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Signal transducer and activator of transcription 6 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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4-(Benzylamino)-2-((3-chloro-4-hydroxyphenethyl)amino)pyrimidine-5-carboxamideIC5021.0 [1]
4-(Benzylamino)-2-(4-morpholinophenylamino)pyrimidine-5-carboxamideIC506.5 [1]
2-(4-Hydroxyphenethylamino)-4-(benzylamino)pyrimidine-5-carboxamideIC5088.0 [1]
2-(4-Morpholin-4-ylanilino)-4-[(2,3,6-trifluorophenyl)methylamino]pyrimidine-5-carboxamideIC500.7 [1]
CID 86292328IC5028.0 [1]
4-[(2-Methoxybenzyl)amino]-2-[(4-morpholin-4-ylphenyl)amino]pyrimidine-5-carboxamideIC508.2 [1]
4-(Benzylamino)-2-{[2-(3,5-dichloro-4-hydroxyphenyl)ethyl]amino}pyrimidine-5-carboxamideIC5061.0 [1]
4-[(2,6-Difluorobenzyl)amino]-2-[(4-morpholin-4-ylphenyl)amino]pyrimidine-5-carboxamideIC502.2 [1]
(3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-Acetamido-3-(4-phosphonooxyphenyl)propanoyl]amino]-6-aminohexanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoyl]amino]-5-amino-5-oxopentanoyl]amino]-4-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-4-oxobutanoic acidIC502400.0 [1]
[2-[[(2S)-1-[(2S)-2-[(4-Iodophenyl)-phenylcarbamoyl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamoyl]-1H-indol-5-yl] dihydrogen phosphateIC50140.0 [1]
[4-[(E)-3-[[(2S)-3,3-Dimethyl-1-[(2S)-2-[methyl(phenyl)carbamoyl]pyrrolidin-1-yl]-1-oxobutan-2-yl]amino]-3-oxoprop-1-enyl]phenyl] dihydrogen phosphateIC50870.0 [1]
[4-[(E)-3-[[(2S)-3,3-Dimethyl-1-oxo-1-[(2S)-2-(phenylcarbamoyl)pyrrolidin-1-yl]butan-2-yl]amino]-3-oxoprop-1-enyl]phenyl] dihydrogen phosphateIC501250.0 [1]
[4-[(E)-4-[[(2S)-1-[(2S)-2-(Benzylcarbamoyl)pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]amino]-4-oxobut-2-en-2-yl]phenyl] dihydrogen phosphateIC50340.0 [1]
[4-[(E)-4-[[(2S)-3,3-Dimethyl-1-oxo-1-[2-[(E)-4-phenylbut-1-enyl]pyrrolidin-1-yl]butan-2-yl]amino]-4-oxobut-2-en-2-yl]phenyl] dihydrogen phosphateIC50540.0 [1]
[4-[(E)-4-[[(2S)-3,3-Dimethyl-1-oxo-1-[2-(4-phenylbutyl)pyrrolidin-1-yl]butan-2-yl]amino]-4-oxobut-2-en-2-yl]phenyl] dihydrogen phosphateIC501070.0 [1]
(3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-Acetamido-3-(4-phosphonooxyphenyl)propanoyl]amino]-6-aminohexanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoyl]amino]-5-amino-5-oxopentanoyl]amino]-4-[[(2S)-1-[[(2S,3S)-1-amino-3-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-oxobutanoic acidIC501800.0 [1]
[4-[(E)-4-[[(2S)-3,3-Dimethyl-1-[2-[(N-methylanilino)methyl]pyrrolidin-1-yl]-1-oxobutan-2-yl]amino]-4-oxobut-2-en-2-yl]phenyl] dihydrogen phosphateIC50410.0 [1]
