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Sphingomyelin phosphodiesterase Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
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▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
ChlorpromazineIC5011000.0 [1]
ImipramineIC505000.0 [1]
alpha-MangostinIC5024740.0 [1]
Myo-inositol 1,3,5-trisphosphateIC5026700.0 [1]
6-[4-(3-Chlorophenyl)piperazin-1-yl]sulfonyl-7-methyl-1,4-dihydroquinoxaline-2,3-dioneIC5019952.6 [1]
6-Methyl-7-[4-[3-(trifluoromethyl)phenyl]piperazino]sulfonyl-1,4-dihydroquinoxaline-2,3-quinoneIC5019952.6 [1]
4-(4-Methoxy-benzyl)-4H-benzo[1,4]oxazin-3-oneIC50250000.0 [1]
2-[3-[(E)-[5-(4-Chlorophenyl)-7-methyl-3-oxo-6-(phenylcarbamoyl)-5H-[1,3]thiazolo[3,2-a]pyrimidin-2-ylidene]methyl]phenoxy]acetic acidIC5025118.9 [1]
3-Methyl-5-(morpholin-4-ylsulfonyl)-N-[3-(trifluoromethyl)phenyl]-1-benzofuran-2-carboxamideIC5022382.7 [1]
2-(1-Benzo[e]benzofuranyl)-N-[4-methoxy-3-(4-morpholinylsulfonyl)phenyl]acetamideIC5014125.4 [1]
6-[(E)-[(5-Chloro-3-phenyl-1H-indole-2-carbonyl)hydrazinylidene]methyl]-2,3-dimethoxybenzoic acidIC5014125.4 [1]
N-Hydroxy-4-methoxy-3-phenylmethoxybenzamideIC5010490.0 [1]
3-Decoxy-N-hydroxy-4-methoxybenzamideIC50480.0 [1]
1,3,6-Trihydroxy-7-methoxy-2,8-bis(3-methylbutyl)xanthen-9-oneIC5010090.0 [1]
CowaninIC5019200.0 [1]
1,7-Dihydroxy-3,6-dimethoxy-2,8-diprenylxanthoneIC50169600.0 [1]
2,4-Dioxo-3-(4-methoxybenzyl)-1,2,3,4-tetrahydroquinazolineIC50250000.0 [1]
[(3S,4R)-1,1-Difluoro-3-(hexadecanoylamino)-4-hydroxy-4-phenylbutyl]phosphonic acidIC5049000.0 [1]
(2,4-Dihydroxy-5-methoxyphenyl)-[2,4,6-trihydroxy-3-(3-methylbut-2-enyl)phenyl]methanoneIC5066000.0 [1]
[4,6-Dihydroxy-3-methoxy-2-(3-methylbut-2-enyl)phenyl]-(2,4,6-trihydroxyphenyl)methanoneIC5014700.0 [1]
[(2R,3S,4S,5R)-4,6-Dihydroxy-3,5-diphosphonooxyoxan-2-yl]methyl octane-1-sulfonateIC502340.0 [1]
[(2R,3S,4S,5R)-4,6-Dihydroxy-3,5-diphosphonooxyoxan-2-yl]methyl hexane-1-sulfonateIC504160.0 [1]
3-Carbazol-9-yl-N-[2-(3,4-dimethoxyphenyl)ethyl]-N-methylpropan-1-amineIC5014000.0 [1]
9-(4-Methoxybenzyl)-9H-carbazoleIC50156000.0 [1]
10-[3-[(3S,5R)-4-[2-(4-Methoxyphenyl)ethyl]-3,5-dimethylpiperazin-1-yl]propyl]phenoxazineIC5043000.0 [1]
N-[2-(4-Methoxyphenyl)ethyl]-N-methyl-3-phenothiazin-10-ylpropan-1-amineIC509000.0 [1]
6-[2-(4-Methoxyphenyl)ethyl]-6,10-diazatetracyclo[8.6.1.05,17.011,16]heptadeca-1(17),11,13,15-tetraeneIC5015000.0 [1]
N-[2-(3,4-Dimethoxyphenyl)ethyl]-N-methyl-3-phenothiazin-10-ylpropan-1-amineIC5016000.0 [1]
4-[2-(4-Methoxyphenyl)ethyl]-1,4-diazatetracyclo[7.6.1.05,16.010,15]hexadeca-9(16),10,12,14-tetraeneIC50250000.0 [1]
4-[3-[2-(4-Methoxyphenyl)ethyl-methylamino]propyl]-1,4-benzoxazin-3-oneIC5038000.0 [1]
N-[2-(4-Methoxyphenyl)ethyl]-N-methyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylidene)propan-1-amineIC5010000.0 [1]
2-[(Z)-(2-Imino-1-propan-2-ylindol-3-ylidene)methyl]-3H-quinazolin-4-oneIC5031622.8 [1]
3-(11,12-Dihydro-6H-benzo[c][1]benzazocin-5-yl)-N-[2-(4-methoxyphenyl)ethyl]-N-methylpropan-1-amineIC5017000.0 [1]
N-Benzyl-N-[2-(4-methoxyphenyl)ethyl]pyridin-2-amineIC50250000.0 [1]
