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Sodium/glucose cotransporter 2 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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DapagliflozinIC501.3 [1]
PhlorizinIC5038.0 [1]
PhlorizinKi18.6 [1]
T-1095AIC505.2 [1], 11.0 [2], 50.0 [3]
T-1095AKi4.0 [1]
SotagliflozinIC501.5 [1], 1.8 [2]
EmpagliflozinIC503.1 [1]
CanagliflozinIC502.2 [1], 6.7 [2]
IpragliflozinIC507.4 [1], 8.4 [2]
Sergliflozin AIC504.8 [1], 6.25 [2]
Sergliflozin AKi2.4 [1]
6,8-Dichloro-4-[[5-[2-(4-chlorophenyl)ethyl]-4-(3,3,3-trifluoropropyl)-1,2,4-triazol-3-yl]methyl]-1,4-benzoxazin-3-oneIC5010.0 [1], 19.0 [2], 20.0 [3]
6,8-Dichloro-4-[[5-[2-(4-chlorophenyl)ethyl]-4-propyl-1,2,4-triazol-3-yl]methyl]-1,4-benzoxazin-3-oneIC509.0 [1], 16.0 [2], 40.0 [3]
TofogliflozinIC502.9 [1], 4.0 [2]
LuseogliflozinIC502.26 [1], 2.3 [2]
ErtugliflozinIC500.87 [1], 2.4 [2]
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-[(4-ethylphenyl)methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC501.9 [1], 12.0 [2]
(2S,3R,4S,5S,6R)-2-[[3-[2-(2,3-Dihydro-1-benzofuran-5-yl)ethyl]-1H-indol-4-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triolIC5024.0 [1]
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-[(4-methoxyphenyl)methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC501.0 [1], 1.9 [2]
(2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-[[3-[2-(4-methoxyphenyl)ethyl]-1H-indol-4-yl]oxy]oxane-3,4,5-triolIC50163.0 [1]
(2S,3R,4R,5S,6R)-2-[5-[(4-Ethoxyphenyl)methyl]-2-hydroxyphenyl]-6-(hydroxymethyl)thiane-3,4,5-triolIC5017.4 [1]
(3S,3'R,4'S,5'S,6'R)-6-Chloro-5-[(4-ethylphenyl)methyl]-6'-(hydroxymethyl)spiro[1H-2-benzofuran-3,2'-oxane]-3',4',5'-triolIC501.3 [1], 6.6 [2]
1-[2-Chloro-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-3-(4-ethoxyphenyl)propan-1-oneIC500.8 [1]
1-[2-Chloro-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-3-(4-ethoxyphenyl)propan-1-oneKi1700.0 [1]
D-Glucitol, 1,5-anhydro-1-C-(4-chloro-3-((4-hydroxyphenyl)methyl)phenyl)-, (1S)-IC5033.0 [1], 970.0 [2]
(3S,3'R,4'S,5'S,6'R)-5-[(4-Ethoxyphenyl)methyl]-6'-(hydroxymethyl)spiro[1H-2-benzofuran-3,2'-oxane]-3',4',5'-triolIC509.6 [1], 71.0 [2]
O-Spiroketal glucosideIC506.5 [1]
(2S,3R,4R,5S,6R)-2-[3-[(4-Ethoxyphenyl)methyl]phenyl]-6-(hydroxymethyl)thiane-3,4,5-triolIC5073.6 [1]
(2S,3R,4R,5S,6R)-2-[3-[(4-Ethoxyphenyl)methyl]-4-methylphenyl]-6-(hydroxymethyl)thiane-3,4,5-triolIC502.29 [1]
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-[[5-(furan-2-yl)-1,3-thiazol-2-yl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC500.72 [1], 1.75 [2]
(2R,3R,4S,5S,6R)-2-[3-[(4-Ethylphenyl)methyl]indol-1-yl]-6-(hydroxymethyl)oxane-3,4,5-triolIC507.1 [1]
(2S,3R,4S,5S,6R)-2-[(4-Benzyl-5-propan-2-yl-1H-pyrazol-3-yl)oxy]-6-(hydroxymethyl)oxane-3,4,5-triolIC502020.0 [1]
(2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-[[4-[(4-hydroxyphenyl)methyl]-5-propan-2-yl-1H-pyrazol-3-yl]oxy]oxane-3,4,5-triolIC50285.0 [1]
(2S,3R,4R,5S,6R)-2-[3-[(4-Ethylphenyl)methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC505.1 [1], 10.0 [2]
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-[(5-quinolin-2-yl-1,3,4-thiadiazol-2-yl)methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC50562.0 [1]
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-[(5-pyrazin-2-yl-1,3,4-thiadiazol-2-yl)methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC504.06 [1]
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-[(5-pyridazin-4-yl-1,3,4-thiadiazol-2-yl)methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC50190.0 [1]
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-[[5-(furan-2-yl)-1,3,4-thiadiazol-2-yl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC507.03 [1]
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-[[5-(furan-3-yl)-1,3,4-thiadiazol-2-yl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC5017.7 [1]
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-[[5-(3-methylfuran-2-yl)-1,3,4-thiadiazol-2-yl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC50106.0 [1]
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-[[5-(5-methylfuran-2-yl)-1,3,4-thiadiazol-2-yl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC5058.3 [1]
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-[[5-(5-phenylfuran-2-yl)-1,3,4-thiadiazol-2-yl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC5010.6 [1]
(2S,3R,4R,5S,6R)-2-[3-[[5-(1-Benzofuran-2-yl)-1,3,4-thiadiazol-2-yl]methyl]-4-chlorophenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC50249.0 [1]
