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Squalene monooxygenase Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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▼
CID 10457630IC5050.0 [1], 60.0 [2], 80.0 [3]
TerbinafineIC506000.0 [1]
TerbinafineKi30.0 [1]
4-[[3-[[[(E)-6,6-Dimethylhept-2-en-4-ynyl]-ethylamino]methyl]phenoxy]methyl-dimethylsilyl]benzonitrileIC5020.0 [1]
((E)-6,6-Dimethyl-hept-2-en-4-ynyl)-{3-[(dimethyl-o-tolyl-silanyl)-methoxy]-benzyl}-ethyl-amineIC5030.0 [1]
(6E,10E,14E,18E)-6,10,15,19,23-Pentamethyltetracosa-6,10,14,18,22-pentaen-1-yn-3-olIC50400000.0 [1]
(6E,10E,14E,18E)-6,10,15,19,23-Pentamethyltetracosa-6,10,14,18,22-pentaen-1-yn-3-olKi950000.0 [1]
(6E,10E,14E,18E)-6,10,15,19-Tetramethyltetracosa-6,10,14,18-tetraen-1,23-diyne-3,22-diolIC50400000.0 [1]
(6E,10E,14E,18E)-6,10,15,19-Tetramethyltetracosa-6,10,14,18-tetraen-1,23-diyne-3,22-diolKi1000000.0 [1]
(2Z,10E,14E)-6,11,15,19-Tetramethyl-2-(4-methylpent-3-enyl)icosa-2,6,10,14,18-pentaen-1-amineIC5032000.0 [1], 109000.0 [2]
AmiodaroneIC5012000.0 [1]
PravastatinIC5010000.0 [1]
(E)-N-Ethyl-6,6-dimethyl-N-[[3-[(4-thiophen-3-ylthiophen-2-yl)methoxy]phenyl]methyl]hept-2-en-4-yn-1-amineIC5020.0 [1]
(3E,7E,11E,15E,19E)-3,7,11,16,20,24-Hexamethylpentacosa-1,3,7,11,15,19,23-heptaeneIC50400000.0 [1]
Trisnorsqualene alcoholIC504000.0 [1]
((E)-6,6-Dimethyl-hept-2-en-4-ynyl)-{3-[(dimethyl-p-tolyl-silanyl)-methoxy]-benzyl}-ethyl-amineIC50120.0 [1]
(E)-N-[[3-[[Dimethyl-(4-methylsulfanylphenyl)silyl]methoxy]phenyl]methyl]-N-ethyl-6,6-dimethylhept-2-en-4-yn-1-amineIC501000.0 [1]
N-[[3-[[Dimethyl-(2-methylphenyl)silyl]methoxy]phenyl]methyl]-N-ethyl-6,6-dimethylhepta-2,4-diyn-1-amineIC5090.0 [1]
(E)-N-[[3-[[(4-Bromophenyl)-dimethylsilyl]methoxy]phenyl]methyl]-N-ethyl-6,6-dimethylhept-2-en-4-yn-1-amineIC50210.0 [1]
((E)-6,6-Dimethyl-hept-2-en-4-ynyl)-{3-[(dimethyl-m-tolyl-silanyl)-methoxy]-benzyl}-ethyl-amineIC503000.0 [1]
4-[[3-[[[(E)-6,6-Dimethylhept-2-en-4-ynyl]-ethylamino]methyl]phenoxy]methyl-dimethylsilyl]benzenethiolIC508000.0 [1]
(E)-N-Ethyl-N-[[3-[[(4-ethynylphenyl)-dimethylsilyl]methoxy]phenyl]methyl]-6,6-dimethylhept-2-en-4-yn-1-amineIC501000.0 [1]
N-[[3-[[Dimethyl-(2-methylphenyl)silyl]methoxy]phenyl]methyl]-N-ethyl-6-methoxy-6-methylhepta-2,4-diyn-1-amineIC5070.0 [1]
4-[[3-[[[(E)-6,6-Dimethylhept-2-en-4-ynyl]-ethylamino]methyl]phenoxy]methyl-dimethylsilyl]benzaldehydeIC50100.0 [1]
