Serotonin 7 (5-HT7) receptor Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	(R)-3-((2-(2-(4-Methylpiperidin-1-yl)ethyl)pyrrolidin-1-yl)sulfonyl)phenol	IC50	0.9 [1], 3.71 [2]
	Clozapine	Ki	12.59 [1], 48.0 [2]
	Serotonin	IC50	1.5 [1]
	Methiothepin	IC50	1.5 [1], 3.1 [2], 21.0 [3]
	Methiothepin	Ki	0.9 [1], 1.0 [2], 1.7 [3], 3.7 [4]
	Olanzapine	Ki	79.43 [1], 185.0 [2], 206.0 [3], 365.0 [4], 1000.0 [5]
	2a-[4-(4-Phenylpiperazin-1-yl)butyl]-1,3,4,5-tetrahydrobenzo[cd]indol-2-one	Ki	2.14 [1], 3.16 [2], 3.31 [3]
	2a-[4-[4-(2-Methoxyphenyl)piperazin-1-yl]butyl]-1,3,4,5-tetrahydrobenzo[cd]indol-2-one	Ki	2.14 [1], 5.01 [2], 5.13 [3]
	Chlorpromazine	Ki	10.72 [1], 27.0 [2], 31.62 [3], 119.0 [4]
	Risperidone	Ki	0.4 [1], 1.0 [2], 4.3 [3], 10.0 [4]
	Mianserin	IC50	114.82 [1]
	Mianserin	Ki	56.0 [1], 63.1 [2], 8010.0 [3]
	Spiperone	Ki	19.95 [1], 110.0 [2]
	4-Methyl-1-[2-[(2R)-1-(3-methylphenyl)sulfonylpyrrolidin-2-yl]ethyl]piperidine	Ki	3.0 [1], 3.16 [2]
	CID 10028436	Ki	2.0 [1], 3.2 [2]
	2a-[4-(4-Cyclohexylpiperazin-1-yl)butyl]-1,3,4,5-tetrahydrobenzo[cd]indol-2-one	Ki	1000.0 [1], 10000.0 [2], 100000.0 [3]
	2a-[3-(4-Phenylpiperazin-1-yl)propyl]-1,3,4,5-tetrahydrobenzo[cd]indol-2-one	Ki	5.0 [1], 5.01 [2], 5.25 [3]
	2-[4-[4-(2-Oxo-1,3,4,5-tetrahydrobenzo[cd]indol-2a-yl)butyl]piperazin-1-yl]benzonitrile	Ki	3.8 [1], 3.98 [2]
	2a-[4-(4-Pyridin-2-ylpiperazin-1-yl)butyl]-1,3,4,5-tetrahydrobenzo[cd]indol-2-one	Ki	1.86 [1], 2.0 [2]
	1-(2-Methoxy-phenyl)-4-(1-o-tolyl-1H-pyrrol-3-ylmethyl)-piperazine	Ki	4.3 [1], 4.7 [2], 21.0 [3]
	3-[3-(4-Benzhydrylpiperazin-1-yl)-2-hydroxypropyl]-5-(4-fluorophenyl)-5-methylimidazolidine-2,4-dione	IC50	1807.0 [1]
	3-[3-(4-Benzhydrylpiperazin-1-yl)-2-hydroxypropyl]-5-(4-fluorophenyl)-5-methylimidazolidine-2,4-dione	Ki	79.0 [1]
	Haloperidol	Ki	316.23 [1], 408.0 [2], 1122.02 [3]
	8-OH-Dpat	Ki	388.0 [1], 466.0 [2]
	Ziprasidone	Ki	5.0 [1], 5.01 [2], 6.0 [3]
	Mesulergine	IC50	120.0 [1], 290.0 [2]
	Mesulergine	Ki	7.94 [1]
	6-[4-(2-Methylsulfanylphenyl)piperazin-1-yl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide	Ki	0.22 [1]
	1-[4-(3,4-Dihydro-1H-isoquinolin-2-yl)butyl]-3H-indol-2-one	Ki	7.0 [1]
	(2S)-1-(1-Naphthylsulfonyl)-2-[2-(4-methylpiperidino)ethyl]pyrrolidine	Ki	10.0 [1], 398.11 [2], 400.0 [3]
	2a-[2-(4-Phenylpiperazin-1-yl)ethyl]-1,3,4,5-tetrahydrobenzo[cd]indol-2-one	Ki	100.0 [1], 102.33 [2]
	N-Methyl-N-[4-(3-methylpiperidin-1-yl)butan-2-yl]naphthalene-1-sulfonamide	Ki	63.1 [1], 65.0 [2]
	6-Chloro-2a-[4-[4-(4-chlorophenyl)-3,6-dihydro-2H-pyridin-1-yl]butyl]-1,3,4,5-tetrahydrobenzo[cd]indol-2-one	Ki	7.24 [1]
	N-Methyl-2-[2-[4-(2-oxo-1,3,4,5-tetrahydrobenzo[cd]indol-2a-yl)butyl]-3,4-dihydro-1H-pyrido[3,4-b]indol-9-yl]acetamide	Ki	3.55 [1], 4.0 [2]
	N-(Diaminomethylidene)-9-hydroxy-9-methylfluorene-2-carboxamide;hydrochloride	IC50	59.0 [1]
