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Sodium/hydrogen exchanger 1 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
▲
▼
CariporideIC50560.0 [1]
EniporideIC505.0 [1], 140.0 [2], 400.0 [3]
Cyclopropanecarboxamide, N-(aminoiminomethyl)-3-(2,3-dihydro-4-benzofuranyl)-2,2-dimethyl-, (1R,3R)-IC509.0 [1], 10.0 [2]
ZoniporideIC5059.0 [1]
(E)-N-(Diaminomethylidene)-3-[2-[(E)-3-(diaminomethylideneamino)-2-methyl-3-oxoprop-1-enyl]-4-methylphenyl]-2-methylprop-2-enamideIC503600.0 [1]
(E)-N-(Diaminomethylidene)-3-[3-[(E)-3-(diaminomethylideneamino)-2-methyl-3-oxoprop-1-enyl]phenyl]-2-methylprop-2-enamideIC502.0 [1]
AmilorideIC5060000.0 [1], 66730.0 [2]
SabiporideIC5028.0 [1], 172.0 [2]
N-[3-(3-Chloro-phenyl)-2,2-dimethyl-cyclopropanecarbonyl]-guanidineIC5014.0 [1], 21.0 [2]
N-[3-(3,5-Dichloro-phenyl)-2,2-dimethyl-cyclopropanecarbonyl]-guanidineIC506.0 [1]
N-[2-(2,3-Dihydro-benzofuran-4-yl)-cyclopropanecarbonyl]-guanidineIC50120.0 [1]
4-(1-Acetylpiperidin-4-yl)-N-(diaminomethylidene)-3-(trifluoromethyl)benzamideIC506.0 [1], 31.0 [2]
4-(1-Acetylpiperidin-4-yl)-N-(diaminomethylidene)-2-methyl-5-(trifluoromethyl)benzamideIC505.0 [1], 28.0 [2]
N-(Diaminomethylidene)-4-[1-[4-(methylcarbamoyl)benzoyl]piperidin-4-yl]-3-(trifluoromethyl)benzamideIC5052.0 [1], 214.0 [2]
4-[1-(Cyclopropanecarbonyl)piperidin-4-yl]-N-(diaminomethylidene)-3-(trifluoromethyl)benzamideIC5016.0 [1], 50.0 [2]
N-(Diaminomethylidene)-4-[1-(4-hydroxybenzoyl)piperidin-4-yl]-3-(trifluoromethyl)benzamideIC5021.0 [1], 138.0 [2]
4-(1-Benzoylpiperidin-4-yl)-N-(diaminomethylidene)-3-(trifluoromethyl)benzamideIC5068.0 [1], 109.0 [2]
N-(Diaminomethylidene)-4-[1-(4-fluorobenzoyl)piperidin-4-yl]-3-(trifluoromethyl)benzamideIC50109.0 [1], 184.0 [2]
N-(Diaminomethylidene)-4-[1-(6-oxo-1H-pyridine-3-carbonyl)piperidin-4-yl]-3-(trifluoromethyl)benzamideIC5019.0 [1], 25.0 [2]
N-(Diaminomethylidene)-4-[1-(3-methylbutanoyl)piperidin-4-yl]-3-(trifluoromethyl)benzamideIC5047.0 [1], 221.0 [2]
N-(Diaminomethylidene)-4-[1-(4-sulfamoylbenzoyl)piperidin-4-yl]-3-(trifluoromethyl)benzamideIC5014.0 [1], 23.0 [2]
N-(Diaminomethylidene)-4-[1-(2-methylsulfonylbenzoyl)piperidin-4-yl]-3-(trifluoromethyl)benzamideIC5058.0 [1], 269.0 [2]
4-(1-Acetylpiperidin-4-yl)-N-(diaminomethylidene)-3-methylsulfonylbenzamideIC5022.0 [1], 189.0 [2]
N-(Diaminomethylidene)-4-[1-(4-imidazol-1-ylbenzoyl)piperidin-4-yl]-3-(trifluoromethyl)benzamideIC5065.0 [1], 169.0 [2]