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-[[5-(5-methyl-1,2-oxazol-3-yl)-1,3,4-thiadiazol-2-yl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC50257.0 [1]
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-[[5-(1-methylpyrrol-2-yl)-1,3,4-thiadiazol-2-yl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC50119.0 [1]
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-[(5-thiophen-2-yl-1,3,4-thiadiazol-2-yl)methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC5014.4 [1]
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-[(5-thiophen-3-yl-1,3,4-thiadiazol-2-yl)methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC503.51 [1]
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-[[5-(3-methylthiophen-2-yl)-1,3,4-thiadiazol-2-yl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC50762.0 [1]
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-[[5-(3-chlorothiophen-2-yl)-1,3,4-thiadiazol-2-yl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC50712.0 [1]
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-[[5-(5-chlorothiophen-2-yl)-1,3,4-thiadiazol-2-yl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC5018.2 [1]
(2S,3R,4R,5S,6R)-2-[3-[[5-(1-Benzothiophen-2-yl)-1,3,4-thiadiazol-2-yl]methyl]-4-chlorophenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC5044.5 [1]
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-[[5-(1,3-thiazol-4-yl)-1,3,4-thiadiazol-2-yl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC5021.8 [1]
(3R,4R,5S,6R)-2-[4-Chloro-3-[(5-cyclohexyl-1,3,4-thiadiazol-2-yl)methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC50542.0 [1]
(3R,4R,5S,6R)-2-[4-Chloro-3-[[5-(4-methylphenyl)-1,3,4-thiadiazol-2-yl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC50103.0 [1]
(3R,4R,5S,6R)-2-[4-Chloro-3-[[5-(4-propylphenyl)-1,3,4-thiadiazol-2-yl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC5024.9 [1]
(3R,4R,5S,6R)-2-[4-Chloro-3-[(5-pyridin-3-yl-1,3,4-thiadiazol-2-yl)methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC5045.3 [1]
(3R,4R,5S,6R)-2-[4-Chloro-3-[(5-pyridin-4-yl-1,3,4-thiadiazol-2-yl)methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC5053.0 [1]
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-[(5-propyl-1,3,4-thiadiazol-2-yl)methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC50214.0 [1]
(2S,3R,4R,5S,6R)-2-[3-[(5-Butyl-1,3,4-thiadiazol-2-yl)methyl]-4-chlorophenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC50379.0 [1]
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-[(5-pentyl-1,3,4-thiadiazol-2-yl)methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC50353.0 [1]
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-[(5-heptyl-1,3,4-thiadiazol-2-yl)methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC50122.0 [1]
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-[(5-methoxy-1,3,4-thiadiazol-2-yl)methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC50146.0 [1]
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-[(5-methylsulfanyl-1,3,4-thiadiazol-2-yl)methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC5010.9 [1]
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-[[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC50155.0 [1]
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-[[5-(2,2,2-trifluoroethyl)-1,3,4-thiadiazol-2-yl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC50758.0 [1]
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-[(5-cyclopentyl-1,3,4-thiadiazol-2-yl)methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC50445.0 [1]
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-[(5-phenyl-1,3,4-thiadiazol-2-yl)methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC5016.6 [1]
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-[[5-(4-chlorophenyl)-1,3,4-thiadiazol-2-yl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC50126.0 [1]
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-[(5-pyridin-2-yl-1,3,4-thiadiazol-2-yl)methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC5030.3 [1]
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-[[5-(6-methylpyridin-2-yl)-1,3,4-thiadiazol-2-yl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC50638.0 [1]
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-[[5-(6-methylpyridin-3-yl)-1,3,4-thiadiazol-2-yl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC5097.4 [1]
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-[[5-(2-methylpyridin-4-yl)-1,3,4-thiadiazol-2-yl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC5036.4 [1]
