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Steroid 5-alpha-reductase 2 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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FinasterideIC505.0 [1]
FinasterideKi2.0 [1]
EpristerideIC500.6 [1]
EpristerideKi0.2 [1], 30.0 [2]
(1S,3As,12aS)-N-tert-butyl-12a-methyl-7-oxo-1,2,3,3a,3b,4,5,8,9,12-decahydroindeno[4,5-c]quinolizine-1-carboxamide;(1S,3aR,12aS)-N-tert-butyl-12a-methyl-7-oxo-1,2,3,3a,4,5,8,9,11,12-decahydroindeno[4,5-c]quinolizine-1-carboxamideIC503.1 [1], 3.4 [2], 4.3 [3], 37.0 [4], 122.0 [5]
17-N,N-Diethylcarbamoyl-4-methyl-4-azaandrostane-3-oneIC500.23 [1], 1.9 [2], 7.48 [3], 8.6 [4]
17-N,N-Diethylcarbamoyl-4-methyl-4-azaandrostane-3-oneKi2.0 [1]
BexlosterideIC501750.0 [1], 10000.0 [2]
BexlosterideKi1200.0 [1]
(1R,4S,9Ar,11aR)-4,6,9a,11a-tetramethyl-1-(6-methylheptan-2-yl)-2,3,3a,3b,4,5,5a,8,9,9b,10,11-dodecahydro-1H-indeno[5,4-f]quinolin-7-oneIC50154.0 [1]
Methyl (1S,9aR,11aS)-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,8,9,9b,10,11-dodecahydrocyclopenta[i]phenanthridine-1-carboxylateIC503.2 [1]
(1S,9Ar,11aS)-N-benzhydryl-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,8,9,9b,10,11-dodecahydrocyclopenta[i]phenanthridine-1-carboxamideIC500.09 [1], 0.1 [2]
(1S,9Ar,11aS)-N-[bis(4-chlorophenyl)methyl]-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,8,9,9b,10,11-dodecahydrocyclopenta[i]phenanthridine-1-carboxamideIC500.12 [1]
(1S,9Ar,11aS)-9a,11a-dimethyl-1-(morpholine-4-carbonyl)-1,2,3,3a,3b,4,5,8,9,9b,10,11-dodecahydrocyclopenta[i]phenanthridin-7-oneIC507.1 [1]
2-Adamantyl (1S,3aS,3bS,9aR,9bS,11aS)-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,8,9,9b,10,11-dodecahydrocyclopenta[i]phenanthridine-1-carboxylateIC500.04 [1], 0.1 [2]
(1S,9Ar,11aS)-9a,11a-dimethyl-1-(3-methylbutanoyl)-1,2,3,3a,3b,4,5,8,9,9b,10,11-dodecahydrocyclopenta[i]phenanthridin-7-oneIC500.08 [1], 0.1 [2]
(1S,9Ar,11aS)-9a,11a-dimethyl-1-(3-methylbutanoyl)-1,2,3,3a,3b,4,5,8,9,9b,10,11-dodecahydrocyclopenta[i]phenanthridin-7-oneKi0.08 [1]
(1S,9Ar,11aS)-N-tert-butyl-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,8,9,9b,10,11-dodecahydrocyclopenta[i]phenanthridine-1-carboxamideIC500.88 [1]
(1S,9Ar,11aS)-N-tert-butyl-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,8,9,9b,10,11-dodecahydrocyclopenta[i]phenanthridine-1-carboxamideKi0.89 [1]
(4As)-7-chloro-4a-methyl-4,9-dihydro-3H-phenanthrene-2-carboxylic acidKi260.0 [1]
4-[3-[3-[Bis[4-(2-methylpropyl)phenyl]methylamino]benzoyl]indol-1-yl]butanoic acidIC5011.0 [1], 36.0 [2]
5-(Benzyloxy)-1H-indole-2-carboxylic acidKi40.0 [1]
4-(4-Phenoxybenzoyl)benzoic AcidIC5053.0 [1]
4-(4-Phenoxybenzoyl)benzoic AcidKi5.0 [1]
17-(N,N-Diisopropylcarboxamide)estra-1,3,5(10)-triene-3-carboxylic acidIC502.1 [1]
17-(N,N-Diisopropylcarboxamide)estra-1,3,5(10)-triene-3-carboxylic acidKi20.0 [1]
7-Bromo-9,10-dihydrophenanthrene-2-carboxylic AcidIC5010000.0 [1]
7-Bromo-9,10-dihydrophenanthrene-2-carboxylic AcidKi10000.0 [1]
