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Tankyrase-2 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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▼
3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-oneIC505.25 [1]
OlaparibIC505.2 [1], 1200.0 [2], 1700.0 [3], 2344.23 [4]
IWR-1-endoIC5038.0 [1], 39.0 [2], 56.0 [3], 134.9 [4]
1-[3-[4-(2-Chlorophenyl)-5-pyrimidin-4-yl-1,2,4-triazol-3-yl]cyclobutyl]-2-oxo-3H-benzimidazole-5-carbonitrileIC506.3 [1], 19.0 [2], 70.0 [3]
3-[4-[4-(2-Chlorophenyl)-5-pyrimidin-4-yl-1,2,4-triazol-3-yl]cyclohexyl]-1H-benzimidazol-2-oneIC50430.0 [1], 1060.0 [2], 1800.0 [3]
1-[4-[4-(2-Chlorophenyl)-5-pyrimidin-4-yl-1,2,4-triazol-3-yl]cyclohexyl]-2-oxo-3H-benzimidazole-5-carbonitrileIC50120.0 [1], 330.0 [2], 1490.0 [3]
3-[3-[4-(2-Chlorophenyl)-5-pyrimidin-4-yl-1,2,4-triazol-3-yl]cyclobutyl]-1H-benzimidazol-2-oneIC509.8 [1], 200.0 [2], 410.0 [3]
N~2~,N~2~-Dimethyl-N~1~-(6-oxo-5,6-dihydrophenanthridin-2-YL)glycinamideIC50219.0 [1], 2951.21 [2]
RucaparibIC5014.0 [1], 891.25 [2]
2-(4-Chlorophenyl)quinazolin-4-olIC5054.0 [1], 200.0 [2]
Nvp-tnks656IC506.0 [1]
4,4'-OxydibenzamideIC50100000.0 [1]
2-(4-Methylphenyl)-4H-chromen-4-oneIC50190.0 [1], 1100.0 [2]
5-[[4-(4-Methoxyphenyl)-5-pyridin-4-yl-1,2,4-triazol-3-yl]sulfanylmethyl]-3-(4-methylphenyl)-1,2,4-oxadiazoleIC50460.0 [1], 650.0 [2]
4-[(3Ar,4r,7s,7as)-1,3-Dioxooctahydro-2h-4,7-Methanoisoindol-2-Yl]-N-(Quinolin-8-Yl)benzamideIC5031.0 [1], 56.0 [2]
2-[4-(Trifluoromethyl)phenyl]-3h-Quinazolin-4-OneIC5021.5 [1], 133.0 [2]
2-[4-(Trifluoromethyl)phenyl]-3,5,6,8-tetrahydrothiopyrano[3,4-d]pyrimidin-4-oneIC502.0 [1], 4.0 [2]
1-[4-[4-(2-Chlorophenyl)-5-pyrimidin-4-yl-1,2,4-triazol-3-yl]phenyl]-2-oxo-3H-benzimidazole-5-carbonitrileIC50340.0 [1], 10000.0 [2]
2-[4-(4-Fluorobenzoyl)piperidin-1-yl]-N-[(4-oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]-N-(thiophen-2-ylmethyl)acetamideIC507.5 [1]
4-[3-(8-Methyl-4-oxo-3H-quinazolin-2-yl)propanoylamino]-N-quinolin-8-ylbenzamideIC500.1 [1]
2-[4-(4-Fluorobenzoyl)piperidin-1-yl]-N-[(4-oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]-N-propylacetamideIC5011.0 [1]
N-[(4-Oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]-3-phenyl-N-(thiophen-2-ylmethyl)propanamideIC50216.0 [1], 222.0 [2]
3-(4-Fluorophenyl)-N-[(4-oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]-N-(thiophen-2-ylmethyl)propanamideIC5078.0 [1]
3-(2-Fluorophenyl)-N-[(4-oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]-N-(thiophen-2-ylmethyl)propanamideIC5064.0 [1]
3-(3-Fluorophenyl)-N-[(4-oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]-N-(thiophen-2-ylmethyl)propanamideIC50284.0 [1]
3-(2-Hydroxyphenyl)-N-[(4-oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]-N-(thiophen-2-ylmethyl)propanamideIC50766.0 [1]
