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Tankyrase 1/2 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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▼
3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-oneIC5011.0 [1], 707.0 [2], 272000.0 [3]
(4S)-3-[4-(6-Amino-5-pyrimidin-2-ylpyridin-3-yl)cyclohexyl]-5,5-dimethyl-4-phenyl-1,3-oxazolidin-2-oneIC5012.0 [1], 91.0 [2], 6550.0 [3]
IWR-1-endoIC50250.0 [1], 136000.0 [2]
(4s)-3-{4-[6-Amino-5-(Pyrimidin-2-Yl)pyridin-3-Yl]phenyl}-5,5-Dimethyl-4-Phenyl-1,3-Oxazolidin-2-OneIC5096.0 [1], 233.0 [2]
2-Amino-5-[4-[(4S)-5,5-dimethyl-2-oxo-4-phenyl-1,3-oxazolidin-3-yl]cyclohexyl]pyridine-3-carbonitrileIC5043.0 [1], 392.0 [2]
Cinnamic acidIC50685.0 [1]
OlaparibIC503000.0 [1]
CID 67960134IC5050.0 [1]
5-[[4-(4-Methoxyphenyl)-5-pyridin-4-yl-1,2,4-triazol-3-yl]sulfanylmethyl]-3-(4-methylphenyl)-1,2,4-oxadiazoleIC501010.0 [1]
N-[4-[[[4-(4-Methoxyphenyl)-4-oxanyl]methylamino]-oxomethyl]phenyl]-2-furancarboxamideIC501230.0 [1]
4-[[3-[(6S)-3-(1,1-Difluoroethyl)-6-methyl-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazine-7-carbonyl]phenyl]-difluoromethyl]-2H-phthalazin-1-oneIC503000.0 [1]
4-[(1R,2S,6R,7S)-3,5-Dioxo-4-azatricyclo[5.2.1.02,6]dec-8-en-4-yl]-N-(4-methylquinolin-8-yl)benzamideIC50163000.0 [1]
N-(2-Methoxyphenyl)-4-{[3-(4-Oxo-3,4-Dihydroquinazolin-2-Yl)propanoyl]amino}benzamideIC5036000.0 [1]
2-[4-(Trifluoromethyl)phenyl]-3,5,6,8-tetrahydrothiopyrano[3,4-d]pyrimidin-4-oneIC5011.0 [1]
2-[4-[3-[(4-Oxo-3H-phthalazin-1-yl)methyl]benzoyl]piperazin-1-yl]pyridine-3-carbonitrileIC50222.0 [1]
N-{4-[(2-Chlorophenyl)(Pyrimidin-4-Yl)carbamoyl]phenyl}-4-MethoxybenzamideIC501910.0 [1]
2-Chloro-4-[(4-methoxybenzoyl)amino]-N-[[4-(4-methoxyphenyl)oxan-4-yl]methyl]benzamideIC50790.0 [1]
2-(4-Tert-butylphenyl)-3H-[1]benzothiolo[3,2-d]pyrimidin-4-oneIC50832.0 [1]
4-[5-[[4-(2-Chlorophenyl)-5-pyridin-4-yl-1,2,4-triazol-3-yl]sulfanylmethyl]-1,3,4-oxadiazol-2-yl]benzonitrileIC50140.0 [1]
2-[2-[4-(2-Chlorophenyl)-5-pyridin-4-yl-1,2,4-triazol-3-yl]ethyl]-5-(4-methylphenyl)-1,3,4-oxadiazoleIC50420.0 [1]
5-[[4-(4-Methoxyphenyl)-5-pyridin-4-yl-1,2,4-triazol-3-yl]oxymethyl]-3-(4-methylphenyl)-1,2,4-oxadiazoleIC5010000.0 [1]
4-[5-[(E)-2-[4-(2-Chlorophenyl)-5-(4-fluorophenyl)-1,2,4-triazol-3-yl]ethenyl]-1,3,4-oxadiazol-2-yl]-1H-pyridin-2-oneIC506300.0 [1]
2-[(E)-2-[4-(2-Chlorophenyl)-5-(5-methylsulfonylpyridin-2-yl)-1,2,4-triazol-3-yl]ethenyl]-5-(2-methoxypyridin-4-yl)-1,3,4-oxadiazoleIC5070.0 [1]
5-(2-Aminoquinazolin-6-Yl)-N-(4,4-Dimethyl-2-Oxo-1,2,3,4-Tetrahydroquinolin-7-Yl)-2-FluorobenzamideIC502000.0 [1]
4-(4-Methoxyphenyl)-N-[[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl]-5-pyridin-4-yl-1,2,4-triazol-3-amineIC5010000.0 [1]
3-(4-Methylphenyl)-5-[[1-(2-methylphenyl)-5-pyridin-4-ylimidazol-2-yl]sulfanylmethyl]-1,2,4-oxadiazoleIC5010000.0 [1]
3-[3-[3-[5-[[4-(2-Chlorophenyl)-5-pyridin-4-yl-1,2,4-triazol-3-yl]sulfanylmethyl]-1,2,4-oxadiazol-3-yl]phenoxy]propoxy]propan-1-amineIC503920.0 [1]
2-[[4-(2-Chlorophenyl)-5-pyridin-4-yl-1,2,4-triazol-3-yl]sulfanylmethyl]-7,8-dimethylpyrido[1,2-a]pyrimidin-4-oneIC504530.0 [1]
2-(4-Chlorophenyl)-5-[[4-(2-chlorophenyl)-5-(5-methylsulfonylpyridin-2-yl)-1,2,4-triazol-3-yl]sulfanylmethyl]-1,3,4-oxadiazoleIC5050.0 [1]
