![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_0a27fe332ef3f961bd8aa1b5f579d652.svg) | Cariporide | IC50 | 1000.0 [1], 30000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_cc27d1a33c3ff82a084c04e6267cbd2b.svg) | Eniporide | IC50 | 30000.0 [1], 100000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_6f830a1fe983912a7acbe583970f330a.svg) | Cyclopropanecarboxamide, N-(aminoiminomethyl)-3-(2,3-dihydro-4-benzofuranyl)-2,2-dimethyl-, (1R,3R)- | IC50 | 30000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_df664602957659e57310360aabb7b538.svg) | (E)-N-(Diaminomethylidene)-3-[2-[(E)-3-(diaminomethylideneamino)-2-methyl-3-oxoprop-1-enyl]-4-methylphenyl]-2-methylprop-2-enamide | IC50 | 20.0 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_8360289f89a949eab5741412a08ec375.svg) | 1-[2-[2-[2-[[3-[(4S)-6,8-Dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethyl]-3-[4-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethylcarbamoylamino]phenyl]urea;dihydrochloride | IC50 | 7.94 [1], 10.0 [2] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_1713c6da99e4ecac53939d682d53046c.svg) | (E)-N-(Diaminomethylidene)-3-[3-[(E)-3-(diaminomethylideneamino)-2-methyl-3-oxoprop-1-enyl]phenyl]-2-methylprop-2-enamide | IC50 | 1320.0 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_0cd18eb329f59eae942532dbcdec1281.svg) | Tenapanor hydrochloride | IC50 | 6.31 [1], 10.0 [2] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_bb3c646f0c140f6fbc9aa1f29e8fd42d.svg) | Tenapanor | IC50 | 5.01 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_0cc659d8eed6a6852a4bf2d20a11617e.svg) | (2S,3S)-N,N'-Bis[2-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethoxy]ethyl]-2,3-dihydroxybutanediamide | IC50 | 5.01 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_0b218c504bee28ba8269dded6c8f5d6b.svg) | 2-[2-[2-[2-[Bis[2-[2-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethoxy]ethylamino]-2-oxoethyl]amino]ethoxy]ethoxy]ethyl-[2-[2-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethoxy]ethylamino]-2-oxoethyl]amino]-N-[2-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethoxy]ethyl]acetamide | IC50 | 10.0 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_dcc70d6626464e244121da7ff54498c1.svg) | N,N'-Bis[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethyl]-4-[3-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethylamino]-3-oxopropyl]-4-[[2-(dimethylamino)acetyl]amino]heptanediamide | IC50 | 10.0 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_9af54fa1fcebdb29cd5c7d1983d0190c.svg) | 3-[2-[2-[2-[2-[2-[2-[2-[2-[3-[Bis[2-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethylcarbamoylamino]ethyl]amino]-3-oxopropoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]-N,N-bis[2-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethylcarbamoylamino]ethyl]propanamide | IC50 | 100.0 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_19d364d687dcb0f5f93660622dceddb5.svg) | 1-[3-[Bis[3-[2-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethoxy]ethylcarbamoylamino]propyl]amino]propyl]-3-[2-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethoxy]ethyl]urea | IC50 | 6.31 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_4badaba3da790fa43d883a4928ea7529.svg) | 2-[2-[2-[2-[Bis[2-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethylamino]-2-oxoethyl]amino]ethoxy]ethoxy]ethyl-[2-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethylamino]-2-oxoethyl]amino]-N-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethyl]acetamide | IC50 | 794.33 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_5d75c79027f24dd61519283a5ec1c029.svg) | 1-[3-[Bis[3-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonyl-ethylamino]ethoxy]ethoxy]ethylcarbamoylamino]propyl]amino]propyl]-3-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonyl-ethylamino]ethoxy]ethoxy]ethyl]urea | IC50 | 19.95 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_1f6fa604855cd89bc425703aed03b974.svg) | 