Serotonin 2 (5-HT2) receptor Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Haloperidol	Ki	16.0 [1], 19.95 [2], 34.0 [3]
	2-Naphthalenecarboxamide, N-(4-(4-(2-methoxyphenyl)-1-piperazinyl)butyl)-	Ki	840.0 [1]
	Clozapine	Ki	5.01 [1], 12.0 [2]
	Cisapride	IC50	6.1 [1]
	3-((4-(4-Chlorophenyl)piperazin-1-yl)methyl)-1H-pyrrolo[2,3-b]pyridine	Ki	200.0 [1], 1000.0 [2]
	4-Amino-5-chloro-N-((hexahydro-1H-pyrrolizin-1-yl)methyl)-2-methoxybenzamide hydrochloride	IC50	10000.0 [1]
	4-Amino-5-chloro-N-((hexahydro-1H-pyrrolizin-1-yl)methyl)-2-methoxybenzamide hydrochloride	Ki	10000.0 [1]
	4-Amino-N-[(4R)-1-azatricyclo[3.3.1.03,7]nonan-4-yl]-5-chloro-2-methoxybenzamide	IC50	10000.0 [1]
	Olanzapine	Ki	10.0 [1]
	Quetiapine	Ki	220.0 [1]
	8-OH-Dpat	Ki	1614.0 [1]
	Zafirlukast	IC50	10000.0 [1]
	Rimcazole	Ki	2482.0 [1]
	DR-4004	Ki	98.0 [1]
	N-[4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]butyl]-1-benzothiophene-2-carboxamide	Ki	2000.0 [1]
	1'-Benzyl-3,4-dihydro-2H-spiro[naphthalene-1,4'-piperidine]	Ki	1934.0 [1]
	N-Desmethylolanzapine	Ki	23.0 [1]
	N-[4-[4-(2-Methoxyphenyl)piperazin-1-yl]butyl]pyrazolo[1,5-a]pyridine-2-carboxamide	Ki	1200.0 [1]
	N-(4-(4-(2-Methoxyphenyl)piperazin-1-yl)butyl)benzo[b]thiophene-2-carboxamide	Ki	350.0 [1]
	N-(4-(4-(2-Methoxyphenyl)piperazin-1-yl)butyl)benzofuran-2-carboxamide	Ki	660.0 [1]
	N-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butyl)benzofuran-2-carboxamide	Ki	11000.0 [1]
	Spipethiane	Ki	7600.0 [1]
	DUP-734 free base	Ki	15.0 [1]
	(1S,13R)-1,13-Dimethyl-10-prop-2-enyl-10-azatricyclo[7.3.1.02,7]trideca-2(7),3,5-trien-4-ol	Ki	10000.0 [1]
	3-Propyl-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indol-9-ol	Ki	1637.0 [1]
	2a-[3-(4-Phenylpiperazin-1-yl)propyl]-1,3,4,5-tetrahydrobenzo[cd]indol-2-one	Ki	16.0 [1]
	N-((Hexahydro-1H-pyrrolizin-1-yl)methyl)-6-chloroimidazo(1,2-a)pyridine-8-carboxamide hydrochloride	IC50	10000.0 [1]
	2-Hydroxymethyl Olanzapine	Ki	18.0 [1]
	N-[4-[4-(2-Methoxyphenyl)piperazin-1-yl]butyl]pyrazolo[1,5-a]pyridine-4-carboxamide	Ki	1600.0 [1]
	N-[4-[4-(2-Methoxyphenyl)piperazin-1-yl]butyl]pyrazolo[1,5-a]pyridine-7-carboxamide	Ki	2000.0 [1]
	N-[4-[4-(2-Methoxyphenyl)piperazin-1-yl]butyl]pyrazolo[1,5-a]pyridine-5-carboxamide	Ki	740.0 [1]
	N-Methyl-2-[2-[4-(2-oxo-1,3,4,5-tetrahydrobenzo[cd]indol-2a-yl)butyl]-3,4-dihydro-1H-pyrido[3,4-b]indol-9-yl]acetamide	Ki	1000.0 [1]
	2-(2-{4-[1-(5-Chloro-thiophen-2-ylmethyl)-1H-indol-3-yl]-piperidin-1-yl}-ethoxy)-benzoic acid	IC50	10000.0 [1]
