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Sodium channel protein type IX alpha subunit Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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4-(1-Adamantylmethoxy)-5-chloro-2-fluoro-N-methylsulfonylbenzamideIC5040.0 [1]
TetracaineIC50200.0 [1]
TetracaineKi500.0 [1], 12000.0 [2]
N-[2-Methyl-3-[[4-[4-[[4-(trifluoromethoxy)phenyl]methoxy]piperidin-1-yl]-1,3,5-triazin-2-yl]amino]phenyl]acetamideIC50170.0 [1], 500.0 [2], 3300.0 [3], 3600.0 [4]
N-[2-Methyl-3-[[4-[4-[[4-(trifluoromethoxy)phenyl]methoxy]piperidin-1-yl]-1,3,5-triazin-2-yl]amino]phenyl]acetamideKi35.0 [1], 400.0 [2], 10000.0 [3]
4-[2-Methoxy-4-(trifluoromethyl)phenyl]-N-(1,3-thiazol-2-yl)quinazoline-7-sulfonamideIC50160.0 [1]
CID 46840946IC5011.0 [1]
3-Cyano-4-[2-(2-methylpyrazol-3-yl)phenoxy]-N-(1,3-thiazol-2-yl)benzenesulfonamideIC5028.0 [1]
N-[7-(1-Adamantylmethoxy)-6-chloro-[1,2,4]triazolo[4,3-a]pyridin-3-yl]methanesulfonamideIC5020.0 [1], 150.0 [2], 6130.0 [3], 7330.0 [4], 30690.0 [5]
MexiletineIC5011000.0 [1], 56000.0 [2], 340000.0 [3], 56000000.0 [4]
MexiletineKi13000.0 [1]
Tert-butyl N-[(2R)-1-oxo-1-[[(3R)-2-oxo-1-propan-2-yl-4,5-dihydro-3H-1-benzazepin-3-yl]amino]-3-[2-(trifluoromethoxy)phenyl]propan-2-yl]carbamateIC5035.0 [1]
Tert-butyl N-[(2R)-1-oxo-1-[[(3R)-2-oxo-1-propan-2-yl-4,5-dihydro-3H-1-benzazepin-3-yl]amino]-3-[2-(trifluoromethoxy)phenyl]propan-2-yl]carbamateKi40.0 [1]
1-[2-Methoxy-4-[3-(trifluoromethyl)phenyl]phenyl]-2-oxo-N-pyrimidin-2-ylquinoline-6-sulfonamideIC505.0 [1], 6.0 [2], 20.0 [3], 21.0 [4], 23.0 [5]
N-(Azetidin-1-ylsulfonyl)-4-[(5-chloro-2-adamantyl)oxy]-5-cyclopropyl-2-fluorobenzamideIC509.0 [1], 10.0 [2], 30.0 [3], 94.0 [4]
(2S)-2-[[(2S)-2-[[(2S)-6-Amino-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(1R,4S,7S,13S,16R,21R,24S,27S,30S,33S,36S,39S,42R,45S,48S,51S,54S,57S,60R,65R,68S,71S,74S)-27,57-bis(4-aminobutyl)-21-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-24-(3-amino-3-oxopropyl)-54,74-bis(3-carbamimidamidopropyl)-13,51-bis(2-carboxyethyl)-45-(carboxymethyl)-39-[(1R)-1-hydroxyethyl]-48-(hydroxymethyl)-30,36,68-tris(1H-indol-3-ylmethyl)-71-(2-methylpropyl)-7,33-bis(2-methylsulfanylethyl)-3,6,9,12,15,22,25,28,31,34,37,40,43,46,49,52,55,58,67,70,73,76,81-tricosaoxo-4-propan-2-yl-18,19,62,63,78,79-hexathia-2,5,8,11,14,23,26,29,32,35,38,41,44,47,50,53,56,59,66,69,72,75,82-tricosazatricyclo[40.34.4.216,60]dooctacontane-65-carbonyl]amino]hexanoyl]amino]hexanoyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]-3-(1H-indol-3-yl)propanoic acidIC500.3 [1], 1.0 [2], 3.0 [3]
