Sodium channel alpha subunits; brain (Types I, II, III) Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Tetracaine	IC50	400.0 [1], 3400.0 [2]
	Brevetoxin B	IC50	15.02 [1]
	Truncated brevetoxin B	IC50	10000.0 [1]
	Cocaine	IC50	49000.0 [1]
	Caffeine	IC50	660000.0 [1]
	Dexpropranolol	IC50	10000.0 [1]
	Lidocaine	IC50	240000.0 [1]
	Verapamil	IC50	3300.0 [1]
	Forskolin	IC50	60000.0 [1]
	Phenobarbital	IC50	10000.0 [1]
	Phenytoin	IC50	18500.0 [1]
	Bupivacaine	IC50	5400.0 [1]
	Chlorpromazine	IC50	4300.0 [1]
	Haloperidol	IC50	1200.0 [1]
	Nifedipine	IC50	37000.0 [1]
	Reserpine	IC50	1600.0 [1]
	Procaine	IC50	110000.0 [1]
	Imipramine	IC50	3600.0 [1]
	Prazosin	IC50	10100.0 [1]
	Quinine	IC50	4400.0 [1]
	Amitriptyline	IC50	10000.0 [1]
	Phentolamine	IC50	8400.0 [1]
	Diltiazem	IC50	45000.0 [1]
	Metoprolol	IC50	117000.0 [1]
	Quinidine	IC50	3200.0 [1]
	Yohimbine	IC50	33000.0 [1]
	3-Isobutyl-1-methylxanthine	IC50	1800.0 [1]
	Desipramine	IC50	2400.0 [1]
	Strychnine	IC50	21000.0 [1]
	Diphenhydramine	IC50	6000.0 [1]
	Phenoxybenzamine	IC50	45000.0 [1]
	Clomipramine	IC50	10000.0 [1]
	Quinacrine	IC50	3300.0 [1]
	Trifluoperazine	IC50	5000.0 [1]
	Promethazine	IC50	6900.0 [1]
	Mianserin	IC50	5500.0 [1]
	Spiperone	IC50	600.0 [1]
	Prilocaine	IC50	54000.0 [1]
	Droperidol	IC50	740.0 [1]
	Thioridazine	IC50	6500.0 [1]
	Fluphenazine	IC50	3700.0 [1]
	Nortriptyline	IC50	10000.0 [1]
	Cyproheptadine	IC50	1000.0 [1]
	Nitrendipine	IC50	36000.0 [1]
	Chlorpheniramine	IC50	10000.0 [1]
	Loperamide	IC50	270.0 [1]
	Benzocaine	IC50	910000.0 [1]
	Tetrabenazine	IC50	85000.0 [1]
	Proadifen	IC50	4200.0 [1]
	Hydroxyzine	IC50	10000.0 [1]
	Felodipine	IC50	37000.0 [1]
	Promazine	IC50	5400.0 [1]
	Flunarizine	IC50	600.0 [1]
	Doxepin	IC50	10000.0 [1]
	Dibucaine	IC50	1400.0 [1]
	Gallopamil	IC50	3600.0 [1]
	Bepridil	IC50	840.0 [1]
	Nisoldipine	IC50	26000.0 [1]
	Cinnarizine	IC50	440.0 [1]
	1-[(7-Methyl-2,3-dihydro-1H-inden-4-yl)oxy]-3-(propan-2-ylamino)-2-butanol	IC50	10000.0 [1]
	Articaine	IC50	51000.0 [1]
	Biperiden	IC50	10000.0 [1]
	Levorphanol	IC50	25000.0 [1]
	Chlorprothixene	IC50	10000.0 [1]
	Dextrorphan	IC50	18000.0 [1]
	Prenylamine	IC50	300.0 [1]
	Proparacaine	IC50	1900.0 [1]
	Dicyclomine	IC50	28000.0 [1]
	Tiapamil	IC50	13500.0 [1]
	Brompheniramine	IC50	11000.0 [1]
	Oxybuprocaine	IC50	2900.0 [1]
	Propoxycaine	IC50	24000.0 [1]
	Etidocaine	IC50	3500.0 [1]
	Pheniramine	IC50	33000.0 [1]
	Dilazep	IC50	600.0 [1]
	Protriptyline	IC50	10000.0 [1]
	(+)-Butaclamol	IC50	3600.0 [1]
	1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanol	IC50	13000.0 [1]
	Butaclamolum	IC50	2000.0 [1]
	Butaxamine	IC50	27000.0 [1]
	Piperoxan	IC50	61000.0 [1]
	Dichloroisoproterenol	IC50	10000.0 [1]
	N-(6-Aminohexyl)-1-naphthalenesulfonamide Hydrochloride	IC50	22000.0 [1]
	Azacyclonol	IC50	14000.0 [1]
	Diphenidol	IC50	3400.0 [1]
	Oxethazaine	IC50	2300.0 [1]
	Hexobendine	IC50	1400.0 [1]
	Pramoxine	IC50	21200.0 [1]
	Butacaine	IC50	2700.0 [1]
	Hexylcaine	IC50	7000.0 [1]
	N-Methylpiperidin-4-yl propionate	IC50	10000.0 [1]
	Dimethisoquin	IC50	3400.0 [1]
	Piperocaine	IC50	13000.0 [1]
	Cns-5161	IC50	1750.0 [1]
	Cyclomethycaine	IC50	2000.0 [1]
	2-n-Butyl-3-(dimethylamino)-5,6-methylenedioxyindene	IC50	12500.0 [1]
	Diperodon	IC50	1300.0 [1]
	Parethoxycaine	IC50	24000.0 [1]
	N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride	IC50	12000.0 [1]
	1'-(3-(Diethylamino)propyl)-3,4-dihydrospiro(naphthalene-1(2H),3'-pyrrolidine)-2',5'-dione	IC50	94000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

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References

This online tool may be cited as follows

MLA	"Quest Database™ Sodium channel alpha subunits; brain (Types I, II, III) Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Dec. 2024, https://www.aatbio.com/data-sets/sodium-channel-alpha-subunits-brain-types-i-ii-iii-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, December 21). Quest Database™ Sodium channel alpha subunits; brain (Types I, II, III) Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/sodium-channel-alpha-subunits-brain-types-i-ii-iii-inhibitors-ic50-ki.
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