1-[3-[[(1S,2S)-2-Piperidin-1-yl-2,3-dihydro-1H-inden-1-yl]oxy]phenyl]-3-[2-[2-[2-[4-[2-[2-[2-[[3-[[(1S,2S)-2-piperidin-1-yl-2,3-dihydro-1H-inden-1-yl]oxy]phenyl]carbamoylamino]ethoxy]ethoxy]ethylcarbamoylamino]butylcarbamoylamino]ethoxy]ethoxy]ethyl]urea | IC50 | 281.84 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_1648dc7ab0907ba282b2b469d5740fa6.svg) | 2,2-Dimethyl-N,N'-bis[2-[2-[2-[2-[[4-[[(1S,2S)-2-piperidin-1-yl-2,3-dihydro-1H-inden-1-yl]oxy]phenyl]sulfonylamino]ethoxy]ethoxy]ethoxy]ethyl]propanediamide | IC50 | 15.85 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_b4c62a4b0617db0aefcb61f954390d47.svg) | 1-[2-[2-[2-[[4-[[(1S,2S)-4,6-Dichloro-2-[(3R)-3-hydroxypyrrolidin-1-yl]-2,3-dihydro-1H-inden-1-yl]oxy]phenyl]sulfonylamino]ethoxy]ethoxy]ethyl]-3-[4-[2-[2-[2-[[4-[[(1S,2S)-4,6-dichloro-2-[(3R)-3-hydroxypyrrolidin-1-yl]-2,3-dihydro-1H-inden-1-yl]oxy]phenyl]sulfonylamino]ethoxy]ethoxy]ethylcarbamoylamino]butyl]urea | IC50 | 6.31 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_a12f07c472ea292f5deccb96b04734f4.svg) | 2-[4-[3-[4-[2-[2-(2-Aminoethoxy)ethoxy]ethyl]piperazin-1-yl]phenyl]-6-chloroquinazolin-2-yl]guanidine | IC50 | 15.85 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_9f3c685ef523b59b2186f6a968961ae5.svg) | 2-[4-[4-[2-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]ethoxy]phenyl]-6-chloroquinazolin-2-yl]guanidine | IC50 | 31.62 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_0f5906d0f3a7cd12d4fc5fc5b9368fef.svg) | 1-N,3-N,5-N-Tris[2-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethoxy]ethyl]benzene-1,3,5-tricarboxamide | IC50 | 100.0 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_37ee1f108fdd9a08651be70d03e539a7.svg) | 1-N,2-N,3-N-Tris[2-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethoxy]ethyl]propane-1,2,3-tricarboxamide | IC50 | 19.95 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_e2989b81cccf1ab3d4481177c64c0eb0.svg) | 1-[2-[4-[4,6-Bis[4-[2-[2-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethoxy]ethylcarbamoylamino]ethyl]piperazin-1-yl]-1,3,5-triazin-2-yl]piperazin-1-yl]ethyl]-3-[2-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethoxy]ethyl]urea | IC50 | 63.1 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_edb9c2d7ca0048798a216ceb48e68cc5.svg) | 3-[(4S)-6,8-Dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]-N-[2-[2-[2-[2-[4-[[[1-[2-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethoxy]ethyl]triazol-4-yl]methyl-[[3-[2-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethoxy]ethyl]triazol-4-yl]methyl]amino]methyl]triazol-1-yl]ethoxy]ethoxy]ethoxy]ethyl]benzenesulfonamide | IC50 | 501.19 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_2e84ed6cbd205424ec5575c401326968.svg) | 3-[Bis[3-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethylamino]-3-oxopropyl]amino]-N-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethyl]propanamide | IC50 | 117.49 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_383f55bffa94036777f4e08c4699cfc1.svg) | (E)-N-(Diaminomethylidene)-3-[4-[4-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[[4-[4-[(E)-3-(diaminomethylideneamino)-2-methyl-3-oxoprop-1-enyl]-2,6-difluorophenoxy]phenyl]sulfonylamino]ethoxy]ethoxy]ethoxy]ethylcarbamoylamino]ethoxy]ethoxy]ethylcarbamoylamino]ethoxy]ethoxy]ethoxy]ethylsulfamoyl]phenoxy]-3,5-difluorophenyl]-2-methylprop-2-enamide | IC50 | 25.12 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_3e066da99101f0f2422ef7a645484e2e.svg) | (E)-N-(Diaminomethylidene)-3-[4-[4-[2-[2-[2-[2-[4-[2-[2-[2-[2-[[4-[4-[(E)-3-(diaminomethylideneamino)-2-methyl-3-oxoprop-1-enyl]-2,6-difluorophenoxy]phenyl]sulfonylamino]ethoxy]ethoxy]ethoxy]ethylcarbamoylamino]butylcarbamoylamino]ethoxy]ethoxy]ethoxy]ethylsulfamoyl]phenoxy]-3,5-difluorophenyl]-2-methylprop-2-enamide | IC50 | 7.94 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_95818c5ff8fbae2a15b6b5a68e5e2d6d.svg) | 1-N,4-N-Bis[2-[2-[2-[2-[[4-[4-[(E)-3-(diaminomethylideneamino)-2-methyl-3-oxoprop-1-enyl]-2,6-difluorophenoxy]phenyl]sulfonylamino]ethoxy]ethoxy]ethoxy]ethyl]piperazine-1,4-dicarboxamide | IC50 | 19.95 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_1b626ab3db9f2d74567e82e110baa8d5.svg) | 