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Squalene synthetase Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
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▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
Zaragozic acid AIC505.0 [1]
N-Geranyl-N'-(2-adamantyl)ethane-1,2-diamineIC50100000.0 [1]
N-Geranyl-N'-(2-adamantyl)ethane-1,2-diamineKi740.0 [1]
LapaquistatIC5045.0 [1], 260.0 [2]
Lapaquistat acetateIC5078.0 [1], 213.0 [2]
Ethyl 4-(1-azabicyclo[2.2.2]oct-2-en-3-yl)benzoateIC507000.0 [1]
(2S)-2-[2-[[(2S,3S)-4-(3,4-Dichlorophenyl)-3-(3-fluoro-4-phenylphenyl)butan-2-yl]amino]-2-oxoethyl]butanedioic acidIC500.52 [1]
AmiodaroneIC508000.0 [1]
Zaragozic acid CIC500.3 [1]
FTase Inhibitor IIC50300.0 [1]
[(5-Chloro-pyridin-2-ylamino)-phosphono-methyl]-phosphonic acidIC50240.0 [1]
(3r)-3-{[2-Benzyl-6-(3-Methoxypropoxy)pyridin-3-Yl]ethynyl}-1-Azabicyclo[2.2.2]octan-3-OlIC506.0 [1]
(3R)-3-[2-[2-Benzyl-6-[(3R,4S)-3-hydroxy-4-methoxypyrrolidin-1-yl]pyridin-3-yl]ethynyl]-1-azabicyclo[2.2.2]octan-3-olIC501.5 [1]
Tripotassium;4-(3-phenoxyphenyl)-1-phosphonatobutane-1-sulfonateIC5023.0 [1]
[[(6-Methylpyridin-2-yl)amino]-phosphonomethyl]phosphonic acidIC501290.0 [1]
Tripotassium (1S)-4-(3-phenoxyphenyl)-1-phosphonatobutane-1-sulfonateIC501900.0 [1]
N-6-Chloro-(3-pyridyl)-aminomethylene-1,1-bisphosphonateIC50100000.0 [1]
{[(4,6-Dimethylpyridin-2-yl)amino]methanediyl}bis(phosphonic acid)IC50100000.0 [1]
(2E, 6E)-FarnesylbisphosphonateIC5018.0 [1]
3-[[2-[(3R,5S)-7-Chloro-5-(2,3-dimethoxyphenyl)-1-(3-hydroxy-2,2-dimethylpropyl)-2-oxo-5H-4,1-benzoxazepin-3-yl]acetyl]amino]propanoic acidIC5015.0 [1]
2-[[2-[(3R,5S)-7-Chloro-5-(2,3-dimethoxyphenyl)-1-(3-hydroxy-2,2-dimethylpropyl)-2-oxo-5H-4,1-benzoxazepin-3-yl]acetyl]amino]acetic acidIC5015.0 [1]
3-(6-Methoxy-2-naphthyl)-1-azabicyclo[2.2.2]oct-2-eneIC502800.0 [1]
Tripotassium;4-[4-(4-methylphenyl)phenyl]-1-phosphonatobutane-1-sulfonateIC50290.0 [1]
Tripotassium;4-[4-(4-butylphenyl)phenyl]-1-phosphonatobutane-1-sulfonateIC50130.0 [1]
3-[1'-{4'-(Benzyloxy)-phenyl}]-quinuclidine-2-eneIC50250.0 [1]
Tripotassium;1-phosphonato-4-[3-(4-propylphenoxy)phenyl]butane-1-sulfonateIC501900.0 [1]
Tripotassium;4-[3-(2-benzylphenoxy)phenyl]-1-phosphonatobutane-1-sulfonateIC503.0 [1]
Tripotassium;4-(3-benzylphenyl)-1-phosphonatobutane-1-sulfonateIC5069.0 [1]
CID 44185378Ki520.0 [1]
CID 44185382Ki300.0 [1]
