Serotonin 4 (5-HT4) receptor Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	(1-(2-(Methylsulfonylamino)ethyl)-4-piperidinyl)methyl 1-methyl-1H-indole-3-carboxylate	IC50	0.21 [1]
	Piboserod	IC50	0.63 [1]
	Piboserod	Ki	0.25 [1]
	Tegaserod	Ki	3.98 [1], 31.0 [2]
	2-Methoxy-4-amino-5-chlorobenzoic acid 2-(4-phenylpiperazino)ethyl ester	Ki	12.5 [1], 14.3 [2], 23.0 [3], 32.0 [4], 55.0 [5]
	2-Methoxy-4-amino-5-chlorobenzoic acid 2-[4-(2-pyrimidinyl)piperazino]ethyl ester	Ki	1.0 [1], 2.47 [2], 3.5 [3], 7.03 [4], 8.1 [5]
	Serotonin	Ki	29.51 [1], 109.65 [2], 500.0 [3], 1049.0 [4]
	Cisapride	IC50	0.36 [1]
	Cisapride	Ki	29.0 [1], 100.0 [2], 125.89 [3]
	PF-04995274	Ki	0.15 [1], 0.32 [2], 0.36 [3], 0.46 [4]
	6-Fluoro-N-[[1-[(4-hydroxyoxan-4-yl)methyl]piperidin-4-yl]methyl]-2-oxo-3-propan-2-ylbenzimidazole-1-carboxamide	Ki	1.7 [1], 4.4 [2], 4.9 [3], 5.5 [4]
	6-Fluoro-N-[[1-[(4-hydroxyoxan-4-yl)methyl]piperidin-4-yl]methyl]-3,3-dimethyl-2-oxoindole-1-carboxamide	Ki	2.7 [1], 4.6 [2], 6.3 [3], 6.8 [4]
	4-Amino-5-chloro-N-{1-[3-(4-fluoro-phenoxy)-propyl]-3-methoxy-piperidin-4-yl}-2-methoxy-benzamide	IC50	483.0 [1]
	4-Amino-5-chloro-N-{1-[3-(4-fluoro-phenoxy)-propyl]-3-methoxy-piperidin-4-yl}-2-methoxy-benzamide	Ki	100.0 [1]
	Prucalopride	Ki	2.51 [1], 7.5 [2], 1000.0 [3]
	N-[(1S,5R)-8-[(2S)-2-Hydroxy-3-(4-methylsulfonylpiperazin-1-yl)propyl]-8-azabicyclo[3.2.1]octan-3-yl]-2-oxo-1-propan-2-ylquinoline-3-carboxamide	Ki	12.59 [1]
	2-[4-[4-[3-[4-[3-[[4-[[1-[2-(4-Amino-5-chloro-2-methoxybenzoyl)oxyethyl]piperidin-4-yl]amino]-4-oxobutyl]-[(2-methylpropan-2-yl)oxycarbonyl]amino]propyl]phenyl]propyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]butanoylamino]piperidin-1-yl]ethyl 4-amino-5-chloro-2-methoxybenzoate	Ki	10.0 [1], 12.0 [2]
	5-Methoxytryptamine	Ki	26.92 [1], 245.47 [2]
	3-Piperidin-1-ylpropyl 4-amino-5-chloro-2-methoxybenzoate	IC50	49.0 [1]
	3-Piperidin-1-ylpropyl 4-amino-5-chloro-2-methoxybenzoate	Ki	31.62 [1]
	5-Chloro-N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-3-methyl-1-benzothiophene-2-sulfonamide	Ki	3162.28 [1]
	Unii-0ZN0AQ6sbv	Ki	10.0 [1]
	3-Cyclopropyl-2-oxo-N-[2-(4-propan-2-ylpiperazin-1-yl)ethyl]benzimidazole-1-carboxamide	Ki	6.7 [1], 16.6 [2]
	N-[(1R,5S)-8-Azabicyclo[3.2.1]octan-3-yl]-1-propan-2-ylindazole-3-carboxamide	Ki	63.1 [1]