	N-(Diaminomethylidene)-9-hydroxy-9-methylfluorene-2-carboxamide;hydrochloride	Ki	4.3 [1]
	2-Bromo-6-[2-(dimethylamino)ethylthio]pyridine	Ki	4.1 [1], 37.0 [2]
	2-Phenyl-6-[2-(dimethylamino)ethylthio]pyridine	Ki	0.6 [1], 6.2 [2]
	(3S)-2-[5-[4-(2-Phenylphenyl)piperazin-1-yl]pentanoyl]-3,4-dihydro-1H-isoquinoline-3-carboxamide	Ki	6.0 [1], 12.0 [2], 94.0 [3]
	5-[4-(2-Phenylphenyl)piperazin-1-yl]-1-[(2S)-2-(piperidine-1-carbonyl)pyrrolidin-1-yl]pentan-1-one	Ki	5.0 [1], 20.0 [2], 91.0 [3]
	Quetiapine	Ki	63.1 [1], 1000.0 [2]
	Lysergide	Ki	6.31 [1], 6.6 [2]
	Ritanserin	Ki	15.85 [1], 45.0 [2]
	Metergoline	Ki	6.31 [1]
	Vortioxetine	Ki	26.0 [1]
	Latrepirdine	Ki	7.94 [1], 8.0 [2]
	5-Chloro-N-(4-methoxy-3-(piperazin-1-yl)phenyl)-3-methylbenzo[b]thiophene-2-sulfonamide	Ki	260.0 [1], 3981.07 [2]
	2-Bromolysergic acid diethylamide	Ki	10.0 [1], 30.0 [2]
	2-[1-(Benzenesulfonyl)-5-methoxyindol-3-yl]-N,N-dimethylethanamine	Ki	600.0 [1], 1900.0 [2]
	2-Ethyl-5-methoxy-N,N-dimethyltryptamine	IC50	1500.0 [1]
	2-Ethyl-5-methoxy-N,N-dimethyltryptamine	Ki	300.0 [1]
	N,N-Diallyl-5-methoxytryptamine	Ki	16.98 [1], 89.13 [2]
	3-Methyl-2-((R)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-11-yl)-benzonitrile	Ki	1.0 [1], 3.79 [2]
	(2S)-(+)-5-(1,3,5-Trimethylpyrazol-4-YL)-2-(dimethylamino)tetralin	Ki	0.6 [1]
	Indole, 3-(2-(dimethylamino)ethyl)-5-methoxy-2-methyl-	Ki	145.0 [1], 1260.0 [2]
	1-[5-(4-Phenylpiperazin-1-yl)pentyl]benzo[cd]indol-2-one	Ki	89.0 [1]
	(6S,14R)-6-Methoxy-6,13-dimethyl-13-azapentacyclo[12.3.1.05,17.07,16.010,15]octadeca-1(17),2,4,7(16),8,10(15)-hexaene	Ki	1.1 [1]
	Piperazine, 1-(4'-methoxy(1,1'-biphenyl)-2-yl)-	IC50	438.0 [1]
	Piperazine, 1-(4'-methoxy(1,1'-biphenyl)-2-yl)-	Ki	2.6 [1]
	5-Chloro-N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-3-methyl-1-benzothiophene-2-sulfonamide	Ki	3162.28 [1]
	(6R,14R)-6-Methoxy-6,13-dimethyl-13-azapentacyclo[12.3.1.05,17.07,16.010,15]octadeca-1(17),2,4,7(16),8,10(15)-hexaene	Ki	1.1 [1]
	(2R)-1-(1-Naphthylsulfonyl)-2-[2-(4-methylpiperidino)ethyl]pyrrolidine	Ki	10.0 [1]
	3-{4-[4-(4-Chlorophenyl)-piperazin-1-yl]-butyl}-3-ethyl-6-fluoro-1,3-dihydro-2H-indol-2-one	Ki	0.79 [1]
	N-[3-[4-(2-Methoxyphenyl)piperazin-1-yl]propyl]naphthalene-2-sulfonamide	IC50	20.0 [1]
	N-[3-[4-(2-Methoxyphenyl)piperazin-1-yl]propyl]naphthalene-2-sulfonamide	Ki	20.0 [1]
	2,8-Dimethyl-5-phenethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole	Ki	0.15 [1], 0.25 [2]
	3-[2-[4-[2-(4-Methoxyphenyl)phenyl]piperazin-1-yl]ethoxy]-N-(pyridin-4-ylmethyl)propanamide	Ki	18.0 [1]
	3-[2-[4-[2-(4-Methoxyphenyl)phenyl]piperazin-1-yl]ethoxy]-N-(pyridin-3-ylmethyl)propanamide	Ki	23.8 [1]
	3-[2-[4-[2-(4-Methoxyphenyl)phenyl]piperazin-1-yl]ethoxy]-N-(pyridin-2-ylmethyl)propanamide	Ki	23.5 [1]
	6-[4-[2-(4-Methoxyphenyl)phenyl]piperazin-1-yl]-N-(pyridin-4-ylmethyl)hexanamide	Ki	11.2 [1]
	6-[4-[2-(4-Methoxyphenyl)phenyl]piperazin-1-yl]-N-(pyridin-2-ylmethyl)hexanamide	Ki	15.2 [1]