[4-[(E)-4-[[(2S)-3,3-Dimethyl-1-[methyl-[2-(N-methylanilino)-2-oxoethyl]amino]-1-oxobutan-2-yl]amino]-4-oxobut-2-en-2-yl]phenyl] dihydrogen phosphateIC50270.0 [1]
[4-[(E)-4-[[(2S)-3,3-Dimethyl-1-[methyl-[(2S)-1-(N-methylanilino)-1-oxopropan-2-yl]amino]-1-oxobutan-2-yl]amino]-4-oxobut-2-en-2-yl]phenyl] dihydrogen phosphateIC50480.0 [1]
(3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-Acetamido-3-(4-phosphonooxyphenyl)propanoyl]amino]-6-aminohexanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoyl]amino]-5-amino-5-oxopentanoyl]amino]-4-amino-4-oxobutanoic acidIC504500.0 [1]
[4-[(2S)-2-Acetamido-3-[[(2S)-6-amino-1-[(2S)-2-[[(2S)-1-[[(2S)-1,5-diamino-1,5-dioxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxohexan-2-yl]amino]-3-oxopropyl]phenyl] dihydrogen phosphateIC504200.0 [1]
[4-[(2S)-2-Acetamido-3-[[(2S)-6-amino-1-[(2S)-2-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxohexan-2-yl]amino]-3-oxopropyl]phenyl] dihydrogen phosphateIC506100.0 [1]
[4-[(2S)-2-Acetamido-3-[[(2S)-6-amino-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-1-oxohexan-2-yl]amino]-3-oxopropyl]phenyl] dihydrogen phosphateIC505200.0 [1]
[4-[(2S)-2-Acetamido-3-[[(2S)-1-[(2S)-2-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]carbamoyl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]amino]-3-oxopropyl]phenyl] dihydrogen phosphateIC504000.0 [1]
[4-[(2S)-2-Acetamido-3-[[(2S)-1-[(2S)-2-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxohexan-2-yl]amino]-3-oxopropyl]phenyl] dihydrogen phosphateIC505200.0 [1]
[4-[(2S)-2-Acetamido-3-[[(2S)-1-[(2S)-2-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-3-oxopropyl]phenyl] dihydrogen phosphateIC5014900.0 [1]
[4-[(2S)-3-[[(2S)-6-Amino-1-[(2S)-2-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxohexan-2-yl]amino]-3-oxo-2-(3-phenylpropanoylamino)propyl]phenyl] dihydrogen phosphateIC508100.0 [1]
[4-[(2S)-3-[[(2S)-6-Amino-1-[(2S)-2-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxohexan-2-yl]amino]-3-oxo-2-[(2-phenylacetyl)amino]propyl]phenyl] dihydrogen phosphateIC504100.0 [1]
[4-[(2S)-3-[[(2S)-6-Amino-1-[(2S)-2-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxohexan-2-yl]amino]-2-benzamido-3-oxopropyl]phenyl] dihydrogen phosphateIC503500.0 [1]
[4-[(2S)-3-[[(2S)-6-Amino-1-[(2S)-2-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxohexan-2-yl]amino]-3-oxo-2-[[(E)-3-phenylprop-2-enoyl]amino]propyl]phenyl] dihydrogen phosphateIC506600.0 [1]
[4-[(E)-3-[[(2S)-6-Amino-1-[(2S)-2-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxohexan-2-yl]amino]-3-oxoprop-1-enyl]phenyl] dihydrogen phosphateIC508600.0 [1]
