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Solute carrier family 2, facilitated glucose transporter member 2 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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▼
QuercetinIC5012000.0 [1]
MyricetinIC5012000.0 [1]
(3S,4S,5S)-5-(Fluoromethyl)-2-(hydroxymethyl)oxolane-2,3,4-triolKi916000.0 [1], 6210000.0 [2]
4-[4-(2-Methoxyphenyl)piperazin-1-yl]-1-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidineIC5010000.0 [1]
1-Cyclopentyl-4-[4-(2-methoxyphenyl)piperazin-1-yl]pyrazolo[3,4-d]pyrimidineIC502000.0 [1]
1-(5-Fluoro-2-methoxyphenyl)-4-[4-(2-methoxyphenyl)piperazin-1-yl]pyrazolo[3,4-d]pyrimidineIC50880.0 [1]
1-(3,5-Difluorophenyl)-4-[4-(2-methoxyphenyl)piperazin-1-yl]pyrazolo[3,4-d]pyrimidineIC5010000.0 [1]
6-[4-(2-Methoxyphenyl)piperazin-1-yl]-9-phenylpurineIC503500.0 [1]
1-(2-Methoxyphenyl)-4-[4-(2-methoxyphenyl)piperazin-1-yl]pyrazolo[3,4-d]pyrimidineIC501200.0 [1]
4-[4-(2-Methoxyphenyl)piperazin-1-yl]-1-phenylpyrazolo[3,4-b]pyridineIC50600.0 [1]
4-Methoxy-3-[4-(1-phenylpyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl]benzonitrileIC5010000.0 [1]
6-[4-(2-Methoxyphenyl)piperazin-1-yl]-9-phenyl-7H-purin-8-oneIC5010000.0 [1]
1-(3-Fluoropyridin-2-yl)-4-[4-(2-methoxyphenyl)piperazin-1-yl]pyrazolo[3,4-d]pyrimidineIC507000.0 [1]
1-(3-Methoxyphenyl)-4-[4-(2-methoxyphenyl)piperazin-1-yl]pyrazolo[3,4-d]pyrimidineIC50900.0 [1]
4-[4-[4-(2-Methoxyphenyl)piperazin-1-yl]pyrazolo[3,4-d]pyrimidin-1-yl]benzonitrileIC5010000.0 [1]
4-[4-(2-Methoxyphenyl)piperazin-1-yl]-1-phenylpyrazolo[4,3-c]pyridineIC505000.0 [1]
4-[4-(2-Methoxyphenyl)piperazin-1-yl]-1-(1-phenylethyl)pyrazolo[3,4-d]pyrimidineIC502100.0 [1]
4-[4-(2-Methoxyphenyl)piperazin-1-yl]-1-pyridin-3-ylpyrazolo[3,4-d]pyrimidineIC506000.0 [1]
4-[4-(2-Methoxyphenyl)piperazin-1-yl]-1-pyridin-4-ylpyrazolo[3,4-d]pyrimidineIC504400.0 [1]
2-[4-(1-Phenylpyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl]benzonitrileIC505990.0 [1]
4-[4-(2-Methoxyphenyl)piperazin-1-yl]-7-phenylpyrazolo[3,4-d]triazineIC5010000.0 [1]
1-Phenyl-4-[4-[2-(trifluoromethyl)phenyl]piperazin-1-yl]pyrazolo[3,4-d]pyrimidineIC5010000.0 [1]
4-[4-(3-Fluorophenyl)piperazin-1-yl]-1-phenylpyrazolo[3,4-d]pyrimidineIC501210.0 [1]
3-[4-(1-Phenylpyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl]benzonitrileIC50220.0 [1]
4-[4-(2-Fluoro-6-methoxyphenyl)piperazin-1-yl]-1-phenylpyrazolo[3,4-d]pyrimidineIC501200.0 [1]
4-[4-(2-Methoxypyridin-3-yl)piperazin-1-yl]-1-phenylpyrazolo[3,4-d]pyrimidineIC501360.0 [1]
1-Phenyl-4-[4-[2-(trifluoromethoxy)phenyl]piperazin-1-yl]pyrazolo[3,4-d]pyrimidineIC5010000.0 [1]
4-[4-(3-Fluoro-2-methoxyphenyl)piperazin-1-yl]-1-phenylpyrazolo[3,4-d]pyrimidineIC5010000.0 [1]
2-Methoxy-3-[4-(1-phenylpyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl]benzonitrileIC5010000.0 [1]