4-(2'-(Trifluoromethoxy)biphenyl-3-yl)thiazole-2-carboxamideIC5015.0 [1], 230.0 [2]
4-(2'-(Trifluoromethoxy)biphenyl-3-yl)thiazole-2-carboxamideKi15.0 [1], 230.0 [2]
CID 118734437IC5013.2 [1], 27.0 [2], 630.0 [3]
[3-(Dimethylamino)-4-methoxyphenyl]-(7-methoxyspiro[5H-pyrrolo[1,2-a]quinoxaline-4,4'-piperidine]-1'-yl)methanoneIC509.0 [1], 331.0 [2]
(2S)-N-[6-[4-(4-Fluorophenoxy)phenyl]pyridin-2-yl]-3-(1H-imidazol-5-yl)-2-(methanesulfonamido)propanamideIC50140.0 [1]
(2S)-N-[6-[4-(4-Fluorophenoxy)phenyl]pyridin-2-yl]-3-(1H-imidazol-5-yl)-2-(methanesulfonamido)propanamideKi19.0 [1]
4-[2-(2-Amino-3H-benzimidazol-5-yl)-4-chlorophenoxy]-2,5-difluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamideIC500.3 [1], 30.0 [2]
4-[2-(3-Amino-1,2-benzoxazol-5-yl)-4-chlorophenoxy]-2,5-difluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamideIC500.4 [1], 0.6 [2]
4-[2-Methoxy-4-(trifluoromethyl)phenyl]-N-(1,3-thiazol-2-yl)-2,3-dihydro-1,4-benzoxazine-7-sulfonamideIC5064.0 [1], 120.0 [2], 124.0 [3]
4-[(4-Aminocyclohexyl)methylamino]-5-chloro-2-fluoro-N-(1,3-thiazol-2-yl)benzenesulfonamideIC504.0 [1], 6.0 [2], 398.0 [3], 9400.0 [4]
6-[[(2S)-1-Amino-1-oxopropan-2-yl]amino]-2-[4-(4-chloro-2-fluorophenoxy)phenyl]pyrimidine-4-carboxamideIC50180.0 [1]
6-[[(2S)-1-Amino-1-oxopropan-2-yl]amino]-2-[4-(4-chloro-2-fluorophenoxy)phenyl]pyrimidine-4-carboxamideKi16.0 [1]
(2R,3S)-3-[6-[4-[3-Cyano-4-(trifluoromethyl)phenoxy]phenyl]pyridin-2-yl]-2,3-dihydroxypropanamideIC50244.0 [1]
(2R,3S)-3-[6-[4-[3-Cyano-4-(trifluoromethyl)phenoxy]phenyl]pyridin-2-yl]-2,3-dihydroxypropanamideKi347.0 [1]
2-[4-(4-Fluorophenoxy)phenyl]-6-methyl-N-[2-(1-methylpiperidin-1-ium-1-yl)ethyl]pyridine-4-carboxamideIC50872.0 [1]
2-[4-(4-Fluorophenoxy)phenyl]-6-methyl-N-[2-(1-methylpiperidin-1-ium-1-yl)ethyl]pyridine-4-carboxamideKi6030.0 [1], 6033.0 [2]
6-Chloro-4-[2-cyano-4-(trifluoromethyl)phenyl]-N-(1,3-thiazol-2-yl)-2,3-dihydro-1,4-benzoxazine-7-sulfonamideIC5020.0 [1], 21.3 [2], 373.0 [3], 390.0 [4]
4-[2-Cyano-4-(trifluoromethyl)phenyl]-6-fluoro-N-(1,3-thiazol-2-yl)-2,3-dihydro-1,4-benzoxazine-7-sulfonamideIC509.86 [1], 37.0 [2], 140.0 [3], 183.0 [4]
4-[2-Cyano-4-(trifluoromethyl)phenyl]-N-(1,2,4-thiadiazol-5-yl)-2,3-dihydro-1,4-benzoxazine-7-sulfonamideIC5016.0 [1], 21.0 [2], 90.0 [3], 91.4 [4]
