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Sphingosine kinase 2 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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▼
3-(4-Chlorophenyl)-N-(pyridin-4-ylmethyl)adamantane-1-carboxamideIC5060000.0 [1]
3-(4-Chlorophenyl)-N-(pyridin-4-ylmethyl)adamantane-1-carboxamideKi9800.0 [1]
N,N-DimethylsphingosineIC5016300.0 [1], 20000.0 [2], 26290.0 [3], 80000.0 [4]
N,N-DimethylsphingosineKi12000.0 [1], 12500.0 [2], 14000.0 [3]
(5Z)-3-(2-Aminoethyl)-5-[3-(4-butoxyphenyl)propylidene]-1,3-thiazolidine-2,4-dioneIC504300.0 [1]
(5Z)-3-(2-Aminoethyl)-5-[3-(4-butoxyphenyl)propylidene]-1,3-thiazolidine-2,4-dioneKi6400.0 [1]
4-[[4-(4-Chlorophenyl)-2-thiazolyl]amino]phenolIC5020000.0 [1]
4-[[4-(4-Chlorophenyl)-2-thiazolyl]amino]phenolKi7900.0 [1], 50000.0 [2]
ROMeIC5027000.0 [1]
ROMeKi16500.0 [1], 27000.0 [2]
{(2R)-1-[4-({3-Methyl-5-[(phenylsulfonyl)methyl]phenoxy}methyl)benzyl]pyrrolidin-2-YL}methanolIC50356.0 [1], 360.0 [2], 10000.0 [3], 17000.0 [4]
(2S)-2-[3-(4-Octylphenyl)-1,2,4-oxadiazol-5-yl]pyrrolidine-1-carboximidamide;hydrochlorideKi1300.0 [1], 1400.0 [2]
(2R,4S)-2-(Hydroxymethyl)-1-[2-[4-[[4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]amino]phenyl]ethyl]piperidin-4-olIC5020.0 [1], 100.0 [2]
(E,2R,3S)-2-(Methylamino)-5-(4-pentylphenyl)pent-4-ene-1,3-diolIC5010000.0 [1]
(E,2R,3S)-2-(Methylamino)-5-(4-pentylphenyl)pent-4-ene-1,3-diolKi100000.0 [1]
(S)-2-Amino-4-hydroxy-N-(4-octylphenyl)butanamideKi31000.0 [1]
(2S)-1-[4-[4-[3-(2-Cyclohexylethyl)phenyl]-1,3-oxazol-2-yl]benzoyl]pyrrolidine-2-carboximidamideKi4200.0 [1]
N'-{(E)-[3-(Benzyloxy)phenyl]methylidene}-3,4,5-trihydroxybenzohydrazideIC5017100.0 [1], 26330.0 [2]
SphingosineIC501560.0 [1]
SpisulosineIC50766000.0 [1]
[(2S)-1-[[4-[[3-(Benzenesulfonylmethyl)-5-methylphenoxy]methyl]phenyl]methyl]pyrrolidin-2-yl]methanolIC5042600.0 [1]
N-(3-Chloro-1,4-dioxonaphthalen-2-yl)-N-cyclohexylacetamideIC50100000.0 [1]
(2S)-1-(4-Dodecylbenzoyl)pyrrolidine-2-carboximidamide;hydrochlorideKi1500.0 [1]
N-[3-[[4-[[(2R)-2-(Hydroxymethyl)pyrrolidin-1-yl]methyl]phenyl]methoxy]phenyl]benzamideIC50145.0 [1]
4-Methyl-N-[2-[[2-[(4-methylphenyl)sulfonylamino]phenyl]iminomethyl]phenyl]benzenesulfonamideKi6900.0 [1]
(2S,3S,4R)-4-Amino-2-tetradecyloxolan-3-olIC50600.0 [1]
4-Methyl-N-[4-(1,3-thiazol-2-yl)-1,3-thiazol-2-yl]-1,3-thiazol-2-amineIC506500.0 [1]
1-[3-(4-Decylphenyl)-1,2,4-oxadiazol-5-yl]cyclopropane-1-carboximidamide;hydrochlorideKi6000.0 [1]
(2R)-2-[3-(4-Octylphenyl)-1,2,4-oxadiazol-5-yl]pyrrolidine-1-carboximidamideKi1300.0 [1]