(6R,7R)-1-[(4S,5R)-4-Acetyloxy-5-methyl-3-methylidene-6-phenylhexyl]-6-[(E,4S,6S)-4,6-dimethyloct-2-enoyl]oxy-4,7-dihydroxy-2,8-dioxabicyclo[3.2.1]octane-3,4,5-tricarboxylic acidIC500.24 [1]
(6R,7R)-1-[(4S,5R)-4-Acetyloxy-5-methyl-3-methylidene-6-phenylhexyl]-4,7-dihydroxy-6-(11-phenoxyundecoxycarbonyloxy)-2,8-dioxabicyclo[3.2.1]octane-3,4,5-tricarboxylic acidIC500.28 [1]
(6R,7R)-1-[(4S,5R)-4-Acetyloxy-5-methyl-3-methylidene-6-phenylhexyl]-6-dodecoxy-4,7-dihydroxy-2,8-dioxabicyclo[3.2.1]octane-3,4,5-tricarboxylic acidIC500.3 [1]
(6R,7R)-1-[(4S,5R)-4-Acetyloxy-5-methyl-3-methylidene-6-phenylhexyl]-6-decoxycarbonyloxy-4,7-dihydroxy-2,8-dioxabicyclo[3.2.1]octane-3,4,5-tricarboxylic acidIC500.64 [1]
Ethyl 2-[4-[2-(3-hydroxy-1-azabicyclo[2.2.2]octan-3-yl)ethynyl]phenyl]acetateIC50660.0 [1]
(2R)-2-[[2-[(3R,5S)-7-Chloro-5-(2,3-dimethoxyphenyl)-1-(3-hydroxy-2,2-dimethylpropyl)-2-oxo-5H-4,1-benzoxazepin-3-yl]acetyl]amino]propanoic acidIC5018.0 [1]
(2S)-2-[[(3S,6R,8Ar)-6-benzyl-6-[[(2R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-sulfanylpropanoyl]amino]-5-oxo-1,2,3,7,8,8a-hexahydroindolizine-3-carbonyl]amino]-4-methylsulfanylbutanoic acidIC505000.0 [1]
2-[[2-[(3R,5S)-7-Chloro-5-(2,3-dimethoxyphenyl)-1-(3-hydroxy-2,2-dimethylpropyl)-2-oxo-5H-4,1-benzoxazepin-3-yl]acetyl]-methylamino]acetic acidIC5018.0 [1]
4-[[2-[(3R,5S)-7-Chloro-5-(2,3-dimethoxyphenyl)-1-(3-hydroxy-2,2-dimethylpropyl)-2-oxo-5H-4,1-benzoxazepin-3-yl]acetyl]amino]butanoic acidIC5032.0 [1]
3-[1-[2-[(3R,5S)-7-Chloro-5-(2,3-dimethoxyphenyl)-1-(3-hydroxy-2,2-dimethylpropyl)-2-oxo-5H-4,1-benzoxazepin-3-yl]acetyl]piperidin-4-yl]propanoic acidIC5061.0 [1]
(2S)-2-[[2-[(3R,5S)-7-Chloro-5-(2,3-dimethoxyphenyl)-1-(3-hydroxy-2,2-dimethylpropyl)-2-oxo-5H-4,1-benzoxazepin-3-yl]acetyl]amino]propanoic acidIC5021.0 [1]
4-[1-[2-[(3R,5S)-7-Chloro-5-(2,3-dimethoxyphenyl)-1-(3-hydroxy-2,2-dimethylpropyl)-2-oxo-5H-4,1-benzoxazepin-3-yl]acetyl]piperidin-4-yl]butanoic acidIC5070.0 [1]
2-[1-[2-[(3R,5S)-7-Chloro-5-(2,3-dimethoxyphenyl)-1-(2,2-dimethyl-3-propanoyloxypropyl)-2-oxo-5H-4,1-benzoxazepin-3-yl]acetyl]piperidin-4-yl]acetic acidIC5087.0 [1]
5-[[2-[(3R,5S)-7-Chloro-5-(2,3-dimethoxyphenyl)-1-(3-hydroxy-2,2-dimethylpropyl)-2-oxo-5H-4,1-benzoxazepin-3-yl]acetyl]amino]pentanoic acidIC5038.0 [1]
2-[1-[2-[(3R,5S)-1-(3-Butanoyloxy-2,2-dimethylpropyl)-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-5H-4,1-benzoxazepin-3-yl]acetyl]piperidin-4-yl]acetic acidIC5093.0 [1]