4-[4-(4-Methoxypyridin-3-yl)piperazin-1-yl]-1-phenylpyrazolo[3,4-d]pyrimidineIC50510.0 [1]
4-[4-(3-Methoxypyridin-2-yl)piperazin-1-yl]-1-phenylpyrazolo[3,4-d]pyrimidineIC50950.0 [1]
2-[4-(1-Phenylpyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl]cyclohexan-1-olIC5010000.0 [1]
4-[4-(2-Methoxyphenyl)piperidin-1-yl]-1-phenylpyrazolo[3,4-d]pyrimidineIC5010000.0 [1]
4-[4-(2-Methoxyphenyl)-3-methylpiperazin-1-yl]-1-phenylpyrazolo[3,4-d]pyrimidineIC501400.0 [1]
4-[4-(2-Methoxyphenyl)-2-methylpiperazin-1-yl]-1-phenylpyrazolo[3,4-d]pyrimidineIC502500.0 [1]
4-[(1S,4S)-5-(2-Methoxyphenyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl]-1-phenylpyrazolo[3,4-d]pyrimidineIC5010000.0 [1]
4-[(1R,4R)-5-(2-Methoxyphenyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl]-1-phenylpyrazolo[3,4-d]pyrimidineIC5010000.0 [1]
4-[4-(3-Methoxyphenyl)piperazin-1-yl]-1-phenyl-1H-pyrazolo[3,4-d]pyrimidineIC501480.0 [1]
1-(4-Methoxyphenyl)-4-[4-(2-methoxyphenyl)piperazin-1-yl]-1H-pyrazolo[3,4-d]pyrimidineIC502600.0 [1]
4-[4-(2-Methoxyphenyl)piperazino]-1-(3-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidineIC5010000.0 [1]
4-[4-(2-Fluorophenyl)piperazin-1-yl]-1-phenyl-1H-pyrazolo[3,4-d]pyrimidineIC501120.0 [1]
4-(4-(2-Methoxyphenyl)piperazin-1-yl)-1-(o-tolyl)-1H-pyrazolo[3,4-d]pyrimidineIC501000.0 [1]
4-(4-(4-Methoxyphenyl)piperazin-1-yl)-1-phenyl-1H-pyrazolo[3,4-d]pyrimidineIC508700.0 [1]
4-[4-(2-Methoxyphenyl)piperazin-1-yl]-1-phenyl-1H-pyrazolo[3,4-d]pyrimidineIC5010000.0 [1]
1-(4-Fluorophenyl)-4-[4-(2-methoxyphenyl)piperazin-1-yl]-1H-pyrazolo[3,4-d]pyrimidineIC5010000.0 [1]
4-[4-(2-Methoxyphenyl)piperazin-1-yl]-1-pyridin-2-ylpyrazolo[3,4-d]pyrimidineIC508000.0 [1]
4-[4-(5-Fluoro-2-methoxyphenyl)piperazin-1-yl]-1-phenylpyrazolo[3,4-d]pyrimidineIC5010000.0 [1]
7-[4-(2-Methoxyphenyl)piperazin-1-yl]-3-phenyltriazolo[4,5-d]pyrimidineIC503300.0 [1]
2-[4-(1-Phenylpyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl]phenolIC5060.0 [1]
1-(3-Fluorophenyl)-4-[4-(2-methoxyphenyl)piperazin-1-yl]pyrazolo[3,4-d]pyrimidineIC5010000.0 [1]
4-[4-(2-Methoxyphenyl)-1,4-diazepan-1-yl]-1-phenylpyrazolo[3,4-d]pyrimidineIC5021.0 [1]
1-(2-Fluorophenyl)-4-[4-(2-methoxyphenyl)piperazin-1-yl]pyrazolo[3,4-d]pyrimidineIC501100.0 [1]
4-Methoxy-3-[4-(1-phenylpyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl]benzamideIC50100.0 [1]
3-Methoxy-4-[4-(1-phenylpyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl]benzonitrileIC501700.0 [1]
4-[4-(4-Fluoro-2-methoxyphenyl)piperazin-1-yl]-1-phenylpyrazolo[3,4-d]pyrimidineIC5010000.0 [1]
4-[[2-(4-Chlorophenyl)-6-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl]methyl]morpholineIC50100000.0 [1]
2-[2-(4-Chlorophenyl)-3-(morpholin-4-ylmethyl)imidazo[1,2-a]pyridin-6-yl]benzonitrileIC506.0 [1]
