![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_31e4aaa56217bf447a4c246d4bcb4e03.svg) | Vismodegib | IC50 | 7.0 [1], 20.0 [2], 23.0 [3], 33.0 [4] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_31e4aaa56217bf447a4c246d4bcb4e03.svg) | Vismodegib | Ki | 16.2 [1] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_59bf0d1025a2457e46724eea5ca6e7e4.svg) | Cyclopamine | IC50 | 64.0 [1], 280.0 [2], 300.0 [3] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_59bf0d1025a2457e46724eea5ca6e7e4.svg) | Cyclopamine | Ki | 12.7 [1], 232.0 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_1251b3fbb90a21d71b34a74be588a20f.svg) | N-[[[3-[(Benzoyl)amino]phenyl]amino](thioxo)methyl]-3,4,5-trimethoxybenzamide | IC50 | 281.0 [1], 300.0 [2], 650.0 [3] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_99d5dcc0ee26a381eb1ec5c99600a6c6.svg) | N-[(3-Benzamidophenyl)carbamoyl]-3,4,5-trimethoxybenzamide | IC50 | 107.0 [1], 160.0 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_a642c1623b360bd9f5ffad64a9d57389.svg) | N-(4,4-Difluorocyclohexyl)-4-(3-quinolin-2-yl-1,2,4-oxadiazol-5-yl)piperazine-1-carboxamide | IC50 | 13.0 [1], 39.0 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_863e8332a3410738e0154a62d36e84a7.svg) | (8As)-8a-methyl-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-N-(2-phenylpyrazol-3-yl)-6,8-dihydro-5H-imidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 13.0 [1], 17.0 [2], 22.0 [3] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_a4751e599ecd70f94654e1afeb891ddb.svg) | (8As)-N-[2-(3-chlorophenyl)pyrazol-3-yl]-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 8.0 [1], 18.0 [2], 32.0 [3] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_cd05fec2304b3dbeb1c5a59472cbae72.svg) | (8As)-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-N-(2-phenylpyrazol-3-yl)-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 15.0 [1], 18.0 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_d0164f91170dcbea257e9430f9ec7364.svg) | (8As)-N-[2,6-dichloro-4-(dimethylcarbamoyl)phenyl]-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 77.0 [1], 120.0 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_266dec80d4f53a8670195bf719456b61.svg) | (8As)-N-(2,6-dichloro-4-fluorophenyl)-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 140.0 [1], 180.0 [2], 520.0 [3] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_b997726f4be7c87e9ab029c5440f83a9.svg) | (8As)-N-(2,6-dichloro-4-cyanophenyl)-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 100.0 [1], 120.0 [2], 450.0 [3] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_37630a6af1500270401c05e6324f6a3d.svg) | (8As)-N-[2-(3-chlorophenyl)pyridin-3-yl]-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 4.0 [1], 5.0 [2], 15.0 [3] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_acfb35feb96a42d1edc2753e88621ee3.svg) | (8As)-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-N-(2-thiophen-3-ylpyridin-3-yl)-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 21.0 [1], 42.0 [2], 89.0 [3] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_737c0268d238d872ba63a36bc5156d58.svg) | (8Ar)-8a-methyl-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-N-(2-phenylphenyl)-6,8-dihydro-5H-imidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 1200.0 [1], 1400.0 [2], 1600.0 [3] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_3d1e17f555b4864dffe4e4b710c869bd.svg) | (8As)-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-N-(2-phenylphenyl)-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 21.0 [1], 42.0 [2], 70.0 [3] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_1a429b949e760feb85316d88710ed6dc.svg) | (8As)-N-(2,3-dichlorophenyl)-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 230.0 [1], 270.0 [2], 690.0 [3] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_dbb4339b6d095cd041aa9a4c1c532ea0.svg) | (8As)-8a-methyl-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-N-(2-phenylphenyl)-6,8-dihydro-5H-imidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 19.0 [1], 23.0 [2], 60.0 [3] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_26f0af9e40d557cd4ac5a51c7381552a.svg) | (8As)-N-[2-(3-cyanophenyl)pyridin-3-yl]-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 5.0 [1], 16.0 [2], 22.0 [3] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_6b7fdea9f79ec84878c0eaea3f6fd31b.svg) | (8As)-N-(2,6-dichloro-4-methylsulfonylphenyl)-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 41.0 [1], 42.0 [2], 68.0 [3] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_c4e0f41c49db36e90bf1ce824197ca92.svg) | (8As)-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-N-(2-phenylpyridin-3-yl)-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 12.0 [1], 28.0 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_4c76baef5dfea5317d8af884d54090ce.svg) | (8As)-N-[2-(3-fluorophenyl)pyrazol-3-yl]-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 6.0 [1], 7.0 [2], 9.0 [3] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_381b9a04305e6df053d9b18e9bc4e76e.svg) | Sant-1 | IC50 | 4.74 [1], 25.0 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_edf5b78cc44d891fb53b724929d45ca7.svg) | 3,4,5-Trimethoxy-N-[N'-[4-methyl-3-[(4-phenylbenzoyl)amino]phenyl]carbamimidoyl]benzamide | IC50 | 5.0 [1], 15.0 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_f8a53cf938a74c2b3f3efe6a2eaa2977.svg) | 1-((5-Methyl-1-phenyl-1H-pyrazol-4-yl)methyl)-4-phenylpiperazine | IC50 | 78.4 [1], 96.0 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_964da2169fb44c4f67bdbdb8d8084632.svg) | (R)-(3-Methyl-4-(4-(4-(trifluoromethyl)phenyl)phthalazin-1-yl)piperazin-1-yl)(phenyl)methanone | IC50 | 2.8 [1] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_e779b369d87314ccde9b4d8174de78e3.svg) | 3-Fluoro-N-[4-methyl-3-[[4-(pyridin-2-ylmethoxy)benzoyl]amino]phenyl]-5-pyrrolidin-1-ylbenzamide | IC50 | 450.0 [1], 30000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_a9d60609c17d3c1e79583960d2330935.svg) | Nvp-leq-506 | IC50 | 100.0 [1] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_4dcf648c93a9682c7986c3e1dd3ba97f.svg) | (R)-(3-Methyl-4-(4-phenylphthalazin-1-yl)piperazin-1-yl)(phenyl)methanone | IC50 | 2.2 [1] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_00cdfe0781adcfc569e6a3725458b1fe.svg) | (S)-(3-Methyl-4-(4-phenylphthalazin-1-yl)piperazin-1-yl)(phenyl)methanone | IC50 | 5.3 [1], 11.0 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_18d602d5a802bec9c6391e15d0cb699b.svg) | (4-(4-(3,4-Dichlorophenyl)phthalazin-1-yl)piperazin-1-yl)(phenyl)methanone | IC50 | 17.0 [1], 17.3 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_76ee5e5934437672d17a85ab09122084.svg) | (R)-(4-(4-(4-(Hydroxymethyl)phenyl)phthalazin-1-yl)-3-methylpiperazin-1-yl)(phenyl)methanone | IC50 | 2.7 [1] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_493ad1d236e8d8f438ecf93d457d9216.svg) | (R)-(4-(4-(4-(Dimethylamino)phenyl)phthalazin-1-yl)-3-methylpiperazin-1-yl)(phenyl)methanone | IC50 | 5.2 [1], 5.3 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_7fc9f48ce94b0186b1b5a6acd81cb188.svg) | Phenyl[4-(4-phenyl-1-phthalazinyl)piperazino]methanone | IC50 | 19.0 [1] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_c06b0cc71acd741717164867ef7e23e0.svg) | N-[N'-(3-Benzamidophenyl)carbamimidoyl]-3,4,5-trimethoxybenzamide | IC50 | 290.0 [1] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_18a2c328e0d5d89867eb83e8c6835c20.svg) | CID 44610687 | IC50 | 380.0 [1], 3500.0 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_9becf55b29e2956e2ea3dc4a4dc45e65.svg) | N-(2-Chloro-5-methylsulfonylphenyl)-4-(3-quinolin-2-yl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxamide | IC50 | 1200.0 [1], 2500.0 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_2b3927a4f268f99cb2a1e55099a35aaf.svg) | N-(2-Chloro-4-methylsulfonylphenyl)-4-(3-quinolin-2-yl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxamide | IC50 | 1500.0 [1], 4100.0 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_31ffb59c10c0e117212edbf39f918288.svg) | N-(2-Chloro-5-cyanophenyl)-4-(3-quinolin-2-yl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxamide | IC50 | 320.0 [1], 2500.0 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_f63c1694b35db36056672d7065a7de77.svg) | N-(2-Chlorophenyl)-4-[3-(5-methoxyquinolin-2-yl)-1,2,4-oxadiazol-5-yl]piperidine-1-carboxamide | IC50 | 2500.0 [1] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_7ba1b40d2a76bf443567b14fb9fde224.svg) | N-[[1-(Cyclohexylamino)cyclopentyl]methyl]-4-(3-quinolin-2-yl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxamide | IC50 | 140.0 [1], 520.0 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_d8fad113bf4f18443fa8ea923ca6fcbe.svg) | N-(2-Chlorophenyl)-4-(3-quinolin-2-yl-1,2,4-oxadiazol-5-yl)piperazine-1-carboxamide | IC50 | 170.0 [1], 700.0 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_3988348ea4d8adc4ffb1aae7e657c5dc.svg) | 1-((3,5-Dimethyl-1-phenyl-1H-pyrazol-4-yl)methyl)-4-(2-methoxyphenyl)piperazine | IC50 | 1870.0 [1], 5000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_c83b04838b1671f1badbdfc2fb900c3e.svg) | 1-((1-(4-Fluorophenyl)-3,5-dimethyl-1H-pyrazol-4-yl)methyl)-4-(4-methoxyphenyl)piperazine | IC50 | 1690.0 [1], 2000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_b5f72bfb85d214a61a7b1c3812f6dd09.svg) | 1-((1-(4-Fluorophenyl)-3,5-dimethyl-1H-pyrazol-4-yl)methyl)-4-(3-methoxyphenyl)piperazine | IC50 | 20.0 [1], 823.0 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_a1dfb2b4c489b0098623bac1fa743898.svg) | 1-(4-Methoxyphenyl)-4-[(3-methyl-1-phenylpyrazol-4-yl)methyl]piperazine | IC50 | 5000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_52df0f74585f67cdc5dea9f1046a4d3c.svg) | 1-(4-Fluorophenyl)-4-[(3-methyl-1-phenylpyrazol-4-yl)methyl]piperazine | IC50 | 5000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_b65a2356e402ecfe4ee1cd1d3d0322cc.svg) | 1-[(5-Methyl-1-phenylpyrazol-4-yl)methyl]-4-[3-(trifluoromethyl)phenyl]piperazine | IC50 | 328.0 [1], 333.0 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_c98e000f7006a62a37e46ca56f1aaa96.svg) | 1-(4-Methoxyphenyl)-4-((5-methyl-1-phenyl-1H-pyrazol-4-yl)methyl)piperazine | IC50 | 105.0 [1], 126.0 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_154c821a242df23ec1209134042043cf.svg) | 1-[[1-(4-Fluorophenyl)-5-methylpyrazol-4-yl]methyl]-4-(3-methoxyphenyl)piperazine | IC50 | 5.0 [1], 64.7 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_39f498e53019c1e82baf2385619b2f7d.svg) | 4-[[3-(2,5-Dimethoxyphenyl)pyrrolidin-1-yl]methyl]-1-(2-fluorophenyl)-5-methylpyrazole | IC50 | 40.8 [1], 216.0 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_6b69866aa7f6500a340b536c462c8b91.svg) | 4-((3-(2-Fluoro-6-methoxyphenoxy)azetidin-1-yl)methyl)-5-methyl-1-phenyl-1H-pyrazole | IC50 | 8.27 [1], 124.0 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_e8a4c7371e62aa948d394cac29077bef.svg) | 1,3-Dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-N-(2-phenylpyrazol-3-yl)-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 13.0 [1], 16.0 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_e5a584b078734894ca2b3ea59bc783f3.svg) | 4-[3-(1-Methylbenzimidazol-2-yl)-1,2,4-oxadiazol-5-yl]-N-[(1-piperidin-1-ylcyclopentyl)methyl]piperazine-1-carboxamide | IC50 | 5.0 [1], 6.0 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_916c35b672c9bc5c58a1e3ee81e3c2a0.svg) | N-[[1-(Ethylamino)cyclopentyl]methyl]-4-(3-quinolin-2-yl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxamide | IC50 | 46.0 [1], 91.0 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_63b7cf33355ff374831e12f7f5dc806d.svg) | N-(2-Morpholin-4-yl-2-pyridin-3-ylethyl)-4-(3-quinolin-2-yl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxamide | IC50 | 2600.0 [1], 9900.0 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_8590e693b38b59d7b085260930780e3e.svg) | N-[[1-(Piperidine-1-carbonyl)cyclopentyl]methyl]-4-(3-quinolin-2-yl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxamide | IC50 | 230.0 [1], 7000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_97f16ae7a6a5ab202b5c177de0be4f2d.svg) | Tert-butyl N-[1-[[[4-(3-quinolin-2-yl-1,2,4-oxadiazol-5-yl)piperidine-1-carbonyl]amino]methyl]cyclopentyl]carbamate | IC50 | 2000.0 [1], 14000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_3a0ef5d6f781b1563dd77e176986733a.svg) | N-(4,4-Difluorocyclohexyl)-4-(3-quinolin-2-yl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxamide | IC50 | 480.0 [1], 1500.0 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_bf8c57e2381c52177326f3fb29d84c90.svg) | N-(2-Chlorophenyl)-4-[3-(4-methoxyquinolin-2-yl)-1,2,4-oxadiazol-5-yl]piperidine-1-carboxamide | IC50 | 2500.0 [1] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_2464fa6578b2da60e4d3076c70d0df33.svg) | N-(2-Chlorophenyl)-4-[3-(7-methoxyquinolin-2-yl)-1,2,4-oxadiazol-5-yl]piperidine-1-carboxamide | IC50 | 2500.0 [1] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_c2e67cb45c238ba01caeecb905fc9737.svg) | 1,3-Dioxo-2-(2-phenylethyl)-N-(2-phenylphenyl)-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 2000.0 [1], 5000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_47d45f66e90901c724d7f5143f27a4e5.svg) | 2-(2,3-Dihydro-1H-inden-2-yl)-1,3-dioxo-N-(2-phenylphenyl)-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 320.0 [1], 880.0 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_0db75ac460f489a3fb0347ffed180a17.svg) | N-(2-Chloro-4-cyano-6-methylphenyl)-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 84.0 [1], 150.0 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_68ef490d3b2fa69933aa6bc1a0f2a456.svg) | 1,3-Dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-N-[2-(trifluoromethyl)phenyl]-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 890.0 [1], 1100.0 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_00bea3fa102acb7cb962550e176d0a5c.svg) | N-(2-Chloro-4-fluorophenyl)-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 1100.0 [1] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_c762b84ffb7609e3511dde9d6f9bc472.svg) | N-(1,3-Benzodioxol-5-yl)-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 700.0 [1], 2700.0 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_c03ca5c18371a509cdaf66a515bdc6c0.svg) | 1,3-Dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-N-(2-thiophen-3-ylphenyl)-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 210.0 [1], 220.0 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_1ad7d1a7eb35ed2f06f6b4dd8be75f07.svg) | N-[2-(3-Methoxyphenyl)pyridin-3-yl]-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 47.0 [1], 82.0 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_0287619d938bf4b7e7c1a2a650845874.svg) | N-[[1-(Diethylamino)cyclopentyl]methyl]-4-(3-quinolin-2-yl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxamide | IC50 | 46.0 [1], 55.0 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_a3c9476bf01f06a89c114d6e6c7c732b.svg) | N-[(1-Propan-2-ylpyrrolidin-2-yl)methyl]-4-(3-quinolin-2-yl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxamide | IC50 | 340.0 [1], 650.0 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_1afd86f22a69694c9038a31cd0b20154.svg) | N-[(1-Ethylpiperidin-2-yl)methyl]-4-(3-quinolin-2-yl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxamide | IC50 | 64.0 [1], 80.0 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_be507d47a71ef75fd349f3134d4b399d.svg) | N-[(1-Morpholin-4-ylcyclohexyl)methyl]-4-(3-quinolin-2-yl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxamide | IC50 | 23.0 [1], 72.0 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_92794ae987b309d8d588e9cd51fe9466.svg) | Methyl 2-chloro-3-[[1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazine-7-carbonyl]amino]benzoate | IC50 | 1100.0 [1], 2200.0 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_6c27c8498165501e806d35dd4985a136.svg) | N-(3-Chloro-2-methylphenyl)-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 370.0 [1], 460.0 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_ce542c506fcfd4e1f5705f79b6055fc0.svg) | 1,3-Dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-N-(2-propan-2-ylphenyl)-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 180.0 [1], 210.0 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_dffde4a2a24504122c21df1af845a18c.svg) | 1,3-Dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-N-(2-phenylpyridin-3-yl)-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 12.0 [1], 28.0 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_bd2aacdeb81ce91d006fd185b2bef740.svg) | 3-Oxo-2-[(1S,2R)-2-phenylcyclopropyl]-N-(2-phenylphenyl)-5,6,8,8a-tetrahydro-1H-imidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 1400.0 [1], 3000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_7eca2eafc52d457f8ebe98dd89e9cda1.svg) | N-(2-Phenyl-2-piperidin-1-ylethyl)-4-(3-quinolin-2-yl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxamide | IC50 | 210.0 [1], 330.0 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_c0e93bf779856257703ebe179d82ecea.svg) | 4-(3-Quinolin-2-yl-1,2,4-oxadiazol-5-yl)-N-(1,2,3,4-tetrahydroisoquinolin-1-ylmethyl)piperidine-1-carboxamide | IC50 | 380.0 [1], 600.0 