2-[(3R,5S)-7-Chloro-5-(2,3-dimethoxyphenyl)-1-(3-hydroxy-2,2-dimethylpropyl)-2-oxo-5H-4,1-benzoxazepin-3-yl]acetic acidIC50223.0 [1]
1-[2-[(3R,5S)-7-Chloro-5-(2,3-dimethoxyphenyl)-1-(3-hydroxy-2,2-dimethylpropyl)-2-oxo-5H-4,1-benzoxazepin-3-yl]acetyl]piperidine-4-carboxylic acidIC5018.0 [1]
2-[1-[2-[(3R,5S)-7-Chloro-5-(2,3-dimethoxyphenyl)-1-[2,2-dimethyl-3-(2-methylpropanoyloxy)propyl]-2-oxo-5H-4,1-benzoxazepin-3-yl]acetyl]piperidin-4-yl]acetic acidIC5089.0 [1]
Tripotassium;4-(4-phenylphenyl)-1-phosphonatobutane-1-sulfonateIC50350.0 [1]
Tetrapotassium;dioxido-oxo-[4-(4-phenylphenyl)-1-phosphonatobutyl]-lambda5-phosphaneIC501.0 [1]
2-[8-Chloro-6-(2,3-dimethoxyphenyl)-1-propan-2-yl-4,6-dihydro-[2]benzoxepino[4,5-c][1,2]oxazol-4-yl]acetic acidIC50169.0 [1]
Tripotassium;4-[3-(3,4-dichlorophenoxy)phenyl]-1-phosphonatobutane-1-sulfonateIC5014.0 [1]
Tripotassium;4-[3-(3,5-difluorophenoxy)phenyl]-1-phosphonatobutane-1-sulfonateIC5032.0 [1]
Tripotassium;4-[2-fluoro-5-(4-fluorophenoxy)phenyl]-1-phosphonatobutane-1-sulfonateIC504.0 [1]
Tripotassium;methyl-[4-(4-phenylphenyl)-1-phosphonatobutyl]phosphinateIC5072.0 [1]
Tripotassium;1-phosphonato-4-[3-[4-(trifluoromethyl)phenoxy]phenyl]butane-1-sulfonateIC50170.0 [1]
Tripotassium;(1R)-4-(3-phenoxyphenyl)-1-phosphonatobutane-1-sulfonateIC501900.0 [1]
Tripotassium;3-(3-phenoxyphenyl)-1-phosphonatopropane-1-sulfonateIC50550.0 [1]
Tripotassium;4-(3-anilinophenyl)-1-phosphonatobutane-1-sulfonateIC5079.0 [1]
Tripotassium;4-[3-(2-fluorophenoxy)phenyl]-1-phosphonatobutane-1-sulfonateIC505.0 [1]
Tripotassium;1-phosphonato-4-[3-[3-(trifluoromethyl)phenoxy]phenyl]butane-1-sulfonateIC5069.0 [1]
Tripotassium;4-[3-(4-chlorophenoxy)phenyl]-1-phosphonatobutane-1-sulfonateIC5020.0 [1]
Tripotassium;4-[3-(4-tert-butylphenoxy)phenyl]-1-phosphonatobutane-1-sulfonateIC504000.0 [1]
Tripotassium;4-[3-(4-benzylphenoxy)phenyl]-1-phosphonatobutane-1-sulfonateIC50720.0 [1]
Dipotassium (2-oxo-2-{[3-(3-phenoxyphenyl)propyl]amino}ethyl)phosphonateKi530.0 [1]
[2-Oxo-2-[3-(4-phenylphenyl)propylamino]ethyl]phosphonic acidKi30000.0 [1]
N-[3-(3-Phenoxyphenyl)propyl]sulfoacetamideKi30000.0 [1]
[2-[Hydroxy-[3-[4-(4-methylphenyl)phenyl]propyl]amino]-2-oxoethyl]phosphonic acidKi30000.0 [1]
3-[3-Allyl-4-[(3-hydroxyquinuclidine-3-yl)ethynyl]phenyl]propionic acid ethyl esterKi43.0 [1]
