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Serotonin transporter Inhibitors (IC50, Ki)

Structure
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▼
Compound Name
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Standard Type
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▼
Standard Values (in nM)
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▼
CocaineIC50325.0 [1]
CocaineKi310.0 [1]
FluoxetineIC509.4 [1]
FluoxetineKi0.72 [1], 48.0 [2]
ImipramineIC505.1 [1]
ImipramineKi5.7 [1], 7.57 [2], 31.0 [3], 1300.0 [4]
DuloxetineIC506.0 [1]
DuloxetineKi0.5 [1], 0.8 [2], 4.6 [3], 5.0 [4], 790.0 [5]
ParoxetineIC500.2 [1], 0.56 [2], 2.0 [3], 20.0 [4]
ParoxetineKi0.04 [1]
CitalopramIC506.27 [1], 6.7 [2], 19.0 [3], 90000.0 [4]
CitalopramKi1.6 [1], 16.0 [2]
VenlafaxineIC5031.0 [1]
VenlafaxineKi3.81 [1], 39.0 [2]
AtomoxetineIC50180.0 [1]
2-[(2-Ethoxyphenoxy)-phenylmethyl]morpholineIC50242.0 [1]
2-[(2-Ethoxyphenoxy)-phenylmethyl]morpholineKi9.0 [1], 129.0 [2], 1400.0 [3]
NisoxetineIC50700.0 [1]
NisoxetineKi1.4 [1], 203.0 [2]
EscitalopramIC502.1 [1], 10.0 [2], 4600.0 [3]
EscitalopramKi1.0 [1], 1.77 [2], 2.2 [3], 7.4 [4]
Venlafaxine hydrochlorideIC50200.0 [1]
Methyl (1R,2S,3S,5R)-3-(4-fluorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylateIC50160.0 [1], 5060.0 [2]
Methyl (1R,2S,3S,5R)-3-(4-fluorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylateKi63.0 [1], 181.0 [2]
MidalcipranIC5050.12 [1], 100.0 [2], 420.0 [3], 3500.0 [4]
MidalcipranKi6.5 [1]
BMS-505130 free baseIC500.36 [1], 0.48 [2], 0.56 [3]
BMS-505130 free baseKi0.18 [1], 0.56 [2]
3,4-MethylenedioxymethamphetamineIC50425.0 [1], 1100.0 [2], 2754.23 [3]
3,4-MethylenedioxymethamphetamineKi0.73 [1], 2.03 [2]
MazindolIC5054.0 [1], 94.0 [2]
MazindolKi45.0 [1], 50.0 [2], 136.0 [3]
VanoxerineIC5073.0 [1], 741.0 [2], 1460.0 [3], 3840.0 [4]
VanoxerineKi126.0 [1], 130.0 [2]
MadamKi0.25 [1]
1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexaneIC5013.8 [1], 14.0 [2], 215.0 [3], 723.0 [4]
1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexaneKi63.0 [1]
Rel-1-(3,4-dichlorophenyl)-6-(methoxymethyl)-3-azabicyclo[4.1.0]heptaneIC503.98 [1], 9.2 [2]
Rel-1-(3,4-dichlorophenyl)-6-(methoxymethyl)-3-azabicyclo[4.1.0]heptaneKi0.63 [1], 1.05 [2], 1.58 [3]
BupropionIC50100.0 [1], 47000.0 [2], 100000.0 [3]
BupropionKi10000.0 [1]
DesipramineIC5052.4 [1], 64.0 [2], 108.0 [3], 560.0 [4]
DesipramineKi20.0 [1]
2-((2-((Dimethylamino)methyl)phenyl)thio)-5-iodophenylamineKi0.01 [1], 1.07 [2], 840.0 [3]
Methyl 3-(3,4-dichlorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylateIC502.47 [1], 2.5 [2], 27.0 [3], 27.7 [4]
3-(3-(Dimethylamino)propyl)-1H-indole-5-carbonitrileIC502.0 [1]
3-(3-(Dimethylamino)propyl)-1H-indole-5-carbonitrileKi2.0 [1]
HaloperidolKi1000.0 [1], 1799.0 [2], 1800.0 [3]
ClozapineIC5010000.0 [1]
ClozapineKi290.0 [1], 1000.0 [2], 3900.0 [3]
AripiprazoleKi31.62 [1], 98.0 [2], 240.0 [3], 1080.0 [4]
NomifensineIC508709.64 [1]
