Serotonin 2c (5-HT2c) receptor Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Clozapine	IC50	10.0 [1]
	Clozapine	Ki	15.85 [1], 21.0 [2], 73.0 [3]
	Risperidone	IC50	1.81 [1], 7.0 [2]
	Risperidone	Ki	12.0 [1], 41.69 [2]
	Serotonin	IC50	81.0 [1]
	Serotonin	Ki	8.3 [1]
	Haloperidol	IC50	10000.0 [1]
	Haloperidol	Ki	4570.88 [1]
	Olanzapine	Ki	14.0 [1]
	Aripiprazole	IC50	1380.0 [1]
	CID 3693566	IC50	1.5 [1], 2.7 [2], 5.5 [3], 8.3 [4]
	CID 3693566	Ki	0.6 [1], 2.0 [2]
	Mianserin	IC50	7.41 [1]
	Mianserin	Ki	4.4 [1], 8.0 [2]
	Mesulergine	IC50	1.9 [1]
	Mesulergine	Ki	0.92 [1], 1.5 [2], 1.82 [3], 2.0 [4]
	Volinanserin	Ki	13.0 [1], 107.0 [2], 316.23 [3]
	SB 243213	IC50	0.7 [1]
	SB 243213	Ki	1.0 [1]
	Chlorpromazine	Ki	2.74 [1], 27.0 [2], 30.0 [3], 39.81 [4]
	Agomelatine	Ki	630.0 [1], 707.95 [2], 708.0 [3]
	6-Chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indoline	Ki	1.0 [1]
	Lorcaserin	Ki	15.0 [1], 167.0 [2], 257.0 [3]
	Benzo(1,2-b:4,5-b')dipyrrole-1(2H)-carboxamide, 3,5-dihydro-5-methyl-N-3-pyridinyl-	IC50	9.4 [1]
	Benzo(1,2-b:4,5-b')dipyrrole-1(2H)-carboxamide, 3,5-dihydro-5-methyl-N-3-pyridinyl-	Ki	10.0 [1], 12.59 [2]
	(S)-2-(6-Chloro-5-fluoro-indol-1-yl)-1-methyl-ethylamine	Ki	1.26 [1], 2.3 [2], 26.0 [3]
	1-(2,4-Difluorophenethyl)-4-(4-fluorophenylsulfonyl)piperidine	Ki	39.0 [1], 92.0 [2]
	6-[[4-(6-Fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]methyl]-6,7-dihydro-5H-1-benzofuran-4-one	Ki	338.84 [1], 3981.07 [2], 10000.0 [3], 18197.01 [4]
	Ketanserin	IC50	2.7 [1]
	Ketanserin	Ki	43.65 [1], 100.0 [2]
	Sumatriptan	IC50	7.3 [1], 7943.28 [2], 10000.0 [3]
	Ritanserin	Ki	1.8 [1], 1.9 [2]
	Quipazine	IC50	61.66 [1]
	Quipazine	Ki	200.0 [1]
	Sertindole	Ki	0.2 [1], 1.0 [2], 1.3 [3]
	5-Carboxamidotryptamine	IC50	588.84 [1]
	5-Carboxamidotryptamine	Ki	620.0 [1], 2511.89 [2]
	alpha-Methyl-5-HT	Ki	6.6 [1], 7.0 [2], 60.0 [3]
	5-Methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole	IC50	290.0 [1], 300.0 [2]
	5-Methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole	Ki	400.0 [1]
	4-(4-Methylpiperazin-1-yl)-7-(trifluoromethyl)pyrrolo[1,2-a]quinoxaline	IC50	10000.0 [1], 97723.72 [2]
	5-Chloro-N-(4-methoxy-3-(piperazin-1-yl)phenyl)-3-methylbenzo[b]thiophene-2-sulfonamide	Ki	530.0 [1], 776.25 [2], 1995.26 [3]
	1-(8-Bromo-2,3,6,7-tetrahydrobenzo[1,2-b:4,5-b']difuran-4-yl)propan-2-amine	Ki	0.3 [1], 2.28 [2]
	4-Imidazolidinone, 5-((6-bromo-1H-indol-3-yl)methylene)-2-imino-1,3-dimethyl-	Ki	330.0 [1], 1704.0 [2], 2202.0 [3]
	(R)-8,9-Dichloro-2,3,4,4a-Tetrahydro-1H-Pyrazino[1,2-a]Quinoxalin-5(6H)-One	Ki	3.0 [1], 3.3 [2], 32.0 [3]
	N,N-Dimethyl-1-(3-oxa-2-azatetracyclo[12.4.0.02,6.07,12]octadeca-1(18),7,9,11,14,16-hexaen-4-yl)methanamine	IC50	12.3 [1], 1000.0 [2]
	1-(2,4-Difluorophenethyl)-4-fluoro-4-(4-fluorophenylsulfonyl)piperidine	Ki	69.0 [1], 176.0 [2], 180.0 [3]
	6-Chloro-5-methyl-N-pyridin-3-yl-2,3-dihydroindole-1-carboxamide	Ki	6.3 [1], 6.31 [2]
	5-[2-[4-(6-Fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-6,7-dihydro-5H-1-benzofuran-4-one	Ki	34.67 [1], 69.18 [2]
	(7S)-7-[(5-Fluoro-2-methylphenyl)methoxy]-2-[(2R)-2-methylpiperazin-1-yl]-6,7-dihydro-5H-cyclopenta[b]pyridine	IC50	1.9 [1], 86.0 [2]
	(7S)-7-[(5-Fluoro-2-methylphenyl)methoxy]-2-[(2R)-2-methylpiperazin-1-yl]-6,7-dihydro-5H-cyclopenta[b]pyridine	Ki	1.5 [1]
	N-[2-(1,3-Benzodioxol-5-yl)ethyl]-N-[2-(3,4-dimethoxyphenyl)ethyl]-3-phenylpropan-1-amine	IC50	12589.25 [1]
