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Sodium/calcium exchanger 1 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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2-[[2-(5-Fluoro-2-methylphenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]-N,N-dimethyl-1,3-thiazole-5-carboxamideIC50640.0 [1], 800.0 [2]
2-[(2-Phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-N-propyl-1,3-thiazole-5-carboxamideIC50400.0 [1], 1500.0 [2]
2-[[2-[[(2S)-2-(2-Methylphenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]-1,3-thiazole-5-carbonyl]amino]ethyl dihydrogen phosphateIC5070.0 [1], 3000.0 [2]
[2-(2-Phenyl-chroman-6-yloxy)-thiazol-5-ylmethyl]-pyridin-4-ylmethyl-amineIC50200.0 [1], 2600.0 [2]
Methyl (2R)-2-[[2-[(2-pyridin-3-yl-3,4-dihydro-2H-chromen-6-yl)oxy]-1,3-thiazole-5-carbonyl]amino]propanoateIC503100.0 [1], 9900.0 [2]
2-[[2-(2-Methylphenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]-N-propyl-1,3-thiazole-5-carboxamideIC50300.0 [1], 350.0 [2]
2-[[2-(5-Fluoro-2-methylphenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]-N-propyl-1,3-thiazole-5-carboxamideIC50500.0 [1], 800.0 [2]
Morpholin-4-yl-[2-[[(2S)-2-phenyl-3,4-dihydro-2H-chromen-6-yl]oxy]-1,3-thiazol-5-yl]methanoneIC50500.0 [1], 4500.0 [2]
N-[[2-[(2-Phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-1,3-thiazol-5-yl]methyl]cyclopropanamineIC50200.0 [1], 3100.0 [2]
N-[[2-[[2-(2-Methylphenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]-1,3-thiazol-5-yl]methyl]-2-(2-oxopyrrolidin-1-yl)acetamideIC50500.0 [1], 3000.0 [2]
N-(2-Hydroxyethyl)-2-[[2-(2-methylphenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]-1,3-thiazole-5-carboxamideIC50400.0 [1], 600.0 [2]
N-(2-Hydroxyethyl)-2-[[(2S)-2-(2-methylphenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]-1,3-thiazole-5-carboxamideIC50100.0 [1], 200.0 [2]
N-[[2-[[2-(2-Methylphenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]-1,3-thiazol-5-yl]methyl]-1,2-oxazole-5-carboxamideIC50600.0 [1], 2500.0 [2]
4-Methyl-2-[[2-(2-methylphenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]-N-(1,2-oxazol-5-ylmethyl)-1,3-thiazole-5-carboxamideIC50500.0 [1], 2100.0 [2]
2-[[2-(5-Fluoro-2-methylphenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]-N-(2-hydroxyethyl)-1,3-thiazole-5-carboxamideIC50400.0 [1], 700.0 [2]
N-(6,7-Dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-3-ylmethyl)-2-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-1,3-thiazole-5-carboxamideIC50300.0 [1], 1900.0 [2]
N-[(2-Chloropyridin-4-yl)methyl]-2-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-1,3-thiazole-5-carboxamideIC50300.0 [1], 1200.0 [2]
N-[(1,5-Dimethylpyrazol-4-yl)methyl]-2-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-1,3-thiazole-5-carboxamideIC50300.0 [1], 2200.0 [2]
2-[[2-(3-Fluorophenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]-N-(1-pyridin-4-ylethyl)-1,3-thiazole-5-carboxamideIC50300.0 [1], 900.0 [2]
2-[[2-(3-Fluorophenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]-N-(pyridin-4-ylmethyl)-1,3-thiazole-5-carboxamideIC50200.0 [1], 600.0 [2]
N-(6,7-Dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-3-ylmethyl)-2-[[2-(3-fluorophenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]-1,3-thiazole-5-carboxamideIC50200.0 [1], 1200.0 [2]
N-(1,2-Oxazol-5-ylmethyl)-2-[(2-pyridin-3-yl-3,4-dihydro-2H-chromen-6-yl)oxy]-1,3-thiazole-5-carboxamideIC50600.0 [1], 8300.0 [2]