	2-[4-[11-[[4-[[11-[[1-[2-(4-Amino-5-chloro-2-methoxybenzoyl)oxyethyl]piperidin-4-yl]amino]-11-oxoundecyl]amino]-6-(benzylamino)-1,3,5-triazin-2-yl]amino]undecanoylamino]piperidin-1-yl]ethyl 4-amino-5-chloro-2-methoxybenzoate	Ki	113.0 [1]
	2-[4-[[11-[[1-[2-(4-Amino-5-chloro-2-methoxybenzoyl)oxyethyl]piperidin-4-yl]amino]-11-oxoundecyl]carbamoyl]piperidin-1-yl]ethyl 4-amino-5-chloro-2-methoxybenzoate	Ki	20.0 [1]
	2-[4-[11-[[11-[[1-[2-(4-Amino-5-chloro-2-methoxybenzoyl)oxyethyl]piperidin-4-yl]amino]-11-oxoundecyl]-[2-oxo-2-(piperidin-4-ylmethylamino)ethyl]amino]undecanoylamino]piperidin-1-yl]ethyl 4-amino-5-chloro-2-methoxybenzoate	Ki	50.0 [1]
	2-[4-[2-[[12-[2-[1-[2-(4-Amino-5-chloro-2-methoxybenzoyl)oxyethyl]piperidin-4-yl]ethylamino]-12-oxododecanoyl]amino]ethyl]piperidin-1-yl]ethyl 4-amino-5-chloro-2-methoxybenzoate	Ki	9.0 [1], 18.0 [2]
	7-Fluoro-5-[(1-propylpiperidin-4-yl)methoxy]benzo[h][1,6]naphthyridine	Ki	0.04 [1]
	4-Fluoro-6-[(1-propylpiperidin-4-yl)methoxy]phenanthridine	Ki	3.1 [1]
	2-Methoxy-4-amino-5-chlorobenzoic acid 2-[4-(2-chlorophenyl)piperazino]ethyl ester	IC50	296.0 [1]
	2-Methoxy-4-amino-5-chlorobenzoic acid 2-[4-(2-chlorophenyl)piperazino]ethyl ester	Ki	296.0 [1]
	2-Methoxy-4-amino-5-chlorobenzoic acid 2-[4-(2-fluorophenyl)piperazino]ethyl ester	IC50	17.0 [1]
	2-Methoxy-4-amino-5-chlorobenzoic acid 2-[4-(2-fluorophenyl)piperazino]ethyl ester	Ki	16.8 [1]
	2-Methoxy-4-amino-5-chlorobenzoic acid 2-[4-(3-chlorophenyl)piperazino]ethyl ester	IC50	162.0 [1]
	2-Methoxy-4-amino-5-chlorobenzoic acid 2-[4-(3-chlorophenyl)piperazino]ethyl ester	Ki	162.0 [1]
	2-Methoxy-4-amino-5-chlorobenzoic acid 2-[4-(4-methoxyphenyl)piperazino]ethyl ester	IC50	18.0 [1]
	2-Methoxy-4-amino-5-chlorobenzoic acid 2-[4-(4-methoxyphenyl)piperazino]ethyl ester	Ki	17.7 [1]
	2-Methoxy-4-amino-5-chlorobenzoic acid 2-[4-(4-chlorophenyl)piperazino]ethyl ester	IC50	715.0 [1]
	2-Methoxy-4-amino-5-chlorobenzoic acid 2-[4-(4-chlorophenyl)piperazino]ethyl ester	Ki	715.0 [1]
	2-Methoxy-4-amino-5-chlorobenzoic acid 2-[4-(2-methoxyphenyl)piperazino]ethyl ester	IC50	64.0 [1]
	2-Methoxy-4-amino-5-chlorobenzoic acid 2-[4-(2-methoxyphenyl)piperazino]ethyl ester	Ki	64.0 [1]
	2-Methoxy-4-amino-5-chlorobenzoic acid 2-[4-(3-methoxyphenyl)piperazino]ethyl ester	IC50	3.0 [1]
	2-Methoxy-4-amino-5-chlorobenzoic acid 2-[4-(3-methoxyphenyl)piperazino]ethyl ester	Ki	3.0 [1]