4-[(4s)-5,5-Dimethyl-2-Oxo-4-Phenyl-1,3-Oxazolidin-3-Yl]-N-(Quinolin-8-Yl)benzamideIC502100.0 [1]
N-(4-(((4-(4-Methoxyphenyl)oxan-4-Yl)methyl)carbamoyl)phenyl)-5-Methylfuran-2-CarboxamideIC50380.0 [1]
4-(2,2-Dimethyl-5-oxopyrrolidin-1-yl)-N-quinolin-8-ylbenzamideIC507300.0 [1]
4-[2-(4-Fluorophenyl)-5-oxopyrrolidin-1-yl]-N-quinolin-8-ylbenzamideIC501100.0 [1]
4-[(4S)-2-Oxo-4-phenyl-1,3-oxazolidin-3-yl]-N-quinolin-8-ylbenzamideIC504000.0 [1]
4-[(4S)-5,5-Dimethyl-2-oxo-4-phenyl-1,3-oxazolidin-3-yl]-N-(1,5-naphthyridin-4-yl)benzamideIC50189.0 [1]
4-[(4S)-5,5-Dimethyl-2-oxo-4-phenyl-1,3-oxazolidin-3-yl]-N-quinolin-8-ylcyclohexane-1-carboxamideIC50390.0 [1]
N-[4-[(4S)-5,5-Dimethyl-2-oxo-4-phenyl-1,3-oxazolidin-3-yl]cyclohexyl]quinoline-8-carboxamideIC50200.0 [1]
N-[4-[(4S)-5,5-Dimethyl-2-oxo-4-phenyl-1,3-oxazolidin-3-yl]cyclohexyl]-1,5-naphthyridine-4-carboxamideIC5073.0 [1]
N-[4-[(4S)-5,5-Dimethyl-2-oxo-4-phenyl-1,3-oxazolidin-3-yl]cyclohexyl]-7-fluoro-1,5-naphthyridine-4-carboxamideIC50270.0 [1]
(4S)-5,5-Dimethyl-3-[4-(2-oxo-3H-imidazo[4,5-c]pyridin-1-yl)cyclohexyl]-4-phenyl-1,3-oxazolidin-2-oneIC50140.0 [1]
(4S)-5,5-Dimethyl-3-[4-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)cyclohexyl]-4-phenyl-1,3-oxazolidin-2-oneIC501100.0 [1]
1-[4-[(4S)-5,5-Dimethyl-2-oxo-4-phenyl-1,3-oxazolidin-3-yl]cyclohexyl]-2-oxo-3H-benzimidazole-5-carbonitrileIC5054.0 [1]
1-[4-[(4S)-5,5-Dimethyl-2-oxo-4-phenyl-1,3-oxazolidin-3-yl]cyclohexyl]-2-oxo-3H-benzimidazole-4-carbonitrileIC50270.0 [1]
1-[4-[(4S)-5,5-Dimethyl-2-oxo-4-phenyl-1,3-oxazolidin-3-yl]cyclohexyl]-6-fluoro-2-oxo-3H-benzimidazole-5-carbonitrileIC5067.0 [1]
1-[4-[(4S)-5,5-Dimethyl-2-oxo-4-phenyl-1,3-oxazolidin-3-yl]cyclohexyl]-4-fluoro-2-oxo-3H-benzimidazole-5-carbonitrileIC50150.0 [1]
3-[4-[(4S)-5,5-Dimethyl-2-oxo-4-phenyl-1,3-oxazolidin-3-yl]cyclohexyl]-2-oxo-1H-imidazo[4,5-b]pyridine-6-carbonitrileIC50170.0 [1]
(4S)-5,5-Dimethyl-3-[4-(2-oxo-1H-imidazo[4,5-b]pyridin-3-yl)cyclohexyl]-4-phenyl-1,3-oxazolidin-2-oneIC50520.0 [1]
(4S)-5,5-Dimethyl-3-[4-(2-oxo-1H-imidazo[4,5-c]pyridin-3-yl)cyclohexyl]-4-phenyl-1,3-oxazolidin-2-oneIC501710.0 [1]
(4S)-5,5-Dimethyl-3-[4-(8-oxo-7H-purin-9-yl)cyclohexyl]-4-phenyl-1,3-oxazolidin-2-oneIC50290.0 [1]
4-[(5R)-2-Oxo-5-phenylpyrrolidin-1-yl]-N-quinolin-8-ylbenzamideIC5010000.0 [1]
2-(4-Chlorophenyl)-5-[[4-(2-chlorophenyl)-5-methyl-1,2,4-triazol-3-yl]sulfanylmethyl]-1,3,4-oxadiazoleIC504500.0 [1]
4-[(1S,2R,6S,7R)-4-Azatricyclo[5.2.1.02,6]dec-8-en-4-yl]-N-quinolin-8-ylbenzamideIC50131.0 [1]
2-[N-(Benzenesulfonyl)-5-chloro-2-methoxyanilino]-N-[4-(2-oxo-3H-benzimidazol-1-yl)cyclohexyl]acetamideIC50150.0 [1]
N-[3-Chloranyl-4-[[4-(4-Methoxyphenyl)oxan-4-Yl]methylcarbamoyl]phenyl]furan-2-CarboxamideIC50360.0 [1]
N-[3-Chloro-4-[[4-(4-methoxyphenyl)oxan-4-yl]methylcarbamoyl]phenyl]-2-methyl-1,3-oxazole-5-carboxamideIC50690.0 [1]
Items per page: 1 - 10 of 55
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References

This online tool may be cited as follows

MLA

"Quest Database™ Tankyrase 1/2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/tankyrase-1-2-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 20). Quest Database™ Tankyrase 1/2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/tankyrase-1-2-inhibitors-ic50-ki.
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