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Steroid 5-alpha-reductase 1 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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FinasterideIC50150.0 [1]
FinasterideKi100.0 [1], 150.0 [2], 366.0 [3]
EpristerideIC501000.0 [1], 1100.0 [2], 1600.0 [3], 7500.0 [4]
EpristerideKi410.0 [1], 1600.0 [2], 5000.0 [3]
BexlosterideIC502.3 [1], 8.0 [2], 8.6 [3]
BexlosterideKi4.0 [1]
1,2,5,6-Tetrahydro pyrido[1,2-a]quinolin-3-oneIC50295.12 [1], 298.0 [2]
4-Methyl-8-chloro-1,2,5,6-tetrahydrobenzo[f]quinolin-3(4H)-oneIC5030.0 [1], 173.78 [2]
4-Methyl-8-chloro-1,2,5,6-tetrahydrobenzo[f]quinolin-3(4H)-oneKi17.0 [1]
3H-Benzo(C)quinolizin-3-one, 1,2,5,6-tetrahydro-4,8-dimethyl-IC5019.95 [1], 20.0 [2], 41.0 [3]
3H-Benzo(C)quinolizin-3-one, 1,2,5,6-tetrahydro-4,8-dimethyl-Ki5.8 [1]
4-Methyl-8-chloro-1,2,5,6-tetrahydro pyrido[1,2-a]quinolin-3-oneIC505.62 [1], 5.8 [2], 7.6 [3], 41.0 [4]
4-Methyl-8-chloro-1,2,5,6-tetrahydro pyrido[1,2-a]quinolin-3-oneKi2.7 [1]
17-N,N-Diethylcarbamoyl-4-methyl-4-azaandrostane-3-oneIC501.7 [1], 4.14 [2]
17-N,N-Diethylcarbamoyl-4-methyl-4-azaandrostane-3-oneKi3.0 [1], 5.0 [2]
(1R,4S,9Ar,11aR)-4,6,9a,11a-tetramethyl-1-(6-methylheptan-2-yl)-2,3,3a,3b,4,5,5a,8,9,9b,10,11-dodecahydro-1H-indeno[5,4-f]quinolin-7-oneIC500.5 [1], 0.9 [2]
8-Chloro-1,2,5,6-tetrahydro-3H-benzo[c]quinolizine-3-oneIC5048.98 [1], 49.0 [2]
(4Ar,10bR)-8-chloro-4,10b-dimethyl-2,4a,5,6-tetrahydro-1H-benzo[f]quinolin-3-oneIC5017.0 [1]
(4Ar,10bR)-8-chloro-4,10b-dimethyl-2,4a,5,6-tetrahydro-1H-benzo[f]quinolin-3-oneKi9.0 [1]
Methyl (1S,9aR,11aS)-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,8,9,9b,10,11-dodecahydrocyclopenta[i]phenanthridine-1-carboxylateKi150.0 [1]
3,4,5,6-Tetrahydrobenzo[c]quinolizin-3-(4aH)-oneIC505130.0 [1]
(1S,9Ar,11aS)-N-benzhydryl-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,8,9,9b,10,11-dodecahydrocyclopenta[i]phenanthridine-1-carboxamideKi30.0 [1]
(1S,9Ar,11aS)-N-[bis(4-chlorophenyl)methyl]-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,8,9,9b,10,11-dodecahydrocyclopenta[i]phenanthridine-1-carboxamideKi20.0 [1]
(1S,9Ar,11aS)-9a,11a-dimethyl-1-(morpholine-4-carbonyl)-1,2,3,3a,3b,4,5,8,9,9b,10,11-dodecahydrocyclopenta[i]phenanthridin-7-oneKi2200.0 [1]
7-Bromo-9,10-dihydrophenanthrene-2-carboxylic AcidIC5026.0 [1]
7-Bromo-9,10-dihydrophenanthrene-2-carboxylic AcidKi26.0 [1]
8-Methyl-1,2,5,6-tetrahydro-3H-benzo[c]quinolizine-3-oneIC50376.0 [1], 380.19 [2]
4-Methyl-1,2,5,6-tetrahydro pyrido[1,2-a]quinolin-3-oneIC50185.0 [1], 186.21 [2]
Ethyl 4-methyl-3-oxo-1,2,5,6-tetrahydrobenzo[c]quinolizine-8-carboxylateIC50218.78 [1], 221.0 [2]
Phenyl 4-methyl-3-oxo-1,2,5,6-tetrahydrobenzo[c]quinolizine-8-carboxylateIC50933.25 [1], 942.0 [2]