4-[4-(4-Methyl-benzoyl)-benzoyl]-benzoic acidKi10.0 [1]
(10R,13S,17S)-N-Tert-butyl-4-chloro-10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthrene-17-carboxamideIC50192.0 [1]
(1S,9Ar,11aS)-6-chloro-N-(4-chlorophenyl)-N-cyclopentyl-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,8,9,9b,10,11-dodecahydrocyclopenta[i]phenanthridine-1-carboxamideIC500.1 [1]
(1S,9Ar,11aS)-N-(4-chlorophenyl)-N-cyclopentyl-6,9a,11a-trimethyl-7-oxo-1,2,3,3a,3b,4,5,8,9,9b,10,11-dodecahydrocyclopenta[i]phenanthridine-1-carboxamideIC500.1 [1]
(10R,13S,17S)-17-[Di(propan-2-yl)carbamoyl]-10,13-dimethyl-2,7,8,9,11,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthrene-3-carboxylic acidKi7.0 [1]
(10R,13S,17S)-4-Bromo-N-tert-butyl-10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthrene-17-carboxamideIC50387.0 [1]
(10R,13S,17S)-N-Tert-butyl-10,13-dimethyl-3-oxo-4-sulfanyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthrene-17-carboxamideIC50437.0 [1]
(1S,9Ar,11aS)-9a,11a-dimethyl-7-oxo-N-phenyl-1,2,3,3a,3b,4,5,8,9,9b,10,11-dodecahydrocyclopenta[i]phenanthridine-1-carboxamideIC501.4 [1]
(1S,9Ar,11aS)-N-(3,5-ditert-butylphenyl)-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,8,9,9b,10,11-dodecahydrocyclopenta[i]phenanthridine-1-carboxamideIC500.1 [1]
CID 44275674IC500.1 [1]
(4Ar,10bR)-4,10b-dimethyl-8-[(E)-2-phenylethenyl]-2,4a,5,6-tetrahydro-1H-benzo[f]quinolin-3-oneIC50180.0 [1]
(1S,9Ar,11aS)-9a,11a-dimethyl-7-oxo-N',N'-diphenyl-1,2,3,3a,3b,4,5,8,9,9b,10,11-dodecahydrocyclopenta[i]phenanthridine-1-carbohydrazideIC500.23 [1]
(1S,9Ar,11aS)-9a,11a-dimethyl-7-oxo-N-trityl-1,2,3,3a,3b,4,5,8,9,9b,10,11-dodecahydrocyclopenta[i]phenanthridine-1-carboxamideIC500.09 [1], 0.1 [2]
(1S,9Ar,11aS)-N,N-diethyl-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,8,9,9b,10,11-dodecahydrocyclopenta[i]phenanthridine-1-carboxamideIC501.5 [1]
(1S,9Ar,11aS)-N-(dicyclohexylmethyl)-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,8,9,9b,10,11-dodecahydrocyclopenta[i]phenanthridine-1-carboxamideIC500.4 [1]
(1S,9Ar,11aS)-9a,11a-dimethyl-1-(piperazine-1-carbonyl)-1,2,3,3a,3b,4,5,8,9,9b,10,11-dodecahydrocyclopenta[i]phenanthridin-7-oneIC5033.0 [1]
(1S,9Ar,11aS)-9a,11a-dimethyl-1-(thiomorpholine-4-carbonyl)-1,2,3,3a,3b,4,5,8,9,9b,10,11-dodecahydrocyclopenta[i]phenanthridin-7-oneIC501.3 [1]
(1S,9Ar,11aS)-N-methoxy-N,9a,11a-trimethyl-7-oxo-1,2,3,3a,3b,4,5,8,9,9b,10,11-dodecahydrocyclopenta[i]phenanthridine-1-carboxamideIC502.4 [1]
(1S,9Ar,11aS)-N-[bis(4-fluorophenyl)methyl]-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,8,9,9b,10,11-dodecahydrocyclopenta[i]phenanthridine-1-carboxamideIC500.16 [1]
(1S,9Ar,11aS)-N-(1-adamantyl)-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,8,9,9b,10,11-dodecahydrocyclopenta[i]phenanthridine-1-carboxamideIC500.07 [1], 0.1 [2]
(9Ar,11aS)-N-benzhydryl-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,8,9,9b,10,11-dodecahydrocyclopenta[i]phenanthridine-1-carboxamideIC500.1 [1]
