Serotonin 1f (5-HT1f) receptor Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	4-Fluoro-N-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]benzamide	Ki	1.6 [1], 2.1 [2]
	Sumatriptan	IC50	1000.0 [1]
	Sumatriptan	Ki	25.7 [1]
	5-Chloro-N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-3-methyl-1-benzothiophene-2-sulfonamide	Ki	251.19 [1]
	4-Fluoro-N-[3-(1-methyl-piperidin-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl]-benzamide	Ki	7.6 [1]
	(R)-3-((2-(2-(4-Methylpiperidin-1-yl)ethyl)pyrrolidin-1-yl)sulfonyl)phenol	Ki	3162.28 [1]
	SB 224289	Ki	10000.0 [1]
	5-Chloro-N-(4-methoxy-3-(piperazin-1-yl)phenyl)-3-methylbenzo[b]thiophene-2-sulfonamide	Ki	1000.0 [1]
	2-[1-(Benzenesulfonyl)-5-methoxyindol-3-yl]-N,N-dimethylethanamine	Ki	2500.0 [1]
	N,3-Dimethyl-N-[(2R)-4-(4-methylpiperidin-1-yl)butan-2-yl]benzenesulfonamide	Ki	6309.57 [1]
	1-(3-(5-(1,2,4-Triazol-4-yl)-1H-indol-3-yl)propyl)-4-(2-(3-fluorophenyl)ethyl)piperazine	IC50	3800.0 [1]
	N-(2,5-Dibromo-3-fluorophenyl)-4-methoxy-3-piperazin-1-ylbenzenesulfonamide	Ki	10000.0 [1]
	4-Methyl-1-[2-[(2R)-1-(3-methylphenyl)sulfonylpyrrolidin-2-yl]ethyl]piperidine	Ki	10000.0 [1]
	[2-(1-Benzenesulfonyl-1H-indol-3-yl)-ethyl]-dimethyl-amine	Ki	770.0 [1]
	CID 10028436	Ki	1995.26 [1]
	CID 10436045	Ki	3.16 [1]
	CID 9847194	IC50	10000.0 [1]
	4-Bromo-N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]benzenesulfonamide	Ki	316.23 [1]
	1-(Phenylsulfonyl)-4-[2-(dimethylamino)ethyl]-1H-indole	Ki	3.9 [1]
	N-[3-[(8As)-3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]-4-methoxyphenyl]-5-chloro-3-methyl-1-benzothiophene-2-sulfonamide	Ki	316.23 [1]
	(2R)-1-(1-Naphthylsulfonyl)-2-[2-(4-methylpiperidino)ethyl]pyrrolidine	Ki	10000.0 [1]
	2-Methyl-5-(2-(4-(quinolin-8-ylmethyl)piperazin-1-yl)ethoxy)quinoline	Ki	1995.26 [1]
	N-(3-(1-(2-(2-Methylquinolin-5-yloxy)ethyl)piperidin-4-ylmethyl)phenyl)methanesulfonamide	Ki	501.19 [1]
	6-Iodo-1-indolinyl 3-piperazino-4-methoxyphenyl sulfone	Ki	7943.28 [1]
	N-[3-(1-Methyl-piperidin-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl]-acetamide	Ki	5.0 [1]
	3-(2-Dimethylamino-ethyl)-1H-indole-2-carboxylic acid ethyl ester	Ki	2000.0 [1]
	Benzamide,N-[(3S)-1-[[3-bromo-4-(4-piperidinyloxy)phenyl]methyl]-3-pyrrolidinyl]-3,4-dichloro-	Ki	7200.0 [1]
	1-(2-Iodophenyl)-N-[3-[[(2R)-pyrrolidin-2-yl]methyl]-1H-indol-5-yl]methanesulfonamide	Ki	17.8 [1]
	7-[2-[2-(3-Chlorophenyl)ethylamino]ethyl]quinolin-2-Amine	Ki	100.0 [1]
	N-[3-(2-Dimethylamino-ethyl)-2-methyl-1H-indol-5-yl]-4-fluoro-benzamide	Ki	8.2 [1]
	4-Fluoro-N-[3-(1-methyl-piperidin-4-yl)-furo[3,2-b]pyridin-5-yl]-benzamide	Ki	3.1 [1]
	2-[2-[4-(5-Fluoro-2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]ethyl]-4,5-dihydro-3H-2-benzazepin-1-one	Ki	10000.0 [1]
	N-[3-[(8Ar)-3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]-4-methoxyphenyl]-5-chloro-3-methyl-1-benzothiophene-2-sulfonamide	Ki	199.53 [1]
	N-[3-(1-Methyl-piperidin-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl]-propionamide	Ki	5.5 [1]
	2,4,6-Trifluoro-N-[3-(1-methyl-piperidin-4-yl)-furo[3,2-b]pyridin-5-yl]-benzamide	Ki	2.3 [1]
	5-Methoxy-3-(1-methyl-piperidin-4-yl)-1H-pyrrolo[3,2-b]pyridine	Ki	23.0 [1]
	3-(1-Methyl-piperidin-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-ylamine	Ki	100.0 [1]
	3-(1-Methyl-piperidin-4-yl)-1,4-dihydro-pyrrolo[3,2-b]pyridin-5-one	Ki	100.0 [1]
	(E)-3-(3,4-Dichlorophenyl)-N-[4-[[(1R,5S)-3-(5-hydroxy-1H-indol-3-yl)-8-azabicyclo[3.2.1]octan-8-yl]methyl]cyclohexyl]prop-2-enamide	Ki	3162.28 [1]
