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TCF4/beta-catenin Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
ToxoflavinKi3650.0 [1], 3700.0 [2], 5800.0 [3], 5820.0 [4]
CercosporinKi5870.0 [1], 5900.0 [2], 35560.0 [3], 36000.0 [4]
4-Fluoro-N-[4-[[[2-(methylamino)-4-quinazolinyl]amino]methyl]phenyl]benzamideIC50413.0 [1], 423.0 [2], 3500.0 [3]
N-[4-[[[2-(Ethylamino)quinazolin-4-yl]amino]methyl]phenyl]-4-fluorobenzamideIC50588.0 [1], 942.0 [2], 3000.0 [3]
[(2R)-1-[3,10-Dihydroxy-12-[(2R)-2-(4-hydroxyphenoxy)carbonyloxypropyl]-2,6,7,11-tetramethoxy-4,9-dioxoperylen-1-yl]propan-2-yl] benzoateKi17780.0 [1], 18000.0 [2]
1-Hydroxy-5-[2-(2H-tetrazol-5-yl)ethyl]indazoleKi3100.0 [1], 3800.0 [2]
2,3-Bis(4-chlorophenyl)quinoxaline-6-carboxylic acidKi8800.0 [1], 13000.0 [2]
5-[4-(4-Chlorophenoxy)phenyl]-3-isoxazolecarboxylic acidKi21000.0 [1], 77000.0 [2]
6-Chloro-N-[4-[[[2-(methylamino)quinazolin-4-yl]amino]methyl]phenyl]pyridine-3-carboxamideIC50596.0 [1], 690.0 [2]
2-Chloro-N-[4-({[2-(methylamino)quinazolin-4-yl]amino}methyl)phenyl]isonicotinamideIC50680.0 [1], 787.0 [2]
4-Chloro-N-[4-({[2-(methylamino)quinazolin-4-yl]amino}methyl)phenyl]benzamideIC50771.0 [1], 1188.0 [2]
4-Chloro-N-[4-[[[6-methyl-2-(methylamino)quinazolin-4-yl]amino]methyl]phenyl]benzamideIC50630.0 [1], 1030.0 [2]
N-[4-[[[2-(Methylamino)quinazolin-4-yl]amino]methyl]phenyl]-4-(trifluoromethyl)benzamideIC50692.0 [1], 1120.0 [2]
N-[4-({[2-(Methylamino)quinazolin-4-yl]amino}methyl)phenyl]biphenyl-4-carboxamideIC50941.0 [1], 2720.0 [2]
4-Methyl-N-[4-({[2-(methylamino)quinazolin-4-yl]amino}methyl)phenyl]benzamideIC5025158.0 [1]
3-Chloro-N-[4-({[2-(methylamino)quinazolin-4-yl]amino}methyl)phenyl]benzamideIC502274.0 [1], 2771.0 [2]
4-Cyano-N-[4-({[2-(methylamino)quinazolin-4-yl]amino}methyl)phenyl]benzamideIC503647.0 [1], 5641.0 [2]
N-[4-({[7-Acetyl-2-(dimethylamino)quinazolin-4-yl]amino}methyl)phenyl]-4-fluorobenzamideIC502331.0 [1], 2592.0 [2]
N-[4-[[[2-(Dimethylamino)-7-(1-hydroxyethyl)quinazolin-4-yl]amino]methyl]phenyl]-4-fluorobenzamideIC501900.0 [1], 2013.0 [2]
N-[4-[[[2-(Dimethylamino)-7-(hydroxymethyl)quinazolin-4-yl]amino]methyl]phenyl]-4-fluorobenzamideIC50811.0 [1], 855.0 [2]
N-[4-({[2-(Dimethylamino)-7-formylquinazolin-4-yl]amino}methyl)phenyl]-4-fluorobenzamideIC50884.0 [1], 895.0 [2]
N-[4-({[7-Cyano-2-(dimethylamino)quinazolin-4-yl]amino}methyl)phenyl]-4-fluorobenzamideIC501479.0 [1], 2138.0 [2]
N-[4-[[[2-(Dimethylamino)-7-[(dimethylamino)methyl]quinazolin-4-yl]amino]methyl]phenyl]-4-fluorobenzamideIC501046.0 [1], 1222.0 [2]
