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Serotonin 2a (5-HT2a) receptor Inhibitors (IC50, Ki)

Structure
Compound Name
Standard Type
Standard Values (in nM)
ClozapineIC5012.0 [1]
ClozapineKi6.3 [1], 9.1 [2]
KetanserinIC5014.0 [1]
AripiprazoleIC501100.0 [1], 2790.0 [2]
OlanzapineIC509.0 [1], 100.0 [2]
OlanzapineKi2.3 [1]
HaloperidolIC50288.0 [1]
HaloperidolKi435.0 [1]
RisperidoneIC504.67 [1]
RisperidoneKi0.81 [1]
SerotoninKi8.2 [1]
MianserinIC5010.47 [1], 20.89 [2]
MianserinKi4.3 [1], 8.1 [2]
ZiprasidoneIC500.42 [1]
VolinanserinKi0.1 [1]
LysergideKi2.6 [1], 3.1 [2], 3.16 [3], 3.5 [4], 4.0 [5]
SpiperoneIC505.67 [1]
SpiperoneKi1.1 [1], 1.58 [2], 2.24 [3], 2.9 [4]
ChlorpromazineIC503.4 [1]
ChlorpromazineKi1.1 [1], 5.9 [2], 6.31 [3]
SumatriptanIC507943.28 [1], 10000.0 [2]
SumatriptanKi376.0 [1], 1000.0 [2]
CyproheptadineKi0.28 [1], 0.46 [2], 1.6 [3], 3.0 [4]
6-Chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indolineKi158.49 [1]
CinanserinKi13.0 [1], 17.0 [2], 22.0 [3], 24.0 [4]
Benzo(1,2-b:4,5-b')dipyrrole-1(2H)-carboxamide, 3,5-dihydro-5-methyl-N-3-pyridinyl-Ki1621.81 [1], 1995.26 [2]
(S)-2-(6-Chloro-5-fluoro-indol-1-yl)-1-methyl-ethylamineKi31.62 [1], 38.0 [2], 39.0 [3]
SB 243213IC5032.4 [1]
SB 243213Ki158.49 [1]
2,2-DiphenylethylamineKi4140.0 [1], 4610.0 [2]
1-(2,4-Difluorophenethyl)-4-(4-fluorophenylsulfonyl)piperidineKi0.42 [1]
(S)-1-(5,6-Difluoro-1H-indol-1-yl)propan-2-amineKi12.0 [1], 39.0 [2], 100.0 [3]
ImipramineIC50220.0 [1]
ImipramineKi94.0 [1], 160.0 [2]
BuspironeKi653.0 [1], 851.0 [2], 3240.0 [3]
N,N-Dimethyl-5-methoxytryptamineKi15.0 [1], 620.0 [2]
ZotepineKi0.5 [1], 0.91 [2], 2.7 [3]
CariprazineKi22.0 [1], 23.0 [2]
BrolamfetamineKi0.6 [1], 41.0 [2]
4-Bromo-2,5-dimethoxyphenethylamineKi0.66 [1], 1.0 [2], 34.0 [3]
FananserinKi0.04 [1], 0.37 [2]
NelotanserinIC500.63 [1]
NelotanserinKi0.51 [1], 0.63 [2]
1-(8-Bromo-2,3,6,7-tetrahydrobenzo[1,2-b:4,5-b']difuran-4-yl)propan-2-amineKi0.48 [1], 10.73 [2]
4-[3-(4-Chlorophenyl)-3-hydroxy-8-azabicyclo[3.2.1]oct-8-yl]-1-(4-fluorophenyl)butan-1-oneKi30.9 [1]
7-[4-[4-(2,3-Dichlorophenyl)-1,4-diazepan-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-oneKi0.6 [1], 2.0 [2], 16.0 [3]
N,N-Dimethyl-1-(3-oxa-2-azatetracyclo[12.4.0.02,6.07,12]octadeca-1(18),7,9,11,14,16-hexaen-4-yl)methanamineIC5022.91 [1], 1000.0 [2]
1-(2,4-Difluorophenethyl)-4-fluoro-4-(4-fluorophenylsulfonyl)piperidineKi0.39 [1]
9-(Methylaminomethyl)-9,10-dihydroanthraceneKi52.0 [1]
2-Phenyl-3-(2-piperidin-1-yl-ethyl)-1H-indoleKi2.6 [1], 2.7 [2]
6-Chloro-5-methyl-N-pyridin-3-yl-2,3-dihydroindole-1-carboxamideKi158.49 [1], 159.0 [2]
5-[2-[4-(6-Fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-6,7-dihydro-5H-1-benzofuran-4-oneKi0.56 [1], 0.72 [2]
N-[2-(1,3-Benzodioxol-5-yl)ethyl]-N-[2-(3,4-dimethoxyphenyl)ethyl]-3-phenylpropan-1-amineIC505011.87 [1]