N-(Azetidin-1-ylsulfonyl)-5-cyclopropyl-2-fluoro-4-[(4-methylcyclohexyl)methoxy]benzamideIC506.0 [1], 7.0 [2], 87.0 [3], 280.0 [4]
4-[(5-Chloro-2-adamantyl)oxy]-5-cyclopropyl-2-fluoro-N-(3-fluoroazetidin-1-yl)sulfonylbenzamideIC5020.0 [1], 28.0 [2], 890.0 [3], 1200.0 [4]
N-(Azetidin-1-ylsulfonyl)-5-chloro-2-fluoro-4-[(5-methoxy-2-adamantyl)oxy]benzamideIC50300.0 [1], 390.0 [2], 1400.0 [3], 3600.0 [4]
N-(Azetidin-1-ylsulfonyl)-5-cyclopropyl-2-fluoro-4-[(5-fluoro-2-adamantyl)oxy]benzamideIC5020.0 [1], 21.0 [2], 24.0 [3], 100.0 [4]
TetrodotoxinIC506.0 [1], 25.0 [2], 30.0 [3]
5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-carboxamideIC506740.0 [1], 35340.0 [2]
4-Amino-2-[(4-tert-butylphenyl)methylsulfanyl]-1H-pyrimidin-6-oneIC50340.0 [1], 680.0 [2], 2200.0 [3]
6-Amino-2-heptylthiopyrimidin-4-olIC50400.0 [1], 940.0 [2], 1400.0 [3]
(1R,2R)-1-N-Methyl-1-N-[[4-(2-sulfamoylphenyl)phenyl]methyl]-2-N-[[4-(trifluoromethoxy)phenyl]methyl]cyclopentane-1,2-dicarboxamideIC50830.0 [1]
(1R,2R)-1-N-Methyl-1-N-[[4-(2-sulfamoylphenyl)phenyl]methyl]-2-N-[[4-(trifluoromethoxy)phenyl]methyl]cyclopentane-1,2-dicarboxamideKi250.0 [1], 290.0 [2]
N-[[4-(2-Sulfamoylphenyl)phenyl]methyl]-N'-[(5-thiophen-2-ylthiophen-2-yl)methyl]butanediamideIC50150.0 [1]
N-[[4-(2-Sulfamoylphenyl)phenyl]methyl]-N'-[(5-thiophen-2-ylthiophen-2-yl)methyl]butanediamideKi150.0 [1]
4-[[(3S,4R)-4-(4-Chlorophenyl)piperidin-3-yl]methoxy]-2,5-difluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamideIC502.0 [1], 3.3 [2], 59.0 [3]
CID 91666633IC503.0 [1], 7.0 [2], 10.0 [3]
4-(1-Adamantylmethoxy)-N-(azetidin-1-ylsulfonyl)-5-cyclopropyl-2-fluorobenzamideIC500.4 [1], 2.0 [2]
CID 118734430IC5010.0 [1], 90.0 [2]
CID 118734436IC5027.0 [1], 270.0 [2]
CID 118734482IC504.0 [1], 7.0 [2]
CID 118734547IC508.0 [1], 90.0 [2]
N-Me-aminopyrimidinone 9IC5080.0 [1], 420.0 [2], 500.0 [3]
{2-[2-(4-Chloro-phenyl)-thiazol-4-ylmethoxy]-phenyl}-pyrrolidin-1-yl-methanoneIC501000.0 [1]
{2-[2-(4-Chloro-phenyl)-thiazol-4-ylmethoxy]-phenyl}-pyrrolidin-1-yl-methanoneKi160.0 [1]
N-[6-Cyclopropyl-7-[(3,5-dichlorophenoxy)methyl]-[1,2,4]triazolo[4,3-a]pyridin-3-yl]methanesulfonamideIC501.0 [1], 2.0 [2], 20.0 [3]
1-[1-(2-Fluorophenyl)indazol-4-yl]-3-[2-[(3S)-3-fluoropyrrolidin-1-yl]-2-oxoethyl]imidazolidin-2-oneIC50370.0 [1], 480.0 [2], 570.0 [3]
1-[5-Fluoro-2-methoxy-4-[3-(trifluoromethyl)phenyl]phenyl]-N-(1,2-oxazol-3-yl)isoquinoline-6-sulfonamideIC5017.0 [1], 36.0 [2], 4000.0 [3]
