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TGF-beta receptor type II Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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4-(4-(Benzo[d][1,3]dioxol-5-yl)-5-(pyridin-2-yl)-1H-imidazol-2-yl)benzamideIC5066.0 [1]
DorsomorphinIC50102.9 [1]
4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinolineIC50140.4 [1]
GalunisertibIC501300.0 [1]
4-[2-[4-(2-Pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinolin-7-yl]oxyethyl]morpholineIC50190.0 [1]
4-(3-Pyridin-2-YL-1H-pyrazol-4-YL)quinolineIC50400.0 [1]
LY-2090314IC501200.0 [1]
3-Imidazo[1,2-a]pyridin-3-yl-4-[10-(morpholine-4-carbonyl)-1,10-diazatricyclo[6.4.1.04,13]trideca-2,4,6,8(13)-tetraen-3-yl]pyrrole-2,5-dioneIC502000.0 [1]
5-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinolineIC50327.0 [1]
Ethyl 2,7,7-trimethyl-5-oxo-4-(4-phenylphenyl)-1,4,6,8-tetrahydroquinoline-3-carboxylateIC50850.0 [1]
Methyl 2,7,7-trimethyl-5-oxo-4-phenyl-1,4,5,6,7,8-hexahydroquinoline-3-carboxylateIC5010000.0 [1]
3-(4-Imidazo[1,2-a]pyridin-3-yl-2,5-dioxopyrrol-3-yl)-N,N-dimethyl-1,10-diazatricyclo[6.4.1.04,13]trideca-2,4,6,8(13)-tetraene-10-carboxamideIC5020000.0 [1]
3-[6-(2-Pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)benzimidazol-1-yl]propan-1-olIC50352.0 [1]
4-[3-[6-[2-(6-Methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]benzimidazol-1-yl]propyl]morpholineIC5019750.0 [1]
3-Imidazo[1,2-a]pyridin-3-yl-4-[10-(piperidine-1-carbonyl)-1,10-diazatricyclo[6.4.1.04,13]trideca-2,4,6,8(13)-tetraen-3-yl]pyrrole-2,5-dioneIC503100.0 [1]
3-[6-[2-(6-Methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]benzimidazol-1-yl]propan-1-olIC50690.0 [1]
N-Ethyl-2-hydroxy-N-methyl-3-[C-phenyl-N-[4-(piperidin-1-ylmethyl)phenyl]carbonimidoyl]-1H-indole-6-carboxamideIC5019000.0 [1]
Methyl 4-(biphenyl-4-yl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylateIC501490.0 [1]
4-Methoxybenzyl 4-(biphenyl-4-yl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylateIC50830.0 [1]
Methyl 4-(4-tert-butylphenyl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarboxylateIC50560.0 [1]
Methyl 4-(4-fluorophenyl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylateIC5010000.0 [1]
4-(6-(4-Methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinolineIC50236.0 [1]
N,N-Diethyl-3-[6-[2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]benzimidazol-1-yl]propan-1-amineIC5020000.0 [1]
6-(2-Pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)-1-(3-pyrrolidin-1-ylpropyl)benzimidazoleIC5010840.0 [1]
Ethyl 2-ethyl-7,7-dimethyl-5-oxo-4-(4-pyridin-2-ylphenyl)-1,4,6,8-tetrahydroquinoline-3-carboxylateIC503570.0 [1]
[(4-{2-[(3-Hydroxyphenyl)amino]-1h-Benzimidazol-1-Yl}-1,3,5-Triazin-2-Yl)amino]acetonitrileIC502000.0 [1]