	4-Fluoro-N-[6-(1-methylpiperidine-4-carbonyl)pyridin-2-yl]benzamide	Ki	9.5 [1]
	N-(2,5-Dibromophenyl)-4-methoxy-3-piperazin-1-ylbenzenesulfonamide	Ki	10000.0 [1]
	4-Methoxy-3-piperazin-1-yl-N-(2,3,5-trichlorophenyl)benzenesulfonamide	Ki	10000.0 [1]
	(2R)-1-(3-Bromophenylsulfonyl)-2-[2-(4-methylpiperidino)ethyl]pyrrolidine	Ki	5011.87 [1]
	(2R)-1-(1-Naphthylsulfonyl)-2-[2-(4-methylpiperidino)ethyl]piperidine	Ki	10000.0 [1]
	(2R)-1-(3,4-Dichlorophenylsulfonyl)-2-[2-(4-methylpiperidino)ethyl]pyrrolidine	Ki	3162.28 [1]
	4-Fluoro-N-[3-(1-isopropyl-piperidin-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl]-benzamide	Ki	30.0 [1]
	N-[3-(1-Methyl-piperidin-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl]-4-nitro-benzamide	Ki	7.7 [1]
	4-Fluoro-N-[3-(1-phenethyl-piperidin-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl]-benzamide	Ki	75.0 [1]
	N-[3-(1-Ethyl-1,2,3,6-tetrahydro-pyridin-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl]-acetamide	Ki	21.0 [1]
	N-[7-(1-Methylpiperidin-4-yl)-5H-pyrrolo[3,2-d]pyrimidin-2-yl]acetamide	Ki	220.0 [1]
	4-Fluoro-N-[3-(1-methylpiperidin-4-yl)-1H-pyrrolo[2,3-c]pyridin-5-yl]benzamide	Ki	13.0 [1]
	3-Cyano-N-[3-(1-methyl-piperidin-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl]-benzamide	Ki	11.0 [1]
	N-[3-(1-Methylpiperidin-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl]pentanamide	Ki	14.0 [1]
	N-[3-(1-Methylpiperidin-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl]furan-2-carboxamide	Ki	13.0 [1]
	3-Methyl-N-[3-(1-methyl-piperidin-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl]-benzamide	Ki	5.8 [1]
	N-(3-Piperidin-4-yl-1H-pyrrolo[3,2-b]pyridin-5-yl)-acetamide	Ki	45.0 [1]
	N-(3-Piperidin-4-yl-1H-pyrrolo[3,2-b]pyridin-5-yl)-propionamide	Ki	35.0 [1]
	N-[3-(1-Methylpiperidin-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl]cyclobutanecarboxamide	Ki	8.7 [1]
	4-Fluoro-N-[3-(1-propyl-piperidin-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl]-benzamide	Ki	18.0 [1]
	1-(4-Fluoro-phenyl)-3-[3-(1-methyl-piperidin-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl]-urea	Ki	11.0 [1]
	2,4-Dichloro-N-[3-(1-methyl-piperidin-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl]-benzamide	Ki	4.1 [1]
	N-[3-(1-Methylpiperidin-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl]hexanamide	Ki	13.0 [1]
	N-[3-(2-Dimethylamino-ethyl)-2-methyl-furo[3,2-b]pyridin-5-yl]-4-fluoro-benzamide	Ki	13.5 [1]
	N-[3-(1-Methyl-piperidin-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl]-2-nitro-benzamide	Ki	19.0 [1]
	N-[3-(1-Methylpiperidin-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl]cyclopropanecarboxamide	Ki	9.8 [1]
	N-[3-(1-Ethyl-1,2,3,6-tetrahydro-pyridin-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl]-4-fluoro-benzamide	Ki	25.0 [1]
	4-Fluoro-N-[7-(1-methylpiperidin-4-yl)-5H-pyrrolo[3,2-d]pyrimidin-2-yl]benzamide	Ki	67.0 [1]
	2-Methyl-N-[3-(1-methyl-piperidin-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl]-benzamide	Ki	12.0 [1]
	N-[3-(1-Methylpiperidin-4-yl)-1H-pyrrolo[2,3-c]pyridin-5-yl]acetamide	Ki	210.0 [1]
	N-[3-(1-Methyl-piperidin-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl]-butyramide	Ki	6.9 [1]
	N-[3-(1-Methylpiperidin-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl]thiophene-3-carboxamide	Ki	7.4 [1]
	N-[3-(1-Methyl-piperidin-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl]-3-nitro-benzamide	Ki	42.0 [1]