N-(Diaminomethylidene)-4-[1-[4-(dimethylsulfamoyl)benzoyl]piperidin-4-yl]-3-(trifluoromethyl)benzamideIC5036.0 [1], 241.0 [2]
N-(Diaminomethylidene)-3-(trifluoromethyl)-4-[1-[4-(trifluoromethyl)benzoyl]piperidin-4-yl]benzamideIC50320.0 [1], 539.0 [2]
N-(Diaminomethylidene)-4-[1-(3-methylsulfonylbenzoyl)piperidin-4-yl]-3-(trifluoromethyl)benzamideIC5050.0 [1], 60.0 [2]
N-(Diaminomethylidene)-4-[1-(4-methylsulfonylbenzoyl)piperidin-4-yl]-3-(trifluoromethyl)benzamideIC5015.0 [1], 93.0 [2]
4-[1-(4-Chlorobenzoyl)piperidin-4-yl]-N-(diaminomethylidene)-3-(trifluoromethyl)benzamideIC50306.0 [1], 1130.0 [2]
N-(Diaminomethylidene)-4-[1-(4-phenylbenzoyl)piperidin-4-yl]-3-(trifluoromethyl)benzamideIC504705.0 [1], 10000.0 [2]
N-(Diaminomethylidene)-4-[1-(2-methoxyacetyl)piperidin-4-yl]-3-(trifluoromethyl)benzamideIC5010.0 [1], 48.0 [2]
N-(Diaminomethylidene)-4-[1-(4-methoxybenzoyl)piperidin-4-yl]-3-(trifluoromethyl)benzamideIC50132.0 [1], 498.0 [2]
N-(Diaminomethylidene)-4-[1-(2-methylpropanoyl)piperidin-4-yl]-3-(trifluoromethyl)benzamideIC5028.0 [1], 79.0 [2]
4-[1-(3-Cyanobenzoyl)piperidin-4-yl]-N-(diaminomethylidene)-3-(trifluoromethyl)benzamideIC5035.0 [1], 111.0 [2]
N-(Diaminomethylidene)-4-[1-(1H-pyrrole-2-carbonyl)piperidin-4-yl]-3-(trifluoromethyl)benzamideIC5045.0 [1], 241.0 [2]
4-[1-(4-Carbamoylbenzoyl)piperidin-4-yl]-N-(diaminomethylidene)-3-(trifluoromethyl)benzamideIC5026.0 [1], 36.0 [2]
N-(Diaminomethylidene)-4-[1-[3-(1,3-oxazol-5-yl)benzoyl]piperidin-4-yl]-3-(trifluoromethyl)benzamideIC5033.0 [1], 353.0 [2]
N-(Diaminomethylidene)-4-[1-(pyridine-3-carbonyl)piperidin-4-yl]-3-(trifluoromethyl)benzamideIC5018.0 [1], 32.0 [2]
N-(Diaminomethylidene)-4-[1-(2,2-dimethylpropanoyl)piperidin-4-yl]-3-(trifluoromethyl)benzamideIC5072.0 [1], 127.0 [2]
N-(Diaminomethylidene)-3-methylsulfonyl-4-(1-propanoylpiperidin-4-yl)benzamideIC5029.0 [1], 266.0 [2]
N-(Diaminomethylidene)-4-[1-[4-(1,3-oxazol-5-yl)benzoyl]piperidin-4-yl]-3-(trifluoromethyl)benzamideIC50102.0 [1], 368.0 [2]
N-(Diaminomethylidene)-4-[1-[4-(dimethylcarbamoyl)benzoyl]piperidin-4-yl]-3-(trifluoromethyl)benzamideIC5050.0 [1], 77.0 [2]
4-[1-(4-Cyanobenzoyl)piperidin-4-yl]-N-(diaminomethylidene)-3-(trifluoromethyl)benzamideIC5024.0 [1], 152.0 [2]
4-[1-(Cyclopentanecarbonyl)piperidin-4-yl]-N-(diaminomethylidene)-3-(trifluoromethyl)benzamideIC5064.0 [1], 416.0 [2]
N-(Diaminomethylidene)-4-[1-(3-methylimidazole-4-carbonyl)piperidin-4-yl]-3-(trifluoromethyl)benzamideIC5018.0 [1], 62.0 [2]
