Serotonin 1e (5-HT1e) receptor Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Serotonin	Ki	4.0 [1], 11.0 [2]
	N,N-Diallyl-5-methoxytryptamine	Ki	416.87 [1], 501.19 [2]
	5-Chloro-N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-3-methyl-1-benzothiophene-2-sulfonamide	Ki	2511.89 [1]
	3-[4-[7-[[4-(5-Carbamoyl-1H-indol-3-yl)cyclohex-3-en-1-yl]amino]heptylamino]cyclohexen-1-yl]-1H-indole-5-carboxamide	IC50	99.0 [1]
	Clozapine	Ki	1000.0 [1]
	Risperidone	Ki	1000.0 [1]
	Olanzapine	Ki	1000.0 [1]
	Quetiapine	Ki	1000.0 [1]
	Lysergide	Ki	93.0 [1]
	Aripiprazole	Ki	1000.0 [1]
	Sumatriptan	IC50	5500.0 [1]
	alpha-Methyl-5-HT	Ki	10000.0 [1]
	2-Methyl-5-hydroxytryptamine	Ki	10000.0 [1]
	(R)-3-((2-(2-(4-Methylpiperidin-1-yl)ethyl)pyrrolidin-1-yl)sulfonyl)phenol	Ki	6309.57 [1]
	3-((4-(4-Chlorophenyl)piperazin-1-yl)methyl)-1H-pyrrolo[2,3-b]pyridine	Ki	10000.0 [1]
	Benzo(1,2-b:4,5-b')dipyrrole-1(2H)-carboxamide, 3,5-dihydro-5-methyl-N-3-pyridinyl-	Ki	5011.87 [1]
	SB 224289	Ki	10000.0 [1]
	alpha-Methyltryptamine	Ki	1905.46 [1]
	5-Chloro-N-(4-methoxy-3-(piperazin-1-yl)phenyl)-3-methylbenzo[b]thiophene-2-sulfonamide	Ki	10000.0 [1]
	SB 204070 hydrochloride	Ki	10000.0 [1]
	1-(1-Methylindol-5-yl)-3-(3-methyl-1,2-thiazol-5-yl)urea	Ki	100000.0 [1]
	2-[1-(Benzenesulfonyl)-5-methoxyindol-3-yl]-N,N-dimethylethanamine	Ki	4220.0 [1]
	Piboserod	Ki	10000.0 [1]
	N,3-Dimethyl-N-[(2R)-4-(4-methylpiperidin-1-yl)butan-2-yl]benzenesulfonamide	Ki	15848.93 [1]
	2-Ethyl-5-methoxy-N,N-dimethyltryptamine	Ki	520.0 [1]
	Benzonitrile, 3-fluoro-5-(2-(2-(fluoromethyl)-4-thiazolyl)ethynyl)-	Ki	10000.0 [1]
	1-(3-(5-(1,2,4-Triazol-4-yl)-1H-indol-3-yl)propyl)-4-(2-(3-fluorophenyl)ethyl)piperazine	IC50	10000.0 [1]
	N-(2,5-Dibromo-3-fluorophenyl)-4-methoxy-3-piperazin-1-ylbenzenesulfonamide	Ki	10000.0 [1]
	4-Methyl-1-[2-[(2R)-1-(3-methylphenyl)sulfonylpyrrolidin-2-yl]ethyl]piperidine	Ki	10000.0 [1]
	2-Phenethyl-5-hydroxychromone	Ki	10000.0 [1]
	CID 10028436	Ki	5011.87 [1]
	1H-Indole-3-ethanamine, 5-methoxy-N,N-dimethyl-2-phenyl-	Ki	10000.0 [1]
	CID 10436045	Ki	6.31 [1]
	Methylaplysinopsin	Ki	10000.0 [1]
	Thalictruberine	Ki	10000.0 [1]
	CID 9847194	IC50	10000.0 [1]
	N~2~-(3-Bromophenyl)-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine	Ki	10000.0 [1]
	Indole, 3-(2-(dimethylamino)ethyl)-5-methoxy-2-methyl-	Ki	1800.0 [1]
	4-Bromo-N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]benzenesulfonamide	Ki	1584.89 [1]
	N-[3-[(8As)-3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]-4-methoxyphenyl]-5-chloro-3-methyl-1-benzothiophene-2-sulfonamide	Ki	1584.89 [1]
	(2R)-1-(1-Naphthylsulfonyl)-2-[2-(4-methylpiperidino)ethyl]pyrrolidine	Ki	10000.0 [1]
	2-Methyl-5-(2-(4-(quinolin-8-ylmethyl)piperazin-1-yl)ethoxy)quinoline	Ki	10000.0 [1]