	3-{4-[1-(5-Chloro-thiophen-2-ylmethyl)-1H-indol-3-yl]-piperidin-1-ylmethyl}-benzoic acid	IC50	10000.0 [1]
	1-[4-(Acetylaminomethyl)benzyl]-4-(2,4-difluorophenyl)piperazine	Ki	1000.0 [1]
	6-Chloro-1'-(2-phenylethyl)spiro[3,4-dihydronaphthalene-2,4'-piperidine]-1-one	Ki	119.0 [1]
	5-{4-[1-(2-Ethoxyethyl)-1H-indol-3-yl]piperidin-1-ylmethyl}-2-methoxybenzoic acid	IC50	10000.0 [1]
	1'-Benzylspiro[3,4-dihydrochromene-2,4'-piperidine]	Ki	10000.0 [1]
	N-[4-[4-(2-Methoxyphenyl)piperazin-1-yl]butyl]pyrazolo[1,5-a]pyridine-6-carboxamide	Ki	950.0 [1]
	N-[4-[4-(2-Methoxyphenyl)piperazin-1-yl]butyl]pyrazolo[1,5-a]pyridine-3-carboxamide	Ki	1300.0 [1]
	2-(2-{4-[1-(2-Ethoxy-ethyl)-1H-indol-3-yl]-piperidin-1-yl}-ethoxy)-benzoic acid	IC50	10000.0 [1]
	2-(2-{4-[1-(2-Ethoxyethyl)-1H-indol-3-yl]piperidin-1-yl}ethoxy)-4-methoxybenzoic acid	IC50	3900.0 [1]
	N-[4-[4-(2-Methoxyphenyl)piperazin-1-yl]butyl]tricyclo[8.2.2.24,7]hexadeca-1(13),4,6,10(14),11,15-hexaene-5-carboxamide	Ki	2300.0 [1]
	1-[4-(Acetylaminomethyl)benzyl]-4-phenylpiperazine	Ki	1000.0 [1]
	5'-Chloro-N,N-dimethylspiro[cyclohex-2-ene-4,2'-tricyclo[9.4.0.03,8]pentadeca-1(15),3(8),4,6,9,11,13-heptaene]-1-amine	Ki	1.3 [1]
	5'-Chloro-N,N-dimethylspiro[cyclohex-2-ene-4,2'-tricyclo[9.4.0.03,8]pentadeca-1(15),3(8),4,6,11,13-hexaene]-1-amine	Ki	30.0 [1]
	1'-(2-Phenylethyl)spiro[3,4-dihydro-1H-naphthalene-2,4'-piperidine]-1-ol	Ki	4.2 [1]
	2-{2-[4-(1-Butyl-1H-indol-3-yl)-piperidin-1-yl]-ethoxy}-benzoic acid	IC50	10000.0 [1]
	4-{4-[1-(2-Ethoxyethyl)-1H-indol-3-yl]piperidin-1-ylmethyl}benzoic acid	IC50	4950.0 [1]
	19-Methoxy-5-methyl-2,5-diazatetracyclo[13.4.0.02,7.08,13]nonadeca-1(15),8,10,12,16,18-hexaene	Ki	56.0 [1]
	2-[1-(4-Tert-Butylbenzyl)-4-piperidinyl]-3,4-dihydronaphthalen-1(2H)-one	Ki	176.0 [1]
	N-[4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]butyl]-1-benzotellurophene-2-carboxamide	Ki	730.0 [1]
	6-Methoxy-2-[1-benzyl-4-piperidinyl]-3,4-dihydronaphthalen-1(2H)-one	Ki	282.0 [1]
	6-Methoxy-2-[1-phenethyl-4-piperidinyl]-3,4-dihydronaphthalen-1(2H)-one	Ki	7.0 [1]
	5-[4-(1-Furan-3-ylmethyl-1H-indol-3-yl)-piperidin-1-ylmethyl]-2-methoxy-benzoic acid	IC50	10000.0 [1]
	2-{2-[4-(1-Furan-3-ylmethyl-1H-indol-3-yl)-piperidin-1-yl]-ethoxy}-benzoic acid	IC50	10000.0 [1]
	(1R,9S,13S)-1,13-Dimethyl-10-(2-piperidin-1-ylethyl)-10-azatricyclo[7.3.1.02,7]trideca-2(7),3,5-trien-4-ol	Ki	10000.0 [1]
	6-Fluoro-2-[1-benzyl-4-piperidinyl]-3,4-dihydronaphthalen-1(2H)-one	Ki	101.0 [1]
	1-[4-[2-Methylphenyl]piperazin-1-yl]-2-[[3-(2-aminoethyl)-1H-indol-5-yl]oxy]ethanone	IC50	10000.0 [1]
