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Sphingosine 1-phosphate receptor Edg-6 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
▲
▼
Standard Values (in nM)
▲
▼
Sphingosine 1-phosphateIC5023.0 [1]
3-(Tetradecylamino)propylphosphonic acidIC50140.0 [1]
FTY720 phosphateIC5015.0 [1]
\n\n - Open Babel Depiction\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\nN\nO\nS\nF\nF\nF\nO\nHO\n\n\n\n\n1-(4-((4-Phenyl-5-(trifluoromethyl)thiophen-2-yl)methoxy)benzyl)azetidine-3-carboxylic acidIC501600.0 [1]
Merck SIP AgonistIC5070.0 [1]
5-(2,5-Dichlorophenyl)-N-(2,6-dimethylphenyl)furan-2-carboxamideIC5078.0 [1]
[(1R,3R)-3-Amino-1-hydroxy-5-(4-octylphenyl)pentyl]phosphonic acidIC5016.0 [1], 280.0 [2]
[3-(4-Nonyl-benzylamino)-propyl]-phosphonic acidIC5026.0 [1], 260.0 [2]
Phosphonic acid, [3-amino-5-(4-octylphenyl)pentyl]-IC50240.0 [1]
1-(4-Nonylbenzyl)pyrrolidin-3-ylphosphonic acidIC5045.0 [1], 86.0 [2]
(S)-2-Amino-3-(4-(2-(biphenyl-4-yl)ethoxy)phenylamino)-2-methyl-3-oxopropyl dihydrogen phosphateIC504.17 [1], 10.3 [2]
(R)-2-Amino-2-(4-(4-(biphenyl-4-ylmethoxy)phenyl)-1H-imidazol-2-yl)propyl dihydrogen phosphateIC504.87 [1], 4.9 [2]
CID 54580603IC5064.0 [1]
FingolimodIC5010000.0 [1]
5-[4-Phenyl-5-(trifluoromethyl)-2-thienyl]-3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazoleIC5010000.0 [1]
Fingolimod phosphate ester, S-IC502.2 [1]
CeralifimodKi28.8 [1]
5-(2,4-Dichlorophenyl)-N-(2,6-dimethylphenyl)furan-2-carboxamideIC502000.0 [1]
N-(4-(Aminomethyl)-2,6-dimethylphenyl)-5-(2,5-dichlorophenyl)furan-2-carboxamideIC5025.0 [1]
CID 59393720IC5010000.0 [1]
5-(2,5-Difluorophenyl)-N-(2,6-dimethylphenyl)-2-furancarboxamideIC50308.0 [1]
5-(2,5-Dichlorophenyl)-N-(2,6-dimethoxyphenyl)-2-furancarboxamideIC50417.0 [1]
5-(2,5-Dichlorophenyl)-N-[2,6-di(propan-2-yl)phenyl]-2-furancarboxamideIC50105.0 [1]
5-(2,5-Dichlorophenyl)-N-(2,6-diethylphenyl)-2-furancarboxamideIC5089.0 [1]
N-(2,6-Dimethylphenyl)-5-(4-methyl-3-thiophenyl)-2-furancarboxamideIC50286.0 [1]
CID 90309142IC5010000.0 [1]
1-[[4-[5-[4-Phenyl-5-(trifluoromethyl)thiophen-2-yl]-1,2,4-oxadiazol-3-yl]phenyl]methyl]azetidine-3-carboxylic acidIC5010000.0 [1]
3-(4-(5-(3-Cyano-4-isopropyloxyphenyl)-1,2,4-oxadiazol-3-yl)-3-methylphenyl)propanoic acidIC5010000.0 [1]
4-Amino-6-(4-octylphenyl)hexanoic AcidIC5010000.0 [1]
3-(3-Bromo-5-methoxy-4-(octyloxy)benzylamino)propylphosphonic acidIC5080.0 [1]
3-Amino-5-(4-octylphenyl)pentanoic AcidIC5010000.0 [1]
[2-Amino-4-(4-octylphenyl)butyl] dihydrogen phosphateIC501.7 [1]
[3-Amino-3-hydroxymethyl-5-(4-octyl-phenyl)-pentyl]-phosphonic acidIC50210.0 [1]
1-{4-[5-(4-Tert-butylphenyl)-1,3,4-oxadiazol-2-yl]benzyl}azetidine-3-carboxylic acidIC504300.0 [1]
1-{4-[3-(4-Tert-butylphenyl)-1,2,4-oxadiazol-5-yl]benzyl}azetidine-3-carboxylic acidIC50640.0 [1]
3-[3-Methyl-4-[5-[4-propan-2-yloxy-3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]propanoic acidIC5010000.0 [1]
[(2R)-2-Amino-2-[5-[4-[(4-phenylphenyl)methoxy]-3-(trifluoromethyl)phenyl]-1H-imidazol-2-yl]propyl] dihydrogen phosphateIC504.4 [1]
4-[3-(4-Fluorophenoxy)-5-[[4-(4-fluorophenyl)-4-hydroxypiperidine-1-carbonyl]amino]phenoxy]benzoic acidIC5010000.0 [1]