4-Methyl-2-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-N-(pyridin-4-ylmethyl)-1,3-thiazole-5-carboxamideIC50100.0 [1], 200.0 [2]
4-Chloro-2-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-N-(pyridin-4-ylmethyl)-1,3-thiazole-5-carboxamideIC50300.0 [1], 800.0 [2]
N-(1-Cyclopropyl-3-hydroxypropyl)-2-[[(2S)-2-phenyl-3,4-dihydro-2H-chromen-6-yl]oxy]-1,3-thiazole-5-carboxamideIC50300.0 [1], 1600.0 [2]
N-[(2-Chloropyridin-4-yl)methyl]-2-[[2-(2-methylphenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]-1,3-thiazole-5-carboxamideIC50300.0 [1], 1900.0 [2]
N-(3-Azabicyclo[3.1.0]hexan-6-yl)-2-[[(2S)-2-phenyl-3,4-dihydro-2H-chromen-6-yl]oxy]-1,3-thiazole-5-carboxamideIC50300.0 [1], 600.0 [2]
N-(2-Hydroxyethyl)-4-methyl-2-[[2-(2-methylphenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]-1,3-thiazole-5-carboxamideIC50300.0 [1], 900.0 [2]
N-[1-(3,5-Dimethyl-1H-pyrazol-4-yl)ethyl]-2-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-1,3-thiazole-5-carboxamideIC501000.0 [1]
3,5-Dimethyl-N-[[2-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-1,3-thiazol-5-yl]methyl]-1H-pyrazole-4-sulfonamideIC5023800.0 [1]
2-[(2-Phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-1,3-thiazole-5-carboxamideIC50400.0 [1]
[2-(2-Phenyl-chroman-6-yloxy)-thiazol-5-ylmethyl]amineIC50100.0 [1]
N-[[2-[(2-Phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-1,3-thiazol-5-yl]methyl]cyclobutanamineIC50200.0 [1]
Methyl 2-[[2-[[(2S)-2-phenyl-3,4-dihydro-2H-chromen-6-yl]oxy]-1,3-thiazol-5-yl]methylamino]acetateIC50100.0 [1]
2-[(3R)-3-Hydroxypyrrolidin-1-yl]-N-[[2-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-1,3-thiazol-5-yl]methyl]acetamideIC50400.0 [1]
Methyl (2S)-3,3-dimethyl-2-[[2-[[(2S)-2-phenyl-3,4-dihydro-2H-chromen-6-yl]oxy]-1,3-thiazole-5-carbonyl]amino]butanoateIC50600.0 [1]
Methyl 1-[[2-[[(2S)-2-phenyl-3,4-dihydro-2H-chromen-6-yl]oxy]-1,3-thiazole-5-carbonyl]amino]cyclopentane-1-carboxylateIC50600.0 [1]
4-[[2-[(2-Phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-1,3-thiazol-5-yl]methyl]morpholineIC50300.0 [1]
(2R)-2-[[2-[[(2S)-2-Phenyl-3,4-dihydro-2H-chromen-6-yl]oxy]-1,3-thiazole-5-carbonyl]amino]propanoic acidIC50700.0 [1]
N-[[2-[(2-Phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-1,3-thiazol-5-yl]methyl]-2-pyrazol-1-ylacetamideIC501100.0 [1]
N-[(1-Ethyl-3-methylpyrazol-4-yl)methyl]-1-[2-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-1,3-thiazol-5-yl]methanamineIC50500.0 [1]
2,9-Diazaspiro[4.5]decan-2-yl-[2-[[(2S)-2-phenyl-3,4-dihydro-2H-chromen-6-yl]oxy]-1,3-thiazol-5-yl]methanoneIC50600.0 [1]
(2S)-2-Amino-3-hydroxy-N-[[2-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-1,3-thiazol-5-yl]methyl]propanamideIC50900.0 [1]
Ethyl 4-methyl-2-[[[2-[[(2S)-2-phenyl-3,4-dihydro-2H-chromen-6-yl]oxy]-1,3-thiazole-5-carbonyl]amino]methyl]pentanoateIC501500.0 [1]
4-Methyl-2-[[2-(2-methylphenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]-N-propyl-1,3-thiazole-5-carboxamideIC5010000.0 [1]
Ethyl (2S)-2-[[2-[[(2S)-2-phenyl-3,4-dihydro-2H-chromen-6-yl]oxy]-1,3-thiazole-5-carbonyl]amino]propanoateIC50200.0 [1]
1-(1,5-Dimethylpyrazol-3-yl)-N-[[2-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-1,3-thiazol-5-yl]methyl]methanamineIC50300.0 [1]
(2S)-3-Phenyl-2-[[2-[[(2S)-2-phenyl-3,4-dihydro-2H-chromen-6-yl]oxy]-1,3-thiazole-5-carbonyl]amino]propanoic acidIC50600.0 [1]
2-[[(2S)-2-Phenyl-3,4-dihydro-2H-chromen-6-yl]oxy]-N-propyl-1,3-thiazole-4-carboxamideIC50110.0 [1]