	(1R,9S,13S)-1,13-Dimethyl-10-(2-morpholin-4-ylethyl)-10-azatricyclo[7.3.1.02,7]trideca-2(7),3,5-trien-4-ol	Ki	10000.0 [1]
	5-[4-(1-Butyl-1H-indol-3-yl)-piperidin-1-ylmethyl]-2-methoxy-benzoic acid	IC50	10000.0 [1]
	N-[4-[4-(2-Methoxyphenyl)piperazin-1-yl]butyl]-1-benzotellurophene-2-carboxamide	Ki	500.0 [1]
	(1R,9S,13S)-10-[2-(Dimethylamino)ethyl]-1,13-dimethyl-10-azatricyclo[7.3.1.02,7]trideca-2(7),3,5-trien-4-ol	Ki	10000.0 [1]
	1'-Benzylspiro[3,4-dihydrothiochromene-2,4'-piperidine] 1,1-dioxide	Ki	10000.0 [1]
	(1R,9S,13S)-10-[2-(Diethylamino)ethyl]-1,13-dimethyl-10-azatricyclo[7.3.1.02,7]trideca-2(7),3,5-trien-4-ol	Ki	10000.0 [1]
	1'-Benzylspiro[3,4-dihydrothiochromene-2,4'-piperidine] 1-oxide	Ki	10000.0 [1]
	(1R,9S,13S)-10-[2-(Cyclohexylamino)ethyl]-1,13-dimethyl-10-azatricyclo[7.3.1.02,7]trideca-2(7),3,5-trien-4-ol	Ki	10000.0 [1]
	(1R,9S,13S)-10-[2-(Azepan-1-yl)ethyl]-1,13-dimethyl-10-azatricyclo[7.3.1.02,7]trideca-2(7),3,5-trien-4-ol	Ki	10000.0 [1]
	(1R,9S,13S)-1,13-Dimethyl-10-(2-pyrrolidin-1-ylethyl)-10-azatricyclo[7.3.1.02,7]trideca-2(7),3,5-trien-4-ol	Ki	10000.0 [1]
	(7S)-19-Methoxy-5-methyl-2,5-diazatetracyclo[13.4.0.02,7.08,13]nonadeca-1(15),8,10,12,16,18-hexaene	Ki	60.0 [1]
	(7R)-19-Methoxy-5-methyl-2,5-diazatetracyclo[13.4.0.02,7.08,13]nonadeca-1(15),8,10,12,16,18-hexaene	Ki	43.0 [1]
	(1S,7Ar)-hexahydro-1H-pyrrolizin-1-ylmethyl 1H-indazole-3-carboxylate	IC50	10000.0 [1]
	[(1R,8S)-2,3,5,6,7,8-Hexahydro-1H-pyrrolizin-1-yl]methyl 1-methylindazole-3-carboxylate	IC50	10000.0 [1]
	1-[4-(Acetylaminomethyl)benzyl]-4-(4-fluorophenyl)piperazine	Ki	1000.0 [1]
	N-[4-[4-(3-Chloro-2-methoxyphenyl)piperazin-1-yl]butyl]tricyclo[8.2.2.24,7]hexadeca-1(13),4,6,10(14),11,15-hexaene-5-carboxamide	Ki	470.0 [1]
	N-[4-[4-(2-Methoxyphenyl)piperazin-1-yl]butyl]-12-oxatetracyclo[8.5.2.24,7.011,15]nonadeca-1(15),4,6,10,13,16,18-heptaene-13-carboxamide	Ki	2700.0 [1]
	N-[4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]butyl]tricyclo[8.2.2.24,7]hexadeca-1(13),4,6,10(14),11,15-hexaene-5-carboxamide	Ki	3500.0 [1]
	N-[4-[4-(2,3-Difluorophenyl)piperazin-1-yl]butyl]tricyclo[8.2.2.24,7]hexadeca-1(13),4,6,10(14),11,15-hexaene-5-carboxamide	Ki	1200.0 [1]
	4-{4-[4-(4-Phenyl-piperazin-1-yl)-butyl]-phenyl}-thiazol-2-ylamine	Ki	37.0 [1]
	Methyl 2-[(4-ethoxycarbonylpiperidin-1-yl)methyl]-3,7-dihydro-2H-[1,4]dioxino[2,3-e]indole-8-carboxylate	Ki	170.0 [1]
	Methyl 2-[(4-anilino-4-carbamoylpiperidin-1-yl)methyl]-3,7-dihydro-2H-[1,4]dioxino[2,3-e]indole-8-carboxylate	Ki	171.0 [1]
