Sphingomyelin phosphodiesterase Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Chlorpromazine	IC50	11000.0 [1]
	Imipramine	IC50	5000.0 [1]
	alpha-Mangostin	IC50	24740.0 [1]
	Myo-inositol 1,3,5-trisphosphate	IC50	26700.0 [1]
	6-[4-(3-Chlorophenyl)piperazin-1-yl]sulfonyl-7-methyl-1,4-dihydroquinoxaline-2,3-dione	IC50	19952.6 [1]
	6-Methyl-7-[4-[3-(trifluoromethyl)phenyl]piperazino]sulfonyl-1,4-dihydroquinoxaline-2,3-quinone	IC50	19952.6 [1]
	4-(4-Methoxy-benzyl)-4H-benzo[1,4]oxazin-3-one	IC50	250000.0 [1]
	2-[3-[(E)-[5-(4-Chlorophenyl)-7-methyl-3-oxo-6-(phenylcarbamoyl)-5H-[1,3]thiazolo[3,2-a]pyrimidin-2-ylidene]methyl]phenoxy]acetic acid	IC50	25118.9 [1]
	3-Methyl-5-(morpholin-4-ylsulfonyl)-N-[3-(trifluoromethyl)phenyl]-1-benzofuran-2-carboxamide	IC50	22382.7 [1]
	2-(1-Benzo[e]benzofuranyl)-N-[4-methoxy-3-(4-morpholinylsulfonyl)phenyl]acetamide	IC50	14125.4 [1]
	6-[(E)-[(5-Chloro-3-phenyl-1H-indole-2-carbonyl)hydrazinylidene]methyl]-2,3-dimethoxybenzoic acid	IC50	14125.4 [1]
	N-Hydroxy-4-methoxy-3-phenylmethoxybenzamide	IC50	10490.0 [1]
	3-Decoxy-N-hydroxy-4-methoxybenzamide	IC50	480.0 [1]
	1,3,6-Trihydroxy-7-methoxy-2,8-bis(3-methylbutyl)xanthen-9-one	IC50	10090.0 [1]
	Cowanin	IC50	19200.0 [1]
	1,7-Dihydroxy-3,6-dimethoxy-2,8-diprenylxanthone	IC50	169600.0 [1]
	2,4-Dioxo-3-(4-methoxybenzyl)-1,2,3,4-tetrahydroquinazoline	IC50	250000.0 [1]
	[(3S,4R)-1,1-Difluoro-3-(hexadecanoylamino)-4-hydroxy-4-phenylbutyl]phosphonic acid	IC50	49000.0 [1]
	(2,4-Dihydroxy-5-methoxyphenyl)-[2,4,6-trihydroxy-3-(3-methylbut-2-enyl)phenyl]methanone	IC50	66000.0 [1]
	[4,6-Dihydroxy-3-methoxy-2-(3-methylbut-2-enyl)phenyl]-(2,4,6-trihydroxyphenyl)methanone	IC50	14700.0 [1]
	[(2R,3S,4S,5R)-4,6-Dihydroxy-3,5-diphosphonooxyoxan-2-yl]methyl octane-1-sulfonate	IC50	2340.0 [1]
	[(2R,3S,4S,5R)-4,6-Dihydroxy-3,5-diphosphonooxyoxan-2-yl]methyl hexane-1-sulfonate	IC50	4160.0 [1]
	3-Carbazol-9-yl-N-[2-(3,4-dimethoxyphenyl)ethyl]-N-methylpropan-1-amine	IC50	14000.0 [1]
	9-(4-Methoxybenzyl)-9H-carbazole	IC50	156000.0 [1]
	10-[3-[(3S,5R)-4-[2-(4-Methoxyphenyl)ethyl]-3,5-dimethylpiperazin-1-yl]propyl]phenoxazine	IC50	43000.0 [1]
	N-[2-(4-Methoxyphenyl)ethyl]-N-methyl-3-phenothiazin-10-ylpropan-1-amine	IC50	9000.0 [1]
	6-[2-(4-Methoxyphenyl)ethyl]-6,10-diazatetracyclo[8.6.1.05,17.011,16]heptadeca-1(17),11,13,15-tetraene	IC50	15000.0 [1]
