Serotonin 3 (5-HT3) receptor Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	m-Chlorophenylbiguanide	Ki	17.0 [1], 18.0 [2]
	1-(3-Chlorophenyl)guanidine	Ki	32.0 [1], 35.0 [2]
	Quipazine	IC50	0.45 [1]
	Quipazine	Ki	1.8 [1], 2.0 [2]
	1-Phenylbiguanide	Ki	1200.0 [1]
	N-2-Naphthylimidodicarbonimidic diamide	Ki	12.0 [1], 14.0 [2]
	2-Naphthylguanidine	Ki	18.0 [1], 25.0 [2]
	Serotonin	Ki	120.0 [1], 144.54 [2]
	Mianserin	IC50	1412.54 [1]
	Ondansetron	Ki	7.6 [1], 12.0 [2]
	Tropisetron	Ki	5.3 [1], 33.0 [2]
	Granisetron	Ki	2.1 [1], 24.0 [2]
	Bemesetron	IC50	9.3 [1]
	Bemesetron	Ki	10.0 [1]
	Benzamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chloro-	Ki	1662.0 [1], 4540.0 [2]
	SB 204070 hydrochloride	Ki	199.53 [1], 251.19 [2]
	1-Phenylguanidine	Ki	2340.0 [1]
	N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide	Ki	511.0 [1], 628.0 [2]
	4-Chlorophenylbiguanide	Ki	200.0 [1], 210.0 [2]
	1-(4-Chlorophenyl)guanidine	Ki	320.0 [1], 326.0 [2]
	N3-(3-Chlorophenyl)-1H-1,2,4-triazole-3,5-diamine	Ki	10000.0 [1]
	1-(Diaminomethylidene)-2-(4-methylphenyl)guanidine	Ki	890.0 [1], 10000.0 [2]
	8-(4-Benzylpiperazin-1-yl)-3-thia-1,7-diazatricyclo[7.3.0.02,6]dodeca-2(6),4,7,9,11-pentaene	IC50	1.41 [1]
	1-(2-Chlorophenyl)biguanide	Ki	62.0 [1]
	N,N-Dimethyl-1-(3-oxa-2-azatetracyclo[12.4.0.02,6.07,12]octadeca-1(18),7,9,11,14,16-hexaen-4-yl)methanamine	IC50	1202.26 [1]
	N-(2-Chloro-phenyl)-guanidine	Ki	190.0 [1]
	N-(3-Nitrophenyl)imidodicarbonimidic diamide	Ki	220.0 [1]
	N-[3-(Trifluoromethyl)phenyl]guanidine	Ki	2440.0 [1], 5700.0 [2]
	N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-1-benzofuran-6-carboxamide	Ki	310.0 [1], 962.0 [2]
	N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-1-benzothiophene-6-carboxamide	Ki	174.0 [1], 188.0 [2]
	2-(3-Chlorophenyl)ethanimidamide	Ki	1200.0 [1]
	1-(3-Methylphenyl)guanidine	Ki	6520.0 [1]
	3-Chloro-4-Methyl-Phenyl biguanide	Ki	225.0 [1]
	N-(3-Methylphenyl)imidodicarbonimidic diamide	Ki	780.0 [1]
	N-Carbamimidoyl-N'-(3-chloro-phenyl)-urea	Ki	1250.0 [1]
	N-[2-(3-Chlorophenyl)ethyl]guanidine	Ki	40.0 [1]
	1-(3-Methoxyphenyl)guanidine	Ki	1600.0 [1]
	N-[(3R)-1-Azabicyclo[2.2.2]octan-3-yl]-1-benzofuran-5-carboxamide	Ki	580.0 [1], 663.0 [2]
	N,N-Dimethyl-2-[(Z)-(3-methylthieno[2,3-b]pyrrolizin-8-ylidene)amino]oxyethanamine	IC50	0.79 [1], 120.23 [2]
	Nicotine	Ki	71000.0 [1]
	Clozapine	Ki	398.11 [1]
	Olanzapine	Ki	199.53 [1]
	Aripiprazole	Ki	501.19 [1]
	Sumatriptan	IC50	10000.0 [1]
	Ziprasidone	Ki	398.11 [1]
	Cisapride	Ki	152.0 [1]
	Harmine	Ki	10000.0 [1]
	1-(3-Chlorophenyl)piperazine	Ki	62.0 [1]
	Rizatriptan	IC50	10000.0 [1]
	Palonosetron	IC50	0.88 [1]
	1-[3-(Trifluoromethyl)phenyl]piperazine	Ki	1390.0 [1]
	1-Phenylpiperazine	Ki	3000.0 [1]
	GR-127935	Ki	6309.57 [1]
	4-(4-Methylpiperazin-1-yl)-7-(trifluoromethyl)pyrrolo[1,2-a]quinoxaline	IC50	1318.26 [1]
	1-(2-Methoxyphenyl)piperazine	Ki	2500.0 [1]
	1-Naphthylpiperazine	Ki	175.0 [1]
	6-Nitroquipazine	Ki	58.0 [1]
	3-(5-Methyl-1H-imidazol-4-yl)-1-(1-methyl-1H-indol-3-yl)-1-propanone	Ki	1.62 [1]
	4-Phenylpiperidine	Ki	10000.0 [1]