	N-[2-(1,3-Benzodioxol-5-yl)ethyl]-N-[2-(3,4-dimethoxyphenyl)ethyl]-3-phenylpropan-1-amine	Ki	399.0 [1]
	Propranolol	IC50	5011.87 [1]
	Propranolol	Ki	1202.0 [1]
	8-OH-Dpat	Ki	7250.0 [1], 14800.0 [2]
	Spiperone	Ki	630.96 [1], 1150.0 [2]
	Methysergide	Ki	1.09 [1], 2.5 [2]
	Cyproheptadine	Ki	1.28 [1], 11.0 [2]
	Ketotifen	Ki	84.0 [1], 199.53 [2]
	Metergoline	Ki	0.35 [1], 0.5 [2]
	Rizatriptan	IC50	7943.28 [1], 10000.0 [2]
	1-(2-Methylbenzo[d]oxazol-6-yl)-3-(1,5-naphthyridin-4-yl)urea	Ki	1200.0 [1], 5011.87 [2]
	N,N-Dimethyl-5-methoxytryptamine	IC50	250.0 [1]
	N,N-Dimethyl-5-methoxytryptamine	Ki	42.0 [1]
	1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanol	Ki	716.0 [1], 1400.0 [2]
	IB-Meca	Ki	5420.0 [1]
	(R)-3-((2-(2-(4-Methylpiperidin-1-yl)ethyl)pyrrolidin-1-yl)sulfonyl)phenol	Ki	5.0 [1], 10000.0 [2]
	Latrepirdine	Ki	75.86 [1], 76.0 [2]
	(R)-1-(4-Iodo-2,5-dimethoxyphenyl)propan-2-amine	Ki	4.0 [1]
	SB 204070 hydrochloride	Ki	79.43 [1], 125.89 [2]
	(Rac)-WAY-161503	Ki	4.0 [1], 58.0 [2]
	SB 200646 hydrochloride	Ki	109.65 [1], 138.04 [2]
	Aplysinopsin	Ki	10000.0 [1], 14451.0 [2]
	5-Methoxy-alpha-methyltryptamine	Ki	8.3 [1]
	N,N-Diallyl-5-methoxytryptamine	Ki	457.09 [1], 1737.8 [2]
	1-[(1-(4-Chlorophenyl)-1H-pyrazol-4-yl)methyl]-4-phenylpiperazine	Ki	8440.0 [1], 8630.0 [2]
	(S)-2-(7-Ethyl-1H-furo(2,3-g)indazol-1-yl)-1-methylethylamine	Ki	0.89 [1]
	SB 221284	Ki	2.51 [1]
	N-(3-(3-Pyridinyl)-5-fluorophenyl)-5-methoxy-6-(trifluoromethyl)indoline-1-carboxamide	IC50	10.0 [1]
	N-(3-(3-Pyridinyl)-5-fluorophenyl)-5-methoxy-6-(trifluoromethyl)indoline-1-carboxamide	Ki	1.0 [1]
	CP-809101	Ki	1.0 [1], 9.3 [2]
	Nelotanserin	Ki	110.0 [1], 158.49 [2]
	8-(4-Benzylpiperazin-1-yl)-3-thia-1,7-diazatricyclo[7.3.0.02,6]dodeca-2(6),4,7,9,11-pentaene	IC50	1862.09 [1]
	4-[3-(4-Chlorophenyl)-3-hydroxy-8-azabicyclo[3.2.1]oct-8-yl]-1-(4-fluorophenyl)butan-1-one	Ki	872.1 [1]
	3-[4-(4-Fluorobenzoyl)piperidinomethyl]tetralin-1-one	Ki	234.42 [1], 489.78 [2]
	4-(3-(4-Chlorophenyl)-3-hydroxypyrrolidin-1-yl)-1-(4-fluorophenyl)butan-1-one	Ki	1252.0 [1], 3598.0 [2]
	3-[4-(2-Methoxyphenyl)piperazinomethyl]tetralin-1-one	Ki	2818.38 [1]
	2-[[4-(6-Fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]methyl]-1,2,3,9-tetrahydrocarbazol-4-one	Ki	27.54 [1], 57.54 [2]
	6-[[4-(4-Fluorobenzoyl)piperidin-1-yl]methyl]-6,7-dihydro-5H-1-benzofuran-4-one	Ki	1548.82 [1], 10000.0 [2]
	3-[[4-(6-Fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]methyl]-3,4-dihydro-2H-naphthalen-1-one	Ki	104.71 [1], 128.82 [2]
	7-[4-[4-(2,3-Dichlorophenyl)-1,4-diazepan-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-one	Ki	0.6 [1], 115.0 [2]
	5-Chloro-N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-3-methyl-1-benzothiophene-2-sulfonamide	Ki	501.19 [1]
	1-(2,4-Difluorophenethyl)-4-(phenylsulfonyl)piperidine	Ki	25.0 [1]
	2-[2-[4-[4-(4-Fluorophenyl)-4-oxobutyl]piperazin-1-yl]ethyl]-2,3-dihydroinden-1-one	Ki	6165.95 [1], 10000.0 [2]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 95 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Serotonin 2c (5-HT2c) receptor Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 22 Dec. 2024, https://www.aatbio.com/data-sets/serotonin-2c-5-ht2c-receptor-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, December 22). Quest Database™ Serotonin 2c (5-HT2c) receptor Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/serotonin-2c-5-ht2c-receptor-inhibitors-ic50-ki.
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