	N-[2-(3,4-Dimethoxyphenyl)ethyl]-N-methyl-3-phenothiazin-10-ylpropan-1-amine	IC50	16000.0 [1]
	4-[2-(4-Methoxyphenyl)ethyl]-1,4-diazatetracyclo[7.6.1.05,16.010,15]hexadeca-9(16),10,12,14-tetraene	IC50	250000.0 [1]
	4-[3-[2-(4-Methoxyphenyl)ethyl-methylamino]propyl]-1,4-benzoxazin-3-one	IC50	38000.0 [1]
	N-[2-(4-Methoxyphenyl)ethyl]-N-methyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylidene)propan-1-amine	IC50	10000.0 [1]
	2-[(Z)-(2-Imino-1-propan-2-ylindol-3-ylidene)methyl]-3H-quinazolin-4-one	IC50	31622.8 [1]
	3-(11,12-Dihydro-6H-benzo[c][1]benzazocin-5-yl)-N-[2-(4-methoxyphenyl)ethyl]-N-methylpropan-1-amine	IC50	17000.0 [1]
	N-Benzyl-N-[2-(4-methoxyphenyl)ethyl]pyridin-2-amine	IC50	250000.0 [1]
	1-Phosphonooxyundecyl dihydrogen phosphate	IC50	310.0 [1]
	[(2R,3S,4R,5R)-4,6-Dihydroxy-3,5-diphosphonooxyoxan-2-yl] dodecane-1-sulfonate	IC50	440.0 [1]
	3-Dodecoxy-N-hydroxybenzamide	IC50	13060.0 [1]
	N-Hydroxy-3-octoxybenzamide	IC50	17420.0 [1]
	3-Decoxy-N-hydroxybenzamide	IC50	1420.0 [1]
	3-Indol-1-yl-N-[2-(4-methoxyphenyl)ethyl]-N-methylpropan-1-amine	IC50	21000.0 [1]
	9-[3-[(3S,5R)-4-[2-(3,4-Dimethoxyphenyl)ethyl]-3,5-dimethylpiperazin-1-yl]propyl]carbazole	IC50	141000.0 [1]
	(1-Amino-1-phosphonooxydodecyl) dihydrogen phosphate	IC50	290.0 [1]
	(E)-4-(2,8-Dihydroxy-3,6-dimethoxy-9-oxoxanthen-1-yl)-N-ethylbut-2-enamide	IC50	4890.0 [1]
	N-[2-(3,4-Dimethoxyphenyl)ethyl]-N'-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenyl)propane-1,3-diamine	IC50	39000.0 [1]
	N-[2-(2-Chlorophenothiazin-10-yl)ethyl]-2-(3,4-dimethoxyphenyl)-N-methylethanamine	IC50	250000.0 [1]
	[1-(2,4-Dichlorophenyl)-5-phenylpyrazol-3-yl]-morpholin-4-ylmethanone	IC50	28183.8 [1]
	1-Phosphonooxyoctyl dihydrogen phosphate	IC50	350.0 [1]
	3-Carbazol-9-yl-N-[2-[4-[2-[3-carbazol-9-ylpropyl(methyl)amino]ethyl]-2,5-dimethoxyphenyl]ethyl]-N-methylpropan-1-amine	IC50	10000.0 [1]
	3-[(4-Bromophenyl)methoxy]-N-hydroxy-4-methoxybenzamide	IC50	7780.0 [1]
	3-Heptyl-6,8-dihydroxy-1-methyl-3,4-dihydro-1H-isochromene-7-carboxylic acid	IC50	68700.0 [1]
	3-[(4-Cyanophenyl)methoxy]-N-hydroxybenzamide	IC50	52870.0 [1]
	N-(3-Carbazol-9-ylpropyl)-2-(4-methoxyphenyl)-N-methylacetamide	IC50	250000.0 [1]
	(E)-4-(2,8-Dihydroxy-3,6-dimethoxy-9-oxoxanthen-1-yl)-N,N-diethylbut-2-enamide	IC50	4890.0 [1]
	N-Hydroxy-4-methoxy-3-octoxybenzamide	IC50	16090.0 [1]