	4-[2-[4-[(2-Methylpyrrolo[3,4-c]quinolin-4-yl)oxymethyl]piperidin-1-yl]ethyl]benzoic acid	IC50	2.8 [1]
	4-[2-[4-[(2-Methylpyrrolo[3,4-c]quinolin-4-yl)oxymethyl]piperidin-1-yl]ethyl]benzoic acid	Ki	2.0 [1]
	4-[2-[4-[[(1-Propan-2-ylindazole-3-carbonyl)amino]methyl]piperidin-1-yl]ethyl]benzoic acid	IC50	9.8 [1]
	4-[2-[4-[[(1-Propan-2-ylindazole-3-carbonyl)amino]methyl]piperidin-1-yl]ethyl]benzoic acid	Ki	0.79 [1]
	Tropisetron	Ki	199.53 [1]
	GR-127935	Ki	10000.0 [1]
	(R)-3-((2-(2-(4-Methylpiperidin-1-yl)ethyl)pyrrolidin-1-yl)sulfonyl)phenol	Ki	1258.93 [1]
	5-Chloro-N-(4-methoxy-3-(piperazin-1-yl)phenyl)-3-methylbenzo[b]thiophene-2-sulfonamide	Ki	3981.07 [1]
	2-(Diethylamino)ethyl 4-amino-5-chloro-2-methoxybenzoate	Ki	6.31 [1]
	SB 204070 hydrochloride	Ki	0.02 [1]
	1-(1-Methylindol-5-yl)-3-(3-methyl-1,2-thiazol-5-yl)urea	Ki	10000.0 [1]
	1-Phenyl-3-[[3-(trifluoromethyl)phenyl]imino]-1h-indol-2-one	Ki	72.0 [1]
	4-(4-Butylpiperidin-1-yl)-1-o-tolylbutan-1-one	Ki	1000.0 [1]
	(1-Butylpiperidin-4-yl)methyl 5-amino-6-iodo-2,3-dihydro-1,4-benzodioxine-8-carboxylate	Ki	2.2 [1]
	Velusetrag	Ki	19.95 [1]
	Barettin	Ki	1910.0 [1]
	N-(2,5-Dibromo-3-fluorophenyl)-4-methoxy-3-piperazin-1-ylbenzenesulfonamide	Ki	5011.87 [1]
	Naluzotan	Ki	5000.0 [1]
	4-Methyl-1-[2-[(2R)-1-(3-methylphenyl)sulfonylpyrrolidin-2-yl]ethyl]piperidine	Ki	10000.0 [1]
	Methyl 4-[[4-[[(2-propan-2-yl-1H-benzimidazole-4-carbonyl)amino]methyl]piperidin-1-yl]methyl]piperidine-1-carboxylate	Ki	0.4 [1]
	CID 10028436	Ki	1905.46 [1]
	Norcisapride	IC50	19.0 [1]
	N-[1-[3-(3-Oxo-1,4-benzoxazin-4-yl)propyl]piperidin-4-yl]-2-phenylacetamide	Ki	1000.0 [1]
	CID 44240743	Ki	6000.0 [1]
	Unii-7qgn8qxg7I	Ki	36.0 [1]
	4-Bromo-N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]benzenesulfonamide	Ki	2511.89 [1]
	N-[3-[(8As)-3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]-4-methoxyphenyl]-5-chloro-3-methyl-1-benzothiophene-2-sulfonamide	Ki	5011.87 [1]
	2-Methyl-5-(2-(4-(quinolin-8-ylmethyl)piperazin-1-yl)ethoxy)quinoline	Ki	5011.87 [1]
	CID 10331436	Ki	1700.0 [1]
	3-Ethyl-N-(8-methyl-8-azabicyclo[3.2.1]octan-3-yl)-2-oxobenzimidazole-1-carboxamide	Ki	13.0 [1]
	N-(3-(1-(2-(2-Methylquinolin-5-yloxy)ethyl)piperidin-4-ylmethyl)phenyl)methanesulfonamide	Ki	10000.0 [1]
	4-Amino-5-chloro-2-methoxy-N-piperidin-4-YL-benzamide	Ki	1584.89 [1]
	CID 44391713	Ki	0.79 [1]
	4-Amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamide	Ki	316.23 [1]
