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Signal peptide peptidase-like 2A Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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(2S)-2-Cyclopropyl-N-[(6S)-5,11-dioxospiro[3,6-dihydro-1H-pyrazolo[1,2-b][2,3]benzodiazepine-2,1'-cyclopropane]-6-yl]-N'-(5-fluoro-2-methylpyridin-3-yl)butanediamideIC5077.0 [1], 160.0 [2]
LY-411575IC5010.0 [1]
(Z-LL)2 ketoneIC506.0 [1]
(2R)-2-Methyl-N'-(3-methylphenyl)-N-[(6S)-5-oxo-2,3,6,11-tetrahydro-1H-pyrazolo[1,2-b][2,3]benzodiazepin-6-yl]butanediamideIC5070.0 [1]
(2R)-N'-(3,5-Difluorophenyl)-2-methyl-N-[(6S)-5-oxo-2,3,6,11-tetrahydro-1H-pyrazolo[1,2-b][2,3]benzodiazepin-6-yl]butanediamideIC505.0 [1]
(2R)-2-Methyl-N-[(6S)-5-oxo-2,3,6,11-tetrahydro-1H-pyrazolo[1,2-b][2,3]benzodiazepin-6-yl]-N'-[2-(trifluoromethyl)phenyl]butanediamideIC502850.0 [1]
(2R)-2-Methyl-N'-(4-methylphenyl)-N-[(6S)-5-oxo-2,3,6,11-tetrahydro-1H-pyrazolo[1,2-b][2,3]benzodiazepin-6-yl]butanediamideIC501390.0 [1]
(2R)-N-[(6S)-5,11-Dioxo-1,2,3,6-tetrahydropyrazolo[1,2-b][2,3]benzodiazepin-6-yl]-N'-(5-fluoro-2-methylpyridin-3-yl)-2-methylbutanediamideIC50870.0 [1]
(2S)-2-Cyclopropyl-N-[(6S)-5,11-dioxo-1,2,3,6-tetrahydropyrazolo[1,2-b][2,3]benzodiazepin-6-yl]-N'-(5-fluoro-2-methylpyridin-3-yl)butanediamideIC50225.0 [1]
(2R)-N'-(5-Fluoro-2-methylpyridin-3-yl)-2-methyl-N-[(6S)-5-oxo-2,3,6,11-tetrahydro-1H-pyrazolo[1,2-b][2,3]benzodiazepin-6-yl]butanediamideIC5044.0 [1]
(2R)-2-Methyl-N'-(2-methylphenyl)-N-[(6S)-5-oxo-2,3,6,11-tetrahydro-1H-pyrazolo[1,2-b][2,3]benzodiazepin-6-yl]butanediamideIC5035.0 [1]
(2R)-2-Methyl-N'-(2-methylpyridin-3-yl)-N-[(6S)-5-oxo-2,3,6,11-tetrahydro-1H-pyrazolo[1,2-b][2,3]benzodiazepin-6-yl]butanediamideIC501020.0 [1]
(2R)-N'-(5-Fluoro-2-methylpyridin-3-yl)-N-[(6S)-10-fluoro-5-oxo-2,3,6,11-tetrahydro-1H-pyrazolo[1,2-b][2,3]benzodiazepin-6-yl]-2-methylbutanediamideIC5076.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Signal peptide peptidase-like 2A Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Dec. 2024, https://www.aatbio.com/data-sets/signal-peptide-peptidase-like-2a-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, December 21). Quest Database™ Signal peptide peptidase-like 2A Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/signal-peptide-peptidase-like-2a-inhibitors-ic50-ki.
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