13]trideca-1(12),5,7,9(13),10-pentaene-3,4'-naphthalene]-1'-oneIC5050000.0 [1]
8'-[(E)-But-2-enoxy]spiro[2,4-dioxatricyclo[7.3.1.05,13]trideca-1(12),5,7,9(13),10-pentaene-3,4'-naphthalene]-1'-oneIC5050000.0 [1]
8'-[(E)-Hex-3-enoxy]spiro[2,4-dioxatricyclo[7.3.1.05,13]trideca-1(12),5,7,9(13),10-pentaene-3,4'-naphthalene]-1'-oneIC5050000.0 [1]
(1'R,3'R,5'S,7'R)-Spiro[2,4-dioxatricyclo[7.3.1.05,13]trideca-1(12),5,7,9(13),10-pentaene-3,6'-4,12-dioxatetracyclo[5.4.1.01,7.03,5]dodecane]-2',8'-dioneIC5050000.0 [1]
8'-[(E)-3-Phenylprop-2-enoxy]spiro[2,4-dioxatricyclo[7.3.1.05,13]trideca-1(12),5,7,9(13),10-pentaene-3,4'-naphthalene]-1'-oneIC5050000.0 [1]
Spiro[2,4-dioxatricyclo[7.3.1.05,13]trideca-1(12),5,7,9(13),10-pentaene-3,2'-4,5,6,7a-tetrahydro-1aH-naphtho[2,3-b]oxirene]-3',7'-dioneIC5012200.0 [1]
8'-Hexoxyspiro[2,4-dioxatricyclo[7.3.1.05,13]trideca-1(12),5,7,9(13),10-pentaene-3,4'-naphthalene]-1'-oneIC5050000.0 [1]
(1'S,3'R,5'S,7'S)-Spiro[2,4-dioxatricyclo[7.3.1.05,13]trideca-1(12),5,7,9(13),10-pentaene-3,6'-4,12-dioxatetracyclo[5.4.1.01,7.03,5]dodecane]-2',8'-dioneIC5013500.0 [1]
(1R,5S,8S,15S,18R,21S,22S)-5-Methyl-7,16-dioxahexacyclo[13.6.1.01,8.04,21.09,14.018,22]docosa-9(14),11-diene-10,13,17-trioneKi280.0 [1]
Bis(2-nitro-4-(trifluoromethyl)phenyl)sulfaneIC50150000.0 [1]
5-Nitro-2,1,3-benzothiadiazoleIC5090000.0 [1]
4,5-Dinitro-1,3-benzodioxoleIC5080000.0 [1]
(3'S,10'R)-3',10'-Dihydroxyspiro[2,4-dioxatricyclo[7.3.1.05,13]trideca-1(12),5,7,9(13),10-pentaene-3,8'-tetracyclo[10.2.1.02,11.04,9]pentadeca-4(9),6,13-triene]-5'-oneIC508000.0 [1]
8'-(3-Methylbut-2-enoxy)spiro[2,4-dioxatricyclo[7.3.1.05,13]trideca-1(12),5,7,9(13),10-pentaene-3,4'-naphthalene]-1'-oneIC5050000.0 [1]
8'-[(Z)-2-Methylbut-2-enoxy]spiro[2,4-dioxatricyclo[7.3.1.05,13]trideca-1(12),5,7,9(13),10-pentaene-3,4'-naphthalene]-1'-oneIC5050000.0 [1]
8'-[(E)-2-Methylbut-2-enoxy]spiro[2,4-dioxatricyclo[7.3.1.05,13]trideca-1(12),5,7,9(13),10-pentaene-3,4'-naphthalene]-1'-oneIC5050000.0 [1]
5-Methoxy-2-[2-(5-methoxy-3-oxo-1,2-benzoselenazol-2-yl)ethyl]-1,2-benzoselenazol-3-oneIC502000.0 [1]
Items per page: 1 - 10 of 65
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References

This online tool may be cited as follows

MLA

"Quest Database™ Thioredoxin reductase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/thioredoxin-reductase-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ Thioredoxin reductase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/thioredoxin-reductase-inhibitors-ic50-ki.
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