![](https://images.aatbio.com/dataset/ic50/subtilisin-kexin-type-9_3052274f26535825ea7d282e1445a2e5.svg) | N-(3-Chloropyridin-2-yl)-N-[(3R)-piperidin-3-yl]-4-(triazolo[4,5-b]pyridin-3-yl)benzamide | IC50 | 520.0 [1], 800.0 [2] |
![](https://images.aatbio.com/dataset/ic50/subtilisin-kexin-type-9_8ec6ea83dd3db6d72f5290d041450d10.svg) | 4-[4-[(3-Chloropyridin-2-yl)-[(3R)-piperidin-3-yl]carbamoyl]phenyl]-2-methyl-N-methylsulfonylpyrazole-3-carboxamide | IC50 | 14300.0 [1], 20000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/subtilisin-kexin-type-9_412887ccb254298017e57a652baea83d.svg) | N-(3-Methylpyridin-2-yl)-N-[(3R)-piperidin-3-yl]-4-pyrazolo[1,5-a]pyrimidin-3-ylbenzamide | IC50 | 440.0 [1], 3200.0 [2] |
![](https://images.aatbio.com/dataset/ic50/subtilisin-kexin-type-9_1c888ed56ca9ebe491d180307d10a244.svg) | [2-Methyl-1-[5-[2-methyl-4-[4-[(3-methylpyridin-2-yl)-[(3R)-piperidin-3-yl]carbamoyl]phenyl]pyrazol-3-yl]tetrazol-2-yl]propyl] propanoate | IC50 | 15400.0 [1], 20000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/subtilisin-kexin-type-9_925d45c75a3d9172d1a674eb232e6ab6.svg) | Ethyl 1-[5-[2-methyl-4-[4-[(3-methylpyridin-2-yl)-[(3R)-piperidin-3-yl]carbamoyl]phenyl]pyrazol-3-yl]tetrazol-2-yl]propyl carbonate | IC50 | 20000.0 [1], 23700.0 [2] |
![](https://images.aatbio.com/dataset/ic50/subtilisin-kexin-type-9_d8f0a197c4d501a7ef2b761bbf99bfd4.svg) | 4-[4-[(3-Chloropyridin-2-yl)-[(3R)-piperidin-3-yl]carbamoyl]phenyl]-2-methyl-N-(2H-tetrazol-5-yl)pyrazole-3-carboxamide | IC50 | 20000.0 [1], 25300.0 [2] |
![](https://images.aatbio.com/dataset/ic50/subtilisin-kexin-type-9_2f4a43a1400efac6254670795defaa9d.svg) | 4-[4-[(3-Chloropyridin-2-yl)-[(3R)-piperidin-3-yl]carbamoyl]phenyl]-N-hydroxy-2-methylpyrazole-3-carboxamide | IC50 | 2970.0 [1], 20000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/subtilisin-kexin-type-9_b29f57efb2dcf06eb9ed113cb01482a8.svg) | 1-[5-[2-Methyl-4-[4-[(3-methylpyridin-2-yl)-[(3R)-piperidin-3-yl]carbamoyl]phenyl]pyrazol-3-yl]tetrazol-2-yl]ethyl propan-2-yl carbonate | IC50 | 592.0 [1], 19400.0 [2] |
![](https://images.aatbio.com/dataset/ic50/subtilisin-kexin-type-9_c7573dd4a513e7c2e4e41b2a625b4f8f.svg) | [2,2-Dimethyl-1-[5-[2-methyl-4-[4-[(3-methylpyridin-2-yl)-[(3R)-piperidin-3-yl]carbamoyl]phenyl]pyrazol-3-yl]tetrazol-2-yl]propyl] ethyl carbonate | IC50 | 20000.0 [1], 22900.0 [2] |
![](https://images.aatbio.com/dataset/ic50/subtilisin-kexin-type-9_ba8eaf58ddf07db25f8707f54f14241c.svg) | 1-[5-[2-Methyl-4-[4-[(3-methylpyridin-2-yl)-[(3R)-piperidin-3-yl]carbamoyl]phenyl]pyrazol-3-yl]tetrazol-2-yl]propyl 2-methylpropanoate | IC50 | 20000.0 [1], 31800.0 [2] |
![](https://images.aatbio.com/dataset/ic50/subtilisin-kexin-type-9_4c2ee894d406a328f20431546d8ee444.svg) | 1-[5-[2-Methyl-4-[4-[(3-methylpyridin-2-yl)-[(3R)-piperidin-3-yl]carbamoyl]phenyl]pyrazol-3-yl]tetrazol-2-yl]propyl propan-2-yl carbonate | IC50 | 15400.0 [1], 19400.0 [2] |
![](https://images.aatbio.com/dataset/ic50/subtilisin-kexin-type-9_ef085bbe65c573d2884b454e6c42b995.svg) | [2-Methyl-1-[5-[2-methyl-4-[4-[(3-methylpyridin-2-yl)-[(3R)-piperidin-3-yl]carbamoyl]phenyl]pyrazol-3-yl]tetrazol-2-yl]propyl] propan-2-yl carbonate | IC50 | 20000.0 [1], 31900.0 [2] |