2-[2-[Carboxymethyl-[2-oxo-2-[2-[2-[2-[[4-[[(1S,2S)-2-piperidin-1-yl-2,3-dihydro-1H-inden-1-yl]oxy]phenyl]sulfonylamino]ethoxy]ethoxy]ethylamino]ethyl]amino]ethyl-[2-oxo-2-[2-[2-[2-[[4-[[(1S,2S)-2-piperidin-1-yl-2,3-dihydro-1H-inden-1-yl]oxy]phenyl]sulfonylamino]ethoxy]ethoxy]ethylamino]ethyl]amino]acetic acid | IC50 | 10.0 [1], 79.43 [2] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_910f2142b86933b76ae5771421cc0693.svg) | 1-N,2-N,3-N-Tris[2-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethoxy]ethyl]-2-hydroxypropane-1,2,3-tricarboxamide | IC50 | 15.85 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_834174268aefd95ee7747b5b82a6c8ba.svg) | 2-[2-[Carboxymethyl-[2-[2-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethoxy]ethylamino]-2-oxoethyl]amino]ethyl-[2-[2-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethoxy]ethylamino]-2-oxoethyl]amino]acetic acid | IC50 | 2.0 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_f2281f722d8ec8eb6d951ab00e8b70b1.svg) | 2-[Bis[2-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethylamino]-2-oxoethyl]amino]-N-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethyl]acetamide | IC50 | 158.49 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_9c35f442babc56553ae9a4e0456dc1d8.svg) | N,N'-Bis[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethyl]-4-[3-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethylamino]-3-oxopropyl]-4-(dimethylcarbamoylamino)heptanediamide | IC50 | 125.89 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_2577dc2d0e6559083541fa5f4d4ebbb6.svg) | N,N'-Bis[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethyl]-4-[3-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethylamino]-3-oxopropyl]-4-(methylcarbamoylamino)heptanediamide | IC50 | 63.1 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_ad9c4bca7e7c41d91454b3712f85131f.svg) | 5-[[1,7-Bis[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethylamino]-4-[3-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethylamino]-3-oxopropyl]-1,7-dioxoheptan-4-yl]amino]-5-oxopentanoic acid | IC50 | 50.12 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_db7d7de1c4cf7a38c4337368be4db80b.svg) | 1-[2-[2-[2-[2-[4-[4-[6-Chloro-2-(diaminomethylideneamino)quinazolin-4-yl]phenyl]piperazin-1-yl]ethoxy]ethoxy]ethoxy]ethyl]-3-[2-[2-[2-[2-[2-[2-[2-[4-[4-[6-chloro-2-(diaminomethylideneamino)quinazolin-4-yl]phenyl]piperazin-1-yl]ethoxy]ethoxy]ethoxy]ethylcarbamoylamino]ethoxy]ethoxy]ethyl]urea | IC50 | 63.1 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_0581905a78dd8ff5f1df8395c79387c1.svg) | 1-[2-[2-[2-[2-[[4-[[(1S,2S)-2-Piperidin-1-yl-2,3-dihydro-1H-inden-1-yl]oxy]phenyl]sulfonylamino]ethoxy]ethoxy]ethoxy]ethyl]-3-[4-[2-[2-[2-[2-[[4-[[(1S,2S)-2-piperidin-1-yl-2,3-dihydro-1H-inden-1-yl]oxy]phenyl]sulfonylamino]ethoxy]ethoxy]ethoxy]ethylcarbamoylamino]butyl]urea | IC50 | 5.62 [1], 12.59 [2] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_60f444639c666a72acd51d9db489f5c1.svg) | 2-[2-[2-[2-[2-[2-[2-[[4-[4-[(E)-3-(Diaminomethylideneamino)-2-methyl-3-oxoprop-1-enyl]-2,6-difluorophenoxy]phenyl]sulfonylamino]ethoxy]ethoxy]ethoxy]ethylcarbamoyloxy]ethoxy]ethoxy]ethyl N-[2-[2-[2-[2-[[4-[4-[(E)-3-(diaminomethylideneamino)-2-methyl-3-oxoprop-1-enyl]-2,6-difluorophenoxy]phenyl]sulfonylamino]ethoxy]ethoxy]ethoxy]ethyl]carbamate | IC50 | 19.95 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_444e661c7fe9a81777f96c170d17d1ea.svg) | (E)-N-(Diaminomethylidene)-3-[4-[4-[2-[2-[2-[2-[[4-[2-[2-[2-[2-[[4-[4-[(E)-3-(diaminomethylideneamino)-2-methyl-3-oxoprop-1-enyl]-2,6-difluorophenoxy]phenyl]sulfonylamino]ethoxy]ethoxy]ethoxy]ethylcarbamoyl-methylamino]butyl-methylcarbamoyl]amino]ethoxy]ethoxy]ethoxy]ethylsulfamoyl]phenoxy]-3,5-difluorophenyl]-2-methylprop-2-enamide | IC50 | 3.98 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_31ae44d6e23807df1fcce53011de0d65.svg) | 