Methyl 4-[3-(3-chlorophenyl)phenyl]-2,7,7-trimethyl-5-oxo-1,4,6,8-tetrahydroquinoline-3-carboxylateIC5010000.0 [1]
Methyl 7-ethyl-2-methyl-5-oxo-4-(4-phenylphenyl)-4,6,7,8-tetrahydro-1H-quinoline-3-carboxylateIC50790.0 [1]
Methyl 4-[4-(3-chlorophenyl)phenyl]-2,7,7-trimethyl-5-oxo-1,4,6,8-tetrahydroquinoline-3-carboxylateIC501520.0 [1]
Ethyl 7,7-dimethyl-5-oxo-4-(4-phenylphenyl)-2-propyl-1,4,6,8-tetrahydroquinoline-3-carboxylateIC50830.0 [1]
Methyl 2,7,7-trimethyl-5-oxo-4-(4-pyrazol-1-ylphenyl)-1,4,6,8-tetrahydroquinoline-3-carboxylateIC508800.0 [1]
Methyl 2-methyl-5-oxo-7-phenyl-4-(4-phenylphenyl)-4,6,7,8-tetrahydro-1H-quinoline-3-carboxylateIC501920.0 [1]
CID 60182364IC5015.0 [1]
CID 60182389IC5026.0 [1]
4-(4-(3-(1H-Pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-6-yl)phenyl)morpholineIC501.37 [1]
Methyl 4-[3-(1H-indol-5-yl)phenyl]-2,7,7-trimethyl-5-oxo-1,4,6,8-tetrahydroquinoline-3-carboxylateIC504450.0 [1]
6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-oneIC5010000.0 [1]
Methyl 2-methyl-5-oxo-4-(4-phenylphenyl)-7-propyl-4,6,7,8-tetrahydro-1H-quinoline-3-carboxylateIC50530.0 [1]
Methyl 7-[4-(dimethylamino)phenyl]-2-methyl-5-oxo-4-(4-phenylphenyl)-4,6,7,8-tetrahydro-1H-quinoline-3-carboxylateIC503970.0 [1]
Methyl 2-methyl-7-(2-methylpropyl)-5-oxo-4-(4-phenylphenyl)-4,6,7,8-tetrahydro-1H-quinoline-3-carboxylateIC50590.0 [1]
Methyl 2,7,7-trimethyl-5-oxo-4-(3-pyridin-3-ylphenyl)-1,4,6,8-tetrahydroquinoline-3-carboxylateIC5010000.0 [1]
Methyl 2,7-dimethyl-5-oxo-4-(4-phenylphenyl)-4,6,7,8-tetrahydro-1H-quinoline-3-carboxylateIC502730.0 [1]
Methyl 4-(3-fluoro-4-phenylphenyl)-2,7,7-trimethyl-5-oxo-1,4,6,8-tetrahydroquinoline-3-carboxylateIC501840.0 [1]
2-Methylpropyl 4-(4-tert-butylphenyl)-2-methyl-5-oxo-7-propyl-4,6,7,8-tetrahydro-1H-quinoline-3-carboxylateIC50170.0 [1]
2-Methylpropyl 2,7,7-trimethyl-5-oxo-4-(4-phenylphenyl)-1,4,6,8-tetrahydroquinoline-3-carboxylateIC50530.0 [1]
3-Methylbutyl 2,7,7-trimethyl-5-oxo-4-(4-phenylphenyl)-1,4,6,8-tetrahydroquinoline-3-carboxylateIC501460.0 [1]
Methyl 4-[4-(2-fluorophenyl)phenyl]-2,7,7-trimethyl-5-oxo-1,4,6,8-tetrahydroquinoline-3-carboxylateIC502060.0 [1]
Methyl 2-methyl-5-oxo-4-(4-phenylphenyl)-7-propan-2-yl-4,6,7,8-tetrahydro-1H-quinoline-3-carboxylateIC50940.0 [1]
Methyl 4-(4-cyclohexylphenyl)-2,7,7-trimethyl-5-oxo-1,4,6,8-tetrahydroquinoline-3-carboxylateIC50590.0 [1]
Methyl 4-[4-(1H-indol-5-yl)phenyl]-2,7,7-trimethyl-5-oxo-1,4,6,8-tetrahydroquinoline-3-carboxylateIC504050.0 [1]
Methyl 4-[3-(4-methoxyphenyl)phenyl]-2,7,7-trimethyl-5-oxo-1,4,6,8-tetrahydroquinoline-3-carboxylateIC5010000.0 [1]
N-[(4-Methoxyphenyl)methyl]-2,7,7-trimethyl-5-oxo-4-(4-phenylphenyl)-1,4,6,8-tetrahydroquinoline-3-carboxamideIC504060.0 [1]