![](https://images.aatbio.com/dataset/ic50/subtilisin-kexin-type-9_3f599255adb6a52a4216ab19d67608b5.svg) | 1-[5-[2-Methyl-4-[4-[(3-methylpyridin-2-yl)-[(3R)-piperidin-3-yl]carbamoyl]phenyl]pyrazol-3-yl]tetrazol-2-yl]ethyl propanoate | IC50 | 20000.0 [1], 25100.0 [2] |
![](https://images.aatbio.com/dataset/ic50/subtilisin-kexin-type-9_288ac345e629acd98ee5513ca18cf0c8.svg) | Ethyl [2-methyl-1-[5-[2-methyl-4-[4-[(3-methylpyridin-2-yl)-[(3R)-piperidin-3-yl]carbamoyl]phenyl]pyrazol-3-yl]tetrazol-2-yl]propyl] carbonate | IC50 | 6200.0 [1], 20000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/subtilisin-kexin-type-9_aafbeaad4790949e77ba4b5820c95cc9.svg) | 1-[5-[2-Methyl-4-[4-[(3-methylpyridin-2-yl)-[(3R)-piperidin-3-yl]carbamoyl]phenyl]pyrazol-3-yl]tetrazol-2-yl]propyl propanoate | IC50 | 20000.0 [1], 33400.0 [2] |
![](https://images.aatbio.com/dataset/ic50/subtilisin-kexin-type-9_19d06689b4f0f2b55d2fe0c08755b9e3.svg) | 4-[1-Methyl-5-(5-oxo-4H-1,2,4-oxadiazol-3-yl)pyrazol-4-yl]-N-(3-methylpyridin-2-yl)-N-[(3R)-piperidin-3-yl]benzamide | IC50 | 5610.0 [1], 20000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/subtilisin-kexin-type-9_9b7d8bcca9341215adf2434abee3b784.svg) | N-(3-Chloropyridin-2-yl)-N-[(3R)-piperidin-3-yl]-4-pyrazolo[1,5-a]pyrimidin-3-ylbenzamide | IC50 | 690.0 [1], 1700.0 [2] |
![](https://images.aatbio.com/dataset/ic50/subtilisin-kexin-type-9_fa72dfcc5701bc4a1cd1705947923ecc.svg) | 4-[4-[Isoquinolin-1-yl-[(3R)-piperidin-3-yl]carbamoyl]phenyl]-2-methylpyrazole-3-carboxylic acid | IC50 | 3800.0 [1], 20000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/subtilisin-kexin-type-9_162e98977c4daada87b9da022d1a0d8b.svg) | Ethyl 4-[4-[(3-chloropyridin-2-yl)-[(3R)-piperidin-3-yl]carbamoyl]phenyl]-2-methylpyrazole-3-carboxylate | IC50 | 1500.0 [1], 1700.0 [2] |
![](https://images.aatbio.com/dataset/ic50/subtilisin-kexin-type-9_f83e490dff20bae525e7071d4972031d.svg) | 4-[4-[(3-Chloropyridin-2-yl)-[(3R)-piperidin-3-yl]carbamoyl]phenyl]-2-methylpyrazole-3-carboxylic acid | IC50 | 18000.0 [1], 20000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/subtilisin-kexin-type-9_05796a367c64e00091f723e48c8d5a91.svg) | 1-Ethoxycarbonyloxyethyl 4-[4-[(3-chloropyridin-2-yl)-[(3R)-piperidin-3-yl]carbamoyl]phenyl]-2-methylpyrazole-3-carboxylate | IC50 | 3700.0 [1], 9500.0 [2] |
![](https://images.aatbio.com/dataset/ic50/subtilisin-kexin-type-9_610ed882f6701b431b7f6bfe2fe15780.svg) | [(1S)-1-Ethoxycarbonyloxyethyl] 4-[4-[(3-chloropyridin-2-yl)-[(3R)-piperidin-3-yl]carbamoyl]phenyl]-2-methylpyrazole-3-carboxylate | IC50 | 3100.0 [1], 7300.0 [2] |
![](https://images.aatbio.com/dataset/ic50/subtilisin-kexin-type-9_307225ea93b6c3088d571a167063c360.svg) | [(1R)-1-Ethoxycarbonyloxyethyl] 4-[4-[(3-chloropyridin-2-yl)-[(3R)-piperidin-3-yl]carbamoyl]phenyl]-2-methylpyrazole-3-carboxylate | IC50 | 5000.0 [1], 10700.0 [2] |
![](https://images.aatbio.com/dataset/ic50/subtilisin-kexin-type-9_ad2f29724beeaeaaf24eea1902e97c62.svg) | Methyl 4-[4-[(3-chloropyridin-2-yl)-[(3R)-piperidin-3-yl]carbamoyl]phenyl]-2-methylpyrazole-3-carboxylate | IC50 | 640.0 [1], 1500.0 [2] |