4-[[[2-[(2-Phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-1,3-thiazol-5-yl]methylamino]methyl]-1H-pyridin-2-oneIC50300.0 [1]
Methyl 2-[[2-[[(2S)-2-phenyl-3,4-dihydro-2H-chromen-6-yl]oxy]-1,3-thiazole-5-carbonyl]amino]acetateIC50200.0 [1]
2-[[2-[[(2S)-2-Phenyl-3,4-dihydro-2H-chromen-6-yl]oxy]-1,3-thiazol-5-yl]methylamino]acetic acidIC50600.0 [1]
Methyl 2-[[2-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-1,3-thiazole-5-carbonyl]amino]acetateIC50200.0 [1]
2,4-Dimethyl-2-[[2-[[(2S)-2-phenyl-3,4-dihydro-2H-chromen-6-yl]oxy]-1,3-thiazole-5-carbonyl]amino]pentanoic acidIC50700.0 [1]
2-[4-[2-[[(2S)-2-Phenyl-3,4-dihydro-2H-chromen-6-yl]oxy]-1,3-thiazole-5-carbonyl]piperazin-1-yl]acetic acidIC501300.0 [1]
Ethyl (2S)-3-methyl-2-[[2-[(2-pyridin-3-yl-3,4-dihydro-2H-chromen-6-yl)oxy]-1,3-thiazole-5-carbonyl]amino]butanoateIC5025200.0 [1]
2-(3-Methylpyrazol-1-yl)-N-[[2-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-1,3-thiazol-5-yl]methyl]acetamideIC50300.0 [1]
[2-(Aminomethyl)pyrrolidin-1-yl]-[2-[[(2S)-2-phenyl-3,4-dihydro-2H-chromen-6-yl]oxy]-1,3-thiazol-5-yl]methanoneIC50400.0 [1]
Methyl 2,4-dimethyl-2-[[2-[[(2S)-2-phenyl-3,4-dihydro-2H-chromen-6-yl]oxy]-1,3-thiazole-5-carbonyl]amino]pentanoateIC501500.0 [1]
N-[[2-[[2-(3-Fluorophenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]-1,3-thiazol-5-yl]methyl]pyridine-3-carboxamideIC50200.0 [1]
3,3-Dimethyl-N-[[2-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-1,3-thiazol-5-yl]methyl]butan-2-amineIC50800.0 [1]
5-[[[2-[(2-Phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-1,3-thiazol-5-yl]methylamino]methyl]pyridine-2-carbonitrileIC50200.0 [1]
(4-Methylpiperazin-1-yl)-[2-[[(2S)-2-phenyl-3,4-dihydro-2H-chromen-6-yl]oxy]-1,3-thiazol-5-yl]methanoneIC50800.0 [1]
(4-Methylpiperazin-1-yl)-[2-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-1,3-thiazol-5-yl]methanoneIC50400.0 [1]
N-[[2-[(2-Phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-1,3-thiazol-5-yl]methyl]-2-pyridin-4-ylacetamideIC50300.0 [1]
2-(2,5-Dioxoimidazolidin-1-yl)-N-[[2-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-1,3-thiazol-5-yl]methyl]acetamideIC50600.0 [1]
Methyl (1R,2S,5S)-3-[2-[[(2S)-2-phenyl-3,4-dihydro-2H-chromen-6-yl]oxy]-1,3-thiazole-5-carbonyl]-3-azabicyclo[3.1.0]hexane-2-carboxylateIC50900.0 [1]
Methyl (2S)-1-[2-[[(2S)-2-phenyl-3,4-dihydro-2H-chromen-6-yl]oxy]-1,3-thiazole-5-carbonyl]pyrrolidine-2-carboxylateIC50500.0 [1]
2-(3,5-Dimethyl-1,2-oxazol-4-yl)-N-[[2-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-1,3-thiazol-5-yl]methyl]acetamideIC50400.0 [1]
1-(5-Methyl-1,2-oxazol-3-yl)-N-[[2-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-1,3-thiazol-5-yl]methyl]methanamineIC50200.0 [1]
Methyl 2-methyl-2-[[2-[[(2S)-2-phenyl-3,4-dihydro-2H-chromen-6-yl]oxy]-1,3-thiazole-5-carbonyl]amino]propanoateIC50600.0 [1]
2-[[(2S)-2-Phenyl-3,4-dihydro-2H-chromen-6-yl]oxy]-N-propyl-1,3-thiazole-5-carboxamideIC50600.0 [1]
2-(2-Oxopyrrolidin-1-yl)-N-[[2-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-1,3-thiazol-5-yl]methyl]acetamideIC50500.0 [1]
5-[(4-Methylpiperazin-1-yl)methyl]-2-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-1,3-thiazoleIC50800.0 [1]
2-Methoxy-N-[[2-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-1,3-thiazol-5-yl]methyl]ethanamineIC50200.0 [1]
N-Cyclopropyl-2-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-1,3-thiazole-5-carboxamideIC503300.0 [1]
2-[2-Hydroxyethyl-[[2-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-1,3-thiazol-5-yl]methyl]amino]ethanolIC50800.0 [1]