	2-Amino-5-[(Z)-indol-3-ylidenemethyl]-3-methylimidazol-4-ol	Ki	10000.0 [1]
	2-Amino-5-[(E)-(5-bromoindol-3-ylidene)methyl]-1-methylimidazol-4-ol	Ki	10000.0 [1]
	Watasemycin A	Ki	10000.0 [1]
	Watasemycin B	Ki	10000.0 [1]
	2-(2-Hydroxyphenyl)-4-thiazolecarbaldehyde	Ki	10000.0 [1]
	N-(3-(1-(2-(2-Methylquinolin-5-yloxy)ethyl)piperidin-4-ylmethyl)phenyl)methanesulfonamide	Ki	2511.89 [1]
	Ethyl 3-[(4-amino-1,3,5-triazaspiro[5.5]undeca-2,4-dien-2-yl)amino]benzoate	Ki	10000.0 [1]
	3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonitrile	Ki	10000.0 [1]
	2-(5-Methoxy-2-methyl-1H-indol-3-yl)ethanamine	Ki	10000.0 [1]
	4-Fluoro-N-[3-(1-methyl-piperidin-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl]-benzamide	Ki	660.0 [1]
	6-Iodo-1-indolinyl 3-piperazino-4-methoxyphenyl sulfone	Ki	10000.0 [1]
	4-N-(3-Bromophenyl)-1,3,5-triazaspiro[5.5]undeca-1,4-diene-2,4-diamine	Ki	10000.0 [1]
	2-[4-[4-(3-Methoxyphenyl)piperazin-1-yl]butyl]-4-methyl-1,2,4-triazine-3,5-dione	Ki	10000.0 [1]
	5-[(Z)-Indol-3-ylidenemethyl]-3-methyl-2-(methylamino)imidazol-4-ol	Ki	10000.0 [1]
	5-[(Z)-(6-Bromoindol-3-ylidene)methyl]-3-methyl-2-(methylamino)imidazol-4-ol	Ki	10000.0 [1]
	Pulicatin A	Ki	10000.0 [1]
	Pulicatin B	Ki	10.0 [1]
	Aerugine	Ki	10000.0 [1]
	Pulicatin G	Ki	10000.0 [1]
	Pulicatin F	Ki	10000.0 [1]
	2-Amino-5-[(Z)-(7-bromoindol-3-ylidene)methyl]-3-methylimidazol-4-ol	Ki	10000.0 [1]
	5-[(Z)-(7-Bromoindol-3-ylidene)methyl]-1-methyl-2-(methylamino)imidazol-4-ol	Ki	10000.0 [1]
	5-[(Z)-(4-Bromoindol-3-ylidene)methyl]-2-imino-1,3-dimethylimidazol-4-ol	Ki	10000.0 [1]
	5-[(Z)-(7-Bromoindol-3-ylidene)methyl]-2-imino-1,3-dimethylimidazol-4-ol	Ki	10000.0 [1]
	5-[(Z)-(7-Bromoindol-3-ylidene)methyl]-3-methyl-2-(methylamino)imidazol-4-ol	Ki	10000.0 [1]
	5-[(Z)-(4-Bromoindol-3-ylidene)methyl]-1,3-dimethyl-2-methyliminoimidazol-4-ol	Ki	10000.0 [1]
	2-Amino-5-[(Z)-(6-bromoindol-3-ylidene)methyl]-1H-imidazol-4-ol	Ki	10000.0 [1]
	2-Amino-5-[(Z)-(7-bromoindol-3-ylidene)methyl]-1H-imidazol-4-ol	Ki	10000.0 [1]
	2-Amino-5-[(Z)-(7-bromoindol-3-ylidene)methyl]-1-methylimidazol-4-ol	Ki	10000.0 [1]
	4-Fluoro-N-methyl-N-(4-(6-(methylamino)pyrimidin-4-yl)-1,3-thiazol-2-yl)benzamide	Ki	10000.0 [1]
	Benzamide,N-[(3S)-1-[[3-bromo-4-(4-piperidinyloxy)phenyl]methyl]-3-pyrrolidinyl]-3,4-dichloro-	Ki	10000.0 [1]
	(1-(4-Fluorophenethyl)piperidin-4-yl)(3-(2-fluoroethoxy)-2-methoxyphenyl)methanol	Ki	10000.0 [1]
	(1-Butylpiperidin-4-yl)methyl 4-amino-3-methoxybenzoate	Ki	10000.0 [1]
	7-Fluoro-5-[(1-propylpiperidin-4-yl)methoxy]benzo[h][1,6]naphthyridine	Ki	10000.0 [1]
	4-Fluoro-6-[(1-propylpiperidin-4-yl)methoxy]phenanthridine	Ki	10000.0 [1]
	7-[2-[2-(3-Chlorophenyl)ethylamino]ethyl]quinolin-2-Amine	Ki	100.0 [1]