Methyl 4-methyl-3-oxo-1,2,5,6-tetrahydrobenzo[c]quinolizine-8-carboxylateIC50117.0 [1], 117.49 [2]
Tert-butyl 4-methyl-3-oxo-1,2,5,6-tetrahydrobenzo[c]quinolizine-8-carboxylateIC501000.0 [1]
(4-Methylphenyl) 4-methyl-3-oxo-1,2,5,6-tetrahydrobenzo[c]quinolizine-8-carboxylateIC50102.0 [1], 1047.13 [2], 1050.0 [3]
(3-Methoxycarbonylphenyl) 4-methyl-3-oxo-1,2,5,6-tetrahydrobenzo[c]quinolizine-8-carboxylateIC50954.99 [1], 965.0 [2]
(4-Tert-butylphenyl) 4-methyl-3-oxo-1,2,5,6-tetrahydrobenzo[c]quinolizine-8-carboxylateIC50560.0 [1], 562.34 [2]
Propan-2-yl 4-methyl-3-oxo-1,2,5,6-tetrahydrobenzo[c]quinolizine-8-carboxylateIC50724.44 [1], 731.0 [2]
(4-Methoxycarbonylphenyl) 4-methyl-3-oxo-1,2,5,6-tetrahydrobenzo[c]quinolizine-8-carboxylateIC50120.23 [1], 121.0 [2], 129.0 [3]
Benzyl 4-methyl-3-oxo-1,2,5,6-tetrahydrobenzo[c]quinolizine-8-carboxylateIC5096.8 [1], 97.0 [2], 97.72 [3]
(1S,9Ar,11aS)-9a,11a-dimethyl-1-(3-methylbutanoyl)-1,2,3,3a,3b,4,5,8,9,9b,10,11-dodecahydrocyclopenta[i]phenanthridin-7-oneKi9.0 [1]
(1S,9Ar,11aS)-N-tert-butyl-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,8,9,9b,10,11-dodecahydrocyclopenta[i]phenanthridine-1-carboxamideKi820.0 [1]
4-[3-[3-[Bis[4-(2-methylpropyl)phenyl]methylamino]benzoyl]indol-1-yl]butanoic acidIC503.0 [1], 38.0 [2]
5-(Benzyloxy)-1H-indole-2-carboxylic acidKi2500.0 [1]
4-Methyl-1,4,4a,5,6,10b-hexahydro-2H-benzo[f]quinolin-3-oneIC50560.0 [1]
2-Adamantyl (1S,3aS,3bS,9aR,9bS,11aS)-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,8,9,9b,10,11-dodecahydrocyclopenta[i]phenanthridine-1-carboxylateKi6.9 [1]
(10R,13S,17S)-N-Tert-butyl-4-chloro-10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthrene-17-carboxamideIC501000.0 [1]
8-Chloro-1,2,5,6-tetrahydrobenzo[f]quinolin-3(4H)-oneIC50460.0 [1]
1,4,5,6-Tetrahydro-2H-benzo[f]quinolin-3-oneIC506500.0 [1]
(1S,9Ar,11aS)-6-chloro-N-(4-chlorophenyl)-N-cyclopentyl-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,8,9,9b,10,11-dodecahydrocyclopenta[i]phenanthridine-1-carboxamideKi0.6 [1]
(1S,9Ar,11aS)-N-(4-chlorophenyl)-N-cyclopentyl-6,9a,11a-trimethyl-7-oxo-1,2,3,3a,3b,4,5,8,9,9b,10,11-dodecahydrocyclopenta[i]phenanthridine-1-carboxamideKi0.3 [1]
(10Br)-8-chloro-4,10b-dimethyl-2,4a,5,6-tetrahydro-1H-benzo[f]quinolin-3-oneIC5017.0 [1]
(10Br)-8-chloro-4,10b-dimethyl-2,4a,5,6-tetrahydro-1H-benzo[f]quinolin-3-oneKi9.0 [1]
(10R,13S,17S)-4-Bromo-N-tert-butyl-10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthrene-17-carboxamideIC50981.0 [1]
(10R,13S,17S)-N-Tert-butyl-10,13-dimethyl-3-oxo-4-sulfanyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthrene-17-carboxamideIC50709.0 [1]
(1S,9Ar,11aS)-9a,11a-dimethyl-7-oxo-N-phenyl-1,2,3,3a,3b,4,5,8,9,9b,10,11-dodecahydrocyclopenta[i]phenanthridine-1-carboxamideKi240.0 [1]
