Serotonin 5a (5-HT5a) receptor Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Serotonin	IC50	79.0 [1], 184.0 [2]
	Serotonin	Ki	110.0 [1], 126.0 [2], 130.0 [3], 170.0 [4], 250.0 [5]
	Ergotamine	Ki	14.0 [1], 16.0 [2], 22.0 [3], 40.0 [4]
	8-OH-Dpat	Ki	1000.0 [1], 2500.0 [2]
	Methiothepin	Ki	1.0 [1], 100.0 [2]
	2-[3-(4-Fluorophenoxy)propyl]-5-methyl-3,4-dihydro-1H-pyrido[4,3-b]indole	Ki	13.0 [1], 55.0 [2]
	Clozapine	Ki	1000.0 [1]
	Lysergide	Ki	9.0 [1], 10.0 [2]
	Ketanserin	Ki	20000.0 [1]
	Harmine	Ki	10000.0 [1]
	5-Carboxamidotryptamine	Ki	20.0 [1]
	(R)-3-((2-(2-(4-Methylpiperidin-1-yl)ethyl)pyrrolidin-1-yl)sulfonyl)phenol	Ki	63.1 [1], 65.0 [2]
	6-Methoxyharmalan	Ki	10000.0 [1]
	N,N-Diallyl-5-methoxytryptamine	Ki	3311.31 [1], 10000.0 [2]
	7-Methoxy-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole	Ki	10000.0 [1]
	5-Chloro-4-methyl-1,4-dihydroquinazolin-2-amine	Ki	5.01 [1], 5.13 [2]
	Benzyl N-[[(6aR,9S,10aR)-7-methyl-6,6a,8,9,10,10a-hexahydro-4H-indolo[4,3-fg]quinolin-9-yl]methyl]carbamate	Ki	630.0 [1], 1000.0 [2]
	4-Methyl-1,4-dihydroquinazolin-2-amine;hydroiodide	Ki	38.0 [1]
	5-(2-Pyridin-2-ylethyl)-5-azahexacyclo[5.4.1.02,6.03,10.04,8.09,12]dodecan-4-ol	Ki	10000.0 [1]
	3-[2-(Dimethylamino)ethyl]-N-methyl-1H-indole-5-sulfonamide	Ki	5000.0 [1]
	Risperidone	Ki	1000.0 [1]
	Olanzapine	Ki	1000.0 [1]
	Sorafenib	Ki	3296.0 [1]
	Quetiapine	Ki	1000.0 [1]
	Aripiprazole	Ki	1000.0 [1]
	Sumatriptan	IC50	501.19 [1]
	Spiperone	Ki	63000.0 [1]
	4-Iodo-2,5-dimethoxyphenylisopropylamine	Ki	1000.0 [1]
	Harmaline	Ki	10000.0 [1]
	Tryptoline	Ki	3200.0 [1]
	2-Methyl-5-hydroxytryptamine	Ki	10000.0 [1]
	Zacopride	Ki	16000.0 [1]
	Penfluridol	Ki	1000.0 [1]
	3-((4-(4-Chlorophenyl)piperazin-1-yl)methyl)-1H-pyrrolo[2,3-b]pyridine	Ki	10000.0 [1]
	1-Naphthylpiperazine	Ki	40.0 [1]
	alpha-Methyltryptamine	Ki	10000.0 [1]
	2-Bromolysergic acid diethylamide	Ki	10.0 [1]
	5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-carboxamide	IC50	10000.0 [1]
	Harmalol	Ki	10000.0 [1]
	(1S,2R)-5-Methoxy-1-methyl-N,N-dipropyl-1,2,3,4-tetrahydronaphthalen-2-amine	Ki	168.0 [1]
	5-Methoxy-1-methyl-2-(n-propylamino)tetralin	Ki	2331.0 [1]
	Tetrahydroharman	Ki	10000.0 [1]
	Tetrahydroharmine	Ki	10000.0 [1]
	Harmalan	Ki	845.0 [1]
	2-Ethyl-5-methoxy-N,N-dimethyltryptamine	Ki	4620.0 [1]
	Benzonitrile, 3-fluoro-5-(2-(2-(fluoromethyl)-4-thiazolyl)ethynyl)-	Ki	10000.0 [1]
	Barettin	Ki	10000.0 [1]
	Naluzotan	Ki	5000.0 [1]
	3-(2-Aminopyrimidin-4-yl)-1H-indol-4-ol	IC50	10000.0 [1]
	CID 10028436	Ki	181.97 [1]
	4,9-Dihydro-7-methoxy-3H-pyrido(3,4b)indole	Ki	10000.0 [1]
	1H-Indole-3-ethanamine, 5-methoxy-N,N-dimethyl-2-phenyl-	Ki	5160.0 [1]
	Unii-N4Y2V13I7F	Ki	10000.0 [1]
	3-Amino-2-[4-(4-quinolin-2-ylpiperazin-1-yl)butyl]-5,6,7,8-tetrahydroquinazolin-4-one	IC50	1000.0 [1]
	N-Methyllaurotetanine	Ki	566.0 [1]
	Thalictruberine	Ki	2224.0 [1]
	1-(Naphthalen-2-yl)piperazine	Ki	2100.0 [1]
	CID 9847194	IC50	10000.0 [1]
	2-Iodolysergic acid diethylamide	Ki	10.0 [1]
	N~2~-(3-Bromophenyl)-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine	Ki	389.0 [1]
	2-Amino-5,6-dichloro-3,4-dihydroquinazoline	Ki	43.0 [1]
	4-Imidazolidinone, 5-((6-bromo-1H-indol-3-yl)methylene)-2-imino-1,3-dimethyl-	Ki	9621.0 [1]