4-[[3-[[[(E)-6,6-Dimethylhept-2-en-4-ynyl]-ethylamino]methyl]phenoxy]methyl-dimethylsilyl]benzamideIC505000.0 [1]
(E)-N-[[3-[[Dimethyl-(2-thiophen-3-ylphenyl)silyl]methoxy]phenyl]methyl]-N-ethyl-6,6-dimethylhept-2-en-4-yn-1-amineIC5010000.0 [1]
4-[[3-[[[(E)-6,6-Dimethylhept-2-en-4-ynyl]-ethylamino]methyl]phenoxy]methyl-dimethylsilyl]phenolIC508000.0 [1]
{3-[(Cyclohexyl-dimethyl-silanyl)-methoxy]-benzyl}-((E)-6,6-dimethyl-hept-2-en-4-ynyl)-ethyl-amineIC5020000.0 [1]
(E)-N-Ethyl-N-[[3-[[(4-fluorophenyl)-dimethylsilyl]methoxy]phenyl]methyl]-6,6-dimethylhept-2-en-4-yn-1-amineIC5060.0 [1]
(E)-N-[[3-[[(4-Ethenylphenyl)-dimethylsilyl]methoxy]phenyl]methyl]-N-ethyl-6,6-dimethylhept-2-en-4-yn-1-amineIC5070.0 [1]
(E)-N-Ethyl-N-[[3-[[(2-methoxyphenyl)-dimethylsilyl]methoxy]phenyl]methyl]-6,6-dimethylhept-2-en-4-yn-1-amineIC50150.0 [1]
(E)-N-[[3-[[Dimethyl-[2-(trifluoromethyl)phenyl]silyl]methoxy]phenyl]methyl]-N-ethyl-6,6-dimethylhept-2-en-4-yn-1-amineIC5070.0 [1]
((E)-6,6-Dimethyl-hept-2-en-4-ynyl)-{3-[(dimethyl-phenethyl-silanyl)-methoxy]-benzyl}-ethyl-amineIC5010000.0 [1]
{3-[(Benzyl-dimethyl-silanyl)-methoxy]-benzyl}-((E)-6,6-dimethyl-hept-2-en-4-ynyl)-ethyl-amineIC50130.0 [1]
1-[4-[[3-[[[(E)-6,6-Dimethylhept-2-en-4-ynyl]-ethylamino]methyl]phenoxy]methyl-dimethylsilyl]phenyl]-2,2,2-trifluoroethanoneIC505000.0 [1]
(E)-N-Ethyl-N-[[3-[[(4-methoxyphenyl)-dimethylsilyl]methoxy]phenyl]methyl]-6,6-dimethylhept-2-en-4-yn-1-amineIC50870.0 [1]
(E)-N-[[3-[[(4-Chlorophenyl)-dimethylsilyl]methoxy]phenyl]methyl]-N-ethyl-6,6-dimethylhept-2-en-4-yn-1-amineIC50400.0 [1]
(5E,9E,13E,17E)-1,1,22,22-Tetrachloro-5,9,14,18-tetramethyldocosa-1,5,9,13,17,21-hexaeneIC50400000.0 [1]
(5E,9E,13E,17E)-5,9,14,18-Tetramethyldocosa-5,9,13,17-tetraen-1,21-diyneIC50400000.0 [1]
CID 14544614IC5060000.0 [1]
[(4E,8E,12E,16E)-4,8,13,17,21-Pentamethyldocosa-4,8,12,16,20-pentaenylidene]cyclopropaneIC50400000.0 [1]
[(2E,6E,10E,14E,18E)-6,10,15,19,23-Pentamethyltetracosa-2,6,10,14,18,22-hexaen-2-yl]cyclopropaneIC50400000.0 [1]
(4E,8E,12E,16E,20E)-4,8,12,17,21,25-Hexamethylhexacosa-4,8,12,16,20,24-hexaen-1-olIC50400000.0 [1]
3,7,12,16,20-Pentamethyl-henicosa-3,7,11,15,19-pentaen-1-olIC5040000.0 [1]
(5E,9E,13E,17E)-5,9,14,18,22-Pentamethyltricosa-5,9,13,17,21-pentaen-1-olIC504000.0 [1]
N-[2-[3-[[[(E)-6,6-Dimethylhept-2-en-4-ynyl]-ethylamino]methyl]phenoxy]ethyl]-4-fluoro-N-methylbenzenesulfonamideIC50255.0 [1]
4-Bromo-N-[2-[3-[[[(E)-6,6-dimethylhept-2-en-4-ynyl]-ethylamino]methyl]phenoxy]ethyl]-N-methylbenzenesulfonamideIC50330.0 [1]