4-[[5-(4-Iodophenyl)-1,3,4-oxadiazol-2-yl]amino]phenolIC501900.0 [1]
5-(4-Chlorophenyl)-N-(pyridin-4-ylmethyl)-1,3,4-oxadiazol-2-amineIC505500.0 [1]
(2S)-2-Amino-2-(methoxymethyl)-4-(4-octylphenyl)butan-1-olKi16500.0 [1]
(2S)-2-[3-(4-Octylphenyl)-1,2,4-oxadiazol-5-yl]azetidine-1-carboximidamide;hydrochlorideKi1200.0 [1]
(2S,3S)-3-Hydroxy-2-[3-(4-octylphenyl)-1,2,4-oxadiazol-5-yl]pyrrolidine-1-carboximidamide;hydrochlorideKi10000.0 [1]
(2S,4R)-4-Hydroxy-2-[3-(4-octylphenyl)-1,2,4-oxadiazol-5-yl]pyrrolidine-1-carboximidamide;hydrochlorideKi5200.0 [1]
(2S,3S,4R)-4-Amino-2-[2-(3-heptylphenyl)ethyl]oxolan-3-olIC502200.0 [1]
(2S,3S,4R)-4-Amino-2-[10-(cyclohexylmethoxy)decyl]oxolan-3-olIC50240.0 [1]
(3R,4S,5S)-4-Methoxy-5-tetradecyloxolan-3-amineIC5030000.0 [1]
(3S,5R)-5-(Hydroxymethyl)-1-[3-[4-[[4-[3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]amino]phenyl]propyl]pyrrolidin-3-olIC50148.0 [1]
N-(1-Carbamimidoylcyclopropyl)-3-dodecylbenzamide;hydrochlorideKi10900.0 [1]
1-[3-(4-Tridecylphenyl)-1,2,4-oxadiazol-5-yl]cyclopropane-1-carboximidamide;hydrochlorideKi11000.0 [1]
1-[3-(3-Decylphenyl)-1,2,4-oxadiazol-5-yl]cyclopropane-1-carboximidamide;hydrochlorideKi10300.0 [1]
1-[3-(3-Undecylphenyl)-1,2,4-oxadiazol-5-yl]cyclopropane-1-carboximidamide;hydrochlorideKi9900.0 [1]
2-[3-(4-Chlorophenyl)-1-adamantyl]-N-(pyridin-4-ylmethyl)acetamideKi9800.0 [1]
3,4,5-Trihydroxy-N-[(E)-[3-[(2-methylphenyl)methoxy]phenyl]methylideneamino]benzamideIC5081170.0 [1]
3,4,5-Trihydroxy-N-[(E)-[3-[(3-methylphenyl)methoxy]phenyl]methylideneamino]benzamideIC5078690.0 [1]
3,4,5-Trihydroxy-N-[(E)-[3-[(4-methylphenyl)methoxy]phenyl]methylideneamino]benzamideIC5065380.0 [1]
3,4,5-Trihydroxy-N-[(E)-[3-[[2-(trifluoromethyl)phenyl]methoxy]phenyl]methylideneamino]benzamideIC5016320.0 [1]
3,4,5-Trihydroxy-N-[(E)-[3-[[3-(trifluoromethyl)phenyl]methoxy]phenyl]methylideneamino]benzamideIC50100000.0 [1]
3,4,5-Trihydroxy-N-[(E)-[3-[[4-(trifluoromethyl)phenyl]methoxy]phenyl]methylideneamino]benzamideIC5022150.0 [1]
3,4,5-Trihydroxy-N-[(E)-[4-[(4-methylphenyl)methoxy]phenyl]methylideneamino]benzamideIC5044500.0 [1]
N-[(E)-[3-[(4-Cyanophenyl)methoxy]phenyl]methylideneamino]-3,4,5-trihydroxybenzamideIC5035110.0 [1]
N-[(E)-[4-[(4-Tert-butylphenyl)methoxy]phenyl]methylideneamino]-3,4,5-trihydroxybenzamideIC5043280.0 [1]
3,4,5-Trihydroxy-N-[(E)-[4-(naphthalen-2-ylmethoxy)phenyl]methylideneamino]benzamideIC5030230.0 [1]
3,4,5-Trihydroxy-N-[(E)-[4-[(2-methoxyphenyl)methoxy]phenyl]methylideneamino]benzamideIC5026620.0 [1]