3-(3-Hydroxyphenyl)-N-[(4-oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]-N-(thiophen-2-ylmethyl)propanamideIC50178.0 [1], 180.0 [2]
3-(4-Hydroxyphenyl)-N-[(4-oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]-N-(thiophen-2-ylmethyl)propanamideIC50341.0 [1], 345.0 [2]
N-[(4-Oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]-3-pyridin-4-yl-N-(thiophen-2-ylmethyl)propanamideIC50958.0 [1], 962.0 [2]
N-Ethyl-N-[(4-oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]-3-phenylpropanamideIC504780.0 [1]
N-[(4-Oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]-3-phenyl-N-(thiophen-3-ylmethyl)propanamideIC501030.0 [1]
2-[4-(4-Fluorobenzoyl)piperidin-1-yl]-N-[(4-oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]acetamideIC5023.0 [1]
2-[4-(4-Fluorobenzoyl)piperidin-1-yl]-N-[(4-oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]-N-(pyridin-2-ylmethyl)acetamideIC5031.0 [1]
N-(Cyclopropylmethyl)-2-[4-(4-fluorobenzoyl)piperidin-1-yl]-N-[(4-oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]acetamideIC5010.7 [1], 11.0 [2]
2-[4-(4-Fluorobenzoyl)piperidin-1-yl]-N-(2-methylpropyl)-N-[(4-oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]acetamideIC5018.0 [1]
2-[4-(4-Fluorobenzoyl)piperidin-1-yl]-N-methyl-N-[(4-oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]acetamideIC5057.0 [1]
N-Benzyl-2-[4-(4-fluorobenzoyl)piperidin-1-yl]-N-[(4-oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]acetamideIC5016.0 [1]
N-[(4-Oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]-3-pyridin-3-yl-N-(thiophen-2-ylmethyl)propanamideIC507960.0 [1], 10100.0 [2]
(4s)-3-{4-[6-Amino-5-(Pyrimidin-2-Yl)pyridin-3-Yl]phenyl}-5,5-Dimethyl-4-Phenyl-1,3-Oxazolidin-2-OneIC5025.9 [1], 26.0 [2]
4-[[1-[[2-Cyano-3-(trifluoromethyl)phenyl]methyl]-2,4-dioxoquinazolin-3-yl]methyl]cyclohexane-1-carboxylic acidIC5019.95 [1], 79.43 [2]
4-[[1-[[2-Cyano-3-(trifluoromethyl)phenyl]methyl]-6-fluoro-5-methyl-2,4-dioxoquinazolin-3-yl]methyl]cyclohexane-1-carboxylic acidIC5019.95 [1], 79.43 [2]
2-[4-(Aminomethyl)phenyl]-8-methyl-3H-quinazolin-4-oneIC5043.0 [1], 100.0 [2]
ApigeninIC502900.0 [1]
LuteolinIC501100.0 [1]
FlavoneIC50140.0 [1]
2-HydroxyquinolineIC5020000.0 [1]
VeliparibIC5023988.33 [1]
NiraparibIC505128.61 [1]
6(5H)-PhenanthridinoneIC5014.0 [1]
Bmn-673 8R,9SIC50107.15 [1]
3',4'-DihydroxyflavoneIC50170.0 [1]
7,3',4'-TrihydroxyflavoneIC50870.0 [1]
4H-Thieno[2,3-c]isoquinolin-5-oneIC5024.0 [1]
2-Phenylquinazolin-4-olIC502200.0 [1]
2-(4-Methoxyphenyl)-1H-quinazolin-4-oneIC50611.0 [1]
CID 67960134IC5025.0 [1]
4-Methylquinolin-2-olIC5012000.0 [1]
PratolIC50450.0 [1]
4-MethoxybenzamideIC50100000.0 [1]
4'-FluoroflavoneIC501100.0 [1]
2-(4-Nitrophenyl)quinazolin-4-olIC50259.0 [1]
7,3'-DihydroxyflavoneIC50620.0 [1]
8-(3-Chloro-5-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-oneIC5015000.0 [1]