	1-Phosphonooxydecyl dihydrogen phosphate	IC50	300.0 [1]
	(1-Amino-1-phosphonooxydecyl) dihydrogen phosphate	IC50	20.0 [1]
	N-Hydroxy-3-[(4-methoxyphenyl)methoxy]benzamide	IC50	42680.0 [1]
	3-Decoxy-N,4-dihydroxybenzamide	IC50	17430.0 [1]
	(2-Butyl-1-benzofuran-3-yl)-[4-[2-(diethylamino)ethoxy]-2,5-diiodophenyl]methanone	IC50	39810.7 [1]
	3-Decoxy-N-(2-hydroxyethyl)-4-methoxybenzamide	IC50	71000.0 [1]
	9-[3-[(3S,5R)-4-[2-(4-Methoxyphenyl)ethyl]-3,5-dimethylpiperazin-1-yl]propyl]carbazole	IC50	9000.0 [1]
	3-Dodecoxy-N-hydroxy-4-methoxybenzamide	IC50	18550.0 [1]
	(1-Hydroxy-1-phosphonooxydodecyl) dihydrogen phosphate	IC50	70.0 [1]
	3-Decoxy-N-(2-hydroxypropyl)-4-methoxybenzamide	IC50	85200.0 [1]
	1-[2-(4-Methoxyphenyl)ethyl]-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenyl)-1,3-diazinane	IC50	11000.0 [1]
	N-[2-(4-Methoxyphenyl)ethyl]-N'-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenyl)propane-1,3-diamine	IC50	17000.0 [1]
	2-(6-Bromo-4H-1,3-benzodioxin-8-yl)-3-amino-6-ethoxy-4H-1-benzopyran-4-one	IC50	3500.0 [1]
	1,3-Bis[(4-methoxyphenyl)methyl]quinazoline-2,4-dione	IC50	250000.0 [1]
	N-[2-(3,4-Dimethoxyphenyl)ethyl]-N-methyl-3-phenoxazin-10-ylpropan-1-amine	IC50	13000.0 [1]
	3-Carbazol-9-yl-N-[(4-methoxyphenyl)methyl]-N-methylpropan-1-amine	IC50	29000.0 [1]
	4-Carbazol-9-yl-1,1,2,2,3,3,4,4-octafluoro-N-[2-(4-methoxyphenyl)ethyl]-N-methylbutan-1-amine	IC50	250000.0 [1]
	2-(4-Methoxyphenyl)-N-(naphthalen-1-ylmethyl)ethanamine	IC50	240000.0 [1]
	(5E)-3-[[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]amino]-2-sulfanylidene-5-[(3,4,5-trimethoxyphenyl)methylidene]-1,3-thiazolidin-4-one	IC50	28183.8 [1]
	5-Acetoxy-6-bromo-2-carbamimidoylsulfanylmethyl-1-methyl-1H-indole-3-carboxylic acid octyl ester	IC50	31622.8 [1]
	3-((4-Bromobenzyl)oxy)-N-hydroxybenzamide	IC50	19420.0 [1]
	2-(3,4-Dimethoxyphenyl)-N-(naphthalen-1-ylmethyl)ethanamine	IC50	96000.0 [1]
	2-(Trifluoromethyl)-3-(4-methylthiazole-2-yl)-6-methyl-7-hydroxy-4H-1-benzopyran-4-one	IC50	10720.0 [1]
	1-[2-(3,4-Dimethoxyphenyl)ethyl]-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenyl)-1,3-diazinane	IC50	22000.0 [1]
	3-(2-Chlorophenothiazin-10-yl)-N-[2-(4-methoxyphenyl)ethyl]-N-methylpropan-1-amine	IC50	134000.0 [1]
	N-[2-(3,4-Dimethoxyphenyl)ethyl]-N-methyl-N',N'-diphenylpropane-1,3-diamine	IC50	56000.0 [1]
