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Signal transducer and activator of transcription 1-alpha/beta Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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4-[(4-Cyclohexylphenyl)methyl-[2-[methyl-(4-methylphenyl)sulfonylamino]acetyl]amino]-2-hydroxybenzoic acidKi25000.0 [1], 50000.0 [2]
SodiumIC509100.0 [1]
NF449 octasodium saltIC507900.0 [1]
5,15-Diphenyl-21H,23H-porphineIC5010000.0 [1]
4,6,8-Trimethyl-N-(4,4,6-trimethyl-1,4-dihydropyrimidin-2-yl)quinazolin-2-amineIC505900.0 [1]
6-(4-Chlorophenyl)-3-(3-phenyl-1H-pyrazol-5-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazineIC5050000.0 [1]
CID 4378002IC5050000.0 [1]
(7-Ethoxy-4-methylquinazolin-2-yl)(4,4,6-trimethyl-1,4-dihydropyrimidin-2-yl)amineIC5050000.0 [1]
6-(4-Chlorophenyl)-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazineIC5050000.0 [1]
6-Phenyl-3-(3-phenyl-1H-pyrazol-5-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazineIC5050000.0 [1]
6-Methyl-3-(3-phenyl-1H-pyrazol-5-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazineIC5050000.0 [1]
6-Phenyl-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazineIC5050000.0 [1]
6-Methyl-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazineIC5050000.0 [1]
CID 665910IC5050000.0 [1]
4-[(4-Cyclohexylphenyl)methyl-[2-[methyl-(2,4,6-trimethylphenyl)sulfonylamino]acetyl]amino]-2-hydroxybenzoic acidKi9700.0 [1]
5,6-Dimethyl-2-[(4,6,8-trimethylquinazolin-2-yl)amino]pyrimidin-4(1H)-oneIC5050000.0 [1]
5-Benzyl-2-[(6-ethoxy-4-methylquinazolin-2-yl)amino]-6-methylpyrimidin-4(1H)-oneIC5050000.0 [1]
2-[(6-Ethoxy-4-methylquinazolin-2-yl)amino]-5,6-dimethylpyrimidin-4(1H)-oneIC5050000.0 [1]
6-Methyl-2-[(4,6,8-trimethylquinazolin-2-yl)amino]pyrimidin-4(3H)-oneIC5012100.0 [1]
2-[(7-Methoxy-4-methylquinazolin-2-yl)amino]-6-methylpyrimidin-4-olIC5050000.0 [1]
4-[[2-[(4-Chlorophenyl)sulfonyl-methylamino]acetyl]-[(4-cyclohexylphenyl)methyl]amino]-2-hydroxybenzoic acidKi22000.0 [1]
4-[(4-Cyclohexylphenyl)methyl-[2-[methyl-(4-phenylphenyl)sulfonylamino]acetyl]amino]-2-hydroxybenzoic acidKi8800.0 [1]
4-[[4-[1-(4-Cyanophenyl)sulfonylpiperidin-4-yl]phenyl]methyl-[2-[methyl-(4-methylphenyl)sulfonylamino]acetyl]amino]-2-hydroxybenzoic acidKi25000.0 [1]
4-[(4-Cyclohexylphenyl)methyl-[2-[(4-methylphenyl)sulfonyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]acetyl]amino]-2-hydroxybenzoic acidKi25000.0 [1]
4-[[4-[4-(4-Carbamoylphenyl)phenyl]phenyl]methyl-[2-[methyl-(4-methylphenyl)sulfonylamino]acetyl]amino]-2-hydroxybenzoic acidKi9500.0 [1]
(2S)-2-[[(2S)-2-[(4-Cyanobenzoyl)amino]-3-(4-phosphonooxyphenyl)propanoyl]amino]-4-methylpentanoic acidIC5042000.0 [1]
4-Methyl-N-phenylquinazolin-2-amineIC5030000.0 [1]
N-Benzyl-4-methylquinazolin-2-amineIC5030000.0 [1]
N-[2-(1H-Indol-3-yl)ethyl]-4-methylquinazolin-2-amineIC5030000.0 [1]
4-Methyl-N-(2-morpholin-4-ylethyl)quinazolin-2-amineIC5030000.0 [1]
N-(1,3-Benzodioxol-5-ylmethyl)-4-methylquinazolin-2-amineIC5030000.0 [1]
4-Methyl-N-[(5-methylfuran-2-yl)methyl]quinazolin-2-amineIC5030000.0 [1]
4-Methyl-N-(naphthalen-1-ylmethyl)quinazolin-2-amineIC5030000.0 [1]
N-Cyclohexyl-4-methylquinazolin-2-amineIC5030000.0 [1]
4-Methyl-N-pyridin-2-ylquinazolin-2-amineIC5030000.0 [1]
6-(3,4-Dichlorophenyl)-7-methyl-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazineIC5050000.0 [1]
6-(4-Methoxyphenyl)-7-methyl-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazineIC5050000.0 [1]
3-(3-Phenyl-1H-pyrazol-5-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazineIC5050000.0 [1]
