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Sodium/nucleoside cotransporter 2 Inhibitors (IC50, Ki)

Structure
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▼
Compound Name
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▼
Standard Type
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▼
Standard Values (in nM)
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▼
PhlorizinIC50100000.0 [1], 1000000.0 [2]
CNT2 inhibitor-1IC50640.0 [1]
AdenosineIC505500.0 [1]
UridineIC5032000.0 [1]
FloxuridineIC501000000.0 [1]
TecadenosonIC50239000.0 [1]
7,8,3'-TrihydroxyflavoneIC501000000.0 [1]
(2R,3R,4S,5R)-2-[6-Amino-8-(benzylamino)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diolIC5052000.0 [1]
(2R,3R,4S,5R)-2-[6-Amino-8-[(4-methylphenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diolIC5011000.0 [1]
(2R,3R,4S,5R)-2-[6-Amino-8-[(4-chlorophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diolIC5011000.0 [1]
[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl hexanoateIC50100000.0 [1]
5'-o-AcetyladenosineIC50100000.0 [1]
(2R,3R,4S,5R)-2-[2-[[3-(4-Hydroxybutoxy)-4-phenylphenyl]methylamino]benzimidazol-1-yl]-5-(hydroxymethyl)oxolane-3,4-diolIC5062.0 [1]
Propionyl adenylateIC50100000.0 [1]
(2R,3R,4S,5R)-2-[6-Amino-8-[(4-pyridin-2-ylphenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diolIC501500.0 [1]
(2R,3R,4S,5R)-2-[6-Amino-8-[[3-(4-hydroxybutoxy)-4-phenylphenyl]methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diolIC50940.0 [1]
(2R,3R,4S,5R)-2-[6-Amino-8-[(2-methylphenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diolIC5065000.0 [1]
(2R,3R,4S,5R)-2-[6-Amino-8-[(3-methylphenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diolIC5019000.0 [1]
8-{[(2-Chlorophenyl)methyl]amino}adenosineIC505700.0 [1]
(2R,3R,4S,5R)-2-[6-Amino-8-[(3-chlorophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diolIC505400.0 [1]
(2R,3R,4S,5R)-2-[6-Amino-8-[(2-methoxyphenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diolIC50100000.0 [1]
(2R,3R,4S,5R)-2-[6-Amino-8-[(3-methoxyphenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diolIC5013000.0 [1]
(2R,3R,4S,5R)-2-[6-Amino-8-[(4-methoxyphenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diolIC5036000.0 [1]
(2R,3R,4S,5R)-2-[6-Amino-8-[(2-phenylphenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diolIC50100000.0 [1]
(2R,3R,4S,5R)-2-[6-Amino-8-[(3-phenylphenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diolIC5021000.0 [1]
[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl 2-phenylacetateIC50100000.0 [1]
[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl methyl carbonateIC50100000.0 [1]
[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl pentyl carbonateIC50100000.0 [1]
[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl benzyl carbonateIC50100000.0 [1]
[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl N-pentylcarbamateIC50100000.0 [1]
[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl N-benzylcarbamateIC50100000.0 [1]
(2R,3R,4S,5R)-2-[6-Amino-8-[(4-phenyl-2-propan-2-yloxyphenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diolIC509300.0 [1]
9-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-8-[[3-(4-hydroxybutoxy)-4-phenylphenyl]methylamino]-1H-purin-6-oneIC5020100.0 [1]
[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl ethyl carbonateIC50100000.0 [1]
[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl N-ethylcarbamateIC50100000.0 [1]
(2R,3R,4S,5R)-2-(6-Amino-8-anilinopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diolIC50289000.0 [1]
[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl N-methylcarbamateIC50100000.0 [1]
(2R,3R,4S,5R)-2-[6-Amino-8-(2-phenylethylamino)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diolIC50233000.0 [1]
(2R,3R,4S,5R)-2-[6-Amino-8-(3-phenylpropylamino)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diolIC50536000.0 [1]
(2R,3R,4S,5R)-2-[6-Amino-8-(naphthalen-1-ylmethylamino)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diolIC505700.0 [1]
(2R,3R,4S,5R)-2-[6-Amino-8-[(4-phenyl-3-propan-2-yloxyphenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diolIC5010400.0 [1]
(2R,3R,4S,5R)-2-[6-Amino-8-[(4-pyridin-3-ylphenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diolIC501000.0 [1]
(2R,3R,4S,5R)-2-[6-Amino-8-[[3-(5-hydroxypentoxy)-4-phenylphenyl]methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diolIC501600.0 [1]
(2R,3R,4S,5R)-2-[6-Amino-8-[(3-hydroxy-4-phenylphenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diolIC501200.0 [1]
(2R,3R,4S,5R)-2-[6-Amino-8-[(2-hydroxy-4-phenylphenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diolIC501300.0 [1]
(2R,3R,4S,5R)-2-[6-Amino-8-[(3-ethoxy-4-phenylphenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diolIC502300.0 [1]
(2R,3R,4S,5R)-2-[6-Amino-8-[(2-ethoxy-4-phenylphenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diolIC505400.0 [1]
(2R,3R,4S,5R)-2-[6-Amino-8-(naphthalen-2-ylmethylamino)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diolIC505300.0 [1]
(2R,3R,4S,5R)-2-[6-Amino-8-[(4-pyridin-4-ylphenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diolIC502700.0 [1]
2-[5-[[[6-Amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-8-yl]amino]methyl]-2-phenylphenoxy]acetamideIC505500.0 [1]
(2R,3R,4S,5R)-2-[6-Amino-8-[(2-methoxy-4-phenylphenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diolIC501100.0 [1]
(2R,3R,4S,5R)-2-[6-Amino-8-[[3-(2-hydroxyethoxy)-4-phenylphenyl]methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diolIC503100.0 [1]
(2R,3R,4S,5R)-2-[6-Amino-8-[(3-methoxy-4-phenylphenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diolIC501300.0 [1]
Methyl 2-[5-[[[6-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-8-yl]amino]methyl]-2-phenylphenoxy]acetateIC503300.0 [1]
(2R,3R,4S,5R)-2-[6-Amino-8-[[3-(3-hydroxypropoxy)-4-phenylphenyl]methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diolIC501100.0 [1]
(2R,3R,4S,5R)-2-[6-Amino-8-[(4-phenyl-3-propoxyphenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diolIC505200.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Sodium/nucleoside cotransporter 2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/sodium-nucleoside-cotransporter-2-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ Sodium/nucleoside cotransporter 2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/sodium-nucleoside-cotransporter-2-inhibitors-ic50-ki.
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