![](https://images.aatbio.com/dataset/ic50/subtilisin-kexin-type-9_3fc4dcdb2209bc60a125ad68195f56fd.svg) | 1-Ethoxycarbonyloxyethyl 4-[4-[isoquinolin-1-yl-[(3R)-piperidin-3-yl]carbamoyl]phenyl]-2-methylpyrazole-3-carboxylate | IC50 | 2100.0 [1], 11700.0 [2] |
![](https://images.aatbio.com/dataset/ic50/subtilisin-kexin-type-9_53ea20712fa70c5152a700dd257b812d.svg) | 2-Methyl-4-[4-[(1-methylpyrrolo[2,3-c]pyridin-7-yl)-[(3R)-piperidin-3-yl]carbamoyl]phenyl]pyrazole-3-carboxylic acid | IC50 | 1700.0 [1], 20000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/subtilisin-kexin-type-9_00a9c173e34212e4b19ec9ca464d3cd0.svg) | Methyl 2-methyl-4-[4-[(3-methylpyridin-2-yl)-[(3R)-piperidin-3-yl]carbamoyl]phenyl]pyrazole-3-carboxylate | IC50 | 800.0 [1], 2300.0 [2] |
![](https://images.aatbio.com/dataset/ic50/subtilisin-kexin-type-9_0a6e339e29b3f036ae5400e3502834a4.svg) | 4-[4-[(3-Chloropyridin-2-yl)-[(3R)-piperidin-3-yl]carbamoyl]phenyl]-2-methyl-N-(trifluoromethylsulfonyl)pyrazole-3-carboxamide | IC50 | 5800.0 [1], 20000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/subtilisin-kexin-type-9_214435e2db65366e0180d24ad0a19a4a.svg) | N-(3-Chloropyridin-2-yl)-4-[1-methyl-5-(2H-tetrazol-5-yl)pyrazol-4-yl]-N-[(3R)-piperidin-3-yl]benzamide | IC50 | 5750.0 [1], 20000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/subtilisin-kexin-type-9_ec49282151c5a31117a01581ba4fd930.svg) | 2-Methyl-4-[4-[(3-methylpyridin-2-yl)-[(3R)-piperidin-3-yl]carbamoyl]phenyl]-N-methylsulfonylpyrazole-3-carboxamide | IC50 | 16800.0 [1], 20000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/subtilisin-kexin-type-9_56d14f59d317d9974856c157321407e6.svg) | N-(3-Methylpyridin-2-yl)-4-[1-methyl-5-(2H-tetrazol-5-yl)pyrazol-4-yl]-N-[(3R)-piperidin-3-yl]benzamide | IC50 | 3050.0 [1], 20000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/subtilisin-kexin-type-9_efe745fce7af674ea692c7a981571ce6.svg) | 1-[5-[2-Methyl-4-[4-[(3-methylpyridin-2-yl)-[(3R)-piperidin-3-yl]carbamoyl]phenyl]pyrazol-3-yl]tetrazol-2-yl]ethyl 2-methylpropanoate | IC50 | 3560.0 [1], 20000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/subtilisin-kexin-type-9_4208c28c5bdf4a873f9ab3b95d486b8f.svg) | [2-Methyl-1-[5-[2-methyl-4-[4-[(3-methylpyridin-2-yl)-[(3R)-piperidin-3-yl]carbamoyl]phenyl]pyrazol-3-yl]tetrazol-2-yl]propyl] 2-methylpropanoate | IC50 | 19200.0 [1], 19800.0 [2] |
![](https://images.aatbio.com/dataset/ic50/subtilisin-kexin-type-9_c487550e2025d656cbc7df72e1128c5f.svg) | Phenylboronic acid | Ki | 470000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/subtilisin-kexin-type-9_96591305d1fa22d520ed4a36123a5ef9.svg) | Diphenylborinic acid | Ki | 30000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/subtilisin-kexin-type-9_a6a9719dcfbb0b4f2999127dc28241d5.svg) | 1-Methyl-2-[3-methyl-2-(3-methylimidazol-4-yl)imidazol-4-yl]-5-(1-methyl-5-phenylimidazol-2-yl)imidazole | IC50 | 11200.0 [1] |