[2-[[(2S)-6-Amino-1-[(2S)-2-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxohexan-2-yl]carbamoyl]-1H-indol-5-yl] dihydrogen phosphateIC503700.0 [1]
[4-[(E)-4-[[(2S)-3,3-Dimethyl-1-oxo-1-[(2S)-2-(2-phenylethylcarbamoyl)pyrrolidin-1-yl]butan-2-yl]amino]-4-oxobut-2-en-2-yl]phenyl] dihydrogen phosphateIC50250.0 [1]
[4-[(E)-4-[[(2S)-1-[(2S)-2-(Dimethylcarbamoyl)pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]amino]-4-oxobut-2-en-2-yl]phenyl] dihydrogen phosphateIC50740.0 [1]
[4-[(E)-4-[[(2S)-3,3-Dimethyl-1-oxo-1-[2-[(E)-2-phenylethenyl]pyrrolidin-1-yl]butan-2-yl]amino]-4-oxobut-2-en-2-yl]phenyl] dihydrogen phosphateIC503430.0 [1]
[2-[[(2S)-6-Amino-1-[(2S)-2-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxohexan-2-yl]carbamoyl]-1-benzofuran-5-yl] dihydrogen phosphateIC5089600.0 [1]
4-[(2-Acetamidophenyl)methylamino]-2-(4-morpholin-4-ylanilino)pyrimidine-5-carboxamideIC505200.0 [1]
4-Benzylamino-2-[(4-piperazin-1-ylphenyl)amino]-pyrimidine-5-carboxamideIC507.0 [1]
4-[(2-Aminobenzyl)amino]-2-[(4-morpholin-4-ylphenyl)amino]pyrimidine-5-carboxamideIC50310.0 [1]
2-[4-[4-[[7-[(3,5-Difluorophenyl)methyl]pyrrolo[2,3-d]pyrimidin-2-yl]amino]phenyl]piperazin-1-yl]acetamideIC501.9 [1]
2-[2-(4-Hydroxyphenyl)ethylamino]-4-(3-methylanilino)pyrimidine-5-carboxamideIC50190.0 [1]
2-[2-(4-Hydroxyphenyl)ethylamino]-N-methyl-4-(3-methylanilino)pyrimidine-5-carboxamideIC50170.0 [1]
N-Ethyl-2-[2-(4-hydroxyphenyl)ethylamino]-4-(3-methylanilino)pyrimidine-5-carboxamideIC50380.0 [1]
2-[2-(3-Hydroxyphenyl)ethylamino]-4-(3-methylanilino)pyrimidine-5-carboxamideIC503000.0 [1]
2-[2-(4-Hydroxyphenyl)ethylamino]-4-(3-methylanilino)-N-propan-2-ylpyrimidine-5-carboxamideIC501100.0 [1]
2-[2-(4-Hydroxy-3-methylphenyl)ethylamino]-4-(3-methylanilino)pyrimidine-5-carboxamideIC50130.0 [1]
2-[2-(4-Hydroxy-3-methoxyphenyl)ethylamino]-4-(3-methylanilino)pyrimidine-5-carboxamideIC50660.0 [1]
2-[2-(4-Hydroxyphenyl)ethylamino]-N,N-dimethyl-4-(3-methylanilino)pyrimidine-5-carboxamideIC508200.0 [1]
4-Anilino-2-[2-(4-hydroxyphenyl)ethylamino]pyrimidine-5-carboxamideIC50410.0 [1]
2-[2-(3-Fluoro-4-hydroxyphenyl)ethylamino]-4-(3-methylanilino)pyrimidine-5-carboxamideIC5064.0 [1]
2-{[2-(4-Hydroxyphenyl)ethyl]amino}-4-cyclohexylaminopyrimidine-5-carboxamideIC50100.0 [1]
2-[2-(3-Chloro-4-hydroxyphenyl)ethylamino]-4-(3-methylanilino)pyrimidine-5-carboxamideIC5045.0 [1]
4-(Benzylamino)-2-[2-(3-chloro-4-hydroxyphenyl)ethylamino]-N-methylpyrimidine-5-carboxamideIC5030.0 [1]
2-{[2-(3-Bromo-4-hydroxyphenyl)ethyl]amino}-4-[(3-methylphenyl)amino]pyrimidine-5-carboxamideIC5083.0 [1]
4-[(2-Methylsulfonylphenyl)methylamino]-2-(4-morpholin-4-ylanilino)pyrimidine-5-carboxamideIC502000.0 [1]