1-Phosphonooxyundecyl dihydrogen phosphateIC50310.0 [1]
[(2R,3S,4R,5R)-4,6-Dihydroxy-3,5-diphosphonooxyoxan-2-yl] dodecane-1-sulfonateIC50440.0 [1]
3-Dodecoxy-N-hydroxybenzamideIC5013060.0 [1]
N-Hydroxy-3-octoxybenzamideIC5017420.0 [1]
3-Decoxy-N-hydroxybenzamideIC501420.0 [1]
3-Indol-1-yl-N-[2-(4-methoxyphenyl)ethyl]-N-methylpropan-1-amineIC5021000.0 [1]
9-[3-[(3S,5R)-4-[2-(3,4-Dimethoxyphenyl)ethyl]-3,5-dimethylpiperazin-1-yl]propyl]carbazoleIC50141000.0 [1]
(1-Amino-1-phosphonooxydodecyl) dihydrogen phosphateIC50290.0 [1]
(E)-4-(2,8-Dihydroxy-3,6-dimethoxy-9-oxoxanthen-1-yl)-N-ethylbut-2-enamideIC504890.0 [1]
N-[2-(3,4-Dimethoxyphenyl)ethyl]-N'-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenyl)propane-1,3-diamineIC5039000.0 [1]
N-[2-(2-Chlorophenothiazin-10-yl)ethyl]-2-(3,4-dimethoxyphenyl)-N-methylethanamineIC50250000.0 [1]
[1-(2,4-Dichlorophenyl)-5-phenylpyrazol-3-yl]-morpholin-4-ylmethanoneIC5028183.8 [1]
1-Phosphonooxyoctyl dihydrogen phosphateIC50350.0 [1]
3-Carbazol-9-yl-N-[2-[4-[2-[3-carbazol-9-ylpropyl(methyl)amino]ethyl]-2,5-dimethoxyphenyl]ethyl]-N-methylpropan-1-amineIC5010000.0 [1]
3-[(4-Bromophenyl)methoxy]-N-hydroxy-4-methoxybenzamideIC507780.0 [1]
3-Heptyl-6,8-dihydroxy-1-methyl-3,4-dihydro-1H-isochromene-7-carboxylic acidIC5068700.0 [1]
3-[(4-Cyanophenyl)methoxy]-N-hydroxybenzamideIC5052870.0 [1]
N-(3-Carbazol-9-ylpropyl)-2-(4-methoxyphenyl)-N-methylacetamideIC50250000.0 [1]
(E)-4-(2,8-Dihydroxy-3,6-dimethoxy-9-oxoxanthen-1-yl)-N,N-diethylbut-2-enamideIC504890.0 [1]
N-Hydroxy-4-methoxy-3-octoxybenzamideIC5016090.0 [1]
1-Phosphonooxydecyl dihydrogen phosphateIC50300.0 [1]
(1-Amino-1-phosphonooxydecyl) dihydrogen phosphateIC5020.0 [1]
N-Hydroxy-3-[(4-methoxyphenyl)methoxy]benzamideIC5042680.0 [1]
3-Decoxy-N,4-dihydroxybenzamideIC5017430.0 [1]
(2-Butyl-1-benzofuran-3-yl)-[4-[2-(diethylamino)ethoxy]-2,5-diiodophenyl]methanoneIC5039810.7 [1]
3-Decoxy-N-(2-hydroxyethyl)-4-methoxybenzamideIC5071000.0 [1]
9-[3-[(3S,5R)-4-[2-(4-Methoxyphenyl)ethyl]-3,5-dimethylpiperazin-1-yl]propyl]carbazoleIC509000.0 [1]
3-Dodecoxy-N-hydroxy-4-methoxybenzamideIC5018550.0 [1]
(1-Hydroxy-1-phosphonooxydodecyl) dihydrogen phosphateIC5070.0 [1]
3-Decoxy-N-(2-hydroxypropyl)-4-methoxybenzamideIC5085200.0 [1]
1-[2-(4-Methoxyphenyl)ethyl]-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenyl)-1,3-diazinaneIC5011000.0 [1]
N-[2-(4-Methoxyphenyl)ethyl]-N'-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenyl)propane-1,3-diamineIC5017000.0 [1]
2-(6-Bromo-4H-1,3-benzodioxin-8-yl)-3-amino-6-ethoxy-4H-1-benzopyran-4-oneIC503500.0 [1]
1,3-Bis[(4-methoxyphenyl)methyl]quinazoline-2,4-dioneIC50250000.0 [1]
N-[2-(3,4-Dimethoxyphenyl)ethyl]-N-methyl-3-phenoxazin-10-ylpropan-1-amineIC5013000.0 [1]
3-Carbazol-9-yl-N-[(4-methoxyphenyl)methyl]-N-methylpropan-1-amineIC5029000.0 [1]
4-Carbazol-9-yl-1,1,2,2,3,3,4,4-octafluoro-N-[2-(4-methoxyphenyl)ethyl]-N-methylbutan-1-amineIC50250000.0 [1]
2-(4-Methoxyphenyl)-N-(naphthalen-1-ylmethyl)ethanamineIC50240000.0 [1]
(5E)-3-[[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]amino]-2-sulfanylidene-5-[(3,4,5-trimethoxyphenyl)methylidene]-1,3-thiazolidin-4-oneIC5028183.8 [1]