4-Cyano-N-[2-[3-[[[(E)-6,6-dimethylhept-2-en-4-ynyl]-ethylamino]methyl]phenoxy]ethyl]-N-methylbenzenesulfonamideIC50200.0 [1]
N-[2-[3-[[[(E)-6,6-Dimethylhept-2-en-4-ynyl]-ethylamino]methyl]phenoxy]ethyl]-N-methylthiophene-3-sulfonamideIC50250.0 [1]
5-Bromo-N-[2-[3-[[[(E)-6,6-dimethylhept-2-en-4-ynyl]-ethylamino]methyl]phenoxy]ethyl]-N-methylthiophene-2-sulfonamideIC50390.0 [1]
(E)-N-Ethyl-6,6-dimethyl-N-[[3-(3-thiophen-2-ylsulfonylpropoxy)phenyl]methyl]hept-2-en-4-yn-1-amineIC50290.0 [1]
N-[2-[3-[[[(E)-6,6-Dimethylhept-2-en-4-ynyl]-ethylamino]methyl]phenoxy]ethyl]thiophene-2-sulfonamideIC50450.0 [1]
N-[2-[3-[[[(E)-6,6-Dimethylhept-2-en-4-ynyl]-ethylamino]methyl]phenoxy]ethyl]-N-methyl-5-thiophen-3-ylthiophene-2-sulfonamideIC50210.0 [1]
N-[2-[3-[[[(E)-6,6-Dimethylhept-2-en-4-ynyl]-ethylamino]methyl]phenoxy]ethyl]-N-methyl-4-thiophen-3-ylthiophene-2-sulfonamideIC5090.0 [1]
N-Cyclopropyl-N-[2-[3-[[[(E)-6,6-dimethylhept-2-en-4-ynyl]-ethylamino]methyl]phenoxy]ethyl]thiophene-2-sulfonamideIC50230.0 [1]
N-[2-[3-[[[(E)-6,6-Dimethylhept-2-en-4-ynyl]-ethylamino]methyl]phenoxy]ethyl]-N-methylpyridine-3-sulfonamideIC50150.0 [1]
N-[2-[3-[[[(E)-6,6-Dimethylhept-2-en-4-ynyl]-ethylamino]methyl]phenoxy]ethyl]-N-methyl-1,3-thiazole-2-sulfonamideIC50170.0 [1]
N-[2-[3-[[[(E)-6,6-Dimethylhept-2-en-4-ynyl]-ethylamino]methyl]phenoxy]ethyl]-N-propylthiophene-2-sulfonamideIC50170.0 [1]
N-[2-[3-[[[(E)-6,6-Dimethylhept-2-en-4-ynyl]-ethylamino]methyl]phenoxy]ethyl]-N-ethylthiophene-2-sulfonamideIC5090.0 [1]
4-Bromo-N-[2-[3-[[[(E)-6,6-dimethylhept-2-en-4-ynyl]-ethylamino]methyl]phenoxy]ethyl]-N-methylthiophene-2-sulfonamideIC50300.0 [1]
N-[2-[3-[[[(E)-6,6-Dimethylhept-2-en-4-ynyl]-ethylamino]methyl]phenoxy]ethyl]-N-methyl-5-thiophen-2-ylthiophene-2-sulfonamideIC5010000.0 [1]
N-[2-[3-[[[(E)-6,6-Dimethylhept-2-en-4-ynyl]-ethylamino]methyl]phenoxy]ethyl]-N-methyl-1-benzothiophene-2-sulfonamideIC501800.0 [1]
N-[2-[3-[[[(E)-6,6-Dimethylhept-2-en-4-ynyl]-ethylamino]methyl]phenoxy]ethyl]-N-methyl-1-thiophen-2-ylmethanesulfonamideIC50200.0 [1]
N-[3-[3-[[[(E)-6,6-Dimethylhept-2-en-4-ynyl]-ethylamino]methyl]phenoxy]propyl]-N-methylthiophene-2-sulfonamideIC506400.0 [1]
4,8,12-Tetradecatrien-1-ol, 5,9,13-trimethyl-IC50400000.0 [1]
4,8,12,16-Octadecatetraen-1-ol, 4,9,13,17-tetramethyl-IC50100000.0 [1]
2-[[3-[[[(E)-6,6-Dimethylhept-2-en-4-ynyl]-ethylamino]methyl]phenoxy]methyl-dimethylsilyl]benzonitrileIC5030.0 [1]