N-[4-[[[2-(Dimethylamino)-7-ethylquinazolin-4-yl]amino]methyl]phenyl]-4-fluorobenzamideIC50335.0 [1], 431.0 [2]
N-[4-({[2-(Dimethylamino)-7-iodoquinazolin-4-yl]amino}methyl)phenyl]-4-fluorobenzamideIC504192.0 [1], 6815.0 [2]
6-Chloro-N-[4-[[[8-methyl-2-(methylamino)quinazolin-4-yl]amino]methyl]phenyl]pyridine-3-carboxamideIC50423.0 [1], 548.0 [2]
3-[[2-[(2-Hydroxy-1-prop-2-enylindol-3-yl)diazenyl]-2-oxoacetyl]amino]benzoic acidKi16000.0 [1], 21000.0 [2]
4-Fluoro-N-[4-[[[8-methyl-2-(methylamino)quinazolin-4-yl]amino]methyl]phenyl]benzamideIC50782.0 [1], 948.0 [2]
4-Fluoro-N-[4-[[[7-methyl-2-(methylamino)quinazolin-4-yl]amino]methyl]phenyl]benzamideIC50299.0 [1], 329.0 [2]
4-Fluoro-N-[4-[[[6-methyl-2-(methylamino)quinazolin-4-yl]amino]methyl]phenyl]benzamideIC50113.0 [1], 148.0 [2]
4-Fluoro-N-[4-[[[5-methyl-2-(methylamino)quinazolin-4-yl]amino]methyl]phenyl]benzamideIC501080.0 [1], 1716.0 [2]
4-Chloro-N-[4-[[[8-methyl-2-(methylamino)quinazolin-4-yl]amino]methyl]phenyl]benzamideIC50405.0 [1], 411.0 [2]
4-Chloro-N-[4-[[[7-methyl-2-(methylamino)quinazolin-4-yl]amino]methyl]phenyl]benzamideIC50270.0 [1], 389.0 [2]
4-Chloro-N-[4-[[[5-methyl-2-(methylamino)quinazolin-4-yl]amino]methyl]phenyl]benzamideIC50492.0 [1], 829.0 [2]
6-Chloro-N-[4-[[[7-methyl-2-(methylamino)quinazolin-4-yl]amino]methyl]phenyl]pyridine-3-carboxamideIC50413.0 [1], 650.0 [2]
6-Chloro-N-[4-[[[5-methyl-2-(methylamino)quinazolin-4-yl]amino]methyl]phenyl]pyridine-3-carboxamideIC50541.0 [1], 848.0 [2]
N-[4-({[2-(Dimethylamino)-7-methylquinazolin-4-yl]amino}methyl)phenyl]-4-fluorobenzamideIC50454.0 [1], 593.0 [2]
4-Fluoro-N-[4-[[[7-methyl-2-(propylamino)quinazolin-4-yl]amino]methyl]phenyl]benzamideIC50506.0 [1], 645.0 [2]
N-(4-{[(2-Azetidin-1-yl-7-methylquinazolin-4-yl)amino]methyl}phenyl)-4-fluorobenzamideIC50300.0 [1], 505.0 [2]
4-Fluoro-N-[4-[[(7-methyl-2-pyrrolidin-1-ylquinazolin-4-yl)amino]methyl]phenyl]benzamideIC50378.0 [1], 659.0 [2]
4-Fluoro-N-(4-{[(7-methyl-2-piperidin-1-ylquinazolin-4-yl)amino]methyl}phenyl)benzamideIC50291.0 [1], 524.0 [2]
4-Fluoro-N-[4-[[(7-methyl-2-piperazin-1-ylquinazolin-4-yl)amino]methyl]phenyl]benzamideIC50322.0 [1], 621.0 [2]
4-Fluoro-N-[4-[[[7-methyl-2-[(3R)-3-methylpiperazin-1-yl]quinazolin-4-yl]amino]methyl]phenyl]benzamideIC50237.0 [1], 273.0 [2]
N-[4-[[[2-(3,3-Dimethylpiperazin-1-yl)-7-methylquinazolin-4-yl]amino]methyl]phenyl]-4-fluorobenzamideIC50511.0 [1], 525.0 [2]
4-Fluoro-N-[4-[[[7-methyl-2-(4-methylpiperazin-1-yl)quinazolin-4-yl]amino]methyl]phenyl]benzamideIC50677.0 [1], 767.0 [2]