6-Cyclohexyl-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazineIC5050000.0 [1]
6-Cyclohexyl-3-(3-phenyl-1H-pyrazol-5-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazineIC5050000.0 [1]
3-(3-Phenyl-1H-pyrazol-5-yl)-6-pyridin-4-yl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazineIC5050000.0 [1]
6-(5-Chlorothiophen-2-yl)-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazineIC5050000.0 [1]
6-(5-Chlorothiophen-2-yl)-3-(3-phenyl-1H-pyrazol-5-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazineIC5050000.0 [1]
6-(3-Chlorophenyl)-3-(3-phenyl-1H-pyrazol-5-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazineIC5045900.0 [1]
6-Pyridin-4-yl-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazineIC5050000.0 [1]
3-(1,4,5,6-Tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazineIC5050000.0 [1]
6-(4-Methoxyphenyl)-7-propan-2-yl-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazineIC5050000.0 [1]
6-(3-Chlorophenyl)-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazineIC5050000.0 [1]
6-(4-Methoxyphenyl)-7-(2-methylpropyl)-3-(3-phenyl-1H-pyrazol-5-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazineIC5050000.0 [1]
3-[3-(4-Fluorophenyl)-1H-pyrazol-5-yl]-6-(4-methoxyphenyl)-7-methyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazineIC5030000.0 [1]
6-(3,4-Dichlorophenyl)-7-propan-2-yl-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazineIC5050000.0 [1]
6-(3,4-Dichlorophenyl)-7-(2-methylpropyl)-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazineIC5050000.0 [1]
7-Benzyl-6-(3,4-dichlorophenyl)-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazineIC5050000.0 [1]
6-(3,4-Dichlorophenyl)-7,7-dimethyl-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazineIC5050000.0 [1]
7-Methyl-6-phenyl-3-(3-phenyl-1H-pyrazol-5-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazineIC5015000.0 [1]
3-[3-(4-Fluorophenyl)-1H-pyrazol-5-yl]-7-methyl-6-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazineIC5030000.0 [1]
(1S,3R,4S,6S,8R,9R,10R,12R,13R)-10-Hydroxy-4,9,12-trimethyl-13-propan-2-yl-7-oxapentacyclo[7.6.0.01,12.03,8.06,8]pentadecane-5,11-dioneIC507000.0 [1]
(1S,3R,4S,6S,8R,9S,12R,13R)-4,9,12-Trimethyl-13-propan-2-yl-7-oxapentacyclo[7.6.0.01,12.03,8.06,8]pentadecane-5,11-dioneIC502000.0 [1]
(1S,3R,4S,5R,6R,8R,9S,12R,13R)-13-Ethenyl-5-hydroxy-4,9,12-trimethyl-7-oxapentacyclo[7.6.0.01,12.03,8.06,8]pentadecan-11-oneIC5050000.0 [1]
(1R,3R,4S,6S,8R,9S,11S,12R,13R)-13-Ethenyl-11-hydroxy-4,9,12-trimethyl-7-oxapentacyclo[7.6.0.01,12.03,8.06,8]pentadecan-5-oneIC502000.0 [1]
2-[(6-Ethoxy-4-methylquinazolin-2-yl)amino]-6-methylpyrimidin-4-olIC5050000.0 [1]
5,6-Dimethyl-2-[(4,6,7-trimethyl-2-quinazolinyl)amino]-4(1H)-pyrimidinoneIC5050000.0 [1]
2-[(6-Methoxy-4-methylquinazolin-2-yl)amino]-6-methylpyrimidin-4-olIC5050000.0 [1]
2-[(4,7-Dimethyl-2-quinazolinyl)amino]-5,6-dimethyl-4(1H)-pyrimidinoneIC5035200.0 [1]
6-Phenyl-2-[(4,6,8-trimethyl-2-quinazolinyl)amino]-4-pyrimidinolIC5050000.0 [1]
2-[(4,7-Dimethylquinazolin-2-yl)amino]-6-methylpyrimidin-4(3H)-oneIC5039700.0 [1]
6-Methyl-2-[(4,6,7-trimethylquinazolin-2-yl)amino]pyrimidin-4-olIC5050000.0 [1]
2-[(6-Ethoxy-4-methylquinazolin-2-yl)amino]-6-phenylpyrimidin-4-olIC5050000.0 [1]
6-Methyl-5-(prop-2-en-1-yl)-2-[(4,6,8-trimethylquinazolin-2-yl)amino]pyrimidin-4(3H)-oneIC5050000.0 [1]
5-Benzyl-2-[(6-methoxy-4-methylquinazolin-2-yl)amino]-4-methyl-1H-pyrimidin-6-oneIC5050000.0 [1]
4-Methyl-2-[(8-methyl-[1,3]dioxolo[4,5-g]quinazolin-6-yl)amino]-1H-pyrimidin-6-oneIC5050000.0 [1]
4,5-Dimethyl-2-[(8-methyl-[1,3]dioxolo[4,5-g]quinazolin-6-yl)amino]-1H-pyrimidin-6-oneIC5050000.0 [1]
