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Sodium/glucose cotransporter 1 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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DapagliflozinIC50885.0 [1]
PhlorizinIC50210.0 [1]
PhlorizinKi180.0 [1]
SotagliflozinIC5034.6 [1], 36.0 [2], 36.2 [3]
T-1095AIC50139.0 [1], 240.0 [2]
T-1095AKi50.0 [1]
PhloretinIC5012400.0 [1]
PhloretinKi86000.0 [1]
CanagliflozinIC50265.0 [1], 1900.0 [2]
ErtugliflozinIC50392.0 [1], 1960.0 [2]
Sergliflozin AIC502300.0 [1]
Sergliflozin etabonateIC5022000.0 [1]
(2S,3R,4S,5S,6R)-2-[[3-[2-(2,3-Dihydro-1-benzofuran-5-yl)ethyl]-1H-indol-4-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triolIC50145.0 [1]
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-[(4-methoxyphenyl)methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC50240.0 [1], 540.0 [2]
(2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-[[3-[2-(4-methoxyphenyl)ethyl]-1H-indol-4-yl]oxy]oxane-3,4,5-triolIC50611.0 [1]
(2S,3R,4R,5S,6R)-2-[5-[(4-Ethoxyphenyl)methyl]-2-hydroxyphenyl]-6-(hydroxymethyl)thiane-3,4,5-triolIC504040.0 [1]
(3S,3'R,4'S,5'S,6'R)-6-Chloro-5-[(4-ethylphenyl)methyl]-6'-(hydroxymethyl)spiro[1H-2-benzofuran-3,2'-oxane]-3',4',5'-triolIC50158.0 [1], 600.0 [2]
1-[2-Chloro-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-3-(4-ethoxyphenyl)propan-1-oneIC501800.0 [1]
1-[2-Chloro-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-3-(4-ethoxyphenyl)propan-1-oneKi45000.0 [1]
(3S,3'R,4'S,5'S,6'R)-5-[(4-Ethoxyphenyl)methyl]-6'-(hydroxymethyl)spiro[1H-2-benzofuran-3,2'-oxane]-3',4',5'-triolIC5010000.0 [1], 18745.0 [2]
O-Spiroketal glucosideIC501300.0 [1]
(2S,3R,4R,5S,6R)-2-[3-[(4-Ethoxyphenyl)methyl]phenyl]-6-(hydroxymethyl)thiane-3,4,5-triolIC5026100.0 [1]
(2S,3R,4R,5S,6R)-2-[3-[(4-Ethoxyphenyl)methyl]-4-methylphenyl]-6-(hydroxymethyl)thiane-3,4,5-triolIC50671.0 [1]
(6S,7R,8R,9S)-6-[3-[(4-Methoxyphenyl)methyl]-4-methylphenyl]-2,5-dioxaspiro[3.5]nonane-7,8,9-triolIC501540.0 [1]
6,8-Dichloro-4-[[5-[2-(4-chlorophenyl)ethyl]-4-(3,3,3-trifluoropropyl)-1,2,4-triazol-3-yl]methyl]-1,4-benzoxazin-3-oneIC506290.0 [1], 9000.0 [2]
(2S,3R,4S,5S,6R)-2-[(4-Benzyl-5-propan-2-yl-1H-pyrazol-3-yl)oxy]-6-(hydroxymethyl)oxane-3,4,5-triolIC50738.0 [1]
(2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-[[4-[(4-hydroxyphenyl)methyl]-5-propan-2-yl-1H-pyrazol-3-yl]oxy]oxane-3,4,5-triolIC50207.0 [1]
2-[[2-Chloro-5-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]phenyl]methyl]-[1,2,4]triazolo[4,3-a]pyridin-3-oneIC5024183.0 [1], 90000.0 [2]
2-[[2-Chloro-5-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]phenyl]methyl]-6-methyl-[1,2,4]triazolo[4,3-a]pyridin-3-oneIC5067442.0 [1], 90000.0 [2]
2-[[2-Chloro-5-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]phenyl]methyl]-7-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridin-3-oneIC5049500.0 [1], 90000.0 [2]
7-Chloro-2-[[2-chloro-5-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]phenyl]methyl]-[1,2,4]triazolo[4,3-a]pyridin-3-oneIC5090000.0 [1]
2-[[2-Chloro-5-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]phenyl]methyl]-6-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridin-3-oneIC5090000.0 [1]
2-[[2-Chloro-5-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]phenyl]methyl]-6-(hydroxymethyl)-[1,2,4]triazolo[4,3-a]pyridin-3-oneIC5090000.0 [1]
6-Chloro-2-[[2-chloro-5-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]phenyl]methyl]-[1,2,4]triazolo[4,3-a]pyridin-3-oneIC5061159.0 [1], 90000.0 [2]
2-[[2-Chloro-5-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]phenyl]methyl]-7-methyl-[1,2,4]triazolo[4,3-a]pyridin-3-oneIC5090000.0 [1]