4-Fluoro-N-[4-[[(7-methyl-2-morpholin-4-ylquinazolin-4-yl)amino]methyl]phenyl]benzamideIC50635.0 [1], 1779.0 [2]
N-[4-[[[2-(Dimethylamino)-7-ethenylquinazolin-4-yl]amino]methyl]phenyl]-4-fluorobenzamideIC50256.0 [1], 382.0 [2]
1-[(2-Chloro-4-fluorophenyl)methyl]-N-[4-[[[2-(dimethylamino)-7-methylquinazolin-4-yl]amino]methyl]phenyl]piperidine-4-carboxamideIC50215.0 [1], 521.0 [2]
N-[4-[[[2-(Dimethylamino)-7-methylquinazolin-4-yl]amino]methyl]phenyl]-1-(furan-2-ylmethyl)piperidine-4-carboxamideIC501831.0 [1], 1934.0 [2]
N-[4-[[[2-(Dimethylamino)-7-methylquinazolin-4-yl]amino]methyl]phenyl]-1-(1H-imidazol-2-ylmethyl)piperidine-4-carboxamideIC5020055.0 [1]
N-[4-[[[2-(Dimethylamino)-7-methylquinazolin-4-yl]amino]methyl]phenyl]-1-[(2-fluorophenyl)methyl]piperidine-4-carboxamideIC50332.0 [1], 568.0 [2]
1-Benzyl-N-[4-[[[2-(dimethylamino)-7-methylquinazolin-4-yl]amino]methyl]phenyl]piperidine-4-carboxamideIC50738.0 [1], 754.0 [2]
N-[4-[[[2-(Dimethylamino)-7-methylquinazolin-4-yl]amino]methyl]phenyl]-1-[(4-methylphenyl)methyl]piperidine-4-carboxamideIC50467.0 [1], 539.0 [2]
1-Benzyl-N-[4-[[[2-(ethylamino)-7-methylquinazolin-4-yl]amino]methyl]phenyl]piperidine-4-carboxamideIC501138.0 [1], 1388.0 [2]
N-[4-[[[2-(Dimethylamino)-7-methylquinazolin-4-yl]amino]methyl]phenyl]-1-[(3-fluorophenyl)methyl]piperidine-4-carboxamideIC50328.0 [1], 347.0 [2]
N-[4-[[[2-(Azetidin-1-yl)-7-methylquinazolin-4-yl]amino]methyl]phenyl]-1-benzylpiperidine-4-carboxamideIC50782.0 [1], 805.0 [2]
1-[(4-Chlorophenyl)methyl]-N-[4-[[[2-(dimethylamino)-7-methylquinazolin-4-yl]amino]methyl]phenyl]piperidine-4-carboxamideIC50255.0 [1], 390.0 [2]
1-Benzyl-N-[4-[[(7-methyl-2-pyrrolidin-1-ylquinazolin-4-yl)amino]methyl]phenyl]piperidine-4-carboxamideIC50669.0 [1], 793.0 [2]
N-[4-[[[2-(Azepan-1-yl)-7-methylquinazolin-4-yl]amino]methyl]phenyl]-1-benzylpiperidine-4-carboxamideIC50966.0 [1], 1041.0 [2]
1-Benzyl-N-[4-[[[2-[2-(dimethylamino)ethyl-methylamino]-7-methylquinazolin-4-yl]amino]methyl]phenyl]piperidine-4-carboxamideIC501445.0 [1], 2269.0 [2]
1-Benzyl-N-[4-[[[2-[3-(dimethylamino)propyl-methylamino]-7-methylquinazolin-4-yl]amino]methyl]phenyl]piperidine-4-carboxamideIC501316.0 [1], 1416.0 [2]
1-Benzyl-N-[4-[[[7-methyl-2-(4-methylpiperazin-1-yl)quinazolin-4-yl]amino]methyl]phenyl]piperidine-4-carboxamideIC501328.0 [1], 1582.0 [2]
1-Benzyl-N-[4-[[[2-[3-(2-hydroxyethyl)piperazin-1-yl]-7-methylquinazolin-4-yl]amino]methyl]phenyl]piperidine-4-carboxamideIC502124.0 [1], 2277.0 [2]
