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TGF-beta receptor type I Inhibitors (IC50, Ki)

Structure
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▼
Compound Name
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Standard Type
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▼
Standard Values (in nM)
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▼
4-(3-Pyridin-2-YL-1H-pyrazol-4-YL)quinolineIC5051.0 [1]
Benzamide, 3-((4-(6-methyl-2-pyridinyl)-5-(6-quinoxalinyl)-1H-imidazol-2-yl)methyl)-IC5017.2 [1]
4-(4-(Benzo[d][1,3]dioxol-5-yl)-5-(pyridin-2-yl)-1H-imidazol-2-yl)benzamideIC5094.0 [1]
4-(4-(Benzo[d][1,3]dioxol-5-yl)-5-(pyridin-2-yl)-1H-imidazol-2-yl)benzamideKi17.0 [1]
2-(4-(Benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-imidazol-5-yl)-6-methylpyridineIC5054.0 [1]
RepSoxIC504.0 [1], 10.0 [2], 20.0 [3], 181.0 [4]
VactosertibIC507.0 [1], 9.67 [2], 16.5 [3]
VactosertibKi6.3 [1], 20.59 [2]
4-(3-Chlorophenyl)-5-(1,5-naphthyridin-2-yl)-1,3-thiazol-2-amineIC5010.0 [1], 13.0 [2], 20.0 [3]
GalunisertibIC504.1 [1], 51.0 [2], 69.4 [3], 100.0 [4]
4-(4-Fluorophenyl)-5-(1,5-naphthyridin-2-yl)thiazol-2-amineIC5010.0 [1], 11.0 [2], 30.0 [3], 40.0 [4]
5-[1,5]Naphthyridin-2-yl-4-pyridin-2-yl-thiazol-2-ylamineIC5020.0 [1], 40.0 [2], 120.0 [3]
4-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)phenolIC5031.0 [1], 32.0 [2], 44.0 [3]
4-(1-Benzyl-3-pyridin-2-yl-1H-pyrazol-4-yl)-quinolineIC50369.0 [1], 399.0 [2], 1340.0 [3]
4-(5-Cyclopropyl-3-pyridin-2-yl-1H-pyrazol-4-yl)-quinolineIC5094.0 [1], 203.0 [2], 538.0 [3]
2-(4-Phenyl-1H-pyrazol-3-yl)pyridineIC503990.0 [1], 9000.0 [2], 9540.0 [3]
4-(3-(5-Fluoropyridin-2-yl)-1H-pyrazol-4-yl)quinolineIC5076.0 [1], 91.0 [2], 94.0 [3]
4-(3-(Thiophen-2-yl)-1H-pyrazol-4-yl)quinolineIC50353.0 [1], 1660.0 [2], 2810.0 [3]
4-(3-(5-Chloropyridin-2-yl)-1H-pyrazol-4-yl)quinolineIC501760.0 [1], 4670.0 [2], 10000.0 [3]
4-(4-Pyridin-2-yl-1H-pyrazol-3-yl)-quinolineIC50150.0 [1], 683.0 [2], 1680.0 [3]
4-(3-Phenyl-1H-pyrazol-4-yl)quinolineIC50382.0 [1], 1200.0 [2], 2920.0 [3]
4-(3-(3-(Trifluoromethyl)phenyl)-1H-pyrazol-4-yl)quinolineIC50217.0 [1], 355.0 [2], 524.0 [3]
2-(3-Pyridin-2-yl-1H-pyrazol-4-yl)-[1,5]naphthyridineIC5010.0 [1], 19.0 [2], 30.0 [3], 50.0 [4]
N-[4-[3-[5-(Trideuteriomethoxy)pyridin-2-yl]-1H-pyrrolo[3,2-b]pyridin-2-yl]pyridin-2-yl]acetamideIC502.0 [1], 17.0 [2], 110.0 [3], 450.0 [4]
N-[4-[3-[6-(Difluoromethyl)pyridin-2-yl]-1H-pyrrolo[3,2-b]pyridin-2-yl]pyridin-2-yl]acetamideIC501.0 [1], 50.0 [2], 68.0 [3], 94.0 [4]
DorsomorphinIC5010000.0 [1], 10760.0 [2], 17090.0 [3]