NomifensineKi874.0 [1], 1400.0 [2], 2057.0 [3]
1-[2-(Diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazineIC50289.0 [1], 3710.0 [2]
1-[2-(Diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazineKi620.0 [1], 2090.0 [2]
AmitifadineIC5012.3 [1], 411.5 [2]
AmitifadineKi19.95 [1], 141.25 [2]
3-(4-Chloro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl esterIC505.87 [1], 19.0 [2], 998.0 [3]
3-(4-Chloro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl esterKi44.5 [1]
3-(4-Iodo-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl esterIC504.2 [1]
3-(4-Iodo-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl esterKi0.38 [1], 0.67 [2], 4.2 [3]
(R)-Sila-VenlafaxineIC503168.0 [1], 4200.0 [2]
4-(3,4-Dimethoxy-phenyl)-4a,5,8,8a-tetrahydro-2H-phthalazin-1-oneIC50100000.0 [1]
4-(3,4-Dimethoxy-phenyl)-4a,5,8,8a-tetrahydro-2H-phthalazin-1-oneKi100000.0 [1]
(S)-N-(2,3-Dimethylbenzyl)-N-(tetrahydro-2H-pyran-4-yl)pyrrolidin-3-amineIC509.0 [1]
4-(4-Methoxyphenyl)-2-methyl-7-(3-(piperidin-1-yl)propoxy)-1,2,3,4-tetrahydroisoquinolineKi2.0 [1], 5.1 [2]
(1S,5S,6S)-1-(3,4-Dichlorophenyl)-6-(ethoxymethyl)-3-azabicyclo[3.1.0]hexaneIC501.26 [1]
(1S,5S,6S)-1-(3,4-Dichlorophenyl)-6-(ethoxymethyl)-3-azabicyclo[3.1.0]hexaneKi0.16 [1], 0.4 [2]
2-[5-[3-(5-Fluoro-2-methoxyphenyl)propyl]oxolan-2-yl]ethanamineIC502.3 [1], 7.4 [2]
2-[5-[3-(5-Fluoro-2-methoxyphenyl)propyl]oxolan-2-yl]ethanamineKi1.1 [1], 7.0 [2]
Dimethyl-((2S,3S)-3-naphthalen-2-yl-bicyclo[2.2.1]hept-2-ylmethyl)-amineIC509.0 [1]
Dimethyl-((2S,3S)-3-naphthalen-2-yl-bicyclo[2.2.1]hept-2-ylmethyl)-amineKi2.3 [1]
(R)-3-(4-(Dimethylamino)cyclohex-1-enyl)-1H-indole-5-carbonitrileIC500.4 [1], 0.72 [2]
3-[4-(3,4-Dihydro-1H-isoquinolin-2-yl)-cyclohexyl]-1H-indole-5-carbonitrileKi4.51 [1], 90.7 [2], 189.0 [3], 286.0 [4]
(cis)-2-(5-Bromopentyl)-4-(3,4-dimethoxyphenyl)-4a,5,8,8a-tetrahydrophthalazin-1(2H)-oneIC50100000.0 [1]
(cis)-2-(5-Bromopentyl)-4-(3,4-dimethoxyphenyl)-4a,5,8,8a-tetrahydrophthalazin-1(2H)-oneKi100000.0 [1]
3-[4-(6-Methoxy-3,4-dihydro-1H-isoquinolin-2-yl)-cyclohexyl]-1H-indole-5-carbonitrileKi4.1 [1], 73.7 [2], 165.0 [3], 518.0 [4]
N,N-Dimethyl-3-[2-[3-(3-naphthalen-1-yloxypropoxy)prop-1-ynyl]-5,6-dihydrobenzo[b][1]benzazepin-11-yl]propan-1-amineIC50940.0 [1]
N,N-Dimethyl-3-[2-[3-(3-naphthalen-1-yloxypropoxy)prop-1-ynyl]-5,6-dihydrobenzo[b][1]benzazepin-11-yl]propan-1-amineKi1200.0 [1], 3500.0 [2], 27000.0 [3]
N,N-Dimethyl-3-[2-[3-[2-(2-naphthalen-1-ylethoxy)ethoxy]prop-1-ynyl]-5,6-dihydrobenzo[b][1]benzazepin-11-yl]propan-1-amineIC50300.0 [1]
N,N-Dimethyl-3-[2-[3-[2-(2-naphthalen-1-ylethoxy)ethoxy]prop-1-ynyl]-5,6-dihydrobenzo[b][1]benzazepin-11-yl]propan-1-amineKi540.0 [1], 1100.0 [2], 5200.0 [3]
N,N-Dimethyl-3-[2-[3-[2-(2-naphthalen-1-yloxyethoxy)ethoxy]prop-1-ynyl]-5,6-dihydrobenzo[b][1]benzazepin-11-yl]propan-1-amineIC50420.0 [1]
N,N-Dimethyl-3-[2-[3-[2-(2-naphthalen-1-yloxyethoxy)ethoxy]prop-1-ynyl]-5,6-dihydrobenzo[b][1]benzazepin-11-yl]propan-1-amineKi450.0 [1], 6400.0 [2], 6500.0 [3]