	4-Fluoro-N-[3-(1-methyl-piperidin-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl]-benzamide	Ki	4000.0 [1]
	2-[4-[(6-Amino-1,3-dioxobenzo[de]isoquinolin-2-yl)methyl]piperidin-1-yl]ethyl 4-amino-5-chloro-2-methoxybenzoate	Ki	64.0 [1]
	6-Iodo-1-indolinyl 3-piperazino-4-methoxyphenyl sulfone	Ki	3981.07 [1]
	N-Piperidin-4-yl-1-propan-2-ylindazole-3-carboxamide	Ki	398.11 [1]
	N-[2-(4-Methylpiperazin-1-yl)ethyl]-2-oxo-3-propan-2-ylbenzimidazole-1-carboxamide	Ki	91.9 [1]
	1-((S)-2-Aminopropyl)-1H-indazol-6-ol	Ki	515.0 [1]
	4-[(Z)-(4-Bromoindol-3-ylidene)methyl]-5-hydroxy-1,3-dihydroimidazole-2-thione	Ki	2359.0 [1]
	4-[(Z)-(7-Bromoindol-3-ylidene)methyl]-5-hydroxy-1,3-dihydroimidazole-2-thione	Ki	2214.0 [1]
	5-[(Z)-(4-Bromoindol-3-ylidene)methyl]-2-methylsulfanyl-1H-imidazol-4-ol	Ki	1063.0 [1]
	5-[(Z)-(5-Bromoindol-3-ylidene)methyl]-2-methylsulfanyl-1H-imidazol-4-ol	Ki	3799.0 [1]
	5-[(Z)-(6-Bromoindol-3-ylidene)methyl]-2-methylsulfanyl-1H-imidazol-4-ol	Ki	5308.0 [1]
	5-[(Z)-(7-Bromoindol-3-ylidene)methyl]-2-methylsulfanyl-1H-imidazol-4-ol	Ki	2345.0 [1]
	5-[(Z)-Indol-3-ylidenemethyl]-2-(methylamino)-1H-imidazol-4-ol	Ki	928.0 [1]
	5-[(Z)-(4-Bromoindol-3-ylidene)methyl]-2-(methylamino)-1H-imidazol-4-ol	Ki	472.0 [1]
	5-[(Z)-(5-Bromoindol-3-ylidene)methyl]-2-(methylamino)-1H-imidazol-4-ol	Ki	226.0 [1]
	5-[(Z)-(6-Bromoindol-3-ylidene)methyl]-2-(methylamino)-1H-imidazol-4-ol	Ki	1156.0 [1]
	5-[(Z)-(7-Bromoindol-3-ylidene)methyl]-2-(methylamino)-1H-imidazol-4-ol	Ki	603.0 [1]
	(1-Butylpiperidin-4-yl)methyl 4-amino-3-methoxybenzoate	Ki	2.4 [1]
	7-[2-[2-(3-Chlorophenyl)ethylamino]ethyl]quinolin-2-Amine	Ki	100.0 [1]
	1-(3,7,8,9-Tetrahydropyrano[3,2-e]indole-1-yl)propane-2-amine	Ki	1800.0 [1]
	N-[3-[(8Ar)-3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]-4-methoxyphenyl]-5-chloro-3-methyl-1-benzothiophene-2-sulfonamide	Ki	1584.89 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 99 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Serotonin 4 (5-HT4) receptor Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/serotonin-4-5-ht4-receptor-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 21). Quest Database™ Serotonin 4 (5-HT4) receptor Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/serotonin-4-5-ht4-receptor-inhibitors-ic50-ki.
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