N-[2-(1,3-Benzodioxol-5-yl)ethyl]-N-[2-(3,4-dimethoxyphenyl)ethyl]-3-phenylpropan-1-amineKi165.0 [1]
N-[4-[2-[4-(1,2-Benzothiazol-3-yl)piperazin-1-yl]ethyl]cyclohexyl]furan-2-carboxamideIC5031.75 [1]
N-[4-[2-[4-(1,2-Benzothiazol-3-yl)piperazin-1-yl]ethyl]cyclohexyl]furan-2-carboxamideKi0.19 [1], 0.23 [2]
N-[4-[2-[4-(6-Chloro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]cyclohexyl]-2-(4-methoxy-4-methylcyclohexyl)acetamideKi14.0 [1], 16.0 [2], 19.0 [3]
PropranololIC505011.87 [1]
PropranololKi419.0 [1]
PromethazineIC5023.0 [1]
PromethazineKi19.0 [1]
MethysergideKi3.83 [1], 10.0 [2]
CisaprideKi1.1 [1], 6.31 [2]
KetotifenKi8.98 [1], 15.85 [2]
PhenethylamineKi16800.0 [1]
5-MethoxytryptamineKi4.8 [1], 300.0 [2]
SertindoleKi0.6 [1], 0.85 [2]
AmoxapineKi0.44 [1], 1.77 [2]
LorcaserinKi1.3 [1], 2782.0 [2]
GR-127935Ki15.85 [1], 42.7 [2]
(R)-3-((2-(2-(4-Methylpiperidin-1-yl)ethyl)pyrrolidin-1-yl)sulfonyl)phenolKi5.0 [1], 10000.0 [2]
AltanserinKi0.13 [1], 0.3 [2]
3-((4-(4-Chlorophenyl)piperazin-1-yl)methyl)-1H-pyrrolo[2,3-b]pyridineKi200.0 [1], 453.0 [2]
5-Chloro-N-(4-methoxy-3-(piperazin-1-yl)phenyl)-3-methylbenzo[b]thiophene-2-sulfonamideKi1740.0 [1], 2511.89 [2]
GlemanserinKi2.5 [1]
5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-carboxamideIC502000.0 [1], 3000.0 [2]
1-(1-Methylindol-5-yl)-3-(3-methyl-1,2-thiazol-5-yl)ureaKi6309.57 [1]
2,5-DimethoxyamphetamineKi211.0 [1], 5200.0 [2]
SB 200646 hydrochlorideKi6309.57 [1]
3-[2-[4-(6-Fluoro-1H-indol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]ethyl]-2lambda6-thia-1,3-diazatricyclo[6.3.1.04,12]dodeca-4,6,8(12)-triene 2,2-dioxideKi0.81 [1]
2,4,5-TrimethoxyamphetamineKi57.9 [1], 1200.0 [2]
N,N-Diallyl-5-methoxytryptamineKi218.0 [1], 549.54 [2]
N-[4-[4-(2-Methoxyphenyl)piperazin-1-yl]butyl]pyrazolo[1,5-a]pyridine-2-carboxamideKi330.0 [1], 430.0 [2]
CID 9820261IC50150.0 [1]
CID 9820261Ki500.0 [1]
(S)-2-(7-Ethyl-1H-furo(2,3-g)indazol-1-yl)-1-methylethylamineKi13.0 [1]
SB 221284Ki398.11 [1]
1,2,3,4-Tetrahydropyrazino[1,2-a]indoleKi635.0 [1], 1040.0 [2]
5-Methoxy-N-methyltryptamineKi4.1 [1], 450.0 [2]
TemanogrelIC505.2 [1]
TemanogrelKi4.9 [1]
3-[4-(4-Fluorobenzoyl)piperidinomethyl]tetralin-1-oneKi1.62 [1], 23.44 [2]
4-(3-(4-Chlorophenyl)-3-hydroxypyrrolidin-1-yl)-1-(4-fluorophenyl)butan-1-oneKi75.8 [1], 241.5 [2]



References

This online tool may be cited as follows

MLA

"Quest Database™ Serotonin 2a (5-HT2a) receptor Inhibitors (IC50, Ki)." AAT Bioquest, Inc.22 Dec2024https://www.aatbio.com/data-sets/serotonin-2a-5-ht2a-receptor-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024December 22). Quest Database™ Serotonin 2a (5-HT2a) receptor Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/serotonin-2a-5-ht2a-receptor-inhibitors-ic50-ki.
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