2-[2-[Carboxymethyl-[2-[2-[2-[2-[2-[[4-[4-[(E)-3-(diaminomethylideneamino)-2-methyl-3-oxoprop-1-enyl]-2,6-difluorophenoxy]phenyl]sulfonylamino]ethoxy]ethoxy]ethoxy]ethylamino]-2-oxoethyl]amino]ethyl-[2-[2-[2-[2-[2-[[4-[4-[(E)-3-(diaminomethylideneamino)-2-methyl-3-oxoprop-1-enyl]-2,6-difluorophenoxy]phenyl]sulfonylamino]ethoxy]ethoxy]ethoxy]ethylamino]-2-oxoethyl]amino]acetic acid | IC50 | 3.98 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_ce6046549d76961f3c3e2c69b24eb31a.svg) | 2-[Bis[2-[2-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethoxy]ethylamino]-2-oxoethyl]amino]-N-[2-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethoxy]ethyl]acetamide | IC50 | 31.62 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_c13abf2ca7b7dc4c287d951328dd4c24.svg) | 4-[[4-(4-Chlorophenyl)phenyl]methylamino]-N,N'-bis[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethyl]-4-[3-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethylamino]-3-oxopropyl]heptanediamide | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_e4f0034af4f74e45f12bd8dab677e970.svg) | 2-[4-[4,6-Bis[4-[2-[2-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethoxy]ethylamino]-2-oxoethyl]piperazin-1-yl]-1,3,5-triazin-2-yl]piperazin-1-yl]-N-[2-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethoxy]ethyl]acetamide | IC50 | 199.53 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_32c304318b75141adb6e19cee953e57a.svg) | N,N'-Bis[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethyl]-4-[3-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethylamino]-3-oxopropyl]-4-(undecanoylamino)heptanediamide | IC50 | 2511.89 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_275499c5654d355316b694db67b51439.svg) | 2-[2-[Carboxymethyl-[2-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethylamino]-2-oxoethyl]amino]ethyl-[2-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethylamino]-2-oxoethyl]amino]acetic acid | IC50 | 12.59 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_4ea226bb94d06a2a72f92c6bdf87ff33.svg) | 1-[2-[Bis[2-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethylcarbamoylamino]ethyl]amino]ethyl]-3-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethyl]urea | IC50 | 398.11 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_bb1764ed99c618299801a79a7860f070.svg) | (2R,3R)-N,N'-Bis[2-[2-[2-[4-[4-[6-chloro-2-(diaminomethylideneamino)quinazolin-4-yl]phenyl]piperazin-1-yl]ethoxy]ethoxy]ethyl]-2,3-dihydroxybutanediamide | IC50 | 251.19 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_e17d4ff3ac7e34ae8a192e85aa7170b0.svg) | 1-[2-[2-[2-[[3-[(4R)-6,8-Dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethyl]-3-[4-[2-[2-[2-[[3-[(4R)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethylcarbamoylamino]butyl]urea | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_f668bc5b71df7f2d2d08877293ebfdc5.svg) | N,N'-Bis[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethyl]-4-[3-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethylamino]-3-oxopropyl]-4-[[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]carbamoylamino]heptanediamide | IC50 | 53.7 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_c8f9433016a2b808bcc55fc56a4d6e94.svg) | 2-[[2-[[1,7-Bis[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethylamino]-4-[3-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethylamino]-3-oxopropyl]-1,7-dioxoheptan-4-yl]amino]-2-oxoethyl]-methylamino]acetic acid | IC50 | 50.12 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_59ea6771eb16915b3629ab728c5e26ea.svg) | N,N'-Bis[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethyl]-4-[3-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethylamino]-3-oxopropyl]-4-[[methyl-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]carbamoyl]amino]heptanediamide | IC50 | 79.43 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_ce603629bbe6140665a86a43b244174a.svg) | 2-[2-[Carboxymethyl-[2-[2-[2-[2-[2-[2-[2-[2-[3-[6-chloro-2-(diaminomethylideneamino)quinazolin-4-yl]phenoxy]ethoxy]ethoxy]ethoxy]ethylcarbamoylamino]ethoxy]ethoxy]ethylamino]-2-oxoethyl]amino]ethyl-[2-[2-[2-[2-[2-[2-[2-[2-[3-[6-chloro-2-(diaminomethylideneamino)quinazolin-4-yl]phenoxy]ethoxy]ethoxy]ethoxy]ethylcarbamoylamino]ethoxy]ethoxy]ethylamino]-2-oxoethyl]amino]acetic