	5-Methyl-1,5-diazapentacyclo[10.8.1.02,7.08,21.013,18]henicosa-2(7),8(21),9,11,13,15,17-heptaene	Ki	10000.0 [1]
	2-[2-[4-(5-Fluoro-2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]ethyl]-4,5-dihydro-3H-2-benzazepin-1-one	Ki	10000.0 [1]
	3-[4-(4-Methoxyphenyl)piperazinomethyl]-1H-pyrrolo[2,3-b]pyridine	Ki	10000.0 [1]
	(4-Fluorophenyl)(2-(2-((2R)-2-methyl-1-pyrrolidinyl)ethyl)-1-benzofuran-5-yl)methanone	Ki	10000.0 [1]
	N-[3-[(8Ar)-3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]-4-methoxyphenyl]-5-chloro-3-methyl-1-benzothiophene-2-sulfonamide	Ki	1000.0 [1]
	N-[3-(1-Methyl-piperidin-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl]-propionamide	Ki	770.0 [1]
	3-[4-(4-Methylsulfanyl-phenyl)-piperazin-1-ylmethyl]-1H-pyrrolo[2,3-b]pyridine	Ki	10000.0 [1]
	(E)-3-(3,4-Dichlorophenyl)-N-[4-[[(1R,5S)-3-(5-hydroxy-1H-indol-3-yl)-8-azabicyclo[3.2.1]octan-8-yl]methyl]cyclohexyl]prop-2-enamide	Ki	6309.57 [1]
	3-[4-(4-Fluoro-phenyl)-piperazin-1-ylmethyl]-1H-pyrrolo[2,3-b]pyridine	Ki	10000.0 [1]
	3-{[4-(2-Methoxyphenyl)-1-piperazinyl]methyl}-1H-pyrrolo[2,3-b]pyridine	Ki	10000.0 [1]
	N-(2,5-Dibromophenyl)-4-methoxy-3-piperazin-1-ylbenzenesulfonamide	Ki	10000.0 [1]
	4-Methoxy-3-piperazin-1-yl-N-(2,3,5-trichlorophenyl)benzenesulfonamide	Ki	10000.0 [1]
	Lysergic acid 2,4-dimethylazetidide	Ki	280.0 [1]
	(2R)-1-(3-Bromophenylsulfonyl)-2-[2-(4-methylpiperidino)ethyl]pyrrolidine	Ki	2511.89 [1]
	(2R)-1-(1-Naphthylsulfonyl)-2-[2-(4-methylpiperidino)ethyl]piperidine	Ki	10000.0 [1]
	(2R)-1-(3,4-Dichlorophenylsulfonyl)-2-[2-(4-methylpiperidino)ethyl]pyrrolidine	Ki	2511.89 [1]
	[(2S,4R)-2,4-Dimethylazetidin-1-yl]-[(9R)-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinolin-9-yl]methanone	Ki	200.0 [1]
	[(2R,4R)-2,4-Dimethylazetidin-1-yl]-[(9R)-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinolin-9-yl]methanone	Ki	140.0 [1]
	1-[2-Hydroxy-3-methyl-4-[[4-[4-(2H-tetrazol-5-yl)pyridin-2-yl]oxyphenyl]methoxy]phenyl]ethanone	Ki	5370000.0 [1]
	Ethyl 3-[[4-(dimethylamino)-1,3,5-triazaspiro[5.5]undeca-1,4-dien-2-yl]amino]benzoate	Ki	10000.0 [1]
	3-[(2-Amino-1,3,5-triazaspiro[5.5]undeca-1,4-dien-4-yl)amino]-N-ethylbenzamide	Ki	10000.0 [1]
	3-(5-(4-Tert-butylphenyl)-3-((dimethylamino)methyl)-1H-1,2,4-triazol-1-yl)phenol	IC50	10000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Serotonin 1e (5-HT1e) receptor Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Dec. 2024, https://www.aatbio.com/data-sets/serotonin-1e-5-ht1e-receptor-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, December 21). Quest Database™ Serotonin 1e (5-HT1e) receptor Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/serotonin-1e-5-ht1e-receptor-inhibitors-ic50-ki.
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