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_2c5e1b66f8071839be5a0e21d6e9d80f.svg) | N-(2,3-Dichloro-4-fluorophenyl)-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 480.0 [1], 510.0 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_ea905ec5e8513ba32dd3670b5485d62b.svg) | 1,3-Dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-N-(2-thiophen-3-ylpyridin-3-yl)-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 88.0 [1], 240.0 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_974b3d79da557427bb8b2b569dde7e7b.svg) | 1,3-Dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-N-(2-phenylphenyl)isoindole-5-carboxamide | IC50 | 3200.0 [1], 4600.0 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_293c136717d035af8b258cda8a79faf8.svg) | N-[[1-(4-Fluoropiperidin-1-yl)cyclopentyl]methyl]-4-(3-quinolin-2-yl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxamide | IC50 | 110.0 [1], 200.0 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_3c35d69fbbe34b576d7bb10be17cec07.svg) | N-[(1-Acetamidocyclopentyl)methyl]-4-(3-quinolin-2-yl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxamide | IC50 | 320.0 [1], 13000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_d25b19d1702698c455de390abf272423.svg) | N-[(1-Morpholin-4-ylcycloheptyl)methyl]-4-(3-quinolin-2-yl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxamide | IC50 | 240.0 [1], 480.0 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_459c6e1b39c675d051e72e4f309e7f79.svg) | N-[(1-Pyrrolidin-1-ylcyclopentyl)methyl]-4-(3-quinolin-2-yl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxamide | IC50 | 32.0 [1], 42.0 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_12dc60eb384512aa63900d8cb870a314.svg) | N-[(1-Phenylcyclopentyl)methyl]-4-(3-quinolin-2-yl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxamide | IC50 | 810.0 [1], 4500.0 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_cd4d37f9d6d8eeedba0c406a95e63ca0.svg) | N-(2-Chlorophenyl)-4-[3-(1-methylbenzimidazol-2-yl)-1,2,4-oxadiazol-5-yl]piperidine-1-carboxamide | IC50 | 1000.0 [1], 4500.0 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_b87488eeed4ae3db1cdcdf6c6a5e7001.svg) | N-Cyclohexyl-4-(3-quinolin-2-yl-1,2,4-oxadiazol-5-yl)piperazine-1-carboxamide | IC50 | 45.0 [1], 180.0 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_f70fa4836d23d10d3763bbf346a35a60.svg) | 1,3-Dioxo-2-[(1S,2S)-2-phenylcyclopropyl]-N-(2-phenylphenyl)-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 2500.0 [1] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_e6c83e8faae77959cbd09f0023457001.svg) | N-(2,6-Dichloro-4-cyanophenyl)-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 62.0 [1], 120.0 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_1a02cc003ad520dd62e0917734b9ddcc.svg) | N-(3,5-Dichlorophenyl)-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 280.0 [1], 780.0 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_658ecc2d431081b0266fa7fac3dd00a4.svg) | N-Methyl-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-N-(2-phenylphenyl)-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 1000.0 [1], 1600.0 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_d2f006352ce123637f3b883c19bd06ec.svg) | 1,3-Dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-N-(4-phenylphenyl)-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 890.0 [1], 2000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_58507b14da4dab4e48cac59471d18603.svg) | N-[[1-(4-Methoxypiperidin-1-yl)cyclopentyl]methyl]-4-(3-quinolin-2-yl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxamide | IC50 | 210.0 [1], 530.0 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_9e8621300452ff7778c0660146278d92.svg) | N-[(4-Ethylmorpholin-3-yl)methyl]-4-(3-quinolin-2-yl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxamide | IC50 | 300.0 [1], 390.0 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_53093fada24d8c403ec095530b922fc4.svg) | 4-[3-(1-Methylbenzimidazol-2-yl)-1,2,4-oxadiazol-5-yl]-N-[(1-piperidin-1-ylcyclopentyl)methyl]piperidine-1-carboxamide | IC50 | 19.0 [1], 21.0 [2] |
![](https://images.aatbio.com/dataset/ic50/smoothened-homolog_14bc954917b54d4915e5b37e907e60f6.svg) | N-[(1-Piperidin-1-ylcyclopentyl)methyl]-4-(3-quinolin-2-yl-1,2,4-oxadiazol-5-yl)piperazine-1-carboxamide | IC50 | 8.0 [1], 10.0 [2] |