3,4,5-Trihydroxy-N-[(E)-[4-[(3-methoxyphenyl)methoxy]phenyl]methylideneamino]benzamideIC502170.0 [1]
3,4,5-Trihydroxy-N-[(E)-[4-[(4-methoxyphenyl)methoxy]phenyl]methylideneamino]benzamideIC50100000.0 [1]
3-Hydroxy-N-[(E)-[4-[[2-(trifluoromethyl)phenyl]methoxy]phenyl]methylideneamino]benzamideIC50100000.0 [1]
4-Hydroxy-N-[(E)-[4-[[2-(trifluoromethyl)phenyl]methoxy]phenyl]methylideneamino]benzamideIC50100000.0 [1]
4-Hydroxy-N-[(E)-[3-[[2-(trifluoromethyl)phenyl]methoxy]phenyl]methylideneamino]benzamideIC50100000.0 [1]
3,4,5-Trihydroxy-N-[(E)-[4-[[2-(trifluoromethyl)phenyl]methoxy]phenyl]methylideneamino]benzamideIC5015080.0 [1]
3,4,5-Trihydroxy-N-[(E)-[4-[[3-(trifluoromethyl)phenyl]methoxy]phenyl]methylideneamino]benzamideIC5023830.0 [1]
3,4,5-Trihydroxy-N-[(E)-[4-[[4-(trifluoromethyl)phenyl]methoxy]phenyl]methylideneamino]benzamideIC5015640.0 [1]
N-[(E)-[4-[(2-Cyanophenyl)methoxy]phenyl]methylideneamino]-3,4,5-trihydroxybenzamideIC5044540.0 [1]
N-[(E)-[4-[(3-Cyanophenyl)methoxy]phenyl]methylideneamino]-3,4,5-trihydroxybenzamideIC5022590.0 [1]
(2S,3S)-3-Hydroxy-2-[3-(6-pentoxynaphthalen-2-yl)-1,2,4-oxadiazol-5-yl]pyrrolidine-1-carboximidamide;hydrochlorideKi900.0 [1]
N-[(E)-[4-[(4-Cyanophenyl)methoxy]phenyl]methylideneamino]-3,4,5-trihydroxybenzamideIC5017790.0 [1]
4-Hydroxy-N-[(E)-[4-[(3-methoxyphenyl)methoxy]phenyl]methylideneamino]benzamideIC50100000.0 [1]
3,5-Dihydroxy-N-[(E)-[3-[[2-(trifluoromethyl)phenyl]methoxy]phenyl]methylideneamino]benzamideIC50100000.0 [1]
3,4-Dihydroxy-N-[(E)-[3-[[2-(trifluoromethyl)phenyl]methoxy]phenyl]methylideneamino]benzamideIC5013840.0 [1]
3-Hydroxy-N-[(E)-[3-[[2-(trifluoromethyl)phenyl]methoxy]phenyl]methylideneamino]benzamideIC50100000.0 [1]
3,5-Dihydroxy-N-[(E)-[4-[[2-(trifluoromethyl)phenyl]methoxy]phenyl]methylideneamino]benzamideIC50100000.0 [1]
3,4-Dihydroxy-N-[(E)-[4-[[2-(trifluoromethyl)phenyl]methoxy]phenyl]methylideneamino]benzamideIC5011400.0 [1]
N-[(E)-[3-[(2-Cyanophenyl)methoxy]phenyl]methylideneamino]-3,4,5-trihydroxybenzamideIC5068550.0 [1]
N-[(E)-[3-[(3-Cyanophenyl)methoxy]phenyl]methylideneamino]-3,4,5-trihydroxybenzamideIC50100000.0 [1]
3,4,5-Trihydroxy-N-[(E)-[3-(naphthalen-1-ylmethoxy)phenyl]methylideneamino]benzamideIC5040580.0 [1]
3,4,5-Trihydroxy-N-[(E)-[3-[(2-methoxyphenyl)methoxy]phenyl]methylideneamino]benzamideIC5019530.0 [1]
3,4,5-Trihydroxy-N-[(E)-[3-[(3-methoxyphenyl)methoxy]phenyl]methylideneamino]benzamideIC508700.0 [1]
3,4,5-Trihydroxy-N-[(E)-[3-[(4-methoxyphenyl)methoxy]phenyl]methylideneamino]benzamideIC50100000.0 [1]