4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinolineIC5027.15 [1], 500.0 [2], 565.0 [3]
4-[2-[4-(2-Pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinolin-7-yl]oxyethyl]morpholineIC503.7 [1], 69.0 [2], 370.0 [3]
4-(4-(3-(Pyridin-2-yl)-1H-pyrazol-4-yl)pyridin-2-yl)-N-(tetrahydro-2H-pyran-4-yl)benzamideIC5018.0 [1], 446.0 [2]
4-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)quinolineIC502.9 [1], 7.1 [2], 34.0 [3]
4-((5-(6-Ethylpyridin-2-yl)-4-(quinoxalin-6-yl)-1H-imidazol-2-yl)methylamino)benzamideIC5092.0 [1]
4-[4-(4-Fluorophenyl)-5-(2-pyridyl)-1H-imidazole-2-yl]benzoic acidIC501500.0 [1]
4-[3-[6-[2-(6-Methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]benzimidazol-1-yl]propyl]morpholineIC5069.0 [1], 186.0 [2]
5-(6-Methyl-1,5-naphthyridin-4-yl)-4-(pyridin-2-yl)thiazol-2-amineIC50260.0 [1], 380.0 [2]
5-Quinolin-4-yl-4-(1,3-thiazol-2-yl)-1,3-thiazol-2-amineIC501170.0 [1], 1175.0 [2], 6580.0 [3]
4-Pyridin-3-yl-5-quinolin-4-yl-thiazol-2-ylamineIC503980.0 [1], 3981.0 [2], 10000.0 [3]
4-(2-Fluorophenyl)-5-(quinolin-4-yl)thiazol-2-amineIC501250.0 [1], 1259.0 [2], 6670.0 [3]
4-(4-Chloropyridin-2-yl)-5-(quinolin-4-yl)thiazol-2-amineIC501020.0 [1], 1023.0 [2], 10000.0 [3]
5-Naphthalen-1-yl-4-pyridin-2-yl-thiazol-2-ylamineIC5010000.0 [1], 10960.0 [2], 10965.0 [3]
3-[6-[2-(6-Methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]benzimidazol-1-yl]propan-1-olIC5041.0 [1], 78.0 [2]
SB-505124 hydrochlorideIC5054.0 [1], 54.4 [2], 594.0 [3]
N,N-Diethyl-3-[6-[2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]benzimidazol-1-yl]propan-1-amineIC50100.0 [1], 122.0 [2]
6-(2-Pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)-1-(3-pyrrolidin-1-ylpropyl)benzimidazoleIC50226.0 [1], 246.0 [2]
4-Pyridin-2-yl-5-quinolin-4-yl-thiazol-2-ylamineIC50274.0 [1], 420.0 [2], 720.0 [3]
4-[5-Methyl-3-(6-methyl-pyridin-2-yl)-1H-pyrazol-4-yl]-quinolineIC5024.0 [1], 82.0 [2], 148.0 [3]
2-(4-(4-Fluorophenyl)-1H-pyrazol-3-yl)-6-methylpyridineIC5041.0 [1], 70.0 [2], 139.0 [3]
4-[3-(6-Bromo-pyridin-2-yl)-1H-pyrazol-4-yl]-quinolineIC501.2 [1], 2.9 [2], 31.0 [3]
3-(2-Pyridinyl)-4-(4-fluorophenyl)-1H-pyrazoleIC50275.0 [1], 2590.0 [2], 3530.0 [3]
2-[4-(4-Chloro-phenyl)-1H-pyrazol-3-yl]-6-methyl-pyridineIC5057.0 [1], 421.0 [2], 551.0 [3]
2-Methyl-6-(4-phenyl-1H-pyrazol-3-yl)-pyridineIC50543.0 [1], 2160.0 [2], 3370.0 [3]
2-[4-(3,4-Difluoro-phenyl)-1H-pyrazol-3-yl]-6-methyl-pyridineIC50151.0 [1], 683.0 [2], 788.0 [3]
2-[4-(4-Methoxyphenyl)-1-methylpyrazol-3-yl]-6-methylpyridineIC5044.0 [1], 47.0 [2], 61.0 [3]
4-(6-Methyl-pyridin-2-yl)-5-[1,5]naphthyridin-2-yl-thiazol-2-ylamineIC506.0 [1], 10.0 [2], 20.0 [3]