(10Br)-8-chloro-4,10b-dimethyl-1,2,5,6-tetrahydrophenanthridin-3-oneKi20000.0 [1]
(3As,3bS,10aS,12aS)-12a-methyl-3,3a,3b,4,5,8,9,10a,11,12-decahydro-2H-indeno[5,4-f]quinolizine-1,7-dioneIC503.5 [1], 4400.0 [2]
(1S,3As,3bS,10aS,12aS)-1-hydroxy-12a-methyl-1,2,3,3a,3b,4,5,8,9,10a,11,12-dodecahydroindeno[5,4-f]quinolizin-7-oneIC502.7 [1], 4200.0 [2]
(3As,3bS,10aS,12aS)-12a-methyl-3,3a,3b,4,5,5a,6,10a,11,12-decahydro-2H-indeno[5,4-f]quinolizine-1,7-dioneIC502.4 [1], 46000.0 [2]
(1S,3As,3bS,10aS,12aS)-N-tert-butyl-12a-methyl-7-oxo-1,2,3,3a,3b,4,5,8,9,10a,11,12-dodecahydroindeno[4,5-c]quinolizine-1-carboxamideIC505.5 [1], 460.0 [2]
(3As,3bS,5aS,10aS,12aS)-12a-methyl-3,3a,3b,4,5,5a,6,8,9,10a,11,12-dodecahydro-2H-indeno[5,4-f]quinolizine-1,7-dioneIC502.9 [1], 100000.0 [2]
17-[(2E)-2-Hydroxyiminoethyl]-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-oneIC50300.0 [1], 890.0 [2]
(5S,10R,13S,17S)-17-[Di(propan-2-yl)carbamoyl]-10,13-dimethyl-2,5,6,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3-carboxylic acidKi30.0 [1]
17-[(2E)-2-Hydroxyiminopropyl]-10,13-dimethyl-2,7,8,9,11,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthrene-3,6-dioneIC50430.0 [1], 860.0 [2]
(3As,11aS)-11a-methyl-2,3,3a,3b,4,5,6,7,8,11-decahydroindeno[5,4-f]quinoline-1,9-dione;(3aS,11aS)-11a-methyl-2,3,3a,4,5,6,7,8,10,11-decahydroindeno[5,4-f]quinoline-1,9-dioneIC503.8 [1], 100000.0 [2]
(3Z,6As,9aS)-6a-methyl-3-(2-oxobut-3-enylidene)-1,2,4,6,8,9,9a,9b-octahydrocyclopenta[f]quinolin-7-one;(3Z,6aS,9aS)-6a-methyl-3-(2-oxobut-3-enylidene)-1,2,4,5,6,8,9,9a-octahydrocyclopenta[f]quinolin-7-oneIC506.1 [1], 100000.0 [2]
(5S,10R,13S,17S)-10,13-Dimethyl-3-nitro-N,N-di(propan-2-yl)-2,5,6,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-17-carboxamideKi30.0 [1], 50.0 [2]
(12As)-12a-methyl-3,3a,4,5,8,9,11,12-octahydro-2H-indeno[5,4-f]quinolizine-1,7-dioneIC503.4 [1], 4600.0 [2]
(1S,12As)-1-hydroxy-12a-methyl-1,2,3,3a,4,5,8,9,11,12-decahydroindeno[5,4-f]quinolizin-7-oneIC503.0 [1], 2900.0 [2]
gamma-Linolenic acidIC5014000.0 [1]
Indole-2-carboxylic acidKi230.0 [1]
TurosterideIC5055.0 [1]
4-[2-[[2,3-Dimethyl-4-[(1S)-1-[4-(2-methylpropyl)phenyl]ethoxy]benzoyl]amino]phenoxy]butanoic acidIC50256.0 [1]
CID 10474701IC5050.0 [1]
4-Methyl-8-chloro-1,2,5,6-tetrahydrobenzo[f]quinolin-3(4H)-oneKi455.0 [1]
(5R,8S,9S,10R,13S,14S,17S)-17-[Di(propan-2-yl)carbamoyl]-4-fluoro-10,13-dimethyl-2,5,6,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3-carboxylic acidKi26.0 [1]
(5S,8S,9S,10R,13S,14S,17S)-17-(Tert-butylcarbamoyl)-5,10,13-trimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthrene-3-carboxylic acidKi110.0 [1]
(4Ar,10bR)-8-chloro-4,10b-dimethyl-2,4a,5,6-tetrahydro-1H-benzo[f]quinolin-3-oneKi1000.0 [1]
Ethyl 4-methyl-3-oxo-1,2,5,6-tetrahydrobenzo[c]quinolizine-8-carboxylateIC504800.0 [1]
Phenyl 4-methyl-3-oxo-1,2,5,6-tetrahydrobenzo[c]quinolizine-8-carboxylateIC50295.0 [1]
