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Sphingosine kinase 1 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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{(2R)-1-[4-({3-Methyl-5-[(phenylsulfonyl)methyl]phenoxy}methyl)benzyl]pyrrolidin-2-YL}methanolIC502.7 [1]
{(2R)-1-[4-({3-Methyl-5-[(phenylsulfonyl)methyl]phenoxy}methyl)benzyl]pyrrolidin-2-YL}methanolKi3.6 [1], 4.0 [2], 4.3 [3]
4-[[4-(4-Chlorophenyl)-2-thiazolyl]amino]phenolIC5035000.0 [1]
4-[[4-(4-Chlorophenyl)-2-thiazolyl]amino]phenolKi16000.0 [1]
N,N-DimethylsphingosineIC505700.0 [1]
N,N-DimethylsphingosineKi5000.0 [1], 6000.0 [2], 16000.0 [3]
[(2S)-1-[[4-[[3-(Benzenesulfonylmethyl)-5-methylphenoxy]methyl]phenyl]methyl]pyrrolidin-2-yl]methanolIC5043.0 [1], 78.0 [2], 142.0 [3], 703.0 [4]
[(2S)-1-[[4-[[3-(Benzenesulfonylmethyl)-5-methylphenoxy]methyl]phenyl]methyl]pyrrolidin-2-yl]methanolKi4.3 [1]
(S)-2-Amino-4-hydroxy-N-(4-octylphenyl)butanamideIC5050.0 [1]
(S)-2-Amino-4-hydroxy-N-(4-octylphenyl)butanamideKi1400.0 [1]
N-[3-[[4-[[(2R)-2-(Hydroxymethyl)pyrrolidin-1-yl]methyl]phenyl]methoxy]phenyl]benzamideIC501200.0 [1], 3670.0 [2], 8800.0 [3], 9820.0 [4]
[(2R)-1-[[4-[(3-Cyclohexylphenoxy)methyl]phenyl]methyl]pyrrolidin-2-yl]methanolIC500.03 [1], 0.7 [2], 1.5 [3], 1.7 [4]
[(2R)-1-[[4-[[3-(Cyclopropylsulfonylmethyl)phenoxy]methyl]phenyl]methyl]pyrrolidin-2-yl]methanolIC501.7 [1], 10.0 [2], 40.4 [3], 1470.0 [4]
(3R,4S)-1-[[4-[[3-(Benzenesulfonylmethyl)-5-methylphenoxy]methyl]phenyl]methyl]pyrrolidine-3,4-diolIC501.0 [1], 3.9 [2], 38.0 [3]
(3R,4R)-1-[[4-[[3-(Benzenesulfonylmethyl)-5-methylphenoxy]methyl]phenyl]methyl]pyrrolidine-3,4-diolIC500.17 [1], 2.0 [2], 6.4 [3]
[(2R)-1-[[4-[(3-Propan-2-ylphenoxy)methyl]phenyl]methyl]pyrrolidin-2-yl]methanolIC500.6 [1], 0.8 [2], 4.8 [3], 19.0 [4]
[(2R)-1-[[4-[[3-(Benzenesulfonylmethyl)phenoxy]methyl]phenyl]methyl]pyrrolidin-2-yl]methanolIC500.3 [1], 2.0 [2], 2.4 [3], 35.0 [4]
(3S)-1-[[4-[[3-(Benzenesulfonylmethyl)-5-methylphenoxy]methyl]phenyl]methyl]pyrrolidin-3-olIC500.03 [1], 2.6 [2], 3.0 [3], 5.2 [4]
[(2R)-1-[[4-[[3-(5-Methyl-1,2,4-oxadiazol-3-yl)phenoxy]methyl]phenyl]methyl]pyrrolidin-2-yl]methanolIC501.7 [1], 4.5 [2], 25.0 [3], 173.0 [4]
(E,2R,3S)-2-(Methylamino)-5-(4-pentylphenyl)pent-4-ene-1,3-diolKi10000.0 [1]
1-[2-(4-Octylphenyl)ethyl]piperidin-4-olIC503600.0 [1]
(2S)-2-[3-(4-Octylphenyl)-1,2,4-oxadiazol-5-yl]pyrrolidine-1-carboximidamide;hydrochlorideKi13000.0 [1], 13300.0 [2], 16000.0 [3]
(2R,4S)-2-(Hydroxymethyl)-1-[2-[4-[[4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]amino]phenyl]ethyl]piperidin-4-olIC5010.0 [1], 20.0 [2]