[(6-Bromo-pyridin-3-ylamino)-phosphono-methyl]-phosphonic acidIC501400.0 [1]
(1S,3S,4S,5R,6R,7R)-1-[(4R,5S)-4-Acetyloxy-5-methyl-3-methylidene-6-phenylhexyl]-6-[(E,4S,6S)-4,6-dimethyloct-2-enoyl]oxy-4,7-dihydroxy-2,8-dioxabicyclo[3.2.1]octane-3,4,5-tricarboxylic acidIC505.0 [1]
(1S,3S,4S,5R,6R,7R)-1-[(4S,5S)-4-Acetyloxy-3,5-dimethyl-6-phenylhexyl]-4,6,7-trihydroxy-2,8-dioxabicyclo[3.2.1]octane-3,4,5-tricarboxylic acidIC50200.0 [1]
(1S,3S,4S,5R,6R,7R)-1-[(4S,5S)-4-Acetyloxy-3,5-dimethyl-6-phenylhexyl]-6-[(4R,6S)-4,6-dimethyloctanoyl]oxy-4,7-dihydroxy-2,8-dioxabicyclo[3.2.1]octane-3,4,5-tricarboxylic acidIC5093.0 [1]
(1S,3S,4S,5R,6R,7R)-6-[(4R,6S)-4,6-Dimethyloctanoyl]oxy-1-[(5R)-3,5-dimethyl-6-phenylhexyl]-4,7-dihydroxy-2,8-dioxabicyclo[3.2.1]octane-3,4,5-tricarboxylic acidIC5014.0 [1]
(1S,3S,4S,5R,6R,7R)-1-[(E,5S)-3,5-Dimethyl-6-phenylhex-3-enyl]-4,6,7-trihydroxy-2,8-dioxabicyclo[3.2.1]octane-3,4,5-tricarboxylic acidIC50208.0 [1]
(1S,3S,4S,5R,6R,7R)-1-[(5R)-3,5-Dimethyl-6-phenylhexyl]-4,6,7-trihydroxy-2,8-dioxabicyclo[3.2.1]octane-3,4,5-tricarboxylic acidIC50200.0 [1]
(1S,3S,4S,5R,6R,7R)-6-[(4R,6S)-4,6-Dimethyloctanoyl]oxy-4,7-dihydroxy-1-[(4S,5S)-4-hydroxy-3,5-dimethyl-6-phenylhexyl]-2,8-dioxabicyclo[3.2.1]octane-3,4,5-tricarboxylic acidIC509.0 [1]
(6R,7R)-1-[(4S,5R)-4-Acetyloxy-5-methyl-3-methylidene-6-phenylhexyl]-6-(decylcarbamoyloxy)-4,7-dihydroxy-2,8-dioxabicyclo[3.2.1]octane-3,4,5-tricarboxylic acidIC503.2 [1]
(6R,7R)-1-[(4S,5R)-4-Acetyloxy-5-methyl-3-methylidene-6-phenylhexyl]-6-dodecanoyloxy-4,7-dihydroxy-2,8-dioxabicyclo[3.2.1]octane-3,4,5-tricarboxylic acidIC500.96 [1]
2-[[2-[(3R,5S)-7-Chloro-5-(2,3-dimethoxyphenyl)-1-(3-hydroxy-2,2-dimethylpropyl)-2-oxo-5H-4,1-benzoxazepin-3-yl]acetyl]amino]-4-methylpentanoic acidIC5028.0 [1]
2-[1-[2-[(3R,5S)-7-Chloro-5-(2,3-dimethoxyphenyl)-1-[2,2-dimethyl-3-[2-[(2-methylpropan-2-yl)oxy]-2-oxoethoxy]propyl]-2-oxo-5H-4,1-benzoxazepin-3-yl]acetyl]piperidin-4-yl]acetic acidIC50471.0 [1]
(2S)-2-[[(3S,6S,9As)-6-[[(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-sulfanylpropanoyl]amino]-5-oxo-1,2,3,6,7,8,9,9a-octahydropyrrolo[1,2-a]azepine-3-carbonyl]amino]-4-methylsulfanylbutanoic acidIC507000.0 [1]
(3R)-3-[2-(3-Phenylmethoxyphenyl)ethynyl]-1-azabicyclo[2.2.2]octan-3-olIC5020000.0 [1]
3-[(4-Phenylphenyl)methyl]-1-azabicyclo[2.2.2]oct-2-eneIC5020000.0 [1]
3-[2-(4-Phenylmethoxyphenyl)ethynyl]-1-azabicyclo[2.2.2]oct-2-eneIC50250.0 [1]