6-Bromo-2-[[2-chloro-5-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]phenyl]methyl]-[1,2,4]triazolo[4,3-a]pyridin-3-oneIC5045634.0 [1], 90000.0 [2]
6-Chloro-2-[[2-chloro-5-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]phenyl]methyl]-7-methyl-[1,2,4]triazolo[4,3-a]pyridin-3-oneIC5090000.0 [1]
(2R,3R,4R,5S,6R)-2-[3-[[4-[[(1R,5S)-3-Bicyclo[3.1.0]hexanyl]oxy]phenyl]methyl]-4-chlorophenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC5075465.18 [1], 111470.59 [2]
Unii-WK4RT85hcaIC503075.36 [1], 17217.33 [2]
EmpagliflozinIC503235.0 [1]
TofogliflozinIC508444.0 [1]
LuseogliflozinIC503990.0 [1]
KurarinoneIC5010400.0 [1]
Sophoraflavanone GIC5018700.0 [1]
NothofaginIC5019000.0 [1]
Pinocembrin chalconeIC5025400.0 [1]
2',4',6'-TrihydroxydihydrochalconeIC507900.0 [1]
N-(2,5-Dimethylphenyl)-2-{[(2-methyl-5-nitrophenyl)sulfonyl]amino}benzamideIC5022.0 [1]
4-Methoxy-N-(2,4,6-trimethylphenyl)benzenesulfonamideIC5039810.72 [1]
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-[(4-ethylphenyl)methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triolIC50720.0 [1]
BexagliflozinIC502.3 [1]
Gneyulin BIC5037000.0 [1]
N-[2-(Dimethylamino)ethyl]-2-methyl-2-[4-[4-[[2-methyl-5-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-methylsulfanyloxan-2-yl]phenyl]methyl]phenyl]butanoylamino]propanamideIC502.2 [1]
(1R,2S,3R,4R,6R)-4-(Hydroxymethyl)-6-[2-[(4-methoxyphenyl)methyl]phenoxy]cyclohexane-1,2,3-triolIC509300.0 [1]
(2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-[[4-[(4-hydroxy-2-methylphenyl)methyl]-5-propan-2-yl-1H-pyrazol-3-yl]oxy]oxane-3,4,5-triolIC50320.0 [1]
2',4',6'-Trihydroxy-4-fluorochalconeIC5025600.0 [1]
4-Bromo-2',4',6'-trihydroxychalconeIC5034600.0 [1]
(2S,3R,4S,5S,6R)-2-[3-[2-(2,3-Dihydro-1-benzofuran-5-yl)ethyl]-1-methylindol-4-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triolIC50198.0 [1]
2',4',6'-Trihydroxy-4-methoxychalconeIC5050900.0 [1]
3-(4-Cyclopropylbenzyl)-4-fluoroindole-N-glucosideIC50230.0 [1]
4-[[5-[(4-Chlorophenyl)methylsulfanyl]-4-methyl-1,2,4-triazol-3-yl]methyl]-6-(trifluoromethyl)-1,4-benzothiazin-3-oneIC507000.0 [1]
3-(4-Methoxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-oneIC5013300.0 [1]
D-Glucitol, 1,5-anhydro-1-C-(4-chloro-3-((4-hydroxyphenyl)methyl)phenyl)-, (1S)-IC509.4 [1]
Alstiphyllanine DIC505000.0 [1]
(6S,7R,8R,9S)-6-[3-[(4-Ethylphenyl)methyl]-4-methylphenyl]-5-oxa-2-azaspiro[3.5]nonane-7,8,9-triolIC5010000.0 [1]
Gneyulin AIC5027000.0 [1]
Alstiphyllanine EIC5044000.0 [1]
3-Phenyl-1-[2,4,6-trihydroxy-3-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]phenyl]propan-1-oneIC509900.0 [1]
(2R,3R,4S,5S,6R)-2-[3-[(4-Ethylphenyl)methyl]indol-1-yl]-6-(hydroxymethyl)oxane-3,4,5-triolIC501956.0 [1]
(2S,3R,4S,5S,6R)-2-[[4-[(2,4-Dimethylphenyl)methyl]-5-propan-2-yl-1H-pyrazol-3-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triolIC50246.0 [1]
N-(2-Methyl-1-oxo-1-piperazin-1-ylpropan-2-yl)-4-[3-methyl-4-[[5-propan-2-yl-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1H-pyrazol-4-yl]methyl]phenyl]butanamideIC5011.0 [1]
3-Amino-N-[4-[[5-propan-2-yl-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1H-pyrazol-4-yl]methyl]phenyl]propanamideIC50446.0 [1]
(2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-[[4-[(2-phenylmethoxyphenyl)methyl]-5-(trifluoromethyl)-1H-pyrazol-3-yl]oxy]oxane-3,4,5-triolIC5037.0 [1]
N-[4-[[5-Propan-2-yl-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1H-pyrazol-4-yl]methyl]phenyl]acetamideIC50392.0 [1]
N-[4-[[5-Propan-2-yl-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1H-pyrazol-4-yl]methyl]phenyl]methanesulfonamideIC50931.0 [1]