4-[(3-Chlorobenzyl)amino]-2-[(4-morpholin-4-ylphenyl)amino]pyrimidine-5-carboxamideIC5036.0 [1]
2-[(4-Morpholin-4-ylphenyl)amino]-4-[(3-trifluoromethylbenzyl)amino]pyrimidine-5-carboxamideIC50130.0 [1]
4-[(3-Methoxybenzyl)amino]-2-[(4-morpholin-4-ylphenyl)amino]pyrimidine-5-carboxamideIC5025.0 [1]
4-[(3-Hydroxybenzyl)amino]-2-[(4-morpholin-4-ylphenyl)amino]pyrimidine-5-carboxamideIC5019.0 [1]
4-[(2,3-Difluorophenyl)methylamino]-2-(4-morpholin-4-ylanilino)pyrimidine-5-carboxamideIC502.1 [1]
4-[(2,4-Difluorophenyl)methylamino]-2-(4-morpholin-4-ylanilino)pyrimidine-5-carboxamideIC50310.0 [1]
4-[(2,5-Difluorobenzyl)amino]-2-[(4-morpholin-4-ylphenyl)amino]pyrimidine-5-carboxamideIC501.6 [1]
4-[(3,5-Difluorophenyl)methylamino]-2-(4-morpholin-4-ylanilino)pyrimidine-5-carboxamideIC505.5 [1]
2-(4-Morpholin-4-ylanilino)-4-[(2,3,5-trifluorophenyl)methylamino]pyrimidine-5-carboxamideIC501.8 [1]
2-(4-Morpholin-4-ylanilino)-4-[(2,4,6-trifluorophenyl)methylamino]pyrimidine-5-carboxamideIC500.7 [1]
2-(4-Morpholin-4-ylanilino)-4-[(2,4,6-trifluorophenyl)methylamino]pyrimidine-5-carboxamide;hydrochlorideIC5088.0 [1]
4-Benzylamino-2-{[4-(2-hydroxyethyl)phenyl]amino}pyrimidine-5-carboxamideIC5095.0 [1]
4-Benzylamino-2-{[4-(3-hydroxypropyl)phenyl]amino}pyrimidine-5-carboxamideIC5081.0 [1]
4-(Benzylamino)-2-[4-(3-hydroxypyrrolidin-1-yl)anilino]pyrimidine-5-carboxamideIC5098.0 [1]
4-Benzylamino-2-{[4-(4-hydroxypiperidin-1-yl)phenyl]amino}pyrimidine-5-carboxamideIC5016.0 [1]
4-(Benzylamino)-2-[(4-pyrrolidine-1-ylphenyl)-amino]pyrimidine-5-carboxamideIC50650.0 [1]
4-Benzylamino-2-[(4-piperidin-1-ylphenyl)amino]pyrimidine-5-carboxamideIC50120.0 [1]
4-Benzylamino-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidine-5-carboxamideIC506.2 [1]
4-Benzylamino-2-{[4-(1-methylpiperidin-4-yl)phenyl]-amino}pyrimidine-5-carboxamideIC5017.0 [1]
4-[(2-Fluorobenzyl)amino]-2-[(4-morpholin-4-ylphenyl)amino]pyrimidine-5-carboxamideIC501.4 [1]
4-[(3-Fluorobenzyl)amino]-2-[(4-morpholin-4-ylphenyl)amino]pyrimidine-5-carboxamideIC501.8 [1]
4-[(4-Fluorobenzyl)amino]-2-[(4-morpholin-4-ylphenyl)amino]pyrimidine-5-carboxamideIC50650.0 [1]
4-[(2-Methylbenzyl)amino]-2-[(4-morpholin-4-ylphenyl)amino]pyrimidine-5-carboxamideIC5011.0 [1]
4-[(2-Hydroxybenzyl)amino]-2-[(4-morpholin-4-ylphenyl)amino]pyrimidine-5-carboxamideIC5022.0 [1]
4-[(2-Chlorobenzyl)amino]-2-[(4-morpholin-4-ylphenyl)amino]pyrimidine-5-carboxamideIC507.9 [1]
2-[(4-Morpholin-4-ylphenyl)amino]-4-[(2-trifluoromethylbenzyl)amino]pyrimidine-5-carboxamideIC5025.0 [1]
2-[(4-Morpholin-4-ylphenyl)amino]-4-[(2-nitrobenzyl)amino]pyrimidine-5-carboxamideIC5038.0 [1]