2-[4-Methyl-2-(6-methyl-pyridin-2-yl)-2H-pyrazol-3-yl]thieno[3,2-c]pyridineIC506.65 [1], 35.9 [2]
2-[2-(6-Methylpyridin-2-yl)pyrazol-3-yl]thieno[3,2-c]pyridineIC5023.4 [1], 149.0 [2]
2-[5-Methyl-2-(6-methylpyridin-2-yl)pyrazol-3-yl]thieno[3,2-c]pyridineIC5094.1 [1], 440.0 [2]
2-[5-Ethyl-2-(6-methylpyridin-2-yl)pyrazol-3-yl]thieno[3,2-c]pyridineIC50108.0 [1], 403.0 [2]
2-[4-Ethyl-2-(6-methylpyridin-2-yl)pyrazol-3-yl]thieno[3,2-c]pyridineIC504.33 [1], 21.5 [2]
2-[2-(6-Methylpyridin-2-yl)-5,6-dihydro-4H-cyclopenta[c]pyrazol-3-yl]thieno[3,2-c]pyridineIC5012.9 [1], 30.8 [2]
2-[4,5-Dimethyl-2-(6-methylpyridin-2-yl)pyrazol-3-yl]thieno[3,2-c]pyridineIC5035.2 [1], 244.0 [2]
2-[4-Methyl-2-(6-methylpyridin-2-yl)pyrazol-3-yl]thieno[2,3-c]pyridineIC507.94 [1], 42.5 [2]
2-[2-(6-Methylpyridin-2-yl)-5,6-dihydro-4H-cyclopenta[c]pyrazol-3-yl]thieno[2,3-c]pyridineIC5018.9 [1], 57.5 [2]
StaurosporineIC506870.0 [1], 18500.0 [2]
4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazoleIC506000.0 [1], 30000.0 [2]
3-[6-Amino-5-(3,4,5-Trimethoxyphenyl)pyridin-3-Yl]phenolIC50280.0 [1], 3400.0 [2]
1-(4-(6-Methyl-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl)phenyl)piperazineIC503000.0 [1], 16000.0 [2]
2-Phenyl-4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridineIC50107.0 [1]
4-[4-(1,3-Benzodioxole-5-yl)-5-(2-pyridyl)-1H-imidazole-2-yl]benzyl alcoholIC50260.0 [1]
2-(4-(2-(1H-Imidazol-1-yl)ethoxy)phenyl)-4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridineIC5030.0 [1]
3-Benzo[1,3]dioxol-5-yl-2-pyridin-2-yl-6,7-dihydro-5H-pyrrolo[1,2-a]imidazoleIC50460.0 [1]
2-(4-Fluorophenyl)-4-(5-pyridin-2-yl-1H-pyrazol-4-yl)pyridineIC5048.0 [1]
2-[3-Methoxyphenyl]-4-(3-pyridin-2-yl-1H-pyrazol-4-yl)pyridineIC50115.0 [1]
N-[[4-(1,3-Benzothiazol-6-yl)-5-(4-methyl-1,3-thiazol-2-yl)-1H-imidazol-2-yl]methyl]butanamideIC508.2 [1], 32.0 [2]
4-[[4-(1,3-Benzodioxol-5-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl]methylamino]benzonitrileIC5046.0 [1], 174.0 [2]
4-[[4-(1,3-Benzodioxol-5-yl)-5-(6-ethylpyridin-2-yl)-1H-imidazol-2-yl]methylamino]benzonitrileIC50360.0 [1]
3-((5-(6-Methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1H-imidazol-2-yl)methylamino)benzamideIC5010.0 [1]
4-[[[4-(1,3-Benzodioxol-5-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl]amino]methyl]benzonitrileIC5024.0 [1], 153.0 [2]
3-[[4-(1,3-Benzodioxol-5-yl)-5-(6-ethylpyridin-2-yl)-1H-imidazol-2-yl]methylamino]benzonitrileIC5073.0 [1]
4-((5-(6-Ethylpyridin-2-yl)-4-(quinoxalin-6-yl)-1H-imidazol-2-yl)methylamino)benzonitrileIC5047.0 [1]
