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Sphingosine-1-phosphate lyase 1 Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
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▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
FingolimodIC5017000.0 [1], 52000.0 [2]
1-Benzyl-4-[(3R)-4-(5-cyanopyridin-2-yl)-3-methylpiperazin-1-yl]phthalazine-6-carbonitrileIC5024.0 [1], 93.5 [2]
N-[(1S)-2-[(4-Methoxy-2,5-dimethylphenyl)methylamino]-1-phenylethyl]-5-methyl-1,2-oxazole-3-carboxamideIC50485.0 [1], 1300.0 [2]
N-[1-[4-(4-Amino-4-oxobutyl)phenyl]-2-[(4-methoxy-2,5-dimethylphenyl)methylamino]ethyl]-5-methyl-1,2-oxazole-3-carboxamideIC50150.0 [1], 4400.0 [2]
N-[1-[4-(3-Hydroxyprop-1-ynyl)phenyl]-2-[(4-methoxy-2,5-dimethylphenyl)methylamino]ethyl]-5-methyl-1,2-oxazole-3-carboxamideIC50150.0 [1], 3700.0 [2]
N-[2-[(4-Butoxy-2,5-dimethylphenyl)methylamino]-1-phenylethyl]-5-methyl-1,2-oxazole-3-carboxamideIC50117.0 [1], 230.0 [2]
N-[2-[(4-Methoxy-2,5-dimethylphenyl)methylamino]-1-phenylethyl]-5-methyl-1,2-oxazole-3-carboxamideIC501000.0 [1], 1800.0 [2]
N-[2-[(4-Ethoxy-2,5-dimethylphenyl)methylamino]-1-phenylethyl]-5-methyl-1,2-oxazole-3-carboxamideIC50260.0 [1], 930.0 [2]
N-[2-[[2,5-Dimethyl-4-(2,2,2-trifluoroethoxy)phenyl]methylamino]-1-phenylethyl]-5-methyl-1,2-oxazole-3-carboxamideIC50240.0 [1], 590.0 [2]
5-Cyclopropyl-N-[2-[(4-methoxy-2,5-dimethylphenyl)methylamino]-1-phenylethyl]-1,2-oxazole-3-carboxamideIC50730.0 [1], 5500.0 [2]
N-[2-[(4-Methoxy-2,5-dimethylphenyl)methylamino]-1-pyridin-4-ylethyl]-5-methyl-1,2-oxazole-3-carboxamideIC50850.0 [1], 25000.0 [2]
N-[2-[[4-Methoxy-2-methyl-5-(trifluoromethyl)phenyl]methylamino]-1-phenylethyl]-5-methyl-1,2-oxazole-3-carboxamideIC501200.0 [1], 2700.0 [2]
N-[1-(4-Fluorophenyl)-2-[(4-methoxy-2,5-dimethylphenyl)methylamino]ethyl]-5-methyl-1,2-oxazole-3-carboxamideIC50720.0 [1], 7200.0 [2]
2-Acetyl-4(5)-tetrahydroxybutylimidazoleIC50100000.0 [1]
6-[(2r)-4-(4-Benzyl-7-Chlorophthalazin-1-Yl)-2-Methylpiperazin-1-Yl]pyridine-3-CarbonitrileIC50210.0 [1]
1-(4-(1,2,3,4-Tetrahydroxybutyl)-1H-imidazol-2-yl)ethanone oximeIC50100000.0 [1]
6-[4-(4-Benzylphthalazin-1-yl)piperazin-1-yl]nicotinonitrileIC5030000.0 [1]
6-[(S)-4-(4-Benzylphthalazin-1-yl)-2-methylpiperazin-1-yl]nicotinonitrileIC5030000.0 [1]
6-[(R)-4-(4-Benzylphthalazin-1-yl)-2-methylpiperazin-1-yl]nicotinonitrileIC502400.0 [1]
N-[2-[(4-Methoxy-2,5-dimethylphenyl)methylamino]-2-oxo-1-phenylethyl]-5-methyl-1,2-oxazole-3-carboxamideIC5039200.0 [1]
N-[1-[3-(4-Amino-4-oxobutyl)phenyl]-2-[(4-methoxy-2,5-dimethylphenyl)methylamino]ethyl]-5-methyl-1,2-oxazole-3-carboxamideIC509600.0 [1]
N-[2-[[2,5-Dimethyl-4-(pyridin-4-ylmethoxy)phenyl]methylamino]-1-phenylethyl]-5-methyl-1,2-oxazole-3-carboxamideIC501000.0 [1]
N-[2-[(4-Methoxy-2,5-dimethylphenyl)methylamino]-1-phenylethyl]-3-methyl-1,2-oxazole-5-carboxamideIC503800.0 [1]