5-Acetoxy-6-bromo-2-carbamimidoylsulfanylmethyl-1-methyl-1H-indole-3-carboxylic acid octyl esterIC5031622.8 [1]
3-((4-Bromobenzyl)oxy)-N-hydroxybenzamideIC5019420.0 [1]
2-(3,4-Dimethoxyphenyl)-N-(naphthalen-1-ylmethyl)ethanamineIC5096000.0 [1]
2-(Trifluoromethyl)-3-(4-methylthiazole-2-yl)-6-methyl-7-hydroxy-4H-1-benzopyran-4-oneIC5010720.0 [1]
1-[2-(3,4-Dimethoxyphenyl)ethyl]-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenyl)-1,3-diazinaneIC5022000.0 [1]
3-(2-Chlorophenothiazin-10-yl)-N-[2-(4-methoxyphenyl)ethyl]-N-methylpropan-1-amineIC50134000.0 [1]
N-[2-(3,4-Dimethoxyphenyl)ethyl]-N-methyl-N',N'-diphenylpropane-1,3-diamineIC5056000.0 [1]
3-(2-Chlorophenothiazin-10-yl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-N-methylpropan-1-amineIC5012000.0 [1]
N-[2-(4-Methoxyphenyl)ethyl]-N-methyl-3-phenoxazin-10-ylpropan-1-amineIC5025000.0 [1]
2-(4-Methoxyphenyl)-N-methyl-N-(2-phenothiazin-10-ylethyl)ethanamineIC5015000.0 [1]
N-[3-(2-Chlorophenothiazin-10-yl)propyl]-2-(3,4-dimethoxyphenyl)-N-methylacetamideIC50250000.0 [1]
N-[2-(4-Methoxyphenyl)ethyl]-N-methyl-N',N'-diphenylpropane-1,3-diamineIC50250000.0 [1]
N-[2-(3,4-Dimethoxyphenyl)ethyl]-N-methyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylidene)propan-1-amineIC5010000.0 [1]
3-(Benzyloxy)-N-hydroxybenzamideIC5060420.0 [1]
2-(3,4-Dihydro-2H-1,5-benzodioxepin-7-yl)-4H-benzo[h]chromen-4-oneIC5024250.0 [1]
N-(2-Carbazol-9-ylethyl)-2-(4-methoxyphenyl)-N-methylethanamineIC506000.0 [1]
N-[2-(5,6-Dihydrobenzo[b][1]benzazepin-11-yl)ethyl]-2-(4-methoxyphenyl)-N-methylethanamineIC5017000.0 [1]
3-(5,6-Dihydrobenzo[b][1]benzazepin-11-yl)-N-[2-(4-methoxyphenyl)ethyl]-N-methylpropan-1-amineIC5016000.0 [1]
N-[3-(5,6-Dihydrobenzo[b][1]benzazepin-11-yl)propyl]-2-(4-methoxyphenyl)-N-methylacetamideIC50107000.0 [1]
9-[2-[4-[2-(4-Methoxyphenyl)ethyl]piperazin-1-yl]ethyl]carbazoleIC5033000.0 [1]
3-(5,6-Dihydrobenzo[b][1]benzazepin-11-yl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-N-methylpropan-1-amineIC5031000.0 [1]
N-[2-(3,4-Dimethoxyphenyl)ethyl]-N'-naphthalen-1-ylethane-1,2-diamineIC50112000.0 [1]
N-[2-(5,6-Dihydrobenzo[b][1]benzazepin-11-yl)ethyl]-2-(4-methoxyphenyl)-N-methylacetamideIC50250000.0 [1]
N-[2-(5,6-Dihydrobenzo[b][1]benzazepin-11-yl)ethyl]-2-(3,4-dimethoxyphenyl)-N-methylethanamineIC5014000.0 [1]
N-[2-(4-Methoxyphenyl)ethyl]-N'-naphthalen-1-ylethane-1,2-diamineIC50116000.0 [1]
3-Carbazol-9-yl-N-[2-(4-methoxyphenyl)ethyl]-N-methylpropan-1-amineIC5013000.0 [1]
Items per page: 1 - 10 of 99
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References

This online tool may be cited as follows

MLA

"Quest Database™ Sphingomyelin phosphodiesterase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Dec. 2024, https://www.aatbio.com/data-sets/sphingomyelin-phosphodiesterase-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, December 21). Quest Database™ Sphingomyelin phosphodiesterase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/sphingomyelin-phosphodiesterase-inhibitors-ic50-ki.
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