[(2R)-1-[[4-[2-Methyl-3-[[(2S)-oxolan-2-yl]methyl]benzimidazol-5-yl]phenyl]methyl]pyrrolidin-2-yl]methanolIC502100.0 [1], 4600.0 [2], 12700.0 [3]
[(2S)-1-[[4-[2-Methyl-3-[[(2S)-oxolan-2-yl]methyl]benzimidazol-5-yl]phenyl]methyl]pyrrolidin-2-yl]methanolIC50100000.0 [1]
[(2S)-1-[[4-[2-Methyl-3-[[(2R)-oxolan-2-yl]methyl]benzimidazol-5-yl]phenyl]methyl]pyrrolidin-2-yl]methanolIC509800.0 [1], 31000.0 [2], 100000.0 [3]
[(2R)-1-[[4-[2-Methyl-3-[[(2R)-oxolan-2-yl]methyl]benzimidazol-5-yl]phenyl]methyl]pyrrolidin-2-yl]methanolIC5081.0 [1], 190.0 [2], 870.0 [3]
2-[[4-[[3-(Benzenesulfonylmethyl)-5-methylphenoxy]methyl]phenyl]methylamino]ethanolIC503.5 [1], 5.3 [2], 14.6 [3]
6-[[3-(Benzenesulfonylmethyl)-5-methylphenoxy]methyl]-1H-benzimidazoleIC5027000.0 [1], 48000.0 [2]
6-[[3-(Benzenesulfonylmethyl)-5-methylphenoxy]methyl]-1H-benzimidazol-2-amineIC50180.0 [1], 1400.0 [2], 1700.0 [3]
(2S)-1-[4-[4-[3-(2-Cyclohexylethyl)phenyl]-1,3-oxazol-2-yl]benzoyl]pyrrolidine-2-carboximidamideKi47.0 [1], 50.0 [2]
SafingolKi3000.0 [1], 5000.0 [2]
(2S)-1-(4-Dodecylbenzoyl)pyrrolidine-2-carboximidamide;hydrochlorideKi130.0 [1]
Tert-butyl (4S)-4-hexadec-2-ynoyl-2,2-dimethyl-1,3-oxazolidine-3-carboxylateIC503300.0 [1]
Tert-butyl (4S)-4-hexadec-2-ynoyl-2,2-dimethyl-1,3-oxazolidine-3-carboxylateKi3000.0 [1]
(2S,3S)-3-Hydroxy-N-(4-octylphenyl)pyrrolidine-2-carboxamideIC5062.0 [1]
[(2R)-1-[[4-[2-Methyl-3-(2-methylpropyl)benzimidazol-5-yl]phenyl]methyl]pyrrolidin-2-yl]methanolIC50290.0 [1], 440.0 [2]
[(2R)-1-[[4-[2-Methyl-3-(3-methylbutyl)benzimidazol-5-yl]phenyl]methyl]pyrrolidin-2-yl]methanolIC504.0 [1], 7.0 [2]
(3R)-1-[[4-[[3-(Benzenesulfonylmethyl)-5-methylphenoxy]methyl]phenyl]methyl]pyrrolidin-3-olIC5028.0 [1], 30.0 [2]
[(2R)-1-[[4-(3-Benzyl-2-methylbenzimidazol-5-yl)phenyl]methyl]pyrrolidin-2-yl]methanolIC50250.0 [1], 440.0 [2]
[(2R)-1-[[4-[[3-(Methylsulfonylmethyl)phenoxy]methyl]phenyl]methyl]pyrrolidin-2-yl]methanolIC50439.0 [1], 519.0 [2]
[(2R)-1-[[4-[3-(2-Cyclobutylethyl)-2-methylbenzimidazol-5-yl]phenyl]methyl]pyrrolidin-2-yl]methanolIC504.0 [1], 8.0 [2]
[(2R)-1-[[4-[3-(Cyclopentylmethyl)-2-methylbenzimidazol-5-yl]phenyl]methyl]pyrrolidin-2-yl]methanolIC5010.0 [1], 11.0 [2]
Tert-butyl N-[(2S)-1-hydroxy-3-oxooctadec-4-yn-2-yl]carbamateIC501200.0 [1]
Tert-butyl N-[(2S)-1-hydroxy-3-oxooctadec-4-yn-2-yl]carbamateKi1000.0 [1]
N'-{(E)-[3-(Benzyloxy)phenyl]methylidene}-3,4,5-trihydroxybenzohydrazideIC5023070.0 [1], 40210.0 [2]
Dimethyl-[4-(4-octylphenyl)cyclohexyl]-propylazaniumKi22000.0 [1], 47000.0 [2]
1-[3-(4-Dodecylphenyl)-1,2,4-oxadiazol-5-yl]cyclopropane-1-carboximidamideKi40.0 [1], 320.0 [2]
SphingosineIC503860.0 [1]