	N-[3-(1-Methylpiperidin-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl]thiophene-2-carboxamide	Ki	7.1 [1]
	N-[3-(1-Methyl-piperidin-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl]-benzamide	Ki	7.3 [1]
	4-Methyl-N-[3-(1-methyl-piperidin-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl]-benzamide	Ki	12.0 [1]
	3-Methoxy-N-[3-(1-methyl-piperidin-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl]-benzamide	Ki	16.0 [1]
	N-[3-(1-Butyl-piperidin-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl]-4-fluoro-benzamide	Ki	14.0 [1]
	1-Methyl-3-[3-(1-methyl-piperidin-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl]-urea	Ki	2.5 [1]
	4-Fluoro-N-(3-piperidin-4-yl-1H-pyrrolo[3,2-b]pyridin-5-yl)-benzamide	Ki	9.5 [1]
	[3-(1-Methylpiperidin-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl] 4-fluorobenzenesulfonate	Ki	7.5 [1]
	N-[3-(1-Methylpiperidin-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl]pyridine-2-carboxamide	Ki	6.3 [1]
	2-Methoxy-N-[3-(1-methyl-piperidin-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl]-benzamide	Ki	20.0 [1]
	N-[3-(1-Methylpiperidin-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl]furan-3-carboxamide	Ki	4.6 [1]
	2-Fluoro-N-[3-(1-methyl-piperidin-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl]-benzamide	Ki	19.0 [1]
	N-[3-(1-Ethyl-piperidin-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl]-4-fluoro-benzamide	Ki	170.0 [1]
	2,2-Dimethyl-N-[3-(1-methyl-piperidin-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl]-propionamide	Ki	62.0 [1]
	2-Chloro-N-[3-[[(2R)-1-methylpyrrolidin-2-yl]methyl]-1H-indol-5-yl]benzenesulfonamide	Ki	16.0 [1]
	2-Chloro-N-[3-[[(2R)-pyrrolidin-2-yl]methyl]-1H-indol-5-yl]benzenesulfonamide	Ki	12.3 [1]
	2-Chloro-4-fluoro-N-[3-(1-methylpiperidin-4-yl)-1,2-benzoxazol-5-yl]benzamide	Ki	3.6 [1]
	3-Chloro-N-[3-[[(2R)-1-methylpyrrolidin-2-yl]methyl]-1H-indol-5-yl]benzenesulfonamide	Ki	2.7 [1]
	1-[2-Hydroxy-3-methyl-4-[[4-[4-(2H-tetrazol-5-yl)pyridin-2-yl]oxyphenyl]methoxy]phenyl]ethanone	Ki	2970000.0 [1]
	N-[3-(1-Methylpiperidin-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl]cyclopentanecarboxamide	Ki	11.0 [1]
	N-[3-(1-Methylpiperidin-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl]octanamide	Ki	20.0 [1]
	N-[3-(1-Methyl-piperidin-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl]-isonicotinamide	Ki	8.4 [1]
	4-Fluoro-N-[3-(1-methylpiperidin-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl]benzenesulfonamide	Ki	27.0 [1]
	1-Ethyl-3-[3-(1-methyl-piperidin-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl]-urea	Ki	3.8 [1]
	[3-(1-Methylpiperidin-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl] methanesulfonate	Ki	4.7 [1]
	3-Fluoro-N-[3-(1-methyl-piperidin-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl]-benzamide	Ki	11.0 [1]
	N-[3-(1-Methylpiperidin-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl]methanesulfonamide	Ki	19.0 [1]
	N-[3-(1-Methylpiperidin-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl]cyclohexanecarboxamide	Ki	20.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Serotonin 1f (5-HT1f) receptor Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/serotonin-1f-5-ht1f-receptor-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 20). Quest Database™ Serotonin 1f (5-HT1f) receptor Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/serotonin-1f-5-ht1f-receptor-inhibitors-ic50-ki.
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