1-Benzyl-N-[4-[[[7-methyl-2-(4-pyrrolidin-1-ylpiperidin-1-yl)quinazolin-4-yl]amino]methyl]phenyl]piperidine-4-carboxamideIC50853.0 [1], 965.0 [2]
N-[4-[[[2-(Dimethylamino)-7-methylquinazolin-4-yl]amino]methyl]phenyl]-1-methylpiperidine-4-carboxamideIC501675.0 [1], 1923.0 [2]
N-[4-[[[2-(Dimethylamino)-7-methylquinazolin-4-yl]amino]methyl]phenyl]-1-[(4-methoxyphenyl)methyl]piperidine-4-carboxamideIC50213.0 [1], 373.0 [2]
N-[4-[[[2-(Dimethylamino)-7-methylquinazolin-4-yl]amino]methyl]phenyl]-1-(2-methylpropyl)piperidine-4-carboxamideIC50650.0 [1], 962.0 [2]
1-Butyl-N-[4-[[[2-(dimethylamino)-7-methylquinazolin-4-yl]amino]methyl]phenyl]piperidine-4-carboxamideIC501173.0 [1], 1479.0 [2]
1-Cyclohexyl-N-[4-[[[2-(dimethylamino)-7-methylquinazolin-4-yl]amino]methyl]phenyl]piperidine-4-carboxamideIC50754.0 [1], 809.0 [2]
N-[4-[[[2-(Dimethylamino)-7-methylquinazolin-4-yl]amino]methyl]phenyl]-1-[(4-fluorophenyl)methyl]piperidine-4-carboxamideIC50215.0 [1], 262.0 [2]
N-[4-[[[2-(Dimethylamino)quinazolin-4-yl]amino]methyl]phenyl]-4-fluorobenzamideIC50766.0 [1], 1490.0 [2]
4-Fluoro-N-[4-[[[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]amino]methyl]phenyl]benzamideIC503037.0 [1], 3445.0 [2]
4-[[[2-(Dimethylamino)-6-(3-ethenylphenyl)quinazolin-4-yl]amino]methyl]-N-(4-fluorophenyl)benzamideIC50308.0 [1], 397.0 [2]
N-[[[2-(Dimethylamino)-6-[(E)-3,3-dimethylbut-1-enyl]quinazolin-4-yl]amino]methyl]-N-(4-fluorophenyl)benzamideIC50425.0 [1], 556.0 [2]
4-Cyano-N-[4-[[[8-methyl-2-(methylamino)quinazolin-4-yl]amino]methyl]phenyl]benzamide;2,2,2-trifluoroacetic acidIC50962.0 [1], 1100.0 [2]
4-[[[2-(Dimethylamino)-6-[4-[(E)-2-phenylethenyl]phenyl]quinazolin-4-yl]amino]methyl]-N-(4-fluorophenyl)benzamideIC504484.0 [1], 4512.0 [2]
N-[4-[[[2-(Dimethylamino)-6-[5-(dimethylamino)pyridin-2-yl]quinazolin-4-yl]amino]methyl]phenyl]-4-fluorobenzamideIC50229.0 [1], 453.0 [2]
4-Bromo-N-[4-[[[8-methyl-2-(methylamino)quinazolin-4-yl]amino]methyl]phenyl]benzamide;2,2,2-trifluoroacetic acidIC50933.0 [1], 1141.0 [2]
N-[4-[[[2-(Dimethylamino)-6-[(Z)-2-phenylethenyl]quinazolin-4-yl]amino]methyl]phenyl]-4-fluorobenzamideIC502941.0 [1], 4277.0 [2]
3,4-Difluoro-N-[4-[[[6-methyl-2-(methylamino)quinazolin-4-yl]amino]methyl]phenyl]benzamideIC5081.0 [1], 100.0 [2]
N-[4-[[[6-Bromo-8-methyl-2-(methylamino)quinazolin-4-yl]amino]methyl]phenyl]-4-chlorobenzamideIC50649.0 [1], 1006.0 [2]
6-Chloro-N-[4-[[[2-(dimethylamino)-7-fluoro-8-methylquinazolin-4-yl]amino]methyl]phenyl]pyridine-3-carboxamideIC508959.0 [1], 11069.0 [2]