4-[(2-Methylsulfanylphenyl)methylamino]-2-(4-morpholin-4-ylanilino)pyrimidine-5-carboxamideIC5023.0 [1]
2-[4-[4-[[7-[(3,5-Difluorophenyl)methyl]pyrrolo[2,3-d]pyrimidin-2-yl]amino]phenyl]piperazin-1-yl]-N-methylacetamideIC504.7 [1]
7-[(4-Fluorophenyl)methyl]-N-(4-morpholin-4-ylphenyl)pyrrolo[2,3-d]pyrimidin-2-amineIC504100.0 [1]
7-Benzyl-N-(4-morpholin-4-ylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amineIC50400.0 [1]
7-[(2-Fluorophenyl)methyl]-N-(4-morpholin-4-ylphenyl)pyrrolo[2,3-d]pyrimidin-2-amineIC50220.0 [1]
7-[(3,5-Difluorophenyl)methyl]-N-(4-morpholin-4-ylphenyl)pyrrolo[2,3-d]pyrimidin-2-amineIC50120.0 [1]
7-[(3-Fluorophenyl)methyl]-N-(4-morpholin-4-ylphenyl)pyrrolo[2,3-d]pyrimidin-2-amineIC5037.0 [1]
7-[(3,5-Difluorophenyl)methyl]-N-(4-piperazin-1-ylphenyl)pyrrolo[2,3-d]pyrimidin-2-amineIC5012.0 [1]
7-[(3,5-Difluorophenyl)methyl]-N-[4-(4-methylpiperazin-1-yl)phenyl]pyrrolo[2,3-d]pyrimidin-2-amineIC503.2 [1]
2-[4-[4-[[9-[(3,5-Difluorophenyl)methyl]purin-2-yl]amino]phenyl]piperazin-1-yl]ethanolIC505.6 [1]
N-[4-[4-(2-Aminoethyl)piperazin-1-yl]phenyl]-7-[(3,5-difluorophenyl)methyl]pyrrolo[2,3-d]pyrimidin-2-amineIC5034.0 [1]
2-[4-[4-[[7-[(3,5-Difluorophenyl)methyl]pyrrolo[2,3-d]pyrimidin-2-yl]amino]phenyl]piperazin-1-yl]acetic acidIC5026.0 [1]
7-Benzyl-N-(4-morpholin-4-ylphenyl)-5,6-dihydropyrrolo[2,3-d]pyrimidin-2-amineIC508300.0 [1]
6-N-[(2R)-3-Methylbutan-2-yl]-4-(1-methylindol-2-yl)-2-N-(2-pyridin-2-ylethyl)pyridine-2,6-dicarboxamideIC502700.0 [1]
[4-[(E)-3-[[(2S)-1-[(2S)-2-(Diphenylcarbamoyl)pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]amino]-3-oxoprop-1-enyl]phenyl] dihydrogen phosphateIC50120.0 [1]
4-(1-Benzothiophen-2-yl)-6-N-[(2R)-3-methylbutan-2-yl]-2-N-(2-pyridin-2-ylethyl)pyridine-2,6-dicarboxamideIC503200.0 [1]
[4-[(E)-3-[[(2S)-1-[(2S)-2-[(4-Iodophenyl)-phenylcarbamoyl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]amino]-3-oxoprop-1-enyl]phenyl] dihydrogen phosphateIC5044.0 [1]
[4-[(E)-4-[[(2S)-1-[(2S)-2-(Diphenylcarbamoyl)pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]amino]-4-oxobut-2-en-2-yl]phenyl] dihydrogen phosphateIC5089.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Signal transducer and activator of transcription 6 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/signal-transducer-and-activator-of-transcription-6-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ Signal transducer and activator of transcription 6 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/signal-transducer-and-activator-of-transcription-6-inhibitors-ic50-ki.
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