(1S,9Ar,11aS)-N-(3,5-ditert-butylphenyl)-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,8,9,9b,10,11-dodecahydrocyclopenta[i]phenanthridine-1-carboxamideKi8.0 [1]
CID 44275674Ki8.8 [1]
(4Ar,10bR)-4,10b-dimethyl-8-[(E)-2-phenylethenyl]-2,4a,5,6-tetrahydro-1H-benzo[f]quinolin-3-oneIC5023.0 [1]
(1S,9Ar,11aS)-9a,11a-dimethyl-7-oxo-N',N'-diphenyl-1,2,3,3a,3b,4,5,8,9,9b,10,11-dodecahydrocyclopenta[i]phenanthridine-1-carbohydrazideKi14.0 [1]
(1S,9Ar,11aS)-9a,11a-dimethyl-7-oxo-N-trityl-1,2,3,3a,3b,4,5,8,9,9b,10,11-dodecahydrocyclopenta[i]phenanthridine-1-carboxamideKi8.2 [1]
(1S,9Ar,11aS)-N,N-diethyl-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,8,9,9b,10,11-dodecahydrocyclopenta[i]phenanthridine-1-carboxamideKi750.0 [1]
(1S,9Ar,11aS)-N-(dicyclohexylmethyl)-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,8,9,9b,10,11-dodecahydrocyclopenta[i]phenanthridine-1-carboxamideKi20.0 [1]
(1S,9Ar,11aS)-9a,11a-dimethyl-1-(piperazine-1-carbonyl)-1,2,3,3a,3b,4,5,8,9,9b,10,11-dodecahydrocyclopenta[i]phenanthridin-7-oneKi8600.0 [1]
(1S,9Ar,11aS)-9a,11a-dimethyl-1-(thiomorpholine-4-carbonyl)-1,2,3,3a,3b,4,5,8,9,9b,10,11-dodecahydrocyclopenta[i]phenanthridin-7-oneKi570.0 [1]
(1S,9Ar,11aS)-N-methoxy-N,9a,11a-trimethyl-7-oxo-1,2,3,3a,3b,4,5,8,9,9b,10,11-dodecahydrocyclopenta[i]phenanthridine-1-carboxamideKi2300.0 [1]
(1S,9Ar,11aS)-N-[bis(4-fluorophenyl)methyl]-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,8,9,9b,10,11-dodecahydrocyclopenta[i]phenanthridine-1-carboxamideKi20.0 [1]
(1S,9Ar,11aS)-N-(1-adamantyl)-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,8,9,9b,10,11-dodecahydrocyclopenta[i]phenanthridine-1-carboxamideKi11.0 [1]
(9Ar,11aS)-N-benzhydryl-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,8,9,9b,10,11-dodecahydrocyclopenta[i]phenanthridine-1-carboxamideIC50186.0 [1]
(4As)-7-chloro-4a-methyl-4,9-dihydro-3H-phenanthrene-2-carboxylic acidKi1200.0 [1]
(10Br)-8-chloro-4,10b-dimethyl-1,2,5,6-tetrahydrophenanthridin-3-oneKi920.0 [1]
8-Chloro-4-methyl-1,4,4a,5,6,10b-hexahydro-2H-benzo[f]quinolin-3-oneIC5041.0 [1]
8-Chloro-4-methyl-1,4,4a,5,6,10b-hexahydro-2H-benzo[f]quinolin-3-oneKi15.0 [1]
8-Bromo-4-methyl-1,2,5,6-tetrahydrobenzo[f]quinolizin-3-oneIC508.1 [1], 8.13 [2]
8-Methoxy-4-methyl-1,2,5,6-tetrahydro-pyrido[1,2-a]quinolin-3-oneIC50178.0 [1], 181.97 [2]
4-Methyl-8-vinyl-1,2,5,6-tetrahydro-pyrido[1,2-a]quinolin-3-oneIC5021.38 [1], 21.6 [2]
4-Methyl-8-thiophen-2-yl-1,2,5,6-tetrahydrobenzo[f]quinolizin-3-oneIC5079.0 [1], 79.43 [2]
4-Methyl-8-[(Z)-2-phenylethenyl]-1,2,5,6-tetrahydrobenzo[f]quinolizin-3-oneIC5014.13 [1], 14.2 [2]
4-Methyl-8-phenyl-1,2,5,6-tetrahydrobenzo[f]quinolizin-3-oneIC50128.0 [1], 128.82 [2]