Methyl 4-[4-(4-methoxycarbonylphenyl)phenyl]-2,7,7-trimethyl-5-oxo-1,4,6,8-tetrahydroquinoline-3-carboxylateIC501350.0 [1]
Ethyl 4-(4-tert-butylphenyl)-2-methyl-5-oxo-7-propyl-4,6,7,8-tetrahydro-1H-quinoline-3-carboxylateIC50170.0 [1]
Methyl 2,7,7-trimethyl-5-oxo-4-(3-phenylphenyl)-1,4,6,8-tetrahydroquinoline-3-carboxylateIC5010000.0 [1]
2,2,2-Trifluoroethyl 2,7,7-trimethyl-5-oxo-4-(4-phenylphenyl)-1,4,6,8-tetrahydroquinoline-3-carboxylateIC50760.0 [1]
Methyl 2,7,7-trimethyl-4-[4-(2-methylphenyl)phenyl]-5-oxo-1,4,6,8-tetrahydroquinoline-3-carboxylateIC50890.0 [1]
6-(2-Pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)-1H-benzimidazoleIC508730.0 [1]
6-[2-(6-Methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]-1-(3-pyrrolidin-1-ylpropyl)benzimidazoleIC5020000.0 [1]
5-[2-(6-Methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]-1-[3-(oxan-2-yloxy)propyl]benzimidazoleIC5014540.0 [1]
1-Methyl-6-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)benzimidazoleIC50395.0 [1]
1-[3-(Oxan-2-yloxy)propyl]-5-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)benzimidazoleIC5020000.0 [1]
6-[2-(6-Methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]-1-(3-piperidin-1-ylpropyl)benzimidazoleIC5020000.0 [1]
1-Methyl-6-[2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]benzimidazoleIC50668.0 [1]
Propan-2-yl 3-(4-imidazo[1,2-a]pyridin-3-yl-2,5-dioxopyrrol-3-yl)-1,10-diazatricyclo[6.4.1.04,13]trideca-2,4,6,8(13)-tetraene-10-carboxylateIC5020000.0 [1]
5-(2-Pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)-1H-indoleIC5020000.0 [1]
6-[2-(6-Methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]-1H-benzimidazoleIC501300.0 [1]
N-{4-[3-(5-Methoxypyridin-2-yl)-1H-pyrrolo[3,2-b]pyridin-2-yl]pyridin-2-yl}acetamideIC5015000.0 [1]
N-[4-[3-[5-(Trideuteriomethoxy)pyridin-2-yl]-1H-pyrrolo[3,2-b]pyridin-2-yl]pyridin-2-yl]acetamideIC507600.0 [1]
N-[4-[3-(6-Methylpyridin-2-yl)-1H-pyrrolo[3,2-b]pyridin-2-yl]pyridin-2-yl]acetamideIC50730.0 [1]
N-{4-[3-(6-Methoxypyridin-3-yl)-1H-pyrrolo[3,2-b]pyridin-2-yl]pyridin-2-yl}acetamideIC5040.0 [1]
N-[4-[3-[6-(Trifluoromethyl)pyridin-2-yl]-1H-pyrrolo[3,2-b]pyridin-2-yl]pyridin-2-yl]acetamideIC5015000.0 [1]
N-[4-[3-(6-Fluoropyridin-3-yl)-1H-pyrrolo[3,2-b]pyridin-2-yl]pyridin-2-yl]acetamideIC507.0 [1]
N-[4-[3-[5-(Difluoromethoxy)pyridin-2-yl]-1H-pyrrolo[3,2-b]pyridin-2-yl]pyridin-2-yl]acetamideIC5014000.0 [1]
N-[4-[3-(5-Chloropyridin-2-yl)-1H-pyrrolo[3,2-b]pyridin-2-yl]pyridin-2-yl]acetamideIC5014000.0 [1]
N-[4-[3-(5-Methylpyridin-2-yl)-1H-pyrrolo[3,2-b]pyridin-2-yl]pyridin-2-yl]acetamideIC5015000.0 [1]
N-[4-[3-[6-(Difluoromethyl)pyridin-2-yl]-1H-pyrrolo[3,2-b]pyridin-2-yl]pyridin-2-yl]acetamideIC504300.0 [1]