Methyl 4-methyl-3-oxo-1,2,5,6-tetrahydrobenzo[c]quinolizine-8-carboxylateIC502100.0 [1]
(4-Methylphenyl) 4-methyl-3-oxo-1,2,5,6-tetrahydrobenzo[c]quinolizine-8-carboxylateIC50553.0 [1]
(3-Methoxycarbonylphenyl) 4-methyl-3-oxo-1,2,5,6-tetrahydrobenzo[c]quinolizine-8-carboxylateIC50467.0 [1]
Propan-2-yl 4-methyl-3-oxo-1,2,5,6-tetrahydrobenzo[c]quinolizine-8-carboxylateIC5050.0 [1]
(4-Methoxycarbonylphenyl) 4-methyl-3-oxo-1,2,5,6-tetrahydrobenzo[c]quinolizine-8-carboxylateIC50584.0 [1]
Benzyl 4-methyl-3-oxo-1,2,5,6-tetrahydrobenzo[c]quinolizine-8-carboxylateIC509500.0 [1]
(10R,13S)-17-(Benzimidazol-1-yl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15-decahydrocyclopenta[a]phenanthren-3-oneIC50480.0 [1]
17-(N-t-Butylcarboxamide)estra-1,3,5(10)-triene-3-carboxylic acidKi0.4 [1]
1,4-Bis(4-carboxybenzoyl)benzeneKi1000.0 [1]
6-(Benzyloxy)-5-methoxy-1H-indole-2-carboxylic acidKi30.0 [1]
4-(Benzyloxy)-1H-indole-2-carboxylic acidKi10.0 [1]
(10Br)-8-chloro-4,10b-dimethyl-2,4a,5,6-tetrahydro-1H-benzo[f]quinolin-3-oneKi1000.0 [1]
(10R,13S,17S)-17-[Di(propan-2-yl)carbamoyl]-10,13-dimethyl-8,9,11,12,14,15,16,17-octahydro-1H-cyclopenta[a]phenanthrene-3-carboxylic acidKi7.0 [1]
(10R,13S,17S)-17-[Di(propan-2-yl)carbamoyl]-4,10,13-trimethyl-2,7,8,9,11,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthrene-3-carboxylic acidKi35.0 [1]
(4As,4bR,10aR,10bS,12aS)-10a,12a-dimethyl-2-oxo-3,4,4a,4b,5,9,10,10b,11,12-decahydro-1H-naphtho[2,1-f]quinoline-8-carboxylic acidIC5071.0 [1]
(8R,9S,10R,13S,14S)-13-Methyl-17-oxo-2,7,8,9,10,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3-carboxylic acidIC50212.9 [1]
(1S,3As,3bR,9aR,9bS,11aS)-1-hydroxy-6,9a,11a-trimethyl-2,3,3a,3b,4,5,5a,8,9,9b,10,11-dodecahydro-1H-indeno[5,4-f]quinolin-7-oneIC50430.0 [1]
2-[4-[[1-(2,2-Dicyclohexylacetyl)piperidin-4-ylidene]methyl]-3-fluorophenyl]acetic acidIC507.0 [1]
4-[2-[5-(Benzhydrylcarbamoyl)benzofuran-2-yl]phenoxy]butanoic AcidIC50100000.0 [1]
1-Methyl-5-(4-phenylazo-phenyl)-piperidin-2-oneIC50579.0 [1]
4-[(4-Phenoxyphenyl)methyl]benzoic acidKi35.0 [1]
(4Ar,10bR)-4,10b-dimethyl-8-[(E)-2-quinolin-3-ylethenyl]-2,4a,5,6-tetrahydro-1H-benzo[f]quinolin-3-oneIC50320.0 [1]
4-(4-Benzoylbenzoyl)benzoic acidKi40.0 [1]
(9Ar,11aS)-9a,11a-dimethyl-N-naphthalen-1-yl-7-oxo-1,2,3,3a,3b,4,5,5a,6,9b,10,11-dodecahydroindeno[5,4-f]quinoline-1-carboxamideIC500.2 [1]
(1S,9Ar,11aS)-N-[1-(4-chlorophenyl)cyclopentyl]-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,8,9,9b,10,11-dodecahydrocyclopenta[i]phenanthridine-1-carboxamideIC500.1 [1]
5-Methoxy-1-methyl-6-phenylmethoxyindole-2-carboxylic acidKi10.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Steroid 5-alpha-reductase 2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/steroid-5-alpha-reductase-2-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ Steroid 5-alpha-reductase 2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/steroid-5-alpha-reductase-2-inhibitors-ic50-ki.
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