2-N-[4-(4-Chlorophenoxy)phenyl]-1,3,5-triazine-2,4-diamineIC50300.0 [1], 2200.0 [2], 2900.0 [3]
N-[[5-[1-(2-Imidazol-1-ylethyl)indazol-3-yl]-1,2,4-oxadiazol-3-yl]methyl]benzamideIC5014500.0 [1], 28000.0 [2], 37000.0 [3]
N-[[5-[2-(2-Imidazol-1-ylethyl)indazol-3-yl]-1,2,4-oxadiazol-3-yl]methyl]-3-(trifluoromethoxy)benzamideIC503020.0 [1], 4820.0 [2], 5640.0 [3]
2-N-[4-[4-(Trifluoromethoxy)phenoxy]phenyl]pyrazine-2,6-diamineIC50240.0 [1], 800.0 [2], 3000.0 [3]
4-[[4-(7-Benzyl-5,6-dimethylpyrrolo[2,3-d]pyrimidin-4-yl)oxypiperidin-1-yl]methyl]-1,3-thiazoleIC5060.0 [1], 150.0 [2], 6400.0 [3]
N-Pyrimidin-4-yl-5-[2-(1,2,3,6-tetrahydropyridin-4-yl)-4-(trifluoromethyl)phenyl]naphthalene-2-sulfonamideIC5030.0 [1], 90.0 [2]
4-[2-Cyano-4-(trifluoromethyl)phenyl]-N-(1,2-oxazol-5-yl)-2,3-dihydro-1,4-benzoxazine-7-sulfonamideIC503640.0 [1], 9200.0 [2], 9210.0 [3]
4-[2-Cyano-4-(trifluoromethyl)phenyl]-N-pyrimidin-4-yl-2,3-dihydro-1,4-benzoxazine-7-sulfonamideIC5028.5 [1], 460.0 [2], 464.0 [3]
4-[2-Cyano-4-(trifluoromethyl)phenyl]-N-(1,3-oxazol-2-yl)-2,3-dihydro-1,4-benzoxazine-7-sulfonamideIC50924.0 [1], 2590.0 [2], 2600.0 [3]
4-[2-Chloro-4-(trifluoromethyl)phenyl]-N-(1,2,4-thiadiazol-5-yl)-2,3-dihydro-1,4-benzoxazine-7-sulfonamideIC507.83 [1], 38.6 [2]
5-[2-(1,2,3,6-Tetrahydropyridin-4-yl)-4-(trifluoromethyl)phenyl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-1H-isoquinoline-2-sulfonamideIC5022.1 [1], 30.0 [2]
N-[5-Chloro-6-[(3,4-dichlorophenoxy)methyl]-1,2-benzoxazol-3-yl]methanesulfonamideIC506.0 [1], 150.0 [2], 5600.0 [3]
N-[5-Chloro-6-[(3,4-dichlorophenyl)methoxy]-1,2-benzoxazol-3-yl]methanesulfonamideIC5074.0 [1], 1270.0 [2], 74000.0 [3]
N-[7-(1-Adamantylmethoxy)-6-cyclopropyl-[1,2,4]triazolo[4,3-a]pyridin-3-yl]methanesulfonamideIC503.0 [1], 10.0 [2], 12.0 [3]
1-[2-Methoxy-4-(trifluoromethyl)phenyl]-N-(1,3-thiazol-2-yl)isoquinoline-6-sulfonamideIC5010.0 [1], 298.0 [2], 300.0 [3]
1-[4-(3-Fluorophenyl)-2-methoxyphenyl]-N-pyrimidin-4-ylisoquinoline-6-sulfonamideIC5020.0 [1], 150.0 [2], 156.0 [3]
8-[2-Methoxy-4-(trifluoromethyl)phenyl]-N-(1,3-thiazol-2-yl)-1,7-naphthyridine-3-sulfonamideIC50160.0 [1], 2500.0 [2], 2530.0 [3]
4-[2-Cyano-4-(trifluoromethyl)phenyl]-N-(1,3-thiazol-2-yl)-2,3-dihydro-1,4-benzoxazine-7-sulfonamideIC5015.0 [1], 190.0 [2], 193.0 [3]
4-(4-Cyano-2-methoxyphenyl)-N-(1,3-thiazol-2-yl)-2,3-dihydro-1,4-benzoxazine-7-sulfonamideIC507.5 [1], 175.0 [2], 250.0 [3]