5-Methoxy-N-[2-[(4-methoxy-2,5-dimethylphenyl)methylamino]-1-phenylethyl]-1,2-oxazole-3-carboxamideIC509200.0 [1]
5-Cyclopropyl-N-[2-[(4-ethoxy-2,5-dimethylphenyl)methylamino]-1-(4-fluorophenyl)ethyl]-1,2-oxazole-3-carboxamideIC504600.0 [1]
N-[2-[(4-Methoxy-2,5-dimethylphenyl)methylamino]-1-(2-methoxyphenyl)ethyl]-5-methyl-1,2-oxazole-3-carboxamideIC5050000.0 [1]
N-[2-[(4-Methoxy-2,5-dimethylphenyl)methylamino]-1-(3-methoxyphenyl)ethyl]-5-methyl-1,2-oxazole-3-carboxamideIC507300.0 [1]
N-[2-[(4-Methoxy-2,5-dimethylphenyl)methylamino]-1-(4-methoxyphenyl)ethyl]-5-methyl-1,2-oxazole-3-carboxamideIC505000.0 [1]
N-[2-[(4-Methoxyphenyl)methylamino]-1-phenylethyl]-5-methyl-1,2-oxazole-3-carboxamideIC5050000.0 [1]
N-[2-[(4-Methoxy-2,5-dimethylphenyl)methylamino]-1-phenylethyl]-1,2-oxazole-3-carboxamideIC506400.0 [1]
6-[(R)-4-(4-Benzyl-phthalazin-1-yl)-2-methyl-piperazin-1-yl]-nicotinic acid ethyl esterIC503400.0 [1]
1-Benzyl-4-[(3R)-3-methyl-4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]phthalazineIC5030000.0 [1]
1-Benzyl-4-[(3R)-3-methyl-4-(5-nitropyridin-2-yl)piperazin-1-yl]phthalazineIC50740.0 [1]
6-[(2R)-4-(4-Benzylphthalazin-1-yl)-2-methylpiperazin-1-yl]pyridine-3-carboxylic acidIC5030000.0 [1]
6-[(2R)-4-(4-Benzylphthalazin-1-yl)-2-ethylpiperazin-1-yl]pyridine-3-carbonitrileIC501700.0 [1]
6-[(2R)-4-(4-Benzylphthalazin-1-yl)-2-propan-2-ylpiperazin-1-yl]pyridine-3-carbonitrileIC502500.0 [1]
6-[(2R)-4-(4-Benzylphthalazin-1-yl)-2-(hydroxymethyl)piperazin-1-yl]pyridine-3-carbonitrileIC5030000.0 [1]
6-[(2R)-4-(4-Chlorophthalazin-1-yl)-2-methylpiperazin-1-yl]pyridine-3-carbonitrileIC5030000.0 [1]
6-[(2R)-2-Methyl-4-(4-phenylphthalazin-1-yl)piperazin-1-yl]pyridine-3-carbonitrileIC5030000.0 [1]
6-[(2R)-2-Methyl-4-[4-(2-phenylethyl)phthalazin-1-yl]piperazin-1-yl]pyridine-3-carbonitrileIC5030000.0 [1]
6-[(2R)-4-(4-Benzyl-6-chlorophthalazin-1-yl)-2-methylpiperazin-1-yl]pyridine-3-carbonitrileIC502300.0 [1]
6-[(2R)-4-[4-Benzyl-6-(trifluoromethyl)phthalazin-1-yl]-2-methylpiperazin-1-yl]pyridine-3-carbonitrileIC5012000.0 [1]
6-[(2R)-4-[4-Benzyl-7-(trifluoromethyl)phthalazin-1-yl]-2-methylpiperazin-1-yl]pyridine-3-carbonitrileIC50100.0 [1]
4-Benzyl-1-[(3R)-4-(5-cyanopyridin-2-yl)-3-methylpiperazin-1-yl]phthalazine-6-carbonitrileIC501300.0 [1]
Items per page: 1 - 10 of 44
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References

This online tool may be cited as follows

MLA

"Quest Database™ Sphingosine-1-phosphate lyase 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Nov. 2024, https://www.aatbio.com/data-sets/sphingosine-1-phosphate-lyase-1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 20). Quest Database™ Sphingosine-1-phosphate lyase 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/sphingosine-1-phosphate-lyase-1-inhibitors-ic50-ki.
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