Tripotassium;4-[3-(4-fluorophenoxy)phenyl]-1-phosphonatobutane-1-sulfonateIC5017.0 [1]
Tripotassium;4-[3-(3-fluorophenoxy)phenyl]-1-phosphonatobutane-1-sulfonateIC508.0 [1]
Tripotassium;4-[3-(3,4-difluorophenoxy)phenyl]-1-phosphonatobutane-1-sulfonateIC5033.0 [1]
1-[2-[(1R,5R)-7-Chloro-5-(2,3-dimethoxyphenyl)-1-(2-methylpropyl)-2-oxo-4,5-dihydro-1H-3-benzazepin-3-yl]acetyl]piperidine-4-carboxylic acidIC50220.0 [1]
Ethyl 1-[4-[4-chloro-2-[(2-chlorophenyl)-hydroxymethyl]-N-(2,2-dimethylpropyl)anilino]-4-oxobutanoyl]piperidine-4-carboxylateIC500.85 [1]
1-[4-[4-Chloro-N-(2,2-dimethylpropyl)-2-[hydroxy-(2-methoxyphenyl)methyl]anilino]-4-oxobutanoyl]piperidine-3-carboxylic acidIC501.3 [1]
Ethyl 1-[4-[4-chloro-N-(2,2-dimethylpropyl)-2-[hydroxy-(2-methoxyphenyl)methyl]anilino]-4-oxobutanoyl]piperidine-4-carboxylateIC501.1 [1]
N-[4-Chloro-2-[(2-chlorophenyl)-hydroxymethyl]phenyl]-N-(2,2-dimethylpropyl)-4-oxo-4-piperazin-1-ylbutanamideIC502100.0 [1]
Ethyl 1-[5-[4-chloro-2-[(2-chlorophenyl)-hydroxymethyl]-N-(2,2-dimethylpropyl)anilino]-5-oxopentanoyl]piperidine-4-carboxylateIC506000.0 [1]
Ethyl 1-[4-[4-chloro-2-[(2-chloro-4-fluorophenyl)-hydroxymethyl]-N-(2,2-dimethylpropyl)anilino]-4-oxobutanoyl]piperidine-4-carboxylateIC502.0 [1]
Ethyl 1-[4-[4-chloro-2-[(2-chloro-4-fluorophenyl)-hydroxymethyl]-N-(2,2-dimethylpropyl)anilino]-4-oxobutanoyl]piperidine-3-carboxylateIC50600.0 [1]
Ethyl 1-[4-[4-chloro-2-[2,3-dihydro-1,4-benzodioxin-5-yl(hydroxy)methyl]-N-(2,2-dimethylpropyl)anilino]-4-oxobutanoyl]piperidine-3-carboxylateIC5013.0 [1]
1-[4-[4-Chloro-2-[(2-chloro-4-fluorophenyl)-hydroxymethyl]-N-(2,2-dimethylpropyl)anilino]-4-oxobutanoyl]piperidine-4-carboxylic acidIC50600.0 [1]
1-[4-[4-Chloro-N-(2,2-dimethylpropyl)-2-[(2-ethoxyphenyl)-hydroxymethyl]anilino]-4-oxobutanoyl]piperidine-4-carboxylic acidIC50600.0 [1]
1-[4-[4-Chloro-2-[(2-chloro-3-fluorophenyl)-hydroxymethyl]-N-(2,2-dimethylpropyl)anilino]-4-oxobutanoyl]piperidine-3-carboxylic acidIC508.4 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Squalene synthetase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/squalene-synthetase-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 20). Quest Database™ Squalene synthetase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/squalene-synthetase-inhibitors-ic50-ki.
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