1-({4-[5-(4-Butylphenyl)-1,2,4-oxadiazol-3-yl]phenyl}methyl)azetidine-3-carboxylic acidIC5070.0 [1]
(3-Amino-heptadecyl)-phosphonic acidIC5076.0 [1]
2-Hydroxy-4-(4-nonyl-benzylamino)-butyric acidIC501200.0 [1]
3-Fluoro-4-(4-nonyl-benzylamino)-butyric acidIC50600.0 [1]
1-(4-Nonylbenzyl)azetidine-3-carboxylic acidIC505400.0 [1]
[3-Amino-2-hydroxy-5-(4-octylphenyl)pentyl]phosphonic acidIC50140.0 [1]
[3-(3-Bromo-5-methoxy-4-nonyloxy-benzylamino)-propyl]-phosphonic acidIC5033.0 [1]
2,2-Difluoro-4-(4-nonyl-benzylamino)-butyric acidIC504000.0 [1]
1-(4-((4-Phenyl-5-(trifluoromethyl)thiophen-2-yl)methoxy)benzyl)pyrrolidine-3-carboxylic acidIC50790.0 [1]
(3-Amino-hexadecyl)-phosphonic acidIC50140.0 [1]
1-(4-Nonylbenzyl)pyrrolidine-3-carboxylic acidIC502500.0 [1]
(3-Amino-henicosyl)-phosphonic acidIC5010000.0 [1]
1-(3-Chloro-4-((4-phenyl-5-(trifluoromethyl)thiophen-2-yl)methoxy)benzyl)azetidine-3-carboxylic acidIC501300.0 [1]
4-(4-Nonyl-benzylamino)-butyric acidIC5010000.0 [1]
1-({4-[5-(4-Tert-butylphenyl)-1,2,4-oxadiazol-3-yl]phenyl}methyl)azetidine-3-carboxylic acidIC50370.0 [1]
1-[(4-{5-[4-(Propan-2-yloxy)phenyl]-1,2,4-oxadiazol-3-yl}phenyl)methyl]azetidine-3-carboxylic acidIC50370.0 [1]
1-({4-[5-(4-Phenylphenyl)-1,2,4-oxadiazol-3-yl]phenyl}methyl)azetidine-3-carboxylic acidIC50240.0 [1]
Methyl-[3-(4-nonyl-benzylamino)-propyl]-phosphinic acidIC50590.0 [1]
1-(3-Methyl-4-((4-phenyl-5-(trifluoromethyl)thiophen-2-yl)methoxy)benzyl)azetidine-3-carboxylic acidIC501500.0 [1]
3-Hydroxy-4-(4-nonyl-benzylamino)-butyric acidIC501400.0 [1]
3-Amino-5-(4-octyl-phenyl)-pentane-1-sulfonic acidIC5010000.0 [1]
1-[[3-Methoxy-4-[[4-phenyl-5-(trifluoromethyl)thiophen-2-yl]methoxy]phenyl]methyl]azetidine-3-carboxylic acidIC502800.0 [1]
1-({4-[5-(4-Propylphenyl)-1,2,4-oxadiazol-3-yl]phenyl}methyl)azetidine-3-carboxylic acidIC50150.0 [1]
1-[[4-[5-[4-(2-Methylbutan-2-yl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]methyl]azetidine-3-carboxylic acidIC5075.0 [1]
1-({4-[5-(4-Cyclopentylphenyl)-1,2,4-oxadiazol-3-yl]phenyl}methyl)azetidine-3-carboxylic acidIC5049.0 [1]
1-({4-[5-(4-Hexylphenyl)-1,2,4-oxadiazol-3-yl]phenyl}methyl)azetidine-3-carboxylic acidIC5010000.0 [1]
1-[[4-[5-[4-(2,2-Dimethylpropyl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]methyl]azetidine-3-carboxylic acidIC5090.0 [1]
5-(2,5-Dichlorophenyl)-N-(2,5-dimethylphenyl)furan-2-carboxamideIC50165.0 [1]
1-[[4-[[4-Phenyl-5-(trifluoromethyl)thiophen-2-yl]methoxy]-3-(trifluoromethyl)phenyl]methyl]azetidine-3-carboxylic acidIC50340.0 [1]
(5Z)-5-[[3-Chloro-4-[(2S)-2,3-dihydroxypropoxy]phenyl]methylidene]-3-(2-methylphenyl)-2-propylimino-1,3-thiazolidin-4-oneIC501956.0 [1]
1-[[3-Fluoro-4-[[4-phenyl-5-(trifluoromethyl)thiophen-2-yl]methoxy]phenyl]methyl]azetidine-3-carboxylic acidIC502700.0 [1]
1-[[3-Ethyl-4-[[4-phenyl-5-(trifluoromethyl)thiophen-2-yl]methoxy]phenyl]methyl]azetidine-3-carboxylic acidIC5010000.0 [1]
1-[[3,5-Dimethyl-4-[[4-phenyl-5-(trifluoromethyl)thiophen-2-yl]methoxy]phenyl]methyl]azetidine-3-carboxylic acidIC50120.0 [1]
1-[[3-Bromo-4-[[4-phenyl-5-(trifluoromethyl)thiophen-2-yl]methoxy]phenyl]methyl]azetidine-3-carboxylic acidIC502400.0 [1]