	4'-Acetyl-N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-[1,1'-biphenyl]-4-carboxamide	Ki	10000.0 [1]
	4-Amino-5-chloro-N-((hexahydro-1H-pyrrolizin-1-yl)methyl)-2-methoxybenzamide hydrochloride	Ki	152.0 [1]
	1-(4-Methoxyphenyl)piperazine	Ki	1640.0 [1]
	1,3,5-Triazine-2,4-diamine, 1-(3-chlorophenyl)-1,6-dihydro-6,6-dimethyl-	Ki	10000.0 [1]
	Harmalan	Ki	10000.0 [1]
	Benzonitrile, 3-fluoro-5-(2-(2-(fluoromethyl)-4-thiazolyl)ethynyl)-	Ki	10000.0 [1]
	Amanozine	Ki	10000.0 [1]
	6-Methoxyharmalan	Ki	10000.0 [1]
	1H-Benzimidazol-2-amine, 5-chloro-	Ki	725.0 [1]
	1-(4-Chlorophenyl)piperazine	Ki	2160.0 [1]
	N-Methylquipazine	Ki	3.0 [1]
	3-(1H-Indole-3-carbonyloxy)-8,8-dimethyl-8-azonia-bicyclo[3.2.1]octane	Ki	7.2 [1]
	1-(6-Chloropyridin-2-yl)piperidin-4-amine	Ki	103.0 [1]
	Psab-ofp	Ki	73.0 [1]
	1-(Naphthalen-2-yl)piperazine	Ki	32.0 [1]
	CID 5311416	Ki	501.19 [1]
	6-[(1-Naphthalenylmethyl)thio]-9H-purine	IC50	430.0 [1]
	Guanidine, N-2-pyridinyl-	Ki	10000.0 [1]
	3,4-Dichlorophenylbiguanide	Ki	12.0 [1]
	2-Chloro-3-(4-methylpiperazin-1-yl)quinoxaline	Ki	22.0 [1]
	1-(6-Chloropyridin-2-yl)piperazine	Ki	15.0 [1]
	2-(3-Chlorophenyl)ethylamine	Ki	10000.0 [1]
	6-(4-Methylpiperazino)-7,8,9,10-tetrahydrophenanthridine	Ki	0.23 [1]
	7-Methoxy-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole	Ki	10000.0 [1]
	6-(4-Methylpiperazin-1-yl)phenanthridine	Ki	1.9 [1]
	1-(4-Methoxyphenyl)guanidine	Ki	990.0 [1]
	N-p-Tolyl-guanidine	Ki	442.0 [1]
	N-(3,4,5-Trichlorophenyl)guanidine	Ki	0.7 [1]
	6-(4-Methylpiperazino)-7,8,9,10-tetrahydro-8,10-ethanophenanthridine	Ki	0.83 [1]
	5-(3-Chlorophenyl)-6-methyl-5,6-dihydro-1,3,5-triazine-2,4-diamine	Ki	10000.0 [1]
	N-1,3-Benzodioxol-5-ylguanidine	Ki	274.0 [1]
	N-[4-(Trifluoromethyl)phenyl]guanidine	Ki	230.0 [1]
	Endo-Maohqc	Ki	1.5 [1]
	2-Piperidinoquinoline	Ki	10000.0 [1]
	N-(3,5-Dichlorophenyl)imidodicarbonimidic diamide	Ki	1.8 [1]
	7-(4-Benzylpiperazin-1-yl)-2,8,13-triazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaene	IC50	0.0 [1]
	6-Chloro-2a-[4-[4-(4-chlorophenyl)-3,6-dihydro-2H-pyridin-1-yl]butyl]-1,3,4,5-tetrahydrobenzo[cd]indol-2-one	Ki	1000.0 [1]
	1H-Indole-3-carboxylic acid 3-quinuclidinyl ester	Ki	1.1 [1]
	8-(4-Benzylpiperazin-1-yl)-5-thia-1,7-diazatricyclo[7.3.0.02,6]dodeca-2(6),3,7,9,11-pentaene	IC50	4.57 [1]
	4-(4-Methylpiperazino)pyrrolo[1,2-a]quinoxaline	Ki	0.23 [1]
	1-(17-Chloro-3-oxa-2-azatetracyclo[12.4.0.02,6.07,12]octadeca-1(14),7,9,11,15,17-hexaen-4-yl)-N,N-dimethylmethanamine	IC50	478.63 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

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References

This online tool may be cited as follows

MLA	"Quest Database™ Serotonin 3 (5-HT3) receptor Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 30 Mar. 2025, https://www.aatbio.com/data-sets/serotonin-3-5-ht3-receptor-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, March 30). Quest Database™ Serotonin 3 (5-HT3) receptor Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/serotonin-3-5-ht3-receptor-inhibitors-ic50-ki.
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