[4-[[2-(4-Chlorophenyl)-6-phenylimidazo[1,2-a]pyridin-3-yl]methyl]piperazin-1-yl]-(4-methoxyphenyl)methanoneIC506.0 [1]
4-[[2-(4-Chlorophenyl)-6-phenylimidazo[1,2-a]pyridin-3-yl]methyl]-N-(3-fluorophenyl)piperazine-1-carboxamideIC50100000.0 [1]
4-[[2-(4-Chlorophenyl)-6-(2,6-difluorophenyl)imidazo[1,2-a]pyridin-3-yl]methyl]morpholineIC506.0 [1]
4-[[2-(4-Chlorophenyl)-6-cyclopropylimidazo[1,2-a]pyrazin-3-yl]methyl]morpholineIC506.0 [1]
[4-[[2-(4-Chlorophenyl)-6-phenylimidazo[1,2-a]pyridin-3-yl]methyl]piperazin-1-yl]-(oxetan-3-yl)methanoneIC506.0 [1]
1-[4-[[2-(4-Chlorophenyl)-6-cyclopropylimidazo[1,2-a]pyrazin-3-yl]methyl]piperazin-1-yl]ethanoneIC506.0 [1]
4-[[2-(4-Chlorophenyl)-6-propan-2-ylimidazo[1,2-a]pyrazin-3-yl]methyl]morpholineIC506.0 [1]
2-[3-[(4-Acetylpiperazin-1-yl)methyl]-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-6-yl]benzonitrileIC506.0 [1]
2-[3-[(4-Acetylpiperazin-1-yl)methyl]-2-(4-chlorophenyl)imidazo[1,2-a]pyrazin-6-yl]benzonitrileIC506.0 [1]
1-[[2-(4-Chlorophenyl)-6-phenylimidazo[1,2-a]pyridin-3-yl]methyl]-1,4-diazepan-5-oneIC506.0 [1]
1-[[2-(4-Chlorophenyl)-6-phenylimidazo[1,2-a]pyridin-3-yl]methyl]-4-methyl-1,4-diazepan-5-oneIC506.0 [1]
2-[2-(4-Chlorophenyl)-3-(morpholin-4-ylmethyl)imidazo[1,2-a]pyridin-6-yl]-3-fluorobenzonitrileIC506.0 [1]
2-[2-(4-Chlorophenyl)-3-[(4-methyl-3-oxopiperazin-1-yl)methyl]imidazo[1,2-a]pyridin-6-yl]benzonitrileIC506.0 [1]
4-[[2-(4-Chlorophenyl)-6-(2,6-difluorophenyl)imidazo[1,2-a]pyrazin-3-yl]methyl]morpholineIC506.0 [1]
N-[2-(4-Chlorophenyl)-3-(morpholin-4-ylmethyl)imidazo[1,2-a]pyridin-6-yl]-N-methylmethanesulfonamideIC5010000.0 [1]
1-[4-[[2-(4-Chlorophenyl)-6-cyclopropylimidazo[1,2-a]pyrazin-3-yl]methyl]piperazin-1-yl]propan-1-oneIC506.0 [1]
2-[2-(4-Chlorophenyl)-3-(morpholin-4-ylmethyl)imidazo[1,2-a]pyridin-6-yl]pyridine-3-carbonitrileIC5010000.0 [1]
[4-[[2-(4-Chlorophenyl)-6-cyclopropylimidazo[1,2-a]pyridin-3-yl]methyl]piperazin-1-yl]-(oxan-4-yl)methanoneIC5010000.0 [1]
N-[3-[(4-Acetylpiperazin-1-yl)methyl]-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-6-yl]methanesulfonamideIC5010000.0 [1]
7-[[2-(4-Chlorophenyl)-6-cyclopropylimidazo[1,2-a]pyrazin-3-yl]methyl]-6,8-dihydro-5H-[1,2,4]triazolo[1,5-a]pyrazineIC506.0 [1]
[4-[[2-(4-Chlorophenyl)-6-cyclopropylimidazo[1,2-a]pyrazin-3-yl]methyl]piperazin-1-yl]-pyridin-4-ylmethanoneIC506.0 [1]
2-[2-(4-Chlorophenyl)-3-(morpholin-4-ylmethyl)imidazo[1,2-a]pyrazin-6-yl]benzonitrileIC5010000.0 [1]
1-[4-[[6-Cyclopropyl-2-(2,4-dichlorophenyl)imidazo[1,2-a]pyrazin-3-yl]methyl]piperazin-1-yl]ethanoneIC506.0 [1]
4-[[6-Cyclopropyl-2-(2,4-dichlorophenyl)imidazo[1,2-a]pyrazin-3-yl]methyl]piperazin-2-oneIC506.0 [1]
[4-[[6-Cyclopropyl-2-(2,4-dichlorophenyl)imidazo[1,2-a]pyrazin-3-yl]methyl]piperazin-1-yl]-pyrazin-2-ylmethanoneIC506.0 [1]