(2S)-2-[3-(6-Pentoxynaphthalen-2-yl)-1,2,4-oxadiazol-5-yl]pyrrolidine-1-carboximidamide;hydrochlorideKi980.0 [1]
(2S)-2-[3-(6-Hexoxynaphthalen-2-yl)-1,2,4-oxadiazol-5-yl]pyrrolidine-1-carboximidamide;hydrochlorideKi3800.0 [1]
N-[(E)-[3-[(2-Fluorophenyl)methoxy]phenyl]methylideneamino]-3,4,5-trihydroxybenzamideIC5098900.0 [1]
N-[(E)-[3-[(3-Fluorophenyl)methoxy]phenyl]methylideneamino]-3,4,5-trihydroxybenzamideIC50100000.0 [1]
N-[(E)-[3-[(4-Fluorophenyl)methoxy]phenyl]methylideneamino]-3,4,5-trihydroxybenzamideIC50100000.0 [1]
3,5-Dihydroxy-N-[(E)-[3-[(3-methoxyphenyl)methoxy]phenyl]methylideneamino]benzamideIC50100000.0 [1]
3,4-Dihydroxy-N-[(E)-[3-[(3-methoxyphenyl)methoxy]phenyl]methylideneamino]benzamideIC504600.0 [1]
3-Hydroxy-N-[(E)-[3-[(3-methoxyphenyl)methoxy]phenyl]methylideneamino]benzamideIC50100000.0 [1]
4-Hydroxy-N-[(E)-[3-[(3-methoxyphenyl)methoxy]phenyl]methylideneamino]benzamideIC50100000.0 [1]
3,5-Dihydroxy-N-[(E)-[4-[(3-methoxyphenyl)methoxy]phenyl]methylideneamino]benzamideIC50100000.0 [1]
3,4-Dihydroxy-N-[(E)-[4-[(3-methoxyphenyl)methoxy]phenyl]methylideneamino]benzamideIC5010150.0 [1]
3-Hydroxy-N-[(E)-[4-[(3-methoxyphenyl)methoxy]phenyl]methylideneamino]benzamideIC50100000.0 [1]
N-[(E)-[3-[(2-Chlorophenyl)methoxy]phenyl]methylideneamino]-3,4,5-trihydroxybenzamideIC5058790.0 [1]
N-[(E)-[3-[(3-Chlorophenyl)methoxy]phenyl]methylideneamino]-3,4,5-trihydroxybenzamideIC5067370.0 [1]
N-[(E)-[3-[(4-Chlorophenyl)methoxy]phenyl]methylideneamino]-3,4,5-trihydroxybenzamideIC5061200.0 [1]
N-[(E)-[3-[(4-Tert-butylphenyl)methoxy]phenyl]methylideneamino]-3,4,5-trihydroxybenzamideIC5062170.0 [1]
[(2R)-1-[[4-[2-Methyl-3-[[(2S)-oxolan-2-yl]methyl]benzimidazol-5-yl]phenyl]methyl]pyrrolidin-2-yl]methanolIC50100000.0 [1]
[(2R)-1-[[4-[(3-Cyclohexylphenoxy)methyl]phenyl]methyl]pyrrolidin-2-yl]methanolIC501.7 [1]
(2S,3S,4R)-4-Amino-2-[11-(2-methylpropoxy)undecyl]oxolan-3-olIC50840.0 [1]
[(2R)-1-[[4-[[3-(Cyclopropylsulfonylmethyl)phenoxy]methyl]phenyl]methyl]pyrrolidin-2-yl]methanolIC50164.0 [1]
(3R,4S)-1-[[4-[[3-(Benzenesulfonylmethyl)-5-methylphenoxy]methyl]phenyl]methyl]pyrrolidine-3,4-diolIC507230.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Sphingosine kinase 2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/sphingosine-kinase-2-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ Sphingosine kinase 2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/sphingosine-kinase-2-inhibitors-ic50-ki.
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