	Indole, 3-(2-(dimethylamino)ethyl)-5-methoxy-2-methyl-	Ki	10450.0 [1]
	6-Methoxy-1-methyl-9H-pyrido[3,4-b]indole	Ki	10000.0 [1]
	3-(1-Methyl-2-imidazoline-2-ylmethyl)pyridine	Ki	10000.0 [1]
	2-Methyl-5-(2-(4-(quinolin-8-ylmethyl)piperazin-1-yl)ethoxy)quinoline	Ki	3162.28 [1]
	CID 10331436	Ki	10000.0 [1]
	2-Amino-5-[(Z)-(6-bromoindol-3-ylidene)methyl]-3-methylimidazol-4-ol	Ki	5355.0 [1]
	5-[(E)-(5-Bromoindol-3-ylidene)methyl]-2-imino-1,3-dimethylimidazol-4-ol	Ki	6725.0 [1]
	Watasemycin A	Ki	10000.0 [1]
	Watasemycin B	Ki	10000.0 [1]
	2-(2-Hydroxyphenyl)-4-thiazolecarbaldehyde	Ki	10000.0 [1]
	N-(3-(1-(2-(2-Methylquinolin-5-yloxy)ethyl)piperidin-4-ylmethyl)phenyl)methanesulfonamide	Ki	1258.93 [1]
	Ethyl 3-[(4-amino-1,3,5-triazaspiro[5.5]undeca-2,4-dien-2-yl)amino]benzoate	Ki	457.0 [1]
	3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonitrile	Ki	10000.0 [1]
	N,N,N-Trimethylserotonin	Ki	10000.0 [1]
	2-[[3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl]methyl]-5-methyl-1,2,5-thiadiazolidine 1,1-dioxide	IC50	794.33 [1]
	[3-(4-Fluoro-phenoxy)-propyl]-dimethyl-amine	Ki	10000.0 [1]
	2-[4-[4-(7-(111C)Methoxynaphthalen-1-yl)piperazin-1-yl]butyl]-4-methyl-1,2,4-triazine-3,5-dione	Ki	228.6 [1]
	4-N-(3-Bromophenyl)-1,3,5-triazaspiro[5.5]undeca-1,4-diene-2,4-diamine	Ki	227.0 [1]
	2-[4-[4-(3-Methoxyphenyl)piperazin-1-yl]butyl]-4-methyl-1,2,4-triazine-3,5-dione	Ki	10000.0 [1]
	N,N-Dimethyl-3,4-dihydroquinazolin-2-amine	Ki	2800.0 [1]
	1-((S)-2-Aminopropyl)-1H-indazol-6-ol	Ki	10000.0 [1]
	2-Amino-5-[(Z)-(5-bromoindol-3-ylidene)methyl]-1H-imidazol-4-ol	Ki	89.0 [1]
	2-Amino-5-[(Z)-indol-3-ylidenemethyl]-1H-imidazol-4-ol	Ki	101.0 [1]
	Pulicatin A	Ki	10000.0 [1]
	Pulicatin B	Ki	10.0 [1]
	Aerugine	Ki	10000.0 [1]
	Pulicatin G	Ki	10000.0 [1]
	Pulicatin F	Ki	10000.0 [1]
	2-Amino-5-[(Z)-(4-bromoindol-3-ylidene)methyl]-3-methylimidazol-4-ol	Ki	1282.0 [1]
	2-Amino-5-[(Z)-(5-bromoindol-3-ylidene)methyl]-3-methylimidazol-4-ol	Ki	2332.0 [1]
	2-Amino-5-[(Z)-(7-bromoindol-3-ylidene)methyl]-3-methylimidazol-4-ol	Ki	1550.0 [1]
	5-[(Z)-(4-Bromoindol-3-ylidene)methyl]-1-methyl-2-(methylamino)imidazol-4-ol	Ki	1454.0 [1]
	5-[(Z)-(7-Bromoindol-3-ylidene)methyl]-1-methyl-2-(methylamino)imidazol-4-ol	Ki	1425.0 [1]
	5-[(Z)-(4-Bromoindol-3-ylidene)methyl]-2-imino-1,3-dimethylimidazol-4-ol	Ki	7828.0 [1]
	5-[(Z)-(4-Bromoindol-3-ylidene)methyl]-2-(methylamino)-1H-imidazol-4-ol	Ki	3372.0 [1]
	5-[(Z)-(7-Bromoindol-3-ylidene)methyl]-2-(methylamino)-1H-imidazol-4-ol	Ki	3324.0 [1]
	5-[(Z)-(4-Bromoindol-3-ylidene)methyl]-1,3-dimethyl-2-methyliminoimidazol-4-ol	Ki	5080.0 [1]
	5-[(Z)-(5-Bromoindol-3-ylidene)methyl]-1,3-dimethyl-2-methyliminoimidazol-4-ol	Ki	9118.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Serotonin 5a (5-HT5a) receptor Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 22 Feb. 2025, https://www.aatbio.com/data-sets/serotonin-5a-5-ht5a-receptor-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 22). Quest Database™ Serotonin 5a (5-HT5a) receptor Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/serotonin-5a-5-ht5a-receptor-inhibitors-ic50-ki.
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