4-[2-Cyano-4-(trifluoromethyl)phenyl]-5-fluoro-N-(1,3-thiazol-2-yl)-2,3-dihydro-1,4-benzoxazine-7-sulfonamideIC50193.0 [1], 1990.0 [2], 2000.0 [3]
4-(4-Fluoro-2-methoxyphenyl)-N-(1,3-thiazol-2-yl)-2,3-dihydro-1,4-benzoxazine-7-sulfonamideIC5017.0 [1], 192.0 [2], 280.0 [3]
4-[2-Cyano-4-(trifluoromethyl)phenyl]-8-fluoro-N-(1,3-thiazol-2-yl)-2,3-dihydro-1,4-benzoxazine-7-sulfonamideIC5034.0 [1], 516.0 [2], 520.0 [3]
N-Pyrimidin-4-yl-4-[2-(1,2,3,6-tetrahydropyridin-4-yl)-4-(trifluoromethyl)phenyl]-2,3-dihydro-1,4-benzoxazine-7-sulfonamideIC506.2 [1], 135.0 [2], 140.0 [3]
4-(2-Methoxyphenyl)-N-(1,3-thiazol-2-yl)-2,3-dihydro-1,4-benzoxazine-7-sulfonamideIC5038.0 [1], 380.0 [2], 382.0 [3]
4-[2-Cyano-4-(trifluoromethyl)phenyl]-N-(1,3-thiazol-4-yl)-2,3-dihydro-1,4-benzoxazine-7-sulfonamideIC501630.0 [1], 2780.0 [2], 2800.0 [3]
4-[2-Methoxy-4-(trifluoromethyl)phenyl]-3-oxo-N-(1,3-thiazol-2-yl)-1,4-benzoxazine-7-sulfonamideIC5012.0 [1], 210.0 [2], 218.0 [3]
5-Chloro-2-fluoro-N-methylsulfonyl-4-[[4-(trifluoromethyl)cyclohexyl]methoxy]benzamideIC5084.7 [1], 86.0 [2], 158.0 [3]
5-Cyclopropyl-2-fluoro-N-methylsulfonyl-4-[[4-(trifluoromethyl)cyclohexyl]methoxy]benzamideIC507.0 [1], 13.0 [2]
CarbamazepineIC5022000.0 [1]
CarbamazepineKi32700.0 [1]
AmitriptylineIC501000.0 [1], 7000.0 [2]
SafinamideIC5033000.0 [1], 100000.0 [2]
EleclazineIC501100.0 [1], 5200.0 [2]
N-(2-Morpholin-4-ylphenyl)-2-quinolin-8-yloxyacetamideIC5031.0 [1], 10000.0 [2]
2,2-Diphenyl-N-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]acetamideIC505200.0 [1], 10000.0 [2]
6-Amino-N-methyl-5-(2,3,5-trichlorophenyl)picolinamideIC5014000.0 [1], 19000.0 [2]
CID 11998198IC503.0 [1]
N-[(2R)-1-[[(3R)-7-Chloro-2-oxo-1-propan-2-yl-4,5-dihydro-3H-1-benzazepin-3-yl]amino]-3-(2-fluorophenyl)-1-oxopropan-2-yl]-4-fluoro-2-(trifluoromethyl)benzamideIC5030.0 [1]
Sodium Channel inhibitor 1IC5087.0 [1], 280.0 [2]
CID 118734434IC50100.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Sodium channel protein type IX alpha subunit Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Dec. 2024, https://www.aatbio.com/data-sets/sodium-channel-protein-type-ix-alpha-subunit-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, December 21). Quest Database™ Sodium channel protein type IX alpha subunit Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/sodium-channel-protein-type-ix-alpha-subunit-inhibitors-ic50-ki.
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