N-[4-[3-(5-Fluoropyridin-2-yl)-1H-pyrrolo[3,2-b]pyridin-2-yl]pyridin-2-yl]acetamideIC50390.0 [1]
(3S,4S)-4-Amino-1-[[4-[(3-fluoropyridin-4-yl)amino]-2-pyridin-2-ylpyrrolo[2,1-f][1,2,4]triazin-5-yl]methyl]piperidin-3-olIC50810.0 [1]
N-[5-Fluoro-4-[[2-[6-(trifluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl]amino]pyridin-2-yl]acetamideIC5015000.0 [1]
2-(6-Methylpyridin-2-yl)-N-pyridin-4-ylpyrrolo[2,1-f][1,2,4]triazin-4-amineIC50550.0 [1]
N-Pyridin-4-yl-2-[6-(trifluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-amineIC508500.0 [1]
N-(3-Fluoropyridin-4-yl)-2-pyridin-2-ylpyrrolo[2,1-f][1,2,4]triazin-4-amineIC50110.0 [1]
2-(6-Methoxypyridin-2-yl)-N-pyridin-4-ylpyrrolo[2,1-f][1,2,4]triazin-4-amineIC5015000.0 [1]
4-[[2-(6-Methylpyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]amino]-N-propan-2-ylpyridine-3-carboxamideIC5015000.0 [1]
N-(3-Fluoropyridin-4-yl)-2-[6-(trifluoromethyl)pyridin-2-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-amineIC5015000.0 [1]
N-[4-[[2-[6-(Trifluoromethyl)pyridin-2-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino]pyridin-2-yl]acetamideIC50940.0 [1]
N-(3-Fluoropyridin-4-YL)-2-(6-methylpyridin-2-YL)-7H-pyrrolo[2,3-D]pyrimidin-4-amineIC50310.0 [1]
N-(3-Fluoropyridin-4-yl)-2-(6-methylpyridin-2-yl)-7H-purin-6-amineIC501100.0 [1]
CID 126677289IC501100.0 [1]
N-(3,5-Difluoropyridin-4-yl)-2-(6-methylpyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amineIC5015000.0 [1]
2-Pyridin-2-yl-N-pyridin-4-ylpyrrolo[2,1-f][1,2,4]triazin-4-amineIC5077.0 [1]
4-N-[[4-[(3-Fluoropyridin-4-yl)amino]-2-pyridin-2-ylpyrrolo[2,1-f][1,2,4]triazin-5-yl]methyl]cyclohexane-1,4-diamineIC502000.0 [1]
(3R,4R)-4-Amino-1-[[4-[(3-fluoropyridin-4-yl)amino]-2-pyridin-2-ylpyrrolo[2,1-f][1,2,4]triazin-5-yl]methyl]piperidin-3-olIC503000.0 [1]
N-(3-Fluoropyridin-4-yl)-2-(6-methylpyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amineIC50570.0 [1]
Alk2-IN-2IC50698.0 [1]
3-Imidazo[1,2-a]pyridin-3-yl-4-[6-methyl-10-(piperidine-1-carbonyl)-1,10-diazatricyclo[6.4.1.04,13]trideca-2,4,6,8(13)-tetraen-3-yl]pyrrole-2,5-dioneIC509500.0 [1]
N,N-Dimethyl-3-[6-[2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]benzimidazol-1-yl]propan-1-amineIC5020000.0 [1]
N,N-Dimethyl-3-[6-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)benzimidazol-1-yl]propan-1-amineIC5020000.0 [1]
Indolocarbazole deriv. 14mIC5020000.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ TGF-beta receptor type II Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/tgf-beta-receptor-type-ii-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ TGF-beta receptor type II Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/tgf-beta-receptor-type-ii-inhibitors-ic50-ki.
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