N,N-Dimethyl-3-[2-[3-[2-(2-naphthalen-1-ylsulfanylethoxy)ethoxy]prop-1-ynyl]-5,6-dihydrobenzo[b][1]benzazepin-11-yl]propan-1-amineIC50560.0 [1]
N,N-Dimethyl-3-[2-[3-[2-(2-naphthalen-1-ylsulfanylethoxy)ethoxy]prop-1-ynyl]-5,6-dihydrobenzo[b][1]benzazepin-11-yl]propan-1-amineKi500.0 [1], 2000.0 [2], 19000.0 [3]
3-[2-[3-[3-(5,6-Dihydrobenzo[b][1]benzazepin-11-yl)propoxy]prop-1-ynyl]-5,6-dihydrobenzo[b][1]benzazepin-11-yl]-N,N-dimethylpropan-1-amineIC501600.0 [1]
3-[2-[3-[3-(5,6-Dihydrobenzo[b][1]benzazepin-11-yl)propoxy]prop-1-ynyl]-5,6-dihydrobenzo[b][1]benzazepin-11-yl]-N,N-dimethylpropan-1-amineKi1600.0 [1], 13000.0 [2], 16000.0 [3]
N,N-Dimethyl-3-[2-[3-(3-naphthalen-1-yloxypropoxy)propyl]-5,6-dihydrobenzo[b][1]benzazepin-11-yl]propan-1-amineIC50600.0 [1]
N,N-Dimethyl-3-[2-[3-(3-naphthalen-1-yloxypropoxy)propyl]-5,6-dihydrobenzo[b][1]benzazepin-11-yl]propan-1-amineKi620.0 [1], 1200.0 [2], 9400.0 [3]
N,N-Dimethyl-3-[2-[3-(naphthalen-1-ylmethoxy)prop-1-ynyl]-5,6-dihydrobenzo[b][1]benzazepin-11-yl]propan-1-amineIC50340.0 [1]
N,N-Dimethyl-3-[2-[3-(naphthalen-1-ylmethoxy)prop-1-ynyl]-5,6-dihydrobenzo[b][1]benzazepin-11-yl]propan-1-amineKi280.0 [1], 590.0 [2], 5400.0 [3]
N,N-Dimethyl-3-[2-[3-(naphthalen-1-ylmethylsulfanyloxy)prop-1-ynyl]-5,6-dihydrobenzo[b][1]benzazepin-11-yl]propan-1-amineIC50350.0 [1]
N,N-Dimethyl-3-[2-[3-(naphthalen-1-ylmethylsulfanyloxy)prop-1-ynyl]-5,6-dihydrobenzo[b][1]benzazepin-11-yl]propan-1-amineKi475.0 [1], 1100.0 [2], 4700.0 [3]
N,N-Dimethyl-3-[2-[3-[2-(2-naphthalen-1-ylethoxy)ethoxy]propyl]-5,6-dihydrobenzo[b][1]benzazepin-11-yl]propan-1-amineIC50280.0 [1]
N,N-Dimethyl-3-[2-[3-[2-(2-naphthalen-1-ylethoxy)ethoxy]propyl]-5,6-dihydrobenzo[b][1]benzazepin-11-yl]propan-1-amineKi360.0 [1], 1000.0 [2], 6700.0 [3]
3-[2-[3-[3-(5,6-Dihydrobenzo[b][1]benzazepin-11-yl)propoxy]propyl]-5,6-dihydrobenzo[b][1]benzazepin-11-yl]-N,N-dimethylpropan-1-amineIC50270.0 [1]
3-[2-[3-[3-(5,6-Dihydrobenzo[b][1]benzazepin-11-yl)propoxy]propyl]-5,6-dihydrobenzo[b][1]benzazepin-11-yl]-N,N-dimethylpropan-1-amineKi330.0 [1], 6300.0 [2], 15000.0 [3]
3-[2-[3-[3-[3-(5,6-Dihydrobenzo[b][1]benzazepin-11-yl)propoxy]propoxy]propyl]-5,6-dihydrobenzo[b][1]benzazepin-11-yl]-N,N-dimethylpropan-1-amineIC50840.0 [1]
3-[2-[3-[3-[3-(5,6-Dihydrobenzo[b][1]benzazepin-11-yl)propoxy]propoxy]propyl]-5,6-dihydrobenzo[b][1]benzazepin-11-yl]-N,N-dimethylpropan-1-amineKi640.0 [1], 5900.0 [2], 11000.0 [3]
3-[11-[3-(Dimethylamino)propyl]-5,6-dihydrobenzo[b][1]benzazepin-2-yl]prop-2-yn-1-olIC5060.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Serotonin transporter Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/serotonin-transporter-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ Serotonin transporter Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/serotonin-transporter-inhibitors-ic50-ki.
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