	6-[4-[2-(4-Methoxyphenyl)phenyl]piperazin-1-yl]-N-(pyridin-3-ylmethyl)hexanamide	Ki	12.7 [1]
	2-Cyclohexyl-6-[2-(dimethylamino)ethylthio]pyridine	Ki	0.7 [1]
	2-[2-[6-(Trifluoromethyl)indol-1-yl]ethyl]-3,4,5,7,8,9,10,10a-octahydro-1H-pyrido[1,2-a][1,4]diazepine	Ki	7.0 [1]
	2-N-[2-(4-Fluorophenoxy)ethyl]-4-N-[(1S)-1-phenylethyl]pyridine-2,4-diamine	Ki	0.2 [1]
	3,4-Dibromo-N-methyl-N-[(2R)-4-(4-methylpiperidin-1-yl)butan-2-yl]benzenesulfonamide	Ki	19.95 [1]
	N-Methyl-N-[(2R)-4-[(3R)-3-methylpiperidin-1-yl]butan-2-yl]naphthalene-1-sulfonamide	Ki	125.89 [1]
	N-Methyl-N-[(2S)-4-[(3S)-3-methylpiperidin-1-yl]butan-2-yl]naphthalene-1-sulfonamide	Ki	10000.0 [1]
	3,4-Dichloro-N-methyl-N-[(2R)-4-(4-methylpiperidin-1-yl)butan-2-yl]benzenesulfonamide	Ki	31.62 [1]
	(2S)-1-(1-Naphthylsulfonyl)-2-[2-(4-methylpiperidino)ethyl]piperidine	Ki	15.85 [1], 398.11 [2]
	4,5-Dibromo-N-methyl-N-[(2R)-4-(4-methylpiperidin-1-yl)butan-2-yl]thiophene-2-sulfonamide	Ki	15.85 [1]
	N-Methyl-N-[(2S)-4-[(3R)-3-methylpiperidin-1-yl]butan-2-yl]naphthalene-1-sulfonamide	Ki	1584.89 [1]
	2a-[4-[4-(4-Fluorophenyl)-3,6-dihydro-2H-pyridin-1-yl]butyl]-1,3,4,5-tetrahydrobenzo[cd]indol-2-one	Ki	3.55 [1]
	2a-[4-(4-Phenylpiperidin-1-yl)butyl]-1,3,4,5-tetrahydrobenzo[cd]indol-2-one	Ki	2.0 [1], 3.98 [2]
	3-Ethyl-3-[4-[4-(4-fluorophenyl)-3,6-dihydro-2H-pyridin-1-yl]butyl]-1H-indol-2-one	Ki	1.19 [1], 1.2 [2]
	3-{4-[4-(4-Chlorophenyl)-piperazin-1-yl]-butyl}-3-ethyl-1,3-dihydro-2H-indol-2-one	Ki	0.38 [1]
	5,7-Dichloro-3-[4-[4-(4-chlorophenyl)piperazin-1-yl]butyl]-3-ethyl-1H-indol-2-one	Ki	9.5 [1], 10.13 [2]
	3-{4-[4-(4-Chlorophenyl)-piperazin-1-yl]-butyl}-1,3-dihydro-2H-indol-2-one	Ki	0.38 [1], 7.0 [2]
	3-Ethyl-3-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]-1H-indol-2-one	Ki	5.38 [1], 5.4 [2]
	1-(2-Methoxyphenyl)-4-[1-(2-cyanophenyl)-1H-pyrrole-3-ylmethyl]piperazine	Ki	5.4 [1]
	3-[4-[4-(3-Chlorophenyl)piperazin-1-yl]butyl]-3-ethyl-5-fluoro-1H-indol-2-one	Ki	2.1 [1], 2.11 [2]
	3-{4-[4-(3-Chlorophenyl)-piperazin-1-yl]-butyl}-1,3-dihydro-2H-indol-2-one	Ki	0.49 [1]
	Methyl 2-(3-((4-(2-methoxyphenyl)piperazin-1-yl)methyl)-1H-pyrrol-1-yl)-3-methylbenzoate	Ki	18.0 [1]
	3-{4-[4-(4-Chlorophenyl)-piperazin-1-yl]-butyl}-3-ethyl-5-fluoro-1,3-dihydro-2H-indol-2-one	Ki	2.81 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

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References

This online tool may be cited as follows

MLA	"Quest Database™ Serotonin 7 (5-HT7) receptor Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/serotonin-7-5-ht7-receptor-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 21). Quest Database™ Serotonin 7 (5-HT7) receptor Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/serotonin-7-5-ht7-receptor-inhibitors-ic50-ki.
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