	2-[(4-Oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)methyl]-3,7-dihydro-2H-[1,4]dioxino[2,3-e]indole-8-carboxylic acid	Ki	1722.0 [1]
	2-[(4-Oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)methyl]-3,7-dihydro-2H-[1,4]dioxino[2,3-e]indole-8-carboxamide	Ki	1722.0 [1]
	Butyl 2-[(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)methyl]-3,7-dihydro-2H-[1,4]dioxino[2,3-e]indole-8-carboxylate	Ki	92.6 [1]
	Benzyl 2-[(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)methyl]-3,7-dihydro-2H-[1,4]dioxino[2,3-e]indole-8-carboxylate	Ki	143.0 [1]
	N-(3-Phenylpropyl)-2-[(3-phenylpropylamino)methyl]-3,7-dihydro-2H-[1,4]dioxino[2,3-e]indole-8-carboxamide	Ki	27.6 [1]
	8-[[8-(Hydroxymethyl)-3,7-dihydro-2H-[1,4]dioxino[2,3-e]indol-2-yl]methyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one	Ki	1722.0 [1]
	4-(6-(18F)Fluoranylpyridin-2-yl)-N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]benzamide	Ki	450.0 [1]
	4-(6-(18F)Fluoranylpyridin-3-yl)-N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]benzamide	Ki	760.0 [1]
	3-[4-(1-Furan-3-ylmethyl-1H-indol-3-yl)-piperidin-1-ylmethyl]-benzoic acid	IC50	10000.0 [1]
	1-[4-(Acetylaminomethyl)benzyl]-4-(4-chlorophenyl)piperazine	Ki	1000.0 [1]
	1-[4-(Acetylaminomethyl)benzyl]-4-(4-methoxyphenyl)piperazine	Ki	1000.0 [1]
	N,N-Dimethyl-2-[(Z)-(3-methylthieno[2,3-b]pyrrolizin-8-ylidene)amino]oxyethanamine	IC50	3162.28 [1]
	1-[4-(Acetylaminomethyl)phenethyl]-4-phenylpiperazine	Ki	130.0 [1]
	4-Amino-N-(1-azatricyclo[3.3.1.13,7]decan-4-yl)-5-chloro-2-methoxybenzamide	IC50	10000.0 [1]
	(6S,7R)-6-Methyl-N,N-dipropyl-6,7,8,9-tetrahydrobenzo[g][1]benzofuran-7-amine	Ki	70.0 [1]
	Methyl 2-[[4-(2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]methyl]-3,7-dihydro-2H-[1,4]dioxino[2,3-e]indole-8-carboxylate	Ki	31.6 [1]
	2-[1-[(4-Methylphenyl)methyl]piperidin-4-yl]-3,4-dihydro-2H-naphthalen-1-one;hydrate	Ki	52.0 [1]
	2-Hydroxybutanedioic acid;1'-(naphthalen-2-ylmethyl)spiro[3,4-dihydronaphthalene-2,4'-piperidine]-1-one	Ki	1969.0 [1]
	2-Hydroxybutanedioic acid;1'-[[4-(trifluoromethyl)phenyl]methyl]spiro[3,4-dihydronaphthalene-2,4'-piperidine]-1-one	Ki	6336.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Serotonin 2 (5-HT2) receptor Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/serotonin-2-5-ht2-receptor-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 20). Quest Database™ Serotonin 2 (5-HT2) receptor Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/serotonin-2-5-ht2-receptor-inhibitors-ic50-ki.
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