2-[(8-Methyl-[1,3]dioxolo[4,5-g]quinazolin-6-yl)amino]-4-phenyl-1H-pyrimidin-6-oneIC5050000.0 [1]
5-Benzyl-4-methyl-2-[(8-methyl-[1,3]dioxolo[4,5-g]quinazolin-6-yl)amino]-1H-pyrimidin-6-oneIC5050000.0 [1]
6-(4-Methoxyphenyl)-3-(5-phenyl-1H-pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazineIC5050000.0 [1]
6-(4-Methoxyphenyl)-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazineIC5040600.0 [1]
[4-[(2S)-2-[(4-Cyanobenzoyl)amino]-3-[[(2S)-1-(3-methoxyanilino)-4-methyl-1-oxopentan-2-yl]amino]-3-oxopropyl]phenyl] dihydrogen phosphateIC50560000.0 [1]
[4-[(2S)-2-[(4-Cyanobenzoyl)amino]-3-[[(2S)-1-(3-hydroxypropylamino)-4-methyl-1-oxopentan-2-yl]amino]-3-oxopropyl]phenyl] dihydrogen phosphateIC50210000.0 [1]
[4-[(2S)-2-[(4-Cyanobenzoyl)amino]-3-[[(2S)-1-(cyclohexylamino)-4-methyl-1-oxopentan-2-yl]amino]-3-oxopropyl]phenyl] dihydrogen phosphateIC50605000.0 [1]
[4-[(2S)-3-[[(2S)-1-Anilino-4-methyl-1-oxopentan-2-yl]amino]-2-[(4-cyanobenzoyl)amino]-3-oxopropyl]phenyl] dihydrogen phosphateIC50380000.0 [1]
[4-[(2S)-3-[[(2S)-1-(Benzylamino)-4-methyl-1-oxopentan-2-yl]amino]-2-[(4-cyanobenzoyl)amino]-3-oxopropyl]phenyl] dihydrogen phosphateIC50760000.0 [1]
[4-[(2S)-2-[(4-Cyanobenzoyl)amino]-3-[[(2S)-4-methyl-1-(2-methylpropylamino)-1-oxopentan-2-yl]amino]-3-oxopropyl]phenyl] dihydrogen phosphateIC50760000.0 [1]
[4-[(2S)-2-[(4-Cyanobenzoyl)amino]-3-[[(2S)-4-methyl-1-oxo-1-(pyridin-4-ylmethylamino)pentan-2-yl]amino]-3-oxopropyl]phenyl] dihydrogen phosphateIC50402000.0 [1]
6-(3,4-Dichlorophenyl)-3-(5-phenyl-1H-pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazineIC5050000.0 [1]
4,6-Dimethyl-N-(4,4,6-trimethyl-1H-pyrimidin-2-yl)quinazolin-2-amineIC5050000.0 [1]
4-[(4-Cyclohexylphenyl)methyl-[2-[(4-methylphenyl)sulfonyl-[[2-(trifluoromethyl)phenyl]methyl]amino]acetyl]amino]-2-hydroxybenzoic acidIC505800.0 [1]
2-Hydroxy-4-[[4-[4-(3-methoxycarbonylphenyl)phenyl]phenyl]methyl-[2-[methyl-(4-methylphenyl)sulfonylamino]acetyl]amino]benzoic acidKi3200.0 [1]
4-[Benzyl-[2-[(4-methylphenyl)sulfonyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]acetyl]amino]-2-hydroxybenzoic acidKi25000.0 [1]
4-[[4-[1-(4-Carbamoylphenyl)piperidin-4-yl]phenyl]methyl-[2-[methyl-(4-methylphenyl)sulfonylamino]acetyl]amino]-2-hydroxybenzoic acidKi27800.0 [1]
Hexasodium;8-[[3-[[3-[(4,6,8-trisulfonatonaphthalen-1-yl)carbamoyl]phenyl]carbamoylamino]benzoyl]amino]naphthalene-1,3,5-trisulfonate;hydrateIC5033200.0 [1]
4-[(4-Cyclohexylphenyl)methyl-[2-[(2,3,4,5,6-pentafluorophenyl)sulfonyl-[[2-(trifluoromethyl)phenyl]methyl]amino]acetyl]amino]-2-hydroxybenzoic acidIC5010900.0 [1]
[(5R,5As,9R,9aR,9bR)-9,9b-dihydroxy-6,6,9a-trimethyl-1-oxo-3,5,5a,7,8,9-hexahydrobenzo[e][2]benzofuran-5-yl] hexanoateIC5050700.0 [1]
STAT5 InhibitorIC50130000.0 [1]
N-[4-(4-Chlorophenyl)-1,2,5-oxadiazol-3-yl]-4-(trifluoromethyl)benzamideIC507200.0 [1]
Items per page: 1 - 10 of 94
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References

This online tool may be cited as follows

MLA

"Quest Database™ Signal transducer and activator of transcription 1-alpha/beta Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 22 Dec. 2024, https://www.aatbio.com/data-sets/signal-transducer-and-activator-of-transcription-1-alpha-beta-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, December 22). Quest Database™ Signal transducer and activator of transcription 1-alpha/beta Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/signal-transducer-and-activator-of-transcription-1-alpha-beta-inhibitors-ic50-ki.
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