3-(4-Chlorophenyl)-N-(pyridin-4-ylmethyl)adamantane-1-carboxamideIC50100000.0 [1]
SpisulosineIC507100.0 [1]
ROMeIC5050000.0 [1]
(5Z)-3-(2-Aminoethyl)-5-[3-(4-butoxyphenyl)propylidene]-1,3-thiazolidine-2,4-dioneIC5010000.0 [1]
N-[(E)-1-(3,4-Dimethoxyphenyl)ethylideneamino]-3-(4-methoxyphenyl)-1H-pyrazole-5-carboxamideKi1330.0 [1]
N-(3-Chloro-1,4-dioxonaphthalen-2-yl)-N-cyclohexylacetamideIC502000.0 [1]
N-[(E)-(2-Hydroxynaphthalen-1-yl)methylideneamino]-3-naphthalen-2-yl-1H-pyrazole-5-carboxamideKi1060.0 [1]
4-Methyl-N-[2-[[2-[(4-methylphenyl)sulfonylamino]phenyl]iminomethyl]phenyl]benzenesulfonamideKi27000.0 [1]
(2S,3R)-2-Amino-3-hydroxy-N-(4-octylphenyl)butanamideIC50650.0 [1]
(2S,3S)-N-[[4-(5-Heptyl-1,2,4-oxadiazol-3-yl)phenyl]methyl]-3-hydroxypyrrolidine-2-carboxamideIC5068.0 [1]
(2S,3S)-N-[(1S)-1-[4-[5-(2-Cyclopentylethyl)-1,2,4-oxadiazol-3-yl]phenyl]ethyl]-3-hydroxypyrrolidine-2-carboxamideIC5058.0 [1]
(2S,3S,4R)-4-Amino-2-tetradecyloxolan-3-olIC50820.0 [1]
2-Anilino-7-[(1S)-4-hydroxy-2,3-dihydro-1H-inden-1-yl]-5,5-dimethylpyrrolo[2,3-d]pyrimidin-6-oneIC5010000.0 [1]
4-Methyl-N-[4-(1,3-thiazol-2-yl)-1,3-thiazol-2-yl]-1,3-thiazol-2-amineIC507300.0 [1]
2-[3-(3-Piperidin-4-ylpropoxy)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamideKi10000.0 [1]
2-[3-(Methanesulfonamido)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamideKi10000.0 [1]
2-[3-[3-(4-Methylpiperazin-1-yl)propoxy]phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamideKi10000.0 [1]
1-[3-(4-Decylphenyl)-1,2,4-oxadiazol-5-yl]cyclopropane-1-carboximidamide;hydrochlorideKi440.0 [1]
(2R)-2-[3-(4-Octylphenyl)-1,2,4-oxadiazol-5-yl]pyrrolidine-1-carboximidamideKi13000.0 [1]
4-[[5-(4-Iodophenyl)-1,3,4-oxadiazol-2-yl]amino]phenolIC5020000.0 [1]
5-(4-Chlorophenyl)-N-(pyridin-4-ylmethyl)-1,3,4-oxadiazol-2-amineIC503100.0 [1]
(2S,3S)-N-[(1R)-1-[4-[5-(2-Cyclopentylethyl)-1,2,4-oxadiazol-3-yl]phenyl]ethyl]-3-hydroxypyrrolidine-2-carboxamideIC5058.0 [1]
(2S)-2-[3-(4-Octylphenyl)-1,2,4-oxadiazol-5-yl]azetidine-1-carboximidamide;hydrochlorideKi10000.0 [1]
(2S,3S)-3-Hydroxy-2-[3-(4-octylphenyl)-1,2,4-oxadiazol-5-yl]pyrrolidine-1-carboximidamide;hydrochlorideKi10000.0 [1]
(2S,4R)-4-Hydroxy-2-[3-(4-octylphenyl)-1,2,4-oxadiazol-5-yl]pyrrolidine-1-carboximidamide;hydrochlorideKi10000.0 [1]
(2S,3S,4R)-4-Amino-2-[2-(3-heptylphenyl)ethyl]oxolan-3-olIC5030000.0 [1]
(2S,3S,4R)-4-Amino-2-[10-(cyclohexylmethoxy)decyl]oxolan-3-olIC50220.0 [1]
(3R,4S,5S)-4-Methoxy-5-tetradecyloxolan-3-amineIC504000.0 [1]
(3S,5R)-5-(Hydroxymethyl)-1-[3-[4-[[4-[3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]amino]phenyl]propyl]pyrrolidin-3-olIC5020.0 [1]
N-(1-Carbamimidoylcyclopropyl)-3-dodecylbenzamide;hydrochlorideKi4600.0 [1]
1-[3-(4-Tridecylphenyl)-1,2,4-oxadiazol-5-yl]cyclopropane-1-carboximidamide;hydrochlorideKi2500.0 [1]
1-[3-(3-Decylphenyl)-1,2,4-oxadiazol-5-yl]cyclopropane-1-carboximidamide;hydrochlorideKi100.0 [1]
1-[3-(3-Undecylphenyl)-1,2,4-oxadiazol-5-yl]cyclopropane-1-carboximidamide;hydrochlorideKi70.0 [1]
3,4,5-Trihydroxy-N-[(E)-[3-[(2-methylphenyl)methoxy]phenyl]methylideneamino]benzamideIC5063240.0 [1]
3,4,5-Trihydroxy-N-[(E)-[3-[(3-methylphenyl)methoxy]phenyl]methylideneamino]benzamideIC5052100.0 [1]
3,4,5-Trihydroxy-N-[(E)-[3-[(4-methylphenyl)methoxy]phenyl]methylideneamino]benzamideIC5045790.0 [1]
3,4,5-Trihydroxy-N-[(E)-[3-[[2-(trifluoromethyl)phenyl]methoxy]phenyl]methylideneamino]benzamideIC5019570.0 [1]
3,4,5-Trihydroxy-N-[(E)-[3-[[3-(trifluoromethyl)phenyl]methoxy]phenyl]methylideneamino]benzamideIC50100000.0 [1]
3,4,5-Trihydroxy-N-[(E)-[3-[[4-(trifluoromethyl)phenyl]methoxy]phenyl]methylideneamino]benzamideIC5016260.0 [1]
3,4,5-Trihydroxy-N-[(E)-[4-[(4-methylphenyl)methoxy]phenyl]methylideneamino]benzamideIC5032730.0 [1]
N-[(E)-[3-[(4-Cyanophenyl)methoxy]phenyl]methylideneamino]-3,4,5-trihydroxybenzamideIC5069440.0 [1]
N-[(E)-[4-[(4-Tert-butylphenyl)methoxy]phenyl]methylideneamino]-3,4,5-trihydroxybenzamideIC5040550.0 [1]
3,4,5-Trihydroxy-N-[(E)-[4-(naphthalen-2-ylmethoxy)phenyl]methylideneamino]benzamideIC5020610.0 [1]
3,4,5-Trihydroxy-N-[(E)-[4-[(2-methoxyphenyl)methoxy]phenyl]methylideneamino]benzamideIC5018440.0 [1]
3,4,5-Trihydroxy-N-[(E)-[4-[(3-methoxyphenyl)methoxy]phenyl]methylideneamino]benzamideIC504360.0 [1]
3,4,5-Trihydroxy-N-[(E)-[4-[(4-methoxyphenyl)methoxy]phenyl]methylideneamino]benzamideIC50100000.0 [1]
3-Hydroxy-N-[(E)-[4-[[2-(trifluoromethyl)phenyl]methoxy]phenyl]methylideneamino]benzamideIC50100000.0 [1]
4-Hydroxy-N-[(E)-[4-[[2-(trifluoromethyl)phenyl]methoxy]phenyl]methylideneamino]benzamideIC50100000.0 [1]
4-Hydroxy-N-[(E)-[3-[[2-(trifluoromethyl)phenyl]methoxy]phenyl]methylideneamino]benzamideIC50100000.0 [1]
3,4,5-Trihydroxy-N-[(E)-[4-[[2-(trifluoromethyl)phenyl]methoxy]phenyl]methylideneamino]benzamideIC5015010.0 [1]
3,4,5-Trihydroxy-N-[(E)-[4-[[3-(trifluoromethyl)phenyl]methoxy]phenyl]methylideneamino]benzamideIC5054720.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Sphingosine kinase 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/sphingosine-kinase-1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ Sphingosine kinase 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/sphingosine-kinase-1-inhibitors-ic50-ki.
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