	3-(2-Chlorophenothiazin-10-yl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-N-methylpropan-1-amine	IC50	12000.0 [1]
	N-[2-(4-Methoxyphenyl)ethyl]-N-methyl-3-phenoxazin-10-ylpropan-1-amine	IC50	25000.0 [1]
	2-(4-Methoxyphenyl)-N-methyl-N-(2-phenothiazin-10-ylethyl)ethanamine	IC50	15000.0 [1]
	N-[3-(2-Chlorophenothiazin-10-yl)propyl]-2-(3,4-dimethoxyphenyl)-N-methylacetamide	IC50	250000.0 [1]
	N-[2-(4-Methoxyphenyl)ethyl]-N-methyl-N',N'-diphenylpropane-1,3-diamine	IC50	250000.0 [1]
	N-[2-(3,4-Dimethoxyphenyl)ethyl]-N-methyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylidene)propan-1-amine	IC50	10000.0 [1]
	3-(Benzyloxy)-N-hydroxybenzamide	IC50	60420.0 [1]
	2-(3,4-Dihydro-2H-1,5-benzodioxepin-7-yl)-4H-benzo[h]chromen-4-one	IC50	24250.0 [1]
	N-(2-Carbazol-9-ylethyl)-2-(4-methoxyphenyl)-N-methylethanamine	IC50	6000.0 [1]
	N-[2-(5,6-Dihydrobenzo[b][1]benzazepin-11-yl)ethyl]-2-(4-methoxyphenyl)-N-methylethanamine	IC50	17000.0 [1]
	3-(5,6-Dihydrobenzo[b][1]benzazepin-11-yl)-N-[2-(4-methoxyphenyl)ethyl]-N-methylpropan-1-amine	IC50	16000.0 [1]
	N-[3-(5,6-Dihydrobenzo[b][1]benzazepin-11-yl)propyl]-2-(4-methoxyphenyl)-N-methylacetamide	IC50	107000.0 [1]
	9-[2-[4-[2-(4-Methoxyphenyl)ethyl]piperazin-1-yl]ethyl]carbazole	IC50	33000.0 [1]
	3-(5,6-Dihydrobenzo[b][1]benzazepin-11-yl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-N-methylpropan-1-amine	IC50	31000.0 [1]
	N-[2-(3,4-Dimethoxyphenyl)ethyl]-N'-naphthalen-1-ylethane-1,2-diamine	IC50	112000.0 [1]
	N-[2-(5,6-Dihydrobenzo[b][1]benzazepin-11-yl)ethyl]-2-(4-methoxyphenyl)-N-methylacetamide	IC50	250000.0 [1]
	N-[2-(5,6-Dihydrobenzo[b][1]benzazepin-11-yl)ethyl]-2-(3,4-dimethoxyphenyl)-N-methylethanamine	IC50	14000.0 [1]
	N-[2-(4-Methoxyphenyl)ethyl]-N'-naphthalen-1-ylethane-1,2-diamine	IC50	116000.0 [1]
	3-Carbazol-9-yl-N-[2-(4-methoxyphenyl)ethyl]-N-methylpropan-1-amine	IC50	13000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 99 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Sphingomyelin phosphodiesterase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 22 Feb. 2025, https://www.aatbio.com/data-sets/sphingomyelin-phosphodiesterase-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 22). Quest Database™ Sphingomyelin phosphodiesterase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/sphingomyelin-phosphodiesterase-inhibitors-ic50-ki.
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