4-[[2-(4-Chlorophenyl)-6-(1,2,4-oxadiazol-3-yl)imidazo[1,2-a]pyridin-3-yl]methyl]piperazin-2-oneIC5010000.0 [1]
N-[3-[(4-Acetylpiperazin-1-yl)methyl]-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-6-yl]-N-methylmethanesulfonamideIC5010000.0 [1]
1-[4-[[2-(4-Chlorophenyl)-6-(1,1-dioxo-1,2-thiazolidin-2-yl)imidazo[1,2-a]pyridin-3-yl]methyl]piperazin-1-yl]-2-methoxyethanoneIC506.0 [1]
1-[4-[[2-(4-Chlorophenyl)-6-pyridin-2-ylimidazo[1,2-a]pyridin-3-yl]methyl]piperazin-1-yl]ethanoneIC506.0 [1]
4-[[2-(4-Chlorophenyl)-6-pyridin-2-ylimidazo[1,2-a]pyridin-3-yl]methyl]piperazin-2-oneIC506.0 [1]
[4-[[6-Cyclopropyl-2-(2,4-dichlorophenyl)imidazo[1,2-a]pyrazin-3-yl]methyl]piperazin-1-yl]-pyridazin-4-ylmethanoneIC506.0 [1]
7-[[2-(2,4-Dichlorophenyl)-6-pyridin-2-ylimidazo[1,2-a]pyridin-3-yl]methyl]-6,8-dihydro-5H-[1,2,4]triazolo[1,5-a]pyrazineIC506.0 [1]
[4-[[6-Cyclopropyl-2-(2,4-dichlorophenyl)imidazo[1,2-a]pyrazin-3-yl]methyl]piperazin-1-yl]-(oxan-4-yl)methanoneIC506.0 [1]
N-[2-(4-Chlorophenyl)-3-(piperazin-1-ylmethyl)imidazo[1,2-a]pyridin-6-yl]-N-methylmethanesulfonamideIC50100000.0 [1]
Ethyl 2-[2-(4-chlorophenyl)-6-phenylimidazo[1,2-a]pyridin-3-yl]acetateIC5010000.0 [1]
4-[[2-(2,4-Dichlorophenyl)-6-(1,2,4-oxadiazol-3-yl)imidazo[1,2-a]pyridin-3-yl]methyl]piperazin-2-oneIC506.0 [1]
4-[[2-(4-Chlorophenyl)-6-(oxetan-3-yl)imidazo[1,2-a]pyridin-3-yl]methyl]morpholineIC50100000.0 [1]
2-[2-(4-Chlorophenyl)-6-phenylimidazo[1,2-a]pyridin-3-yl]-1-morpholin-4-ylethanoneIC5010000.0 [1]
[4-[[6-Cyclopropyl-2-(2,4-dichlorophenyl)imidazo[1,2-a]pyrazin-3-yl]methyl]piperazin-1-yl]-(1,3-thiazol-4-yl)methanoneIC506.0 [1]
N-[2-(4-Chlorophenyl)-3-[[4-(2-methoxyacetyl)piperazin-1-yl]methyl]imidazo[1,2-a]pyridin-6-yl]-N-methylmethanesulfonamideIC5010000.0 [1]
1-[4-[[2-(4-Chlorophenyl)-6-phenylimidazo[1,2-a]pyridin-3-yl]methyl]piperazin-1-yl]-2-hydroxy-2-methylpropan-1-oneIC506.0 [1]
4-[[2-(Oxan-4-yl)-6-phenylimidazo[1,2-a]pyridin-3-yl]methyl]morpholineIC50100000.0 [1]
N-[2-(4-Chlorophenyl)-3-[[4-(oxetane-3-carbonyl)piperazin-1-yl]methyl]imidazo[1,2-a]pyridin-6-yl]-N-methylmethanesulfonamideIC5010000.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Solute carrier family 2, facilitated glucose transporter member 2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 19 Feb. 2025, https://www.aatbio.com/data-sets/solute-carrier-family-2-facilitated-glucose-transporter-member-2-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 19). Quest Database™ Solute carrier family 2, facilitated glucose transporter member 2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/solute-carrier-family-2-facilitated-glucose-transporter-member-2-inhibitors-ic50-ki.
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