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-[(5-isoquinolin-3-yl-1,3,4-thiadiazol-2-yl)methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC5081.6 [1]
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-[(6-chloropyridazin-3-yl)methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC50202.0 [1]
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-[(6-ethoxypyridazin-3-yl)methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC5043.0 [1]
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-[(6-propoxypyridazin-3-yl)methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC5070.8 [1]
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-[(6-propan-2-yloxypyridazin-3-yl)methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC50110.0 [1]
(2S,3R,4R,5S,6R)-2-[3-[(6-Butoxypyridazin-3-yl)methyl]-4-chlorophenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC50109.0 [1]
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-[[6-(2-methylpropoxy)pyridazin-3-yl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC50435.0 [1]
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-[(6-pentoxypyridazin-3-yl)methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC5017.0 [1]
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-[(6-hexoxypyridazin-3-yl)methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC5017.3 [1]
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-[(6-cyclohexyloxypyridazin-3-yl)methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC50111.0 [1]
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-[[6-(oxan-4-yloxy)pyridazin-3-yl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC5077.6 [1]
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-[(6-methylsulfanylpyridazin-3-yl)methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC5013.4 [1]
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-[(6-ethylsulfanylpyridazin-3-yl)methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC5071.3 [1]
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-[(6-phenylsulfanylpyridazin-3-yl)methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC501870.0 [1]
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-[(6-methylpyridazin-3-yl)methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC50293.0 [1]
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-[(6-ethylpyridazin-3-yl)methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC50131.0 [1]
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-[(6-propylpyridazin-3-yl)methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC50237.0 [1]
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-[(6-propan-2-ylpyridazin-3-yl)methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC50259.0 [1]
(2S,3R,4R,5S,6R)-2-[3-[(6-Butylpyridazin-3-yl)methyl]-4-chlorophenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC50356.0 [1]
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-[[6-(2-methylpropyl)pyridazin-3-yl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC50811.0 [1]
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-[(6-pentylpyridazin-3-yl)methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC50134.0 [1]
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-[[6-(2-phenylethynyl)pyridazin-3-yl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC50176.0 [1]
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-[[6-(furan-2-yl)pyridazin-3-yl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC5064.3 [1]
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-[[6-(furan-3-yl)pyridazin-3-yl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC5061.3 [1]
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-[(6-thiophen-2-ylpyridazin-3-yl)methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC5071.4 [1]
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-[(6-thiophen-3-ylpyridazin-3-yl)methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC5075.4 [1]
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-[[6-(5-methylthiophen-2-yl)pyridazin-3-yl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC50168.0 [1]
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-[(6-phenylpyridazin-3-yl)methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC50222.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Sodium/glucose cotransporter 2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/sodium-glucose-cotransporter-2-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ Sodium/glucose cotransporter 2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/sodium-glucose-cotransporter-2-inhibitors-ic50-ki.
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