4-Methyl-8-(2-phenylethynyl)-1,2,5,6-tetrahydrobenzo[f]quinolizin-3-oneIC508.71 [1], 8.75 [2]
8-[(2-Chlorophenyl)methoxy]-4-methyl-1,2,5,6-tetrahydrobenzo[f]quinolizin-3-oneIC50194.0 [1], 194.98 [2]
4-Methyl-8-phenylmethoxy-1,2,5,6-tetrahydrobenzo[f]quinolizin-3-oneIC50111.0 [1], 112.2 [2]
8-[[2,5-Bis(trifluoromethyl)phenyl]methoxy]-4-methyl-1,2,5,6-tetrahydrobenzo[f]quinolizin-3-oneIC50389.05 [1], 393.0 [2]
8-[(4-Chlorophenyl)methoxy]-4-methyl-1,2,5,6-tetrahydrobenzo[f]quinolizin-3-oneIC5092.9 [1], 93.33 [2]
8-[(3-Chlorophenyl)methoxy]-4-methyl-1,2,5,6-tetrahydrobenzo[f]quinolizin-3-oneIC5093.0 [1], 93.33 [2]
4-Methyl-8-[[4-(trifluoromethyl)phenyl]methoxy]-1,2,5,6-tetrahydrobenzo[f]quinolizin-3-oneIC5083.18 [1], 83.7 [2]
8-[[2,4-Bis(trifluoromethyl)phenyl]methoxy]-4-methyl-1,2,5,6-tetrahydrobenzo[f]quinolizin-3-oneIC50147.91 [1], 149.0 [2]
4-Methyl-8-[(E)-2-phenylethenyl]-1,2,5,6-tetrahydrobenzo[f]quinolizin-3-oneIC50380.0 [1], 380.19 [2]
8-(Furan-2-yl)-4-methyl-1,2,5,6-tetrahydrobenzo[f]quinolizin-3-oneIC50131.83 [1], 133.0 [2]
4-Methyl-8-pyridin-3-yl-1,2,5,6-tetrahydrobenzo[f]quinolizin-3-oneIC50169.82 [1], 170.0 [2]
8-Ethyl-4-methyl-1,2,5,6-tetrahydro-pyrido[1,2-a]quinolin-3-oneIC5014.0 [1], 14.13 [2]
(R)-8-Chloro-4,10b-dimethyl-1,4,6,10b-tetrahydro-2H-benzo[f]quinolin-3-oneIC50120.0 [1]
(R)-8-Chloro-4,10b-dimethyl-1,4,6,10b-tetrahydro-2H-benzo[f]quinolin-3-oneKi180.0 [1]
17-[(2E)-2-Hydroxyiminoethyl]-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-oneIC501950.0 [1], 2440.0 [2]
(17S)-17-[(Z)-N-Hydroxy-C-methylcarbonimidoyl]-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-oneIC501630.0 [1], 1770.0 [2]
17-[(2E)-2-Hydroxyiminopropyl]-10,13-dimethyl-2,7,8,9,11,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthrene-3,6-dioneIC50900.0 [1], 2900.0 [2]
8-Chloro-4,10b-dimethyl-2,4a,5,6-tetrahydro-1H-benzo[f]quinolin-3-oneIC5032.36 [1]
8-Chloro-4,10b-dimethyl-2,4a,5,6-tetrahydro-1H-benzo[f]quinolin-3-oneKi20.0 [1]
(10R,13S)-17-(Benzimidazol-1-yl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15-decahydrocyclopenta[a]phenanthren-3-oneIC50770.0 [1]
17-(N-t-Butylcarboxamide)estra-1,3,5(10)-triene-3-carboxylic acidKi1600.0 [1]
6-(Benzyloxy)-5-methoxy-1H-indole-2-carboxylic acidKi460.0 [1]
4-(Benzyloxy)-1H-indole-2-carboxylic acidKi2500.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Steroid 5-alpha-reductase 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Dec. 2024, https://www.aatbio.com/data-sets/steroid-5-alpha-reductase-1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, December 21). Quest Database™ Steroid 5-alpha-reductase 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/steroid-5-alpha-reductase-1-inhibitors-ic50-ki.
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