4-[[4-(1,3-Benzodioxol-5-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl]methylamino]benzamideIC5021.0 [1], 262.0 [2]
4-[[4-(1,3-Benzodioxol-5-yl)-5-(6-ethylpyridin-2-yl)-1H-imidazol-2-yl]methylamino]benzamideIC5046.0 [1], 385.0 [2]
4-((5-(6-Methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1H-imidazol-2-yl)methylamino)benzamideIC5075.0 [1]
4-(4-(Benzo[d][1,3]dioxol-5-yl)-5-(pyridin-2-yl)-1H-imidazol-2-yl)benzoic acidIC50170.0 [1]
N-[2-(Methoxy)ethyl]-4-{4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]-pyridin-2-yl}benzamideIC5091.0 [1]
4-(3-(Pyridin-2-yl)-1H-pyrazol-4-yl)-2-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)pyridineIC5040.0 [1]
3-[6-(2-Pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)benzimidazol-1-yl]propan-1-olIC5079.0 [1]
3-(4-Methoxyphenyl)-2-(2-pyridyl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazoleIC505100.0 [1]
2-(4-(2-Cyclohexylethoxy)phenyl)-4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridineIC5081.0 [1]
2-[4-Cyanophenyl]-4-(3-pyridin-2-yl-1H-pyrazol-4-yl)pyridineIC5035.0 [1]
2-[3-(Trifluoromethyl)phenyl]-4-(3-pyridin-2-yl-1H-pyrazol-4-yl)pyridineIC50240.0 [1]
N-(4-{4-[3-(Pyridin-2-yl)-1H-pyrazol-4-yl]-pyridin-2-yl}phenyl)-tetrahydro-2H-pyran-4-carboxamideIC50112.0 [1]
N-Methyl-4-{4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]-pyridin-2-yl}-N-(tetrahydro-2H-pyran-4-yl)benzamideIC50214.0 [1]
2-[2-Fluorophenyl]-4-(3-pyridin-2-yl-1H-pyrazol-4-yl)pyridineIC5059.0 [1]
1-(4-(4-(3-(Pyridin-2-yl)-1H-pyrazol-4-yl)pyridin-2-yl)phenoxy)propan-2-oneIC5025.0 [1]
Dimethyl-{2-[(4-{4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]-2-pyridinyl}phenyl)oxy]ethyl}amineIC5015.0 [1], 19.0 [2]
6-[4-(4-Methyl-2-thiazolyl)-1H-imidazole-5-yl]benzothiazoleIC502.7 [1], 8.7 [2]
5-(4-Fluorophenyl)-6-(2-pyridyl)-2,3-dihydroimidazo[2,1-b]thiazoleIC501600.0 [1]
5-(5-Fluoro-6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1H-imidazol-2-amineIC5033.5 [1]
5-(5-Fluoro-6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1H-imidazol-2-amineKi0.7 [1]
N-(4-Methoxyphenyl)-3-(6-methylpyridin-2-yl)-4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)pyrazole-1-carbothioamideIC500.57 [1], 6360.0 [2]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ TGF-beta receptor type I Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 22 Feb. 2025, https://www.aatbio.com/data-sets/tgf-beta-receptor-type-i-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 22). Quest Database™ TGF-beta receptor type I Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/tgf-beta-receptor-type-i-inhibitors-ic50-ki.
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