((E)-6,6-Dimethyl-hept-2-en-4-ynyl)-{3-[(dimethyl-phenyl-silanyl)-methoxy]-benzyl}-ethyl-amineIC50150.0 [1]
(E)-N-[[3-[[(4-Azidophenyl)-dimethylsilyl]methoxy]phenyl]methyl]-N-ethyl-6,6-dimethylhept-2-en-4-yn-1-amineIC50520.0 [1]
3-(3-Azidophenyl)-N-ethyl-N-[[3-[(4-thiophen-3-ylthiophen-2-yl)methoxy]phenyl]methyl]prop-2-yn-1-amineIC50270.0 [1]
3-[[[(E)-6,6-Dimethylhept-2-en-4-ynyl]-ethylamino]methyl]-N-[[dimethyl-(2-methylphenyl)silyl]methyl]anilineIC50100.0 [1]
(2Z,6E,10E,14E)-6,11,15,19-Tetramethyl-2-(4-methylpent-3-enyl)icosa-2,6,10,14,18-pentaen-1-olKi4000.0 [1]
N-Methyl-N-[(4E,8E,12E,16E)-4,8,13,17,21-pentamethyldocosa-4,8,12,16,20-pentaenyl]hydroxylamineIC5013000.0 [1]
N-Ethyl-3-phenyl-N-[[3-[(4-thiophen-3-ylthiophen-2-yl)methoxy]phenyl]methyl]prop-2-yn-1-amineIC50100.0 [1]
3-(2-Azidophenyl)-N-ethyl-N-[[3-[(4-thiophen-3-ylthiophen-2-yl)methoxy]phenyl]methyl]prop-2-yn-1-amineIC50100000.0 [1]
3-(4-Azidophenyl)-N-ethyl-N-[[3-[(4-thiophen-3-ylthiophen-2-yl)methoxy]phenyl]methyl]prop-2-yn-1-amineIC50960.0 [1]
(1E,5E,9E,13E,17E)-5,9,14,18,22-Pentamethyl-1-nitrotricosa-1,5,9,13,17,21-hexaeneIC50400000.0 [1]
(6E,10E,14E,18E)-6,10,15,19,23-Pentamethyl-1-nitrotetracosa-6,10,14,18,22-pentaen-2-olIC50270000.0 [1]
[4-(Chloromethyl)phenyl]-[4-[ethyl-[[3-[(4-thiophen-2-ylthiophen-2-yl)methoxy]phenyl]methyl]amino]phenyl]methanoneIC50500000.0 [1]
[3-[[3-[[[(E)-6,6-Dimethylhept-2-en-4-ynyl]-ethylamino]methyl]phenoxy]methyl]-5-[3-(trifluoromethyl)diazirin-3-yl]phenyl]methanolIC50500000.0 [1]
3-[Ethyl-[[3-[(4-thiophen-2-ylthiophen-2-yl)methoxy]phenyl]methyl]amino]-5-[3-(trifluoromethyl)diazirin-3-yl]phenolIC50500000.0 [1]
2-[Ethyl-[[3-[(4-thiophen-2-ylthiophen-2-yl)methoxy]phenyl]methyl]amino]-4-[3-(trifluoromethyl)diazirin-3-yl]phenolIC50500000.0 [1]
(4E,8E,16E)-N-(6-Aminohexyl)-N'-cyclopropyl-4,8,13,17-tetramethylicosa-4,8,12,16-tetraene-1,20-diamineKi2400.0 [1]
Items per page: 1 - 10 of 83
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References

This online tool may be cited as follows

MLA

"Quest Database™ Squalene monooxygenase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 22 Feb. 2025, https://www.aatbio.com/data-sets/squalene-monooxygenase-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 22). Quest Database™ Squalene monooxygenase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/squalene-monooxygenase-inhibitors-ic50-ki.
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