1-Benzyl-N-[4-[[[2-(dimethylamino)-7-propan-2-ylquinazolin-4-yl]amino]methyl]phenyl]piperidine-4-carboxamideIC501191.0 [1], 2152.0 [2]
N-[4-[[[2-(Dimethylamino)-6-fluoroquinazolin-4-yl]amino]methyl]phenyl]-4-fluorobenzamideIC501954.0 [1], 5388.0 [2]
6-Chloro-N-[4-[[[2-(dimethylamino)-7-propan-2-ylquinazolin-4-yl]amino]methyl]phenyl]pyridine-3-carboxamideIC50808.0 [1], 1111.0 [2]
N-[4-[[[2-(Dimethylamino)-7-propan-2-ylquinazolin-4-yl]amino]methyl]phenyl]-4-fluorobenzamideIC50327.0 [1], 532.0 [2]
N-[4-[[[2-(Azepan-1-yl)-6-methylquinazolin-4-yl]amino]methyl]phenyl]-4-fluorobenzamideIC501736.0 [1], 2011.0 [2]
Ethyl 4-[4-[[4-[(4-fluorobenzoyl)amino]phenyl]methylamino]-6-methylquinazolin-2-yl]piperazine-1-carboxylateIC50846.0 [1], 1230.0 [2]
N-[4-[[[2-(Dimethylamino)-6-[6-(dimethylamino)pyridin-3-yl]quinazolin-4-yl]amino]methyl]phenyl]-4-fluorobenzamideIC50229.0 [1], 453.0 [2]
4-Fluoro-N-[4-[[[6-methyl-2-[methyl(pyridin-2-ylmethyl)amino]quinazolin-4-yl]amino]methyl]phenyl]benzamideIC502079.0 [1], 2500.0 [2]
N-[4-[[[2-(4-Ethylpiperazin-1-yl)-6-methylquinazolin-4-yl]amino]methyl]phenyl]-4-fluorobenzamideIC50923.0 [1], 1597.0 [2]
4-Fluoro-N-[4-[[[6-methyl-2-(4-pyridin-2-ylpiperazin-1-yl)quinazolin-4-yl]amino]methyl]phenyl]benzamideIC503261.0 [1], 8653.0 [2]
4-Chloro-N-[4-[[[2-(dimethylamino)-6-methylquinazolin-4-yl]amino]methyl]phenyl]benzamideIC50306.0 [1], 462.0 [2]
N-[4-[[[6,8-Dimethyl-2-(4-methylpiperazin-1-yl)quinazolin-4-yl]amino]methyl]phenyl]-4-fluorobenzamideIC502507.0 [1]
4-Fluoro-N-[4-[[[6-methyl-2-(4-methylpiperazin-1-yl)quinazolin-4-yl]amino]methyl]phenyl]benzamideIC5020637.0 [1]
4-Fluoro-N-[4-[[(6-methyl-2-piperazin-1-ylquinazolin-4-yl)amino]methyl]phenyl]benzamideIC501484.0 [1], 1804.0 [2]
2-Fluoro-N-[4-[[[6-methyl-2-(methylamino)quinazolin-4-yl]amino]methyl]phenyl]benzamideIC5011965.0 [1], 12815.0 [2]
4-Fluoro-N-[2-methyl-3-[[6-methyl-2-(4-methylpiperazin-1-yl)quinazolin-4-yl]amino]phenyl]benzamideIC5020767.0 [1]
4-Fluoro-N-[4-[[(6-methyl-2-pyrrolidin-1-ylquinazolin-4-yl)amino]methyl]phenyl]benzamideIC5021952.0 [1]
N-[4-[[[2-(Diethylamino)-6-methylquinazolin-4-yl]amino]methyl]phenyl]-4-fluorobenzamideIC50492.0 [1], 738.0 [2]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ TCF4/beta-catenin Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 22 Feb. 2025, https://www.aatbio.com/data-sets/tcf4-beta-catenin-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 22). Quest Database™ TCF4/beta-catenin Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/tcf4-beta-catenin-inhibitors-ic50-ki.
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