![](https://images.aatbio.com/dataset/ic50/subtilisin-kexin-type-9_dc7d342fa955bda24b69e654cb34de2e.svg) | (4S)-5-[[(2S)-1-[[(2S)-1-[(2S)-2-[[2-[[(2S)-1-[[(2S)-4-Amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-carbamimidamido-1-[[(2S,3S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(1S)-4-carbamimidamido-1-carboxybutyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-2-oxoethyl]carbamoyl]pyrrolidin-1-yl]-1-oxo-3-phenylpropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-4-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-5-oxopentanoic acid | IC50 | 8300.0 [1] |
![](https://images.aatbio.com/dataset/ic50/subtilisin-kexin-type-9_01f3e1abed96069d5eabd0edcab80c18.svg) | (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-Amino-2-[[(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-amino-4-methylpentanoyl]amino]-3-methylpentanoyl]amino]-4-methylpentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]propanoyl]amino]butanedioic acid | IC50 | 1600.0 [1] |
![](https://images.aatbio.com/dataset/ic50/subtilisin-kexin-type-9_cf8d1503604b27eabdb3b0f8bdb338d6.svg) | (S)-2-Acetylamino-3-[4-(oxiran-2-ylmethoxy)phenyl]propionic acid ethyl ester | Ki | 200000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/subtilisin-kexin-type-9_b083ca7f904ec5a3dd7f27a4cc3b8a43.svg) | N-(3-Chloropyridin-2-yl)-4-(6-methyltriazolo[4,5-b]pyridin-3-yl)-N-[(3R)-piperidin-3-yl]benzamide | IC50 | 800.0 [1] |
![](https://images.aatbio.com/dataset/ic50/subtilisin-kexin-type-9_3fcab3a79ce5c31081a91449766c4405.svg) | N-(3-Chloropyridin-2-yl)-N-[(3R)-piperidin-3-yl]-5-(triazolo[4,5-b]pyridin-3-yl)pyridine-2-carboxamide | IC50 | 1500.0 [1] |
![](https://images.aatbio.com/dataset/ic50/subtilisin-kexin-type-9_c297c013b0d9f4a7d04940ad5c571a66.svg) | N-(3-Chloropyridin-2-yl)-5-(6-methyltriazolo[4,5-b]pyridin-3-yl)-N-[(3R)-piperidin-3-yl]pyridine-2-carboxamide | IC50 | 1800.0 [1] |
![](https://images.aatbio.com/dataset/ic50/subtilisin-kexin-type-9_150ad1259549b74a9e54d71f4bfb2c62.svg) | Phenyl butyl borinic acid | Ki | 1000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/subtilisin-kexin-type-9_8a3c6af6247e2abb92473b4ba3467bb3.svg) | 1-Ethoxycarbonyloxyethyl 2-methyl-4-[4-[(1-methylpyrrolo[2,3-c]pyridin-7-yl)-[(3R)-piperidin-3-yl]carbamoyl]phenyl]pyrazole-3-carboxylate | IC50 | 4500.0 [1] |
![](https://images.aatbio.com/dataset/ic50/subtilisin-kexin-type-9_bacda4396c6f7eec9b4b2291c8fb1d8b.svg) | Ethyl 1-[[2-methyl-4-[4-[(3-methylpyridin-2-yl)-[(3R)-piperidin-3-yl]carbamoyl]phenyl]pyrazole-3-carbonyl]-methylsulfonylamino]ethyl carbonate | IC50 | 20000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/subtilisin-kexin-type-9_d6d9cf1d9255eccc9d15490cf316cf57.svg) | Ethyl [(1S)-1-[5-[2-methyl-4-[4-[(3-methylpyridin-2-yl)-[(3R)-piperidin-3-yl]carbamoyl]phenyl]pyrazol-3-yl]tetrazol-2-yl]ethyl] carbonate | IC50 | 16700.0 [1] |
![](https://images.aatbio.com/dataset/ic50/subtilisin-kexin-type-9_20475ebea1ae7bbb6075e234fccd4336.svg) | Ethyl 1-[5-[2-methyl-4-[4-[(3-methylpyridin-2-yl)-[(3R)-piperidin-3-yl]carbamoyl]phenyl]pyrazol-3-yl]tetrazol-1-yl]ethyl carbonate | IC50 | 20000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/subtilisin-kexin-type-9_a934f810df0d71e2ddcfbbdf892394e0.svg) | Ethyl [(1R)-1-[5-[2-methyl-4-[4-[(3-methylpyridin-2-yl)-[(3R)-piperidin-3-yl]carbamoyl]phenyl]pyrazol-3-yl]tetrazol-2-yl]ethyl] carbonate | IC50 | 20000.0 [1] |