4-[1-(3-Chlorobenzoyl)piperidin-4-yl]-N-(diaminomethylidene)-3-(trifluoromethyl)benzamideIC50385.0 [1], 989.0 [2]
N-(Diaminomethylidene)-4-[1-(1-methylimidazole-2-carbonyl)piperidin-4-yl]-3-(trifluoromethyl)benzamideIC5014.0 [1], 111.0 [2]
N-(Diaminomethylidene)-4-[1-(pyridine-2-carbonyl)piperidin-4-yl]-3-(trifluoromethyl)benzamideIC5018.0 [1], 79.0 [2]
4-[1-(2-Cyanobenzoyl)piperidin-4-yl]-N-(diaminomethylidene)-3-(trifluoromethyl)benzamideIC5061.0 [1], 200.0 [2]
N-(Diaminomethylidene)-4-[1-(pyridine-4-carbonyl)piperidin-4-yl]-3-(trifluoromethyl)benzamideIC5018.0 [1], 70.0 [2]
N-(Diaminomethylidene)-4-(1-propanoylpiperidin-4-yl)-3-(trifluoromethyl)benzamideIC5011.0 [1], 31.0 [2]
4-[1-(2-Chlorobenzoyl)piperidin-4-yl]-N-(diaminomethylidene)-3-(trifluoromethyl)benzamideIC50108.0 [1], 495.0 [2]
4-(1-Butanoylpiperidin-4-yl)-N-(diaminomethylidene)-3-(trifluoromethyl)benzamideIC5029.0 [1], 201.0 [2]
4-(1-Acetylpiperidin-4-yl)-N-(diaminomethylidene)-2-methyl-5-methylsulfonylbenzamideIC5015.0 [1], 56.0 [2]
4-(1-Acetylpiperidin-4-yl)-N-(diaminomethylidene)-2-methoxy-5-(trifluoromethyl)benzamideIC5019.0 [1], 432.0 [2]
N-(Diaminomethylidene)-4-[1-(1,5-dimethylpyrazole-3-carbonyl)piperidin-4-yl]-3-(trifluoromethyl)benzamideIC5027.0 [1], 115.0 [2]
N-(Diaminomethylidene)-2-methyl-5-methylsulfonyl-4-(1-propanoylpiperidin-4-yl)benzamideIC5015.0 [1], 88.0 [2]
N-(Diaminomethylidene)-4-[1-[4-(methylsulfamoyl)benzoyl]piperidin-4-yl]-3-(trifluoromethyl)benzamideIC5030.0 [1], 88.0 [2]
N-[1-[4-(Diaminomethylidenecarbamoyl)-2-(trifluoromethyl)phenyl]piperidin-3-yl]-1H-pyrrole-2-carboxamideIC50172.0 [1], 3477.0 [2]
N-[1-[4-(Diaminomethylidenecarbamoyl)-2-(trifluoromethyl)phenyl]pyrrolidin-3-yl]-1H-pyrrole-2-carboxamideIC5036.0 [1], 1586.0 [2]
N-[1-[4-(Diaminomethylidenecarbamoyl)-2-(trifluoromethyl)phenyl]piperidin-4-yl]-1H-pyrrole-2-carboxamideIC5041.0 [1], 950.0 [2]
2-[(E)-[(3S)-3-(5-Fluoro-2-methylphenyl)-8-methyl-3,4-dihydro-2H-naphthalen-1-ylidene]amino]guanidineIC501.0 [1]
2-[(E)-[(3R)-3-(5-Fluoro-2-methylphenyl)-8-methyl-3,4-dihydro-2H-naphthalen-1-ylidene]amino]guanidineIC5035000.0 [1]
1H-BenzotriazoleIC50192680.0 [1]
EthylisopropylamilorideIC50800.0 [1]
n-[4-Cyano-benzo[b]thiophene-2-carbonyl]guanidineIC502000.0 [1]
2-Furancarboxamide, N-(aminoiminomethyl)-5-(5-chloro-2-methoxyphenyl)-IC5081.0 [1]
1-MethylbenzotriazoleIC5097100.0 [1]
1-Benzyl-1H-benzotriazoleIC5072510.0 [1]
1-Benzoyl-1H-benzotriazoleIC5051570.0 [1]