acid | IC50 | 12.59 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_6a479209befe634460abc2d9005be0e5.svg) | 1-[2-[2-[2-[2-[4-[6-Chloro-2-(diaminomethylideneamino)quinazolin-4-yl]phenoxy]ethoxy]ethoxy]ethoxy]ethyl]-3-[2-[2-[2-[4-[2-[2-[2-[2-[2-[2-[2-[4-[6-chloro-2-(diaminomethylideneamino)quinazolin-4-yl]phenoxy]ethoxy]ethoxy]ethoxy]ethylcarbamoylamino]ethoxy]ethoxy]ethylcarbamoylamino]butylcarbamoylamino]ethoxy]ethoxy]ethyl]urea | IC50 | 10.0 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_18c0ad63fef40274a66c57bd326dea70.svg) | N-[2-[2-[2-[2-[2-[2-[4-[3-[6-Chloro-2-(diaminomethylideneamino)quinazolin-4-yl]phenyl]piperazin-1-yl]ethoxy]ethoxy]ethylcarbamoylamino]ethoxy]ethoxy]ethyl]-2-[[2-[2-[2-[2-[2-[2-[2-[4-[3-[6-chloro-2-(diaminomethylideneamino)quinazolin-4-yl]phenyl]piperazin-1-yl]ethoxy]ethoxy]ethylcarbamoylamino]ethoxy]ethoxy]ethylamino]-2-oxoethyl]-methylamino]acetamide | IC50 | 12.59 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_68d8ea1066fba6e45893cec752dff8d2.svg) | N-[2-[2-[2-[2-[2-[2-[2-[3-[6-Chloro-2-(diaminomethylideneamino)quinazolin-4-yl]phenoxy]ethoxy]ethoxy]ethoxy]ethylcarbamoylamino]ethoxy]ethoxy]ethyl]-2-[[2-[2-[2-[2-[2-[2-[2-[2-[3-[6-chloro-2-(diaminomethylideneamino)quinazolin-4-yl]phenoxy]ethoxy]ethoxy]ethoxy]ethylcarbamoylamino]ethoxy]ethoxy]ethylamino]-2-oxoethyl]-methylamino]acetamide | IC50 | 19.95 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_60d87a168103b222880d3f77ce3d6f13.svg) | 3-[3-[Bis[3-[[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethyl-methylcarbamoyl]amino]propyl]amino]propyl]-1-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethyl]-1-methylurea | IC50 | 63.1 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_a270b595d0b909cf05210dd60c37eeb7.svg) | 2-[(E)-[(3S)-3-(5-Fluoro-2-methylphenyl)-8-methyl-3,4-dihydro-2H-naphthalen-1-ylidene]amino]guanidine | IC50 | 11000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_27a8bca20acdc3416cb915763ac89dfe.svg) | 2-[2-[Carboxymethyl-[2-[2-[2-[2-[2-[2-[2-[2-[4-[6-chloro-2-(diaminomethylideneamino)quinazolin-4-yl]phenoxy]ethoxy]ethoxy]ethoxy]ethylcarbamoylamino]ethoxy]ethoxy]ethylamino]-2-oxoethyl]amino]ethyl-[2-[2-[2-[2-[2-[2-[2-[2-[4-[6-chloro-2-(diaminomethylideneamino)quinazolin-4-yl]phenoxy]ethoxy]ethoxy]ethoxy]ethylcarbamoylamino]ethoxy]ethoxy]ethylamino]-2-oxoethyl]amino]acetic acid | IC50 | 5.01 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_dd17f86bf785280196005d24f94113f2.svg) | N-[2-[2-[2-[2-[2-[2-[2-[4-[4-[6-Chloro-2-(diaminomethylideneamino)quinazolin-4-yl]phenyl]piperazin-1-yl]ethoxy]ethoxy]ethoxy]ethylcarbamoylamino]ethoxy]ethoxy]ethyl]-2-[[2-[2-[2-[2-[2-[2-[2-[2-[4-[4-[6-chloro-2-(diaminomethylideneamino)quinazolin-4-yl]phenyl]piperazin-1-yl]ethoxy]ethoxy]ethoxy]ethylcarbamoylamino]ethoxy]ethoxy]ethylamino]-2-oxoethyl]-methylamino]acetamide | IC50 | 12.59 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_e2bbc1c497e102a2c1cbc1436f407516.svg) | 3-[Bis[3-[2-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethoxy]ethylamino]-3-oxopropyl]amino]-N-[2-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethoxy]ethyl]propanamide | IC50 | 63.1 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_8836f5b6ef4acdc3193de514c6af503c.svg) | N-[2-[2-[2-[2-[4-[3-[6-Chloro-2-(diaminomethylideneamino)quinazolin-4-yl]phenyl]piperazin-1-yl]ethoxy]ethoxy]ethoxy]ethyl]-3-[2-[2-[2-[2-[2-[2-[3-[2-[2-[2-[2-[4-[3-[6-chloro-2-(diaminomethylideneamino)quinazolin-4-yl]phenyl]piperazin-1-yl]ethoxy]ethoxy]ethoxy]ethylamino]-3-oxopropoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanamide | IC50 | 3.98 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_f734082d1e3522434733211bbb70d5f1.svg) | N-[2-[2-[2-[2-[2-[2-[2-[4-[6-Chloro-2-(diaminomethylideneamino)quinazolin-4-yl]phenoxy]ethoxy]ethoxy]ethoxy]ethylcarbamoylamino]ethoxy]ethoxy]ethyl]-2-[[2-[2-[2-[2-[2-[2-[2-[2-[4-[6-chloro-2-(diaminomethylideneamino)quinazolin-4-yl]phenoxy]ethoxy]ethoxy]ethoxy]ethylcarbamoylamino]ethoxy]ethoxy]ethylamino]-2-oxoethyl]-methylamino]acetamide | IC50 | 6.31 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_7e66f1f76759f10b8a9930136baf3392.svg) | N-[2-[2-[2-[2-[2-[2-[2-[4-[3-[6-Chloro-2-(diaminomethylideneamino)quinazolin-4-yl]phenyl]piperazin-1-yl]ethoxy]ethoxy]ethoxy]ethylcarbamoylamino]ethoxy]ethoxy]ethyl]-2-[[2-[2-[2-[2-[2-[2-[2-[2-[4-[3-[6-chloro-2-(diaminomethylideneamino)quinazolin-4-yl]phenyl]piperazin-1-yl]ethoxy]ethoxy]ethoxy]ethylcarbamoylamino]ethoxy]ethoxy]ethylamino]-2-oxoethyl]-methylamino]acetamide | IC50 | 6.31 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_0abcc3bb5f16f610f590c151ae58bdda.svg) | 2-[2-[Carboxymethyl-[2-[2-[2-[2-[2-[2-[2-[2-[4-[3-[6-chloro-2-(diaminomethylideneamino)quinazolin-4-yl]phenyl]piperazin-1-yl]ethoxy]ethoxy]ethoxy]ethylcarbamoylamino]ethoxy]ethoxy]ethylamino]-2-oxoethyl]amino]ethyl-[2-[2-[2-[2-[2-[2-[2-[2-[4-[3-[6-chloro-2-(diaminomethylideneamino)quinazolin-4-yl]phenyl]piperazin-1-yl]ethoxy]ethoxy]ethoxy]ethylcarbamoylamino]ethoxy]ethoxy]ethylamino]-2-oxoethyl]amino]acetic acid | IC50 | 6.31 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_4b462a067282d7896ccce143f9315dc6.svg) | N-[2-[2-[2-[2-[4-[3-[6-Chloro-2-(diaminomethylideneamino)quinazolin-4-yl]phenyl]piperazin-1-yl]ethoxy]ethoxy]ethoxy]ethyl]-3-[2-[2-[2-[2-[3-[2-[2-[2-[2-[4-[3-[6-chloro-2-(diaminomethylideneamino)quinazolin-4-yl]phenyl]piperazin-1-yl]ethoxy]ethoxy]ethoxy]ethylamino]-3-oxopropoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanamide | IC50 | 2.82 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_3160e23de51880c1ad965c137c27cc14.svg) | 2-[2-[Carboxymethyl-[2-[2-[2-[2-[2-[2-[2-[2-[4-[4-[6-chloro-2-(diaminomethylideneamino)quinazolin-4-yl]phenyl]piperazin-1-yl]ethoxy]ethoxy]ethoxy]ethylcarbamoylamino]ethoxy]ethoxy]ethylamino]-2-oxoethyl]amino]ethyl-[2-[2-[2-[2-[2-[2-[2-[2-[4-[4-[6-chloro-2-(diaminomethylideneamino)quinazolin-4-yl]phenyl]piperazin-1-yl]ethoxy]ethoxy]ethoxy]ethylcarbamoylamino]ethoxy]ethoxy]ethylamino]-2-oxoethyl]amino]acetic acid | IC50 | 12.59 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_13325faeae79d0e794456cd19441d7d7.svg) | 2-[(E)-[(3R)-3-(5-Fluoro-2-methylphenyl)-8-methyl-3,4-dihydro-2H-naphthalen-1-ylidene]amino]guanidine | IC50 | 30000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_2e13520c9392868612cda548583150f8.svg) | 1-[2-[2-[2-[[3-[(4S)-6,8-Dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethyl]-3-[4-[2-[2-[2-[[4-[(4R)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethylcarbamoylamino]butyl]urea;dihydrochloride | IC50 | 50.12 [1], 2511.89 [2] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_770af548088649eb27547b41deb4d8f1.svg) | (E)-3-[4-[4-[2-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]ethylsulfamoyl]phenoxy]-3,5-difluorophenyl]-N-(diaminomethylidene)-2-methylprop-2-enamide | IC50 | 158.49 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_28f43926e4d8ae08aebed3c3a4efb4df.svg) | N-[2-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]ethyl]-3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]benzenesulfonamide | IC50 | 112.2 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_1f927f4be8e9b335f730b03f3bc66af0.svg) | 1-[2-[2-[2-[[4-[[(1S,2S)-4,6-Dichloro-2-(dimethylamino)-2,3-dihydro-1H-inden-1-yl]oxy]phenyl]sulfonylamino]ethoxy]ethoxy]ethyl]-3-[4-[2-[2-[2-[[4-[[(1S,2S)-4,6-dichloro-2-(dimethylamino)-2,3-dihydro-1H-inden-1-yl]oxy]phenyl]sulfonylamino]ethoxy]ethoxy]ethylcarbamoylamino]butyl]urea | IC50 | 5.01 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_ced835f3be3381791226ba17f4650fcb.svg) | N,N'-Bis[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethyl]-4-[3-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethylamino]-3-oxopropyl]-4-(dimethylamino)heptanediamide | IC50 | 31.62 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_4f9ac5c24341e9e6c0c4509e6dd999a0.svg) | 1-[2-[2-[2-[[4-[[(1S,2S)-4,6-Dichloro-2-(dimethylamino)-2,3-dihydro-1H-inden-1-yl]oxy]phenyl]sulfonylamino]ethoxy]ethoxy]ethyl]-3-[4-[2-[2-[2-[[4-[[(1S,2S)-4,6-dichloro-2-(dimethylamino)-2,3-dihydro-1H-inden-1-yl]oxy]phenyl]sulfonylamino]ethoxy]ethoxy]ethylcarbamoylamino]phenyl]urea | IC50 | 2.0 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_0853dc07aab0a739e1de55b04c6bd4a1.svg) | 4-Amino-N,N'-bis[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethyl]-4-[3-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethylamino]-3-oxopropyl]heptanediamide | IC50 | 11.75 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_2c5983a0b9b77e9b56cb0897e988da83.svg) | 2-[[1,7-Bis[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethylamino]-4-[3-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethylamino]-3-oxopropyl]-1,7-dioxoheptan-4-yl]carbamoylamino]ethanesulfonic acid | IC50 | 16.98 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_f54cc0b015ffc11d4606827522bc6452.svg) | N,N'-Bis[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethyl]-4-[3-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethylamino]-3-oxopropyl]-4-(methanesulfonamido)heptanediamide | IC50 | 158.49 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_7bdbde814fcf0bce1d70816bfb622373.svg) | 2-[2-[[1,7-Bis[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethylamino]-4-[3-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethylamino]-3-oxopropyl]-1,7-dioxoheptan-4-yl]amino]-2-oxoethoxy]acetic acid | IC50 | 15.85 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_8b35ada15d93bee70ba88c5a8a425809.svg) | 2-[[1,7-Bis[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethylamino]-4-[3-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethylamino]-3-oxopropyl]-1,7-dioxoheptan-4-yl]carbamoylamino]acetic acid | IC50 | 7.41 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_3f62d85ea78046a5ec3cec7495f99418.svg) | 4-(Carbamoylamino)-N,N'-bis[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethyl]-4-[3-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethylamino]-3-oxopropyl]heptanediamide | IC50 | 50.12 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_f5e2e720ddb4c44caa447982293015b2.svg) | 4-Amino-N,N'-bis[2-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethoxy]ethyl]-4-[3-[2-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethoxy]ethylamino]-3-oxopropyl]heptanediamide | IC50 | 14.13 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_409564c1860c777744a0b6c1aa688ac8.svg) | N,N'-Bis[2-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethoxy]ethyl]-4-[3-[2-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethoxy]ethylamino]-3-oxopropyl]-4-(propanoylamino)heptanediamide | IC50 | 12.59 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_abb0e44d04e3addfe4dbd3418b1597c9.svg) | N,N'-Bis[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethyl]-4-[3-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethylamino]-3-oxopropyl]-4-(1-hydroxyethyl)heptanediamide | IC50 | 7.94 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_1ccacee0ff1ef6884c9804ffc95272ca.svg) | 4-Amino-N,N'-bis[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethyl]-4-[3-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethyl-methylamino]-3-oxopropyl]-N,N'-dimethylheptanediamide | IC50 | 39.81 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_024c7beae9b48d63dc8366d976a88ac6.svg) | 1-[3-[Bis[3-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonyl-(2-hydroxyethyl)amino]ethoxy]ethoxy]ethylcarbamoylamino]propyl]amino]propyl]-3-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonyl-(2-hydroxyethyl)amino]ethoxy]ethoxy]ethyl]urea | IC50 | 4.47 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_ac5adc55e9d6ecab93f623d800345de7.svg) | 2-[2-[[1,5-Bis[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethylcarbamoylamino]-3-[2-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethylcarbamoylamino]ethyl]pentan-3-yl]amino]-2-oxoethoxy]acetic acid | IC50 | 79.43 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_c6b46e230513d4e19386aa2264886e8e.svg) | N,N'-Bis[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethyl]-4-[3-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethylamino]-3-oxopropyl]-4-(2-morpholin-4-ylethylcarbamoylamino)heptanediamide | IC50 | 16.98 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_1e817cc0233bb013374c6dbc399eb7e8.svg) | 1-[2-[2-[2-[[4-[[(1S,2S)-6-Chloro-2-(dimethylamino)-4-fluoro-2,3-dihydro-1H-inden-1-yl]oxy]phenyl]sulfonylamino]ethoxy]ethoxy]ethyl]-3-[4-[2-[2-[2-[[4-[[(1S,2S)-6-chloro-2-(dimethylamino)-4-fluoro-2,3-dihydro-1H-inden-1-yl]oxy]phenyl]sulfonylamino]ethoxy]ethoxy]ethylcarbamoylamino]butyl]urea | IC50 | 3.98 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_ee0c3b3bd56e561d6db0c5342d5205c2.svg) | (2S)-2-[[1,7-Bis[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethylamino]-4-[3-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethylamino]-3-oxopropyl]-1,7-dioxoheptan-4-yl]carbamoylamino]-3-hydroxypropanoic acid | IC50 | 25.12 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_214ce1d7d067c20527a9cc6cb67c5dfe.svg) | 3-(6,8-Dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl)-N-(2-methoxyethyl)benzenesulfonamide | IC50 | 316.23 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_09b28214a8db50f3cb428b415aefbd3e.svg) | (2R,3R)-N,N'-Bis[2-[2-[2-[2-[[4-[4-[(E)-3-(diaminomethylideneamino)-2-methyl-3-oxoprop-1-enyl]-2,6-difluorophenoxy]phenyl]sulfonylamino]ethoxy]ethoxy]ethoxy]ethyl]-2,3-dihydroxybutanediamide | IC50 | 14.13 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_c55d07e2a253dd0478fb604cd8a24316.svg) | 2-[4-[4-[2-[2-(2-Aminoethoxy)ethoxy]ethylsulfamoyl]phenyl]-6-chloroquinazolin-2-yl]guanidine | IC50 | 398.11 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_3612c67f113d2369fbeab3cc0f61342e.svg) | 2-[4-[3-[2-[2-(2-Aminoethoxy)ethoxy]ethylsulfamoyl]phenyl]-6-chloroquinazolin-2-yl]guanidine | IC50 | 63.1 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_a83296a7f659675b0a413a907cff1324.svg) | 2-[4-[3-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]phenyl]-6-chloroquinazolin-2-yl]guanidine | IC50 | 31.62 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_2e272f378e6673946d4549a63281a8a3.svg) | 2-[2-[[1,7-Bis[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethylcarbamoylamino]-4-[3-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethylcarbamoylamino]propyl]heptan-4-yl]amino]-2-oxoethoxy]acetic acid | IC50 | 25.12 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_b7ec91494789059b4f40dbfd8af883a6.svg) | 1-[2-[2-[2-[[4-[[(1S,2S)-6-Chloro-4-fluoro-2-piperidin-1-yl-2,3-dihydro-1H-inden-1-yl]oxy]phenyl]sulfonylamino]ethoxy]ethoxy]ethyl]-3-[4-[2-[2-[2-[[4-[[(1S,2S)-6-chloro-4-fluoro-2-piperidin-1-yl-2,3-dihydro-1H-inden-1-yl]oxy]phenyl]sulfonylamino]ethoxy]ethoxy]ethylcarbamoylamino]butyl]urea | IC50 | 19.95 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_8fd30d50173619b5adcccf3af8d1fdde.svg) | 2-[4-[3-[2-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]ethylsulfamoyl]phenyl]-6-chloroquinazolin-2-yl]guanidine | IC50 | 100.0 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_c28239e80587f9dce4f686c1be566b7e.svg) | 2-[4-[4-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]phenyl]-6-chloroquinazolin-2-yl]guanidine | IC50 | 158.49 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_bb04c51e582e3e0459ab33fb1795ff54.svg) | (E)-N-(Diaminomethylidene)-3-[4-[4-[2-[2-[2-[2-[[4-[[2-[2-[2-[2-[[4-[4-[(E)-3-(diaminomethylideneamino)-2-methyl-3-oxoprop-1-enyl]-2,6-difluorophenoxy]phenyl]sulfonylamino]ethoxy]ethoxy]ethoxy]ethylamino]methyl]phenyl]methylamino]ethoxy]ethoxy]ethoxy]ethylsulfamoyl]phenoxy]-3,5-difluorophenyl]-2-methylprop-2-enamide | IC50 | 39.81 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_c1a8952c062f72ee474811f7ccc77320.svg) | 4-[[(2S,3R)-1-Amino-3-hydroxy-1-oxobutan-2-yl]carbamoylamino]-N,N'-bis[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethyl]-4-[3-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethylamino]-3-oxopropyl]heptanediamide | IC50 | 50.12 [1] |
![](https://images.aatbio.com/dataset/ic50/sodium-hydrogen-exchanger-3_c5431a7c844879c897ac2c415a65e2bc.svg) | 2-[4-[4-[4-[2-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]ethyl]piperazin-1-yl]phenyl]-6-chloroquinazolin-2-yl]guanidine | IC50 | 125.89 [1] |