(2S,3R,4S,5S,6R)-2-[[4-[(4-Aminophenyl)methyl]-5-propan-2-yl-1H-pyrazol-3-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triolIC50422.0 [1]
(2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-[[3-[(4-thiophen-3-ylphenyl)methyl]-1H-indol-4-yl]oxy]oxane-3,4,5-triolIC502240.0 [1]
(2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-[[3-[(4-propylphenyl)methyl]-1H-indol-4-yl]oxy]oxane-3,4,5-triolIC503200.0 [1]
(2S,3R,4S,5S,6R)-2-[[3-[(4-Ethylphenyl)methyl]-1H-indol-4-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triolIC502140.0 [1]
(2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-[[3-[(4-methylsulfanylphenyl)methyl]-1H-indol-4-yl]oxy]oxane-3,4,5-triolIC502890.0 [1]
(2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-[[3-[2-(4-methoxyphenyl)ethyl]-6-methyl-1H-indol-4-yl]oxy]oxane-3,4,5-triolIC503050.0 [1]
(2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-[[3-(2-naphthalen-2-ylethyl)-1H-indol-4-yl]oxy]oxane-3,4,5-triolIC501100.0 [1]
(2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-[[3-[(4-methylphenyl)methyl]-1H-indol-4-yl]oxy]oxane-3,4,5-triolIC504390.0 [1]
(2S,3R,4S,5S,6R)-2-[[3-[2-(2,3-Dihydro-1,4-benzodioxin-6-yl)ethyl]-1H-indol-4-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triolIC503610.0 [1]
(2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-[[3-[(4-pyridin-3-ylphenyl)methyl]-1H-indol-4-yl]oxy]oxane-3,4,5-triolIC501970.0 [1]
(2S,3R,4S,5S,6R)-2-[[3-[2-(4-Ethoxyphenyl)ethyl]-1H-indol-4-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triolIC501190.0 [1]
(2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-[[3-[(4-methoxyphenyl)methyl]-1H-indol-4-yl]oxy]oxane-3,4,5-triolIC501510.0 [1]
(1R,2R,3S,4R,5R)-1-[3-[(4-Ethylphenyl)methyl]-4-methoxyphenyl]-5-(hydroxymethyl)cyclohexane-1,2,3,4-tetrolIC5031000.0 [1]
(1R,2S,3R,4R,6R)-4-(Hydroxymethyl)-6-[2-[(4-methylsulfanylphenyl)methyl]phenoxy]cyclohexane-1,2,3-triolIC503500.0 [1]
(1R,2R,3S,4R,5R)-1-[5-[(4-Ethylphenyl)methyl]-2-methoxyphenyl]-5-(hydroxymethyl)cyclohexane-1,2,3,4-tetrolIC50100000.0 [1]
(1R,2R,3S,4R,5R)-1-[5-[(4-Ethylphenyl)methyl]-2,4-dimethoxyphenyl]-5-(hydroxymethyl)cyclohexane-1,2,3,4-tetrolIC508600.0 [1]
(1R,2S,3R,4R,6R)-4-[2-[(4-Cyclopropylphenyl)methyl]phenoxy]-6-(hydroxymethyl)cyclohexane-1,2,3-triolIC505600.0 [1]
(1R,2S,3R,4R,6R)-4-(Hydroxymethyl)-6-[2-[[4-(trifluoromethyl)phenyl]methyl]phenoxy]cyclohexane-1,2,3-triolIC5057000.0 [1]
(1R,2R,3S,4S,6R)-4-[5-[(4-Ethylphenyl)methyl]-2,4-dimethoxyphenyl]-6-(hydroxymethyl)cyclohexane-1,2,3-triolIC504500.0 [1]
(1R,2S,3R,4R,6R)-4-(2-Benzylphenoxy)-6-(hydroxymethyl)cyclohexane-1,2,3-triolIC5013000.0 [1]
(1R,2S,3R,4R,6R)-4-(Hydroxymethyl)-6-[2-[(4-propylphenyl)methyl]phenoxy]cyclohexane-1,2,3-triolIC507800.0 [1]
(2S,3R,4S,5S,6R)-2-[3-[2-(2,3-Dihydro-1-benzofuran-5-yl)ethyl]benzimidazol-4-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triolIC50718.0 [1]
(1R,2S,3R,4R,6R)-4-[2-[(4-Ethenylphenyl)methyl]phenoxy]-6-(hydroxymethyl)cyclohexane-1,2,3-triolIC503300.0 [1]
(1R,2R,3S,4S,6R)-4-[5-[(4-Ethylphenyl)methyl]-2-methylphenyl]-6-(hydroxymethyl)cyclohexane-1,2,3-triolIC5025000.0 [1]
(1R,2R,3S,4S,6R)-4-[2-Ethoxy-5-(4-ethylbenzyl)phenyl]-6-(hydroxymethyl)cyclohexane-1,2,3-triolIC50100000.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Sodium/glucose cotransporter 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/sodium-glucose-cotransporter-1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ Sodium/glucose cotransporter 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/sodium-glucose-cotransporter-1-inhibitors-ic50-ki.
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