3-Methyl-N-[[2-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-1,3-thiazol-5-yl]methyl]-1,2-oxazol-5-amineIC50800.0 [1]
4-Methyl-2-[[[2-[[(2S)-2-phenyl-3,4-dihydro-2H-chromen-6-yl]oxy]-1,3-thiazole-5-carbonyl]amino]methyl]pentanoic acidIC50300.0 [1]
4-Methyl-1-[2-[[(2S)-2-phenyl-3,4-dihydro-2H-chromen-6-yl]oxy]-1,3-thiazole-5-carbonyl]pyrrolidine-3-carboxylic acidIC50500.0 [1]
Morpholin-4-yl-[2-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-1,3-thiazol-5-yl]methanoneIC50100.0 [1]
(3S,4S)-5-Cyclohexyl-3-hydroxy-4-[[2-[[(2S)-2-phenyl-3,4-dihydro-2H-chromen-6-yl]oxy]-1,3-thiazole-5-carbonyl]amino]pentanoic acidIC501100.0 [1]
(2S)-3-Methyl-2-[[2-[[(2S)-2-phenyl-3,4-dihydro-2H-chromen-6-yl]oxy]-1,3-thiazole-5-carbonyl]amino]butanoic acidIC50600.0 [1]
(2S)-3-Phenyl-2-[[2-[(2-pyridin-3-yl-3,4-dihydro-2H-chromen-6-yl)oxy]-1,3-thiazole-5-carbonyl]amino]propanoic acidIC5012100.0 [1]
(2S,3S)-3-Methyl-2-[[2-[(2-pyridin-3-yl-3,4-dihydro-2H-chromen-6-yl)oxy]-1,3-thiazole-5-carbonyl]amino]pentanoic acidIC5012500.0 [1]
2-[(2-Phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-N-propan-2-yl-1,3-thiazole-5-carboxamideIC50300.0 [1]
Propan-2-yl 2-[[2-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-1,3-thiazole-5-carbonyl]amino]acetateIC50200.0 [1]
Methyl (2R)-2-[[2-[[(2S)-2-phenyl-3,4-dihydro-2H-chromen-6-yl]oxy]-1,3-thiazole-5-carbonyl]amino]propanoateIC50400.0 [1]
3-Methyl-2-[[2-[[(2S)-2-phenyl-3,4-dihydro-2H-chromen-6-yl]oxy]-1,3-thiazole-5-carbonyl]amino]pentanoic acidIC50500.0 [1]
(2R,3S)-2-Hydroxy-5-methyl-3-[[2-[[(2S)-2-phenyl-3,4-dihydro-2H-chromen-6-yl]oxy]-1,3-thiazole-5-carbonyl]amino]hexanoic acidIC501600.0 [1]
Methyl 2-methyl-3-phenyl-2-[[2-[[(2S)-2-phenyl-3,4-dihydro-2H-chromen-6-yl]oxy]-1,3-thiazole-5-carbonyl]amino]propanoateIC502500.0 [1]
N-[(1,3-Dimethylpyrazol-4-yl)methyl]-1-[2-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-1,3-thiazol-5-yl]methanamineIC50400.0 [1]
2-[(2-Phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-5-(pyrrolidin-1-ylmethyl)-1,3-thiazoleIC50400.0 [1]
5-(3-Azabicyclo[3.2.2]nonan-3-ylmethyl)-2-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-1,3-thiazoleIC501400.0 [1]
2-Methyl-N-[[2-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-1,3-thiazol-5-yl]methyl]propan-1-amineIC50400.0 [1]
3-Methyl-N-[[2-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-1,3-thiazol-5-yl]methyl]butan-1-amineIC50600.0 [1]
Methyl 3-methyl-2-[[2-[[(2S)-2-phenyl-3,4-dihydro-2H-chromen-6-yl]oxy]-1,3-thiazole-5-carbonyl]amino]pentanoateIC501200.0 [1]
N-[[2-[[2-(3-Fluorophenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]-1,3-thiazol-5-yl]methyl]-2-pyridin-4-ylacetamideIC50200.0 [1]
(2S)-3-Methyl-2-[[2-[(2-pyridin-3-yl-3,4-dihydro-2H-chromen-6-yl)oxy]-1,3-thiazole-5-carbonyl]amino]butanoic acidIC5015600.0 [1]
(2S)-4-Methyl-2-[[2-[[(2S)-2-phenyl-3,4-dihydro-2H-chromen-6-yl]oxy]-1,3-thiazole-5-carbonyl]amino]pentanoic acidIC50600.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Sodium/calcium exchanger 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 19 Nov. 2024, https://www.aatbio.com/data-sets/sodium-calcium-exchanger-1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 19). Quest Database™ Sodium/calcium exchanger 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/sodium-calcium-exchanger-1-inhibitors-ic50-ki.
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