2-(4-Methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-oneIC501000.0 [1]
2-(4-Bromophenyl)-3,4-Dihydroquinazolin-4-OneIC50101.0 [1]
3-(4-Oxo-3,4-dihydroquinazolin-2-yl)propanoic acidIC50100000.0 [1]
2-Phenyl-2,3-dihydroquinazolin-4(1h)-oneIC505495.41 [1]
2-(4-Fluorophenyl)quinazolin-4-olIC501102.0 [1]
3'-HydroxyflavoneIC50310.0 [1]
2-(4-Chlorophenyl)-2,3-dihydroquinazolin-4(1H)-oneIC50416.87 [1]
5H-Pyrano[4,3-b]pyridine-3-carbonitrile, 2-hydroxy-7-isopropyl-7,8-dihydro-IC501700.0 [1]
2-(2-Chlorophenyl)-2,3-dihydro-1H-quinazolin-4-oneIC5031200.0 [1]
2-(4-Hydroxyphenyl)-3h-Quinazolin-4-OneIC50189.0 [1]
5-Ethyl-2-[4-(2-fluoro-phenyl)-piperazin-1-yl]-6-methyl-3H-pyrimidin-4-oneIC50724.44 [1]
2-[4-(2-Fluorophenyl)piperazin-1-yl]-6-methyl-5-propylpyrimidin-4(3H)-oneIC5063095.73 [1]
N-[4-[[[4-(4-Methoxyphenyl)-4-oxanyl]methylamino]-oxomethyl]phenyl]-2-furancarboxamideIC501995.26 [1]
4-[[3-[(6S)-3-(1,1-Difluoroethyl)-6-methyl-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazine-7-carbonyl]phenyl]-difluoromethyl]-2H-phthalazin-1-oneIC503000.0 [1]
2-(4-Methoxy-phenyl)-8-methyl-3H-quinazolin-4-oneIC5012.0 [1]
8-Methyl-2-(4-nitro-phenyl)-3H-quinazolin-4-oneIC5030.0 [1]
2-(4-Amino-phenyl)-8-methyl-3H-quinazolin-4-oneIC503.3 [1]
2-(4-Hydroxy-phenyl)-8-methyl-3H-quinazolin-4-oneIC503.0 [1]
8-Methyl-2-phenylquinazolin-4(3H)-oneIC5041.0 [1]
2-(3-Benzyloxyphenyl)-1,2-dihydro-4(3H)-quinazolinoneIC507244.36 [1]
2-(4-Nitrophenyl)-4H-chromen-4-oneIC50140.0 [1]
2-(4-Aminophenyl)-3,4-Dihydroquinazolin-4-OneIC50690.0 [1]
4-Quinazolinol, 5,6,7,8-tetrahydro-2-(4-methyl-1-piperazinyl)-IC50302.0 [1]
2-(4-Methoxyphenyl)-8-methoxyquinazoline-4(3H)-oneIC50128.0 [1]
8-Methoxy-2-(4-nitro-phenyl)-3H-quinazolin-4-oneIC50863.0 [1]
8-Methoxy-2-phenyl-quinazolin-4-olIC501029.0 [1]
2-(4-Methylphenyl)quinazolin-4(3H)-oneIC50540.0 [1]
8-Methyl-2-[4-(Trifluoromethyl)phenyl]-3h-Quinazolin-4-OneIC5010.0 [1]
2-(4-Amino-phenyl)-8-hydroxy-3H-quinazolin-4-oneIC50219.0 [1]
8-Hydroxy-2-(4-nitro-phenyl)-3H-quinazolin-4-oneIC50191.0 [1]
2-(4-Hydroxyphenyl)-8-hydroxyquinazoline-4(3H)-oneIC5086.0 [1]
8-Methoxy-2-[4-(Trifluoromethyl)phenyl]-3,4-Dihydroquinazolin-4-OneIC5087.0 [1]
8-Hydroxy-2-phenyl-3H-quinazolin-4-oneIC50180.0 [1]
5-({[5-(2-Furyl)-4-phenyl-4H-1,2,4-triazol-3-yl]thio}methyl)-3-phenyl-1,2,4-oxadiazoleIC5019000.0 [1]
4'-IsopropylflavoneIC5072.0 [1]
CID 41783892IC502760.0 [1]
2-(4-Tert-Butylphenyl)-2,3-dihydroquinazoline-4(1H)-oneIC50154.88 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Tankyrase-2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/tankyrase-2-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ Tankyrase-2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/tankyrase-2-inhibitors-ic50-ki.
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