[5-(2-Methyl-5-fluorophenyl)furan-2-ylcarbonyl]guanidineIC50230.0 [1]
N-[5-(5-Fluoro-2-methoxy-phenyl)-furan-2-carbonyl]-guanidineIC50480.0 [1]
1-(Phenylsulfonyl)-1H-benzotriazoleIC5050890.0 [1]
[5-(4-Fluorophenyl)furan-2-ylcarbonyl]guanidineIC5039000.0 [1]
N-(5-Phenyl-furan-2-carbonyl)-guanidineIC503100.0 [1]
1-Tosyl-1H-benzotriazoleIC5049950.0 [1]
N-(5-Methyl-1-quinolin-5-yl-1H-pyrazole-4-carbonyl)-guanidineIC50860.0 [1]
1-Pentyl-1H-1,2,3-benzotriazoleIC5063470.0 [1]
1-Propyl-1H-1,2,3-benzotriazoleIC5072380.0 [1]
1-Butyl-1H-benzo[d][1,2,3]triazoleIC5068110.0 [1]
Benzotriazole, 1-(2,4-dichlorobenzyl)-IC5065140.0 [1]
2-MethylbenzotriazoleIC50177000.0 [1]
5-[(1R,3R)-3-(2,3-Dihydro-benzofuran-4-yl)-2,2-dimethyl-cyclopropyl]-1H-imidazoleIC5030000.0 [1]
N-(5-Cyclopropyl-1-naphthalen-1-yl-1H-pyrazole-4-carbonyl)-guanidineIC50160.0 [1]
N-[2-(3-Methoxy-phenyl)-cyclopropanecarbonyl]-guanidineIC50540.0 [1]
N-[3-(4-Fluoro-3-isopropyl-phenyl)-2,2-dimethyl-cyclopropanecarbonyl]-guanidineIC5017.0 [1]
N-[3-(2,5-Dichloro-phenyl)-2,2-dimethyl-cyclopropanecarbonyl]-guanidineIC505.0 [1]
N-[2-(4-Chloro-phenyl)-cyclopropanecarbonyl]-guanidineIC502900.0 [1]
N-[2-(4-Fluoro-phenyl)-cyclopropanecarbonyl]-guanidineIC501600.0 [1]
N-(2-Phenyl-cyclopropanecarbonyl)-guanidineIC503500.0 [1]
N-[3-(3-Ethyl-4-fluoro-phenyl)-2,2-dimethyl-cyclopropanecarbonyl]-guanidineIC505.0 [1]
N-[3-(4-Fluoro-3-methyl-phenyl)-2,2-dimethyl-cyclopropanecarbonyl]-guanidineIC5032.0 [1]
N-[2-(3-Chloro-phenyl)-cyclopropanecarbonyl]-guanidineIC50280.0 [1]
N-[2-(3-Nitro-phenyl)-cyclopropanecarbonyl]-guanidineIC501600.0 [1]
N-[3-(3-Methoxy-phenyl)-2,2-dimethyl-cyclopropanecarbonyl]-guanidineIC5012.0 [1]
N-[2-(3-Bromo-4-fluoro-phenyl)-cyclopropanecarbonyl]-guanidineIC5090.0 [1]
N-[3-(3-Bromo-4-fluoro-phenyl)-2,2-dimethyl-cyclopropanecarbonyl]-guanidineIC503.0 [1]
N-(2,2-Dimethyl-3-phenyl-cyclopropanecarbonyl)-guanidineIC5069.0 [1]
N-[2-(4-Nitro-phenyl)-cyclopropanecarbonyl]-guanidineIC5030000.0 [1]
N-[2-(4-Isopropyl-phenyl)-cyclopropanecarbonyl]-guanidineIC5030000.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Sodium/hydrogen exchanger 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/sodium-hydrogen-exchanger-1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 20). Quest Database™ Sodium/hydrogen exchanger 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/sodium-hydrogen-exchanger-1-inhibitors-ic50-ki.
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