2-(trans-5-(4-(5-(4-Isobutylphenyl)-1,2,4-oxadiazol-3-yl)phenyl)pyrrolidin-3-yl)acetic acidIC50150.0 [1]
3-[3-Methyl-4-[5-[4-propan-2-yloxy-3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]butanoic acidIC5010000.0 [1]
1-({4-[5-(4-Ethoxyphenyl)-1,2,4-oxadiazol-3-yl]phenyl}methyl)azetidine-3-carboxylic acidIC501000.0 [1]
(S)-2-Amino-3-(4-(3-(biphenyl-4-yl)propanoyl)phenylamino)-2-methyl-3-oxopropyl dihydrogen phosphateIC5013.1 [1]
1-[[4-[5-[4-[(1R)-3,3-Difluorocyclopentyl]phenyl]-1,2,4-oxadiazol-3-yl]phenyl]methyl]azetidine-3-carboxylic acidIC5089.0 [1]
1-({4-[5-(4-Cyclopropylphenyl)-1,2,4-oxadiazol-3-yl]phenyl}methyl)azetidine-3-carboxylic acidIC501000.0 [1]
1-[[4-[5-[4-[(1S)-3,3-Difluorocyclopentyl]phenyl]-1,2,4-oxadiazol-3-yl]phenyl]methyl]azetidine-3-carboxylic acidIC5068.0 [1]
1-({4-[5-(4-Cyclobutylphenyl)-1,2,4-oxadiazol-3-yl]phenyl}methyl)azetidine-3-carboxylic acidIC50520.0 [1]
2-Methyl-3-[3-methyl-4-[5-[4-propan-2-yloxy-3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]propanoic acidIC5010000.0 [1]
(S)-2-Amino-3-(4-(biphenyl-4-ylmethoxy)phenylamino)-2-methyl-3-oxopropyl dihydrogen phosphateIC506.15 [1]
(S)-2-Amino-3-(4-(biphenyl-4-yloxy)phenylamino)-2-methyl-3-oxopropyl dihydrogen phosphateIC50123.0 [1]
1-[[4-[5-[4-(3,3,3-Trifluoropropyl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]methyl]azetidine-3-carboxylic acidIC50430.0 [1]
1-[[3,5-Dichloro-4-[[4-phenyl-5-(trifluoromethyl)thiophen-2-yl]methoxy]phenyl]methyl]azetidine-3-carboxylic acidIC50640.0 [1]
4-(2-Ethylbutyl)-N-[3-(4-fluorophenoxy)-5-pyridin-4-yloxyphenyl]-4-hydroxypiperidine-1-carboxamideIC5010000.0 [1]
(3-Hexadecylamino-propyl)-phosphonic acidIC50800.0 [1]
[2-Amino-1-hydroxy-4-(4-octylphenyl)butan-2-yl] dihydrogen phosphateIC5015.0 [1]
3-(5-{5-[3-Cyano-4-(propan-2-yloxy)phenyl]-1,2,4-oxadiazol-3-yl}-6-methylpyridin-2-yl)propanoic acidIC5010000.0 [1]
3-Phenyl-5-(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)-1,2,4-oxadiazoleIC5010000.0 [1]
3-(2,4-Dichlorophenyl)-5-[4-phenyl-5-(trifluoromethyl)thiophen-2-yl]-1,2,4-oxadiazoleIC5010000.0 [1]
[(1S,3R)-3-Amino-1-hydroxy-5-(4-octylphenyl)pentyl]phosphonic acidIC5016.0 [1]
[(1R,3S)-3-Amino-1-hydroxy-5-(4-octylphenyl)pentyl]phosphonic acidIC50880.0 [1]
[3-Amino-2-hydroxy-5-(4-octylphenyl)pentyl]phosphonic acid;[(E)-3-amino-5-(4-octylphenyl)pent-1-enyl]phosphonic acidIC50140.0 [1]
[(1S,3S)-3-Amino-1-hydroxy-5-(4-octylphenyl)pentyl]phosphonic acidIC50500.0 [1]
(3-Tridecylamino-propyl)-phosphonic acidIC50200.0 [1]
(3-Dodecylamino-propyl)-phosphonic acidIC50650.0 [1]
{3-[4-(4-Heptyl-phenyl)-butylamino]-propyl}-phosphonic acidIC5010000.0 [1]
3-[(4-Nonylphenyl)methylamino]propylphosphonous acidIC50900.0 [1]
[3-(10-Phenyl-decylamino)-propyl]-phosphonic acidIC50140.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Sphingosine 1-phosphate receptor Edg-6 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/sphingosine-1-phosphate-receptor-edg-6-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 20). Quest Database™ Sphingosine 1-phosphate receptor Edg-6 